Signatures of the neutrino thermal history in the spectrum of primordial gravitational waves

In this paper we study the effect of the anisotropic