Highlights on Gold TADF complexes

AEI/FEDER, UE Project CTQ2016-76120-P Project PTDC/QUI-QFI/32007/2017Thermally activated delayed fluorescence (TADF) and TADF-organic light-emitting diodes (OLEDs) systems are being given increasing attention in research nowadays. Much more work has been done for organic-based materials in this field, but the use of TADF organometallic systems has also emerged in recent years. In particular, TADF-based gold compounds have not been particularly well-explored, with a higher number of examples of Au(I)-molecules and fewer for the higher oxidation state Au(III) derivatives. Nevertheless, the novelty and observed results deserve attention. A careful analysis has been performed in this review by classifying the reported compounds into two different groups regarding the oxidation state of the metal, and within each group, the ancillary ligands. Specific examples to illustrate their potential applications are included in the different section.publishersversionpublishe

Florística e síndromes de polinização de leguminosae da microrregião de Foz do Iguaçu

Anais do VI Encontro de Iniciação Científica e II Encontro Anual de Iniciação ao Desenvolvimento Tecnológico e Inovação – EICTI 2017 - 04 a 06 de outubro de 2017 - temática Ciências BiológicasNa Flora do Brasil, Leguminosae é a família mais abundante (Forzza et al. 2010) em número de espécies, com 210 gêneros reunidos em 2.694 espécies nativas, dentre as quais 1.458 são endêmicas, sendo bem representada em todos os biomas brasileiros, inclusive na Mata Atlântica (Mendonça et al. 2008; Lima et al. 2009; Lima et al. 2013), onde se encontra inserido o Parque Nacional do Iguaçu(PNI). A microrregião de Foz do Iguaçu, está localizada numa área de transição entre a Floresta Estacional Semidecidual e a Floresta Ombrófila Mista (Veloso et al. 1991; IBGE 1992). O conhecimento da flora e o estudo das interações das plantas com os animais (exemplo: polinização) são fundamentais para a compreensão da estrutura da comunidade e seu processo de regeneração, constituindo importantes ferramentas para a conservação (Jordano et al. 2006). Neste sentido nosso trabalho teve como objetivo realizar um levantamento florístico das Leguminosas do PNI e estudar seus síndromes de polinização, determinando nossos objetivos específicos como: Inventariar gêneros e espécies de Leguminosae ocorrentes na região, fornecer descrições sobre a morfologia floral e as síndromes de polinização e contribuir para a Flora de Leguminosae do ParanáUniversidade Federal da Integração Latino-Americana (Unila); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação Araucária; Parque Tecnológico Itaipu (PTI) e Companhia de Saneamento do Paraná (SANEPAR

Supramolecular Gold Metallogelators: The Key Role of Metallophilic Interactions

Gold metallogelators is an emerging area of research. The number of results published in the literature is still scarce. The majority of these gels is observed in organic solvents, and the potential applications are still to be explored. In this work, we present an overview about gold metallogelators divided in two different groups depending on the type of solvent used in the gelation process (organogelators and hydrogelators). A careful analysis of the data shows that aurophilic interactions are a common motif directly involved in gelation involving Au(I) complexes. There are also some Au(III) derivatives able to produce gels but in this case the organic ligands determine the aggregation process. A last section is included about the potential applications that have been reported until now with this new and amazing class of supramolecular assemblies

An investigation of genetic algorithm-based feature selection techniques applied to keystroke dynamics biometrics

Due to the continuous use of social networks, users can be vulnerable to online situations such as paedophilia treats. One of the ways to do the investigation of an alleged pedophile is to verify the legitimacy of the genre that it claims. One possible technique to adopt is keystroke dynamics analysis. However, this technique can extract many attributes, causing a negative impact on the accuracy of the classifier due to the presence of redundant and irrelevant attributes. Thus, this work using the wrapper approach in features selection using genetic algorithms and as KNN, SVM and Naive Bayes classifiers. Bringing as best result the SVM classifier with 90% accuracy, identifying what is most suitable for both bases

Neglect paves the way for dispossession: The politics of “last frontiers” in Brazil and Myanmar

