The use of teacher facilitation during computer activities to improve the social interaction of preschool children in inclusive classrooms

Social competence is a major focus in early childhood education and there is a need for effective teaching methods to increase social skills for both children with and without disabilities. Even though technology is used as a tool for teaching young children, there is limited research on the use of structured teaching coupled with assistive technology to facilitate social skill development in young children; This study investigated the impact of teacher facilitation during computer activities on the social skill development and concurrent interactions of young children. The study compared dyads comprised of children with and without disabilities who received teacher facilitation during computer activities to a matched group of children who did not receive teacher facilitation. The sessions were videotaped for the purpose of analyzing the social interactions and behaviors of the children. Pre-and post-measures of social skills and systematic observation of social interactions during the study were analyzed using statistical tests. Because younger preschool children often exhibit different social skills and interactions than pre-kindergarten children, the social skills and interactions of the younger children were compared to the older children; In this study preschool teachers perceived that the children with disabilities improved their social skills more than the children without disabilities, regardless of the intervention group assignment. All of the children in the study exhibited few negative social interactions regardless of their age, disability status, or intervention group assignment. The children with and without disabilities in the teacher facilitated computer group had more positive social interactions and demonstrated more effective social behaviors than the children in the computer only group. The older children exhibited more effective social interaction behaviors than the younger children; Qualitative analysis of interviews conducted with the two participating special education teachers also were analyzed. Domain and componential analyses of the interviews indicated that the teachers believed that the computer activities provided an effective context for the facilitation of social interaction. They also believed that the children in the teacher facilitated computer group improved their social competence more than the children in the computer only group

Aquatic Developmental Play Program for Children in Early Intervention: A Case Series

Background: Despite limited evidence, aquatic programming has the potential to be an ideal intervention for young children with disabilities because of its unique and dynamic properties. This study explored the impact of an aquatic developmental play program in addressing sensory integration and motor development needs of children with disabilities as well as its impact on parental isolation. Methods: A case series design was used. Children with disabilities under 3 years of age and their parents participated in a 9-week aquatic developmental play program held in the community. Goals were individualized for each participant and monitored using the Goal Attainment Scaling (GAS) method. The Sensory Profile 2, the Developmental Assessment of Young Children-Second Edition (DAYC-2), and a Parent Support Survey were administered before and after the study. Results: Seventy-nine percent of the individual goals were met or exceeded expectations among the 11 participants with categorical changes observed on the Sensory Profile 2 and the DAYC-2. Parental satisfaction with services increased and parental feelings of isolation decreased following the aquatic play program. Conclusion: The results suggest that aquatic programming held in the community may be beneficial not only for the individual needs of children with disabilities but also for the needs of parents

Developmental Effects of Perfluorononanoic Acid in the Mouse Are Dependent on Peroxisome Proliferator-Activated Receptor-Alpha

Perfluorononanoic acid (PFNA) is one of the perfluoroalkyl acids found in the environment and in tissues of humans and wildlife. Prenatal exposure to PFNA negatively impacts survival and development of mice and activates the mouse and human peroxisome proliferator-activated receptor-alpha (PPARα). In the current study, we used PPARα knockout (KO) and 129S1/SvlmJ wild-type (WT) mice to investigate the role of PPARα in mediating PFNA-induced in vivo effects. Pregnant KO and WT mice were dosed orally with water (vehicle control: 10 ml/kg), 0.83, 1.1, 1.5, or 2 mg/kg PFNA on gestational days (GDs) 1–18 (day of sperm plug = GD 0). Maternal weight gain, implantation, litter size, and pup weight at birth were unaffected in either strain. PFNA exposure reduced the number of live pups at birth and survival of offspring to weaning in the 1.1 and 2 mg/kg groups in WT. Eye opening was delayed (mean delay 2.1 days) and pup weight at weaning was reduced in WT pups at 2 mg/kg. These developmental endpoints were not affected in the KO. Relative liver weight was increased in a dose-dependent manner in dams and pups of the WT strain at all dose levels but only slightly increased in the highest dose group in the KO strain. In summary, PFNA altered liver weight of dams and pups, pup survival, body weight, and development in the WT, while only inducing a slight increase in relative liver weight of dams and pups at 2 mg/kg in KO mice. These results suggest that PPARα is an essential mediator of PFNA-induced developmental toxicity in the mouse

User-centric analytic approach to evaluate the performance of sports facilities: A study of swimming pools

While the performance of sports facilities such as swimming pools is crucial to the health, safety and enjoyment of pool users, little research has been conducted to explore how to analytically evaluate the holistic performance of such facilities from the users' perspective. Even an evaluation framework portraying the key performance attributes of swimming pools is yet to be available. Recognising this research gap, this study aims to adopt a user-centric approach to evaluate the performance of swimming pools and a multi-stage study was initiated. After a thorough literature review, a performance attribute hierarchy for swimming pools was established through a focus group study and then two surveys, covering four swimming pools and 103 pool users interviewed, were conducted in Hong Kong. Analysing the responses using the Analytic Hierarchy Process (AHP) method illustrates that the building services (i.e. utilitarian) aspect of swimming pools is more important than the architectural counterpart, and survey participants cared more about the performance attributes inside water than those outside. This study's novelty lies in that it adopted the user-centric approach, which can differentiate between the relative importance of different swimming pool components and prioritize resources for their maintenance and management. The evaluation framework as well as the findings of the study provides facilities managers with important benchmark criteria for optimising the performance of these sports facilities. In the long run, this study contributes to enabling the project stakeholders to conduct evidence-based decision making over the life cycle of sport facilities development and management

Validation of cardiovascular magnetic resonance assessment of pericardial adipose tissue volume

