801 research outputs found

    The role of performance in aural harmony : discovering, classifying, and evaluating pedagogical approaches

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    Harmony is a fundamental topic that pervades much of tertiary-level aural training. Many activities in aural harmony that are described in the literature, however, represent idiosyncratic prescriptions of set exercises (e.g., harmonic dictation). No researcher has previously attempted to systematically compare a broad range of pedagogical approaches in aural harmony. Furthermore, despite the critical role of performance in music education, there is little understanding of how and why students engage in performance and other actions during aural harmony activities. The primary aim of this dissertation is to investigate the multitude of pedagogical approaches within the subject of aural harmony. This is achieved through the discovery, classification, and evaluation of pedagogical approaches as revealed through class observations and discussions with teachers at ten tertiary institutions in four countries (Japan, the US, Sweden, and Norway). Through an extensive examination of this data, I identify 89 aural harmony activities (Chapter 2). My analysis of these activities results in the creation of a classification system (Chapter 3). There are four categories in this classification system. Each category represents a type of action sequence, which in turn represents one action leading to another action. The four categories thus indicate fundamentally different learning outcomes. I classify each of the 89 collected activities under one or more categories, which enables me to systematically compare the pedagogical approaches within each of the four categories of activities (Chapters 4-6). The secondary aim of this dissertation is to report my experiences of applying the insight and knowledge gained from the above analyses to my own teaching within an Australian tertiary music institution (Chapter 7). Following an explanation of my particular educational context, I describe the process of devising, developing, and implementing five activities. Of these activities, one uniquely enables students to simulate performance actions through gestures. I evaluate these activities based on student feedback as well as my self-reflection. This research has resulted in detailed descriptions of a considerable range of aural harmony activities (Appendix A). My analyses of these activities reveal a range of pedagogical approaches that can maximise our students' acquisition of aural skills. I argue that while student performance is valuable in much of aural training, there are alternative means of engaging students that can also result in favourable learning experiences. This dissertation concludes with a consideration of the applicability of two of the activities presented in Chapter 7, as well as the classification system proposed in Chapter 3, across other areas of aural skills pedagogy

    Biologische Applikationen fĂŒr die Dip-Pen Nanolithographie

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    Im Rahmen dieser Arbeit wurden neue Anwendungsmöglichkeiten fĂŒr die Dip-Pen Nanolithographie entwickelt. Mit Hilfe dieser wurden Beugungsgitter aus Lipiden generiert, die eine markierungsfreie Proteindetektion in Lösung ermöglichten. Zu diesem Zweck wurden auch gezielt dreidimensionale, photonische Strukturen(Toroide) funktionalisiert. DarĂŒber hinaus konnten Click-Chemie Reaktionen in die DPN integriert und so eine neue Substratfunktionalisierung im Mikro-Nanometerbereich realisiert werden

    Stoichiometry and Change of the mRNA Closed-Loop Factors as Translating Ribosomes Transit from Initiation to Elongation

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    Protein synthesis is a highly efficient process and is under exacting control. Yet, the actual abundance of translation factors present in translating complexes and how these abundances change during the transit of a ribosome across an mRNA remains unknown. Using analytical ultracentrifugation with fluorescent detection we have determined the stoichiometry of the closed-loop translation factors for translating ribosomes. A variety of pools of translating polysomes and monosomes were identified, each containing different abundances of the closed-loop factors eIF4E, eIF4G, and PAB1 and that of the translational repressor, SBP1. We establish that closed-loop factors eIF4E/eIF4G dissociated both as ribosomes transited polyadenylated mRNA from initiation to elongation and as translation changed from the polysomal to monosomal state prior to cessation of translation. eIF4G was found to particularly dissociate from polyadenylated mRNA as polysomes moved to the monosomal state, suggesting an active role for translational repressors in this process. Consistent with this suggestion, translating complexes generally did not simultaneously contain eIF4E/eIF4G and SBP1, implying mutual exclusivity in such complexes. For substantially deadenylated mRNA, however, a second type of closed-loop structure was identified that contained just eIF4E and eIF4G. More than one eIF4G molecule per polysome appeared to be present in these complexes, supporting the importance of eIF4G interactions with the mRNA independent of PAB1. These latter closed-loop structures, which were particularly stable in polysomes, may be playing specific roles in both normal and disease states for specific mRNA that are deadenylated and/or lacking PAB1. These analyses establish a dynamic snapshot of molecular abundance changes during ribosomal transit across an mRNA in what are likely to be critical targets of regulation

    (A) Vision for 2050 - Context-Based Image Understanding for a Human-Robot Soccer Match

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    We believe it is possible to create the visual subsystem needed for the RoboCup 2050 challenge - a soccer match between humans and robots - within the next decade.  In this position paper, we argue, that the basic techniques are available, but the main challenge will be to achieve the necessary robustness. We propose to address this challenge through the use of probabilistically modeled context, so for instance a visually indistinct circle is  accepted as the ball, if it fits well with the ball's motion model and vice versa.Our vision is accompanied by a sequence of (partially already conducted) experiments for its verification.  In these experiments, a human soccer player carries a helmet with a camera and an inertial sensor and the vision system has to extract all information from that data, a humanoid robot would need to take the human's place

