1,326 research outputs found
Navigating the Research-Clinical Interface in Genomic Medicine: Analysis From the CSER Consortium
Purpose: The Clinical Sequencing Exploratory Research (CSER) Consortium encompasses nine National Institutes of Healthâ funded U-award projects investigating translation of genomic sequencing into clinical care. Previous literature has distinguished norms and rules governing research versus clinical care. This is the first study to explore how genomics investigators describe and navigate the researchâclinical interface. Methods: A CSER working group developed a 22-item survey. All nine U-award projects participated. Descriptive data were tabulated and qualitative analysis of text responses identified themes and characterizations of the researchâclinical interface. Results: Survey responses described how studies approached the researchâclinical interface, including in consent practices, recording results, and using a research versus clinical laboratory. Responses revealed four characterizations of the interface: clear separation between research and clinical care, interdigitation of the two with steps to maintain separation, a dynamic interface, and merging of the two. All survey respondents utilized at least two different characterizations. Although research has traditionally been differentiated from clinical care, respondents pointed to factors blurring the distinction and strategies to differentiate the domains.
Conclusion: These results illustrate the difficulty in applying the traditional bifurcation of research versus clinical care to translational models of clinical research, including in genomics. Our results suggest new directions for ethics and oversight
Digital interaction: where are we going?
In the framework of the AVI 2018 Conference, the interuniversity center ECONA has organized a thematic workshop on "Digital Interaction: where are we going?". Six contributions from the ECONA members investigate different perspectives around this thematic
Chloride-binding in organicâwater mixtures: the powerful synergy of CâH donor groups within a bowl-shaped cavity
2,3,4,5-Tetrafluorobenzyl and imidazolium groups within an open-chain receptor allow for the effective binding of chloride in organicâwater solution
A Chatbot Solution for eGLU-Box Pro: The Usability Evaluation Platform for Italian Public Administrations
This paper shows a chatbot solution for eGLU-box Pro, a usability testing platform for Italian Public Administration (PA). eGLU-box Pro is a web-based tool designed to help PA practitioners in creating remote usability tests and analyzing participantsâ answers and interaction data after they complete the usability tasks. The impact of the chatbot solution on usersâ experience was assessed by bio-behavioral evaluation methods such as eye tracking, electroencephalography, and facial expression recognition. This work describes the platform and its integrated chatbot solution and shows the results of a preliminary laboratory study involving 20 end-users. The study is part of an ongoing design and development project based on a user-centered approach
Patients' Choices for Return of Exome Sequencing Results to Relatives in the Event of Their Death
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/116009/1/jlme12290.pd
eGLU-Box Mobile:A Smartphone App for Usability Testing by Italian Public Administration Webmasters
Smartphones and tablets now offer consumers unique advantages such as portability and accessibility. Developers are also working with a mobile-first approach, and are prioritizing mobile applications over desktop versions. This study introduces eGLU-box Mobile, an application for performing a drive usability test directly from a smartphone. An experimental study was conducted in which the participants were divided into two groups: an experimental group, which used the new mobile application from a smartphone, and a control group, which used the desktop application from a computer. The participantsâ behavior was assessed using explicit (self-report questionnaires) and implicit measures (eye movement data). The results were encouraging, and showed that both the mobile and desktop versions of eGLU-box enabled participants to test the usability with a similar level of UX, despite some minimal (although significant) differences in terms of satisfaction of use
Is âincidental findingâ the best term?: a study of patientsâ preferences
There is debate within the genetics community about the optimal term to describe genetic variants unrelated to the test indication, but potentially important for health. Given the lack of consensus and the importance of adopting terminology that promotes effective clinical communication, we sought the opinion of clinical genetics patients
Enhanced Electrocatalytic Oxygen Evolution in AuâFe Nanoalloys
Oxygen evolution reaction (OER) is the most critical step in water splitting, still limiting the development of efficient alkaline water electrolyzers. Here we investigate the OER activity of AuâFe nanoalloys obtained by laser-ablation synthesis in solution. This method allows a high amount of iron (up to 11 at %) to be incorporated into the gold lattice, which is not possible in AuâFe alloys synthesized by other routes, due to thermodynamic constraints. The Au0.89Fe0.11 nanoalloys exhibit strongly enhanced OER in comparison to the individual pure metal nanoparticles, lowering the onset of OER and increasing up to 20 times the current density in alkaline aqueous solutions. Such a remarkable electrocatalytic activity is associated to nanoalloying, as demonstrated by comparative examples with physical mixtures of gold and iron nanoparticles. These results open attractive scenarios to the use of kinetically stable nanoalloys for catalysis and energy conversion
- âŠ