A convergence of factors creates a worrisome contemporary pattern of resource dispossession of local populations in developing countries. Growing market demand for commodities, states’ interest in expanding their fiscally fertile territories, and environmental conservation pressures have promoted resource frontiers, where locals all too frequently lose access to land, water and livelihoods. To add momentum and legitimize outsiders’ agendas, such locations are sometimes framed as “last frontiers” – the final places of possibility. While various forms of resource “grabbing” have gained increased attention, we argue that a crucial dimension of frontier dynamics – neglect and its role in facilitating dispossession – warrants further study as it tends to be overlooked. Drawing on the frontiers and political ecology literature, this article analyzes how neglect by state authorities, markets, and environmental organizations paves the way for dispossession in those landscapes. We compare two cases: the Matopiba soy frontier in the savannas of Brazil\u27s Cerrado and the Chin Hills of western Myanmar. Our results show how neglect is critical to imaginatively frame regions as “empty” places of possibility, excluding local actors economically from development and politically from governance initiatives. We argue that neglect not only precedes but is an enduring feature of resource frontiers, and identify four consecutive phases: (I) pre-frontier abandonment, (II) selective support to outsiders, (III) overlooked harms to communities, and (IV) socially exclusive sustainability agendas. As environmental concerns gain increasing global salience, Phase I sometimes leaps to Phase IV as international actors pounce to control what they regard as “last frontiers” for conservation. We conclude that external actors’ inaction enables local communities’ dispossession as much as their actions. This raises critical policy and scholarly questions about actors\u27 responsibility and accountability, not only for harms done but also for systematically failing to heed local actors’ aspirations and needs

Highlights on gold TADF complexes

Thermally activated delayed fluorescence (TADF) and TADF-organic light-emitting diodes (OLEDs) systems are being given increasing attention in research nowadays. Much more work has been done for organic-based materials in this field, but the use of TADF organometallic systems has also emerged in recent years. In particular, TADF-based gold compounds have not been particularly well-explored, with a higher number of examples of Au(I)-molecules and fewer for the higher oxidation state Au(III) derivatives. Nevertheless, the novelty and observed results deserve attention. A careful analysis has been performed in this review by classifying the reported compounds into two different groups regarding the oxidation state of the metal, and within each group, the ancillary ligands. Specific examples to illustrate their potential applications are included in the different sections

Cellular glycosphingolipid imbalance modulates EMT in cancer cells

Sphingolipids are key components of the plasma membrane and are regulators of complex biological processes often altered in cancer cells. In human tumors, genes of key enzymes that regulate levels of glucosylceramide and lactosylceramide are often amplified. However, it is unknown why these traits are positively selected in transformed cells. In this work, we used CRISPR-Cas9 to knockout two key enzymes amplified in tumors in HeLa and H1703 tumor-derived cell-lines. As expected, the knockout lines had dramatic accumulation of GlcCer and LacCer. However, unexpectedly, they showed significantly decreased in-vitro wound-healing capacity and an almost complete loss of in-vitro extra-cellular matrix invasion. Based on these results, we probed for protein markers of the epithelial-to-mesenchymal transition (EMT). Data showed a significant increase of the levels of E-cadherin and a decrease of N-cadherin, suggesting that knockout cells acquired a more epithelial-like phenotype. Knockout lines also had significant changes in SNAIL levels, an important regulator of E-cadherin expression and EMT marker. As SNAIL can be regulated by growth factor receptors such as EGFR, we probed for global changes in growth factor receptor tyrosine kinase (RTK) activation. Results showed that, compared to their otherwise isogenic wild-type counterparts, knockout lines had broad changes in growth factor RTK activation patterns. The knockout cells also had significant changes in their responses to cytotoxic chemotherapeutic agents. Our work suggests that increased expression of key glycosphingolipid regulating enzymes in transformed cells are critical to promote malignant phenotypes by impacting EMT, sustained activity of growth factor RTKs, and responses to therapy.https://scholarscompass.vcu.edu/uresposters/1430/thumbnail.jp