    Evolution of the Okvik/Old Bering Sea culture of the Bering Strait as a major transition

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    Great transitions are thought to embody major shifts in locus of selection,labour diversification and communication systems. Such expectations arerelevant for biological and cultural systems as decades of research hasdemonstrated similar dynamics within the evolution of culture. The evolutionof the Neo-Inuit cultural tradition in the Bering Strait provides anideal context for examination of cultural transitions. The Okvik/OldBering Sea (Okvik/OBS) culture of Bering Strait is the first representativeof the Neo-Inuit tradition. Archaeological evidence drawn for settlementand subsistence data, technological traditions and mortuary contextssuggests that Okvik/OBS fits the definition of a major transition givenchange in the nature of group membership (from families to politicalgroups with social ranking), task organization (emergent labour specialization)and communication (advent of complex art forms conveying socialand ideological information). This permits us to develop a number of implications about the evolutionary process recognizing that transitions mayoccur on three scales: (1) ephemeral variants, as for example, simple technological entities; (2) integrated systems, spanning modular technology tosocio-economic strategies; and (3) simultaneous change across all scaleswith emergent properties.This article is part of the theme issue ‘Human socio-cultural evolution inlight of evolutionary transitions’

    Antithrombin Reduces Inflammation and Microcirculatory Perfusion Failure in Closed Soft-Tissue Injury and Endotoxemia

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    Background: Closed soft-tissue trauma leads to activation of the coagulation cascade and is often complicated by systemic inflammation and infection. Previous investigations have shown potent anti-inflammatory properties of antithrombin. We herein report on the action of antithrombin on skeletal muscle injury in experimental endotoxemia. Materials and Methods: By using a pneumatically driven computer-controlled impact device, closed soft-tissue trauma was applied on the left hind limb of pentobarbital-anesthetized rats. Six hours later, endotoxemia was induced by intraperitoneal injection of Escherichia coli]ipopolysaccharide. An equivalent volume of physiological saline was given in controls. At the same time point, treatment of animals was started by intravenous injection of antithrombin (250 IU/kg body weight) or vehicle solution. Twenty-four hours after trauma, the extensor digitorum longus muscle was microsurgically exposed and analyzed by means of high-resolution multifluorescence microscopy. Results: Traumatic soft-tissue injury with additional endotoxemia was characterized by nutritive perfusion failure (functional capillary density: 379 +/- 20 cm/cm(2)), tissue hypoxia (nicotinamide adenine dinucleotide autofluorescence: 77 +/- 4 aU), and enhanced leukocyte-endothelial cell interaction (773 +/- 35 cells/mm(2)). Therapeutic intervention with antithrombin 6 hrs after trauma restored nutritive perfusion and tissue oxygenation (functional capillary density: 469 +/- 22 cm/cm(2); nicotinamide adenine dinucleotide autofluorescence: 61 +/- 5 aU p < 0.05]) and reduced inflammatory leukocyte adherence (237 +/- 20 cells/mm(2) p < 0.05]) toward values found in nontraumatized controls (functional capillary density: 573 +/- 13 cm/cm(2); nicotinamide adenine dinucleotide autofluorescence: 56 +/- 2 aU; leukocyte adherence: 204 +/- 20 cells/mm(2)). Conclusion: Antithrombin ameliorates microcirculatory dysfunction and tissue injury in traumatized animals during endotoxemia. Furthermore, a reduced inflammatory cell response helps to prevent leukocyte-dependent secondary tissue injury. (Crit Care Med 2013; 41:867-873

    Partial wave contributions to the antikaon potential at finite momentum

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    The momentum dependence of the antikaon optical potential in nuclear matter is obtained from a microscopic and self-consistent calculation using the meson-exchange J\"ulich KˉN\bar{K}N interaction. Two self-consistent schemes are discussed, which would lead to substantially different predictions for the width of Kˉ{\bar K} nuclear bound states. The effect of higher partial waves of the KˉN\bar{K}N interaction, beyond the L=0 component, is studied and found to have moderate but non-negligible effects on the Kˉ{\bar K} nuclear potential at zero momentum. At momenta as large as 500 MeV/c, relevant in the analysis of heavy-ion collisions, the higher partial partial waves modify the Kˉ{\bar K} optical potential by nearly a factor of two.Comment: 20 pages, 7 figure

    Heavy Flavor Probes of Quark Matter

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    A brief survey of the role of heavy flavors as a probe of the state of matter produced by high energy heavy ion collisions is presented. Specific examples include energy loss, initial state gluon saturation, thermalization and flow. The formation of quarkonium bound states from interactions in which multiple heavy quark-antiquark pairs are initially produced is examined in general. Results from statistical hadronization and kinetic models are summarized. New predictions from the kinetic model for J/Psi at RHIC are presented.Comment: Based on invited plenary talk at Strange Quark Matter 2004, Cape Town, South Africa, September 15-20, 2004, references completed, published in J. Phys. G: Nucl. Part. Phys. 31 (2005) S641-S64
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