NBS Impact Evaluation with GREENPASS Methodology Shown by the Case Study ‘Fischbeker Höfe’ in Hamburg/Germany

The implementation of nature-based solutions (NBS) in urban regeneration aims to improve citizens’ health and well-being. Therefore, tools need to be applied to identify the most suitable and efficient location and type of NBS. Within the CLEVER-cities H2020 project, the Greenpass method has been chosen to evaluate different design solutions regarding thermal comfort and physiological equivalent temperature (PET), energy, water and air fluxes. The Greenpass system comprises of standardized tools, reports and a unique set of Key Performance Score (KPS) and Key Performance Indicators (KPI). This paper deals with the impact assessment of NBS by the use of the innovative Greenpass system for the CLEVER-cities project ‘Fischbeker Höfe’ in Hamburg, Germany to ensure human health and well-being improvements for the citizens. To that end and considering the climate change context, thermal comfort is a KPI with high relevance in terms of the NBS co-benefits. Based on the PET within a project area Greenpass calculates the Thermal Comfort Score (TCS). The share of the different PET classes within the project area is multiplied with a weighting factor and summarized to the TCS. The results of the climate resilience analysis of the urban development area ‘Fischbeker Höfe’ in Hamburg are presented and discussed in comparison to a conventional architecture that disregards NBS, showing improvement with regards to four out of five KPS. Based on the evaluation results, advice is given to the co-creative design team on how to further improve the design towards climate resilience. The Greenpass system has proven to be a powerful and tailored tool to support climate resilient urban design and architecture. It provides a standardized and comprehensible but still scientific basis for decisions in a highly efficient and understandable way.This project has been applied in the frame of EU H2020 Project CLEVER-cities funded from the European Union’s Horizon 2020 innovation action program under grant agreement No 776604

Integration of well test analysis into naturally fractured reservoir simulation

Naturally fractured reservoirs (NFR) represent an important percentage of the worldwide hydrocarbon reserves and production. Reservoir simulation is a fundamental technique in characterizing this type of reservoir. Fracture properties are often not available due to difficulty to characterize the fracture system. On the other hand, well test analysis is a well known and widely applied reservoir characterization technique. Well testing in NFR provides two characteristic parameters, storativity ratio and interporosity flow coefficient. The storativity ratio is related to fracture porosity. The interporosity flow coefficient can be linked to shape factor, which is a function of fracture spacing. The purpose of this work is to investigate the feasibility of estimating fracture porosity and fracture spacing from single well test analysis and to evaluate the use of these two parameters in dual porosity simulation models. The following assumptions were considered for this research: 1) fracture compressibility is equal to matrix compressibility; 2) no wellbore storage and skin effects are present; 3) pressure response is in pseudo-steady state; and 4) there is single phase flow. Various simulation models were run and build up pressure data from a producer well was extracted. Well test analysis was performed and the result was compared to the simulation input data. The results indicate that the storativity ratio provides a good estimation of the magnitude of fracture porosity. The interporosity flow coefficient also provides a reasonable estimate of the magnitude of the shape factor, assuming that matrix permeability is a known parameter. In addition, pressure tests must exhibit all three flow regimes that characterizes pressure response in NFR in order to obtain reliable estimations of fracture porosity and shape factor

Regulation of Placental Development and Its Impact on Fetal Growth—New Insights From Mouse Models

The placenta is the chief regulator of nutrient supply to the growing embryo during gestation. As such, adequate placental function is instrumental for developmental progression throughout intrauterine development. One of the most common complications during pregnancy is insufficient growth of the fetus, a problem termed intrauterine growth restriction (IUGR) that is most frequently rooted in a malfunctional placenta. Together with conventional gene targeting approaches, recent advances in screening mouse mutants for placental defects, combined with the ability to rapidly induce mutations in vitro and in vivo by CRISPR-Cas9 technology, has provided new insights into the contribution of the genome to normal placental development. Most importantly, these data have demonstrated that far more genes are required for normal placentation than previously appreciated. Here, we provide a summary of common types of placental defects in established mouse mutants, which will help us gain a better understanding of the genes impacting on human placentation. Based on a recent mouse mutant screen, we then provide examples on how these data can be mined to identify novel molecular hubs that may be critical for placental development. Given the close association between placental defects and abnormal cardiovascular and brain development, these functional nodes may also shed light onto the etiology of birth defects that co-occur with placental malformations. Taken together, recent insights into the regulation of mouse placental development have opened up new avenues for research that will promote the study of human pregnancy conditions, notably those based on defects in placentation that underlie the most common pregnancy pathologies such as IUGR and pre-eclampsia

Aplicación del modelo desarrollista como aporte en el proceso de aprendizaje de los niños del grado transición 4 del Colegio de Educación técnica y académica Celestin Freinet

Análisis del aporte que brinda la aplicación del modelo pedagógico desarrollista en el proceso de aprendizaje de los niños teniendo en cuenta las teorías de los autores Jean Piaget y John Dewey y la relación de estas teorías con el concepto de enseñanza-aprendizaje de los niños, de igual manera se considera indispensable para este análisis la aplicación de instrumentos de recolección de datos como entrevistas, escalas Likert, diarios de campo y rejilla de observación importantes para la realización de este proyecto de investigación con fines pedagógicos

Aplicación del modelo desarrollista como aporte en el proceso de aprendizaje de los niños del grado transición 4 del Colegio de Educación técnica y académica Celestin Freinet

Análisis del aporte que brinda la aplicación del modelo pedagógico desarrollista en el proceso de aprendizaje de los niños teniendo en cuenta las teorías de los autores Jean Piaget y John Dewey y la relación de estas teorías con el concepto de enseñanza-aprendizaje de los niños, de igual manera se considera indispensable para este análisis la aplicación de instrumentos de recolección de datos como entrevistas, escalas Likert, diarios de campo y rejilla de observación importantes para la realización de este proyecto de investigación con fines pedagógicos

Efecto de la adición de grenetina en las propiedades reológicas y de textura de un panqué reducido en margarina

To increase the concentration of gelatin in a formulation for pound cake reduced in margarine and partially replaced by canola oil, there is a proportional increase in specific gravity, apparent viscosity and viscoelastic modules, decreasing the size and number of bubbles formed in the batter. In pound cake, there is a proportional decrease in volume and uniformity of the crumb and increase in the firmness, however, the addition of 1.25% of gelatin was the most accepted sensory formulation due to perceived a crumb more consistent and wet, so, the functionality of the gelatin as hydrocolloid, is limited to the final texture of the pound cake, concluding that it may be an alternative to improve the acceptability of a pound cake reduced in margarine, which is also of lower cost.The use of different hydrocolloids in the partial substitution of margarine by vegetable oils, are evaluated to achieve products with characteristics similar to the traditional product. The objective of this study was to evaluate the effect of the addition of different concentrations of gelatin (0%, 0.75%, 1.25%, and 2.0%) in pound cake formulation reduced in margarine and partially replaced with canola oil. It was determined specific gravity (SG), apparent viscosity, modules of viscoelasticity (G' and G") and number and size of air bubbles in the batter. In the pound cake was determined texture (TPA and sensory evaluation), crumb structure and moisture. By increasing the concentration of gelatin, it was observed a proportional increase of SG, apparent viscosity and elastic and viscous modules, predominating the viscous module with respect to elastic module, and a decrease in the number and size of air bubbles in the batter. In the pound cake, there was a proportional decrease in the volume and uniformity of the crumb, with respect to the size and number of cavities formed, however, sensorially, the most accepted formulation was the addition of 1.25% of gelatin because it perceives a more consistent and moist crumb, therefore, adding gelatin can be an alternative to improve the acceptability of a reduced pancake in margarine, which It's also less expensive.CONACy

Genetic and functional characterization of disease associations explains comorbidity