© 2009 Nelson et al; licensee BioMed Central Ltd.Background Pericardial adipose tissue (PAT) has been shown to be an independent predictor of coronary artery disease. To date its assessment has been restricted to the use of surrogate echocardiographic indices such as measurement of epicardial fat thickness over the right ventricular free wall, which have limitations. Cardiovascular magnetic resonance (CMR) offers the potential to non-invasively assess total PAT, however like other imaging modalities, CMR has not yet been validated for this purpose. Thus, we sought to describe a novel technique for assessing total PAT with validation in an ovine model. Methods 11 merino sheep were studied. A standard clinical series of ventricular short axis CMR images (1.5T Siemens Sonata) were obtained during mechanical ventilation breath-holds. Beginning at the mitral annulus, consecutive end-diastolic ventricular images were used to determine the area and volume of epicardial, paracardial and pericardial adipose tissue. In addition adipose thickness was measured at the right ventricular free wall. Following euthanasia, the paracardial adipose tissue was removed from the ventricle and weighed to allow comparison with corresponding CMR measurements. Results There was a strong correlation between CMR-derived paracardial adipose tissue volume and ex vivo paracardial mass (R2 = 0.89, p < 0.001). In contrast, CMR measurements of corresponding RV free wall paracardial adipose thickness did not correlate with ex vivo paracardial mass (R2 = 0.003, p = 0.878). Conclusion In this ovine model, CMR-derived paracardial adipose tissue volume, but not the corresponding and conventional measure of paracardial adipose thickness over the RV free wall, accurately reflected paracardial adipose tissue mass. This study validates for the first time, the use of clinically utilised CMR sequences for the accurate and reproducible assessment of pericardial adiposity. Furthermore this non-invasive modality does not use ionising radiation and therefore is ideally suited for future studies of PAT and its role in cardiovascular risk prediction and disease in clinical practiceAdam J Nelson, Matthew I Worthley, Peter J Psaltis, Angelo Carbone, Benjamin K Dundon, Rae F Duncan, Cynthia Piantadosi, Dennis H Lau, Prashanthan Sanders, Gary A Wittert and Stephen G Worthle

Environment Tunes Propagation of Cell-to-Cell Variation in the Human Macrophage Gene Network

Cell-to-cell variation in gene expression and the propagation of such variation (PoV or ???noise propagation???) from one gene to another in the gene network, as reflected by gene-gene correlation across single cells, are commonly observed in single-cell transcriptomic studies and can shape the phenotypic diversity of cell populations. While gene network ???rewiring??? is known to accompany cellular adaptation to different environments, how PoV changes between environments and its underlying regulatory mechanisms are less understood. Here, we systematically explored context-dependent PoV among genes in human macrophages, utilizing different cytokines as natural perturbations of multiple molecular parameters that may influence PoV. Our single-cell, epigenomic, computational, and stochastic simulation analyses reveal that environmental adaptation can tune PoV to potentially shape cellular heterogeneity by changing parameters such as the degree of phosphorylation and transcription factor-chromatin interactions. This quantitative tuning of PoV may be a widespread, yet underexplored, property of cellular adaptation to distinct environments

Interannual variability of Great Lakes ice cover and its relationship to NAO and ENSO

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94684/1/jgrc12031.pd

Research priorities for the sustainability of coral-rich western Pacific seascapes

Nearly a billion people depend on tropical seascapes. The need to ensure sustainable use of these vital areas is recognised, as one of 17 policy commitments made by world leaders, in Sustainable Development Goal (SDG) 14 (‘Life below Water’) of the United Nations. SDG 14 seeks to secure marine sustainability by 2030. In a time of increasing social-ecological unpredictability and risk, scientists and policymakers working towards SDG 14 in the Asia–Pacific region need to know: (1) How are seascapes changing? (2) What can global society do about these changes? and (3) How can science and society together achieve sustainable seascape futures? Through a horizon scan, we identified nine emerging research priorities that clarify potential research contributions to marine sustainability in locations with high coral reef abundance. They include research on seascape geological and biological evolution and adaptation; elucidating drivers and mechanisms of change; understanding how seascape functions and services are produced, and how people depend on them; costs, benefits, and trade-offs to people in changing seascapes; improving seascape technologies and practices; learning to govern and manage seascapes for all; sustainable use, justice, and human well-being; bridging communities and epistemologies for innovative, equitable, and scale-crossing solutions; and informing resilient seascape futures through modelling and synthesis. Researchers can contribute to the sustainability of tropical seascapes by co-developing transdisciplinary understandings of people and ecosystems, emphasising the importance of equity and justice, and improving knowledge of key cross-scale and cross-level processes, feedbacks, and thresholds

Chapter 8: Meta-analysis of Test Performance When There is a “Gold Standard”

Synthesizing information on test performance metrics such as sensitivity, specificity, predictive values and likelihood ratios is often an important part of a systematic review of a medical test. Because many metrics of test performance are of interest, the meta-analysis of medical tests is more complex than the meta-analysis of interventions or associations. Sometimes, a helpful way to summarize medical test studies is to provide a “summary point”, a summary sensitivity and a summary specificity. Other times, when the sensitivity or specificity estimates vary widely or when the test threshold varies, it is more helpful to synthesize data using a “summary line” that describes how the average sensitivity changes with the average specificity. Choosing the most helpful summary is subjective, and in some cases both summaries provide meaningful and complementary information. Because sensitivity and specificity are not independent across studies, the meta-analysis of medical tests is fundamentaly a multivariate problem, and should be addressed with multivariate methods. More complex analyses are needed if studies report results at multiple thresholds for positive tests. At the same time, quantitative analyses are used to explore and explain any observed dissimilarity (heterogeneity) in the results of the examined studies. This can be performed in the context of proper (multivariate) meta-regressions