Understanding relationships between diseases, such as comorbidities, has important socio-economic implications, ranging from clinical study design to health care planning. Most studies characterize disease comorbidity using shared genetic origins, ignoring pathway-based commonalities between diseases. In this study, we define the disease pathways using an interactome-based extension of known disease-genes and introduce several measures of functional overlap. The analysis reveals 206 significant links among 94 diseases, giving rise to a highly clustered disease association network. We observe that around 95% of the links in the disease network, though not identified by genetic overlap, are discovered by functional overlap. This disease network portraits rheumatoid arthritis, asthma, atherosclerosis, pulmonary diseases and Crohn's disease as hubs and thus pointing to common inflammatory processes underlying disease pathophysiology. We identify several described associations such as the inverse comorbidity relationship between Alzheimer's disease and neoplasms. Furthermore, we investigate the disruptions in protein interactions by mapping mutations onto the domains involved in the interaction, suggesting hypotheses on the causal link between diseases. Finally, we provide several proof-of-principle examples in which we model the effect of the mutation and the change of the association strength, which could explain the observed comorbidity between diseases caused by the same genetic alterations

La biosíntesis de aminoácidos azufrados en los oídios depende de una enzima fúngica no canónica y de dos genes de la planta

Podosphaera xanthii es el principal agente causal del oídio de las cucurbitáceas. En este estudio se pretende proporcionar nuevas perspectivas sobre la biotrofia de P. xanthii que puedan ser de utilidad para el desarrollo de nuevas herramientas de fitoprotección. Para ello, hemos centrando nuestra atención en el metabolismo del azufre. Hasta la fecha, en los genomas de oídios disponibles no se han encontrado los genes de las enzimas involucradas en los pasos iniciales de la ruta de asimilación de azufre y de biosíntesis de aminoácidos azufrados. Sin embargo, el estudio de un conjunto de proteínas conservadas no anotadas deducidas del transcriptoma de P. xanthii, permitió identificar una de las enzimas involucradas en la asimilación de azufre inorgánico. Por otro lado, los resultados obtenidos a partir de un análisis RNA-seq de los primeros estadios de la infección en melón, mostraron un gran número de genes de la planta desregulados, entre los que se encontraban dos de los genes del metabolismo del azufre no identificados en oídios. Sobre esta base, los resultados de ensayos de silenciamiento génico y de complementación química, nos llevaron a concluir que la biosíntesis de aminoácidos azufrados en los oídios podría depender de una enzima fúngica no canónica y de dos genes de la planta. Este trabajo ha sido financiado por ayudas de la Agencia Estatal de Investigación (AEI) (AGL2016-76216-C2-1-R; PID2019-107464RB-C21), cofinanciada con fondos FEDER (EU). Laura Ruiz Jiménez es beneficiaria de un contrato predoctoral (BES-2017-080414) para la formación de doctores del Ministerio de Ciencia e Innovación.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Improcedencia de la determinación estimativa de las cuotas de seguridad social en sector de la construcción

Esta investigación es importante desarrollarla porque servirá de base, para analizar la problemática en la improcedencia en la estimación de las cuotas obrero-patronales en Las empresas dedicadas a la construcción, demostrando la ilegalidad en el actuar de la autoridad y otorgar a los contribuyentes que se encuentran específicamente en la esta industria certeza jurídica.  Dentro de la problemática podemos darnos cuenta de que se trasgrede el principio de legalidad tributaria al aplicar el “Artículo 18 del Reglamento el Seguro Social obligatorio para los trabajadores de la construcción por obra o tiempo determinado”, a los contribuyentes dedicados a la construcción, de manera supletoria aun y cuando los contribuyentes cumplen con lo que la Propia Ley del Seguro Social le señala. La opción de aplicar el artículo 18 del Reglamento se presenta solamente cuando el contribuyente ha incumplido con las obligaciones que dispone la propia ley, hecho que en la actualidad se aplica de manera discrecional por la autoridad, ocasionando que le determinen diferencias en los montos que pago realmente por la mano de obra. Si los patrones cumplen con todos los requisitos que la ley del Seguro social para la determinación de las Cuotas obrero-Patronales, la Autoridad no se encontraría facultada para aplicar la Estimativa del Artículo 18 del Reglamento. Cuando los contribuyentes cumplan con el soporte documental y legal que la ley le exige, estarán en el derecho de solicitar los medios de defensa que tienen a su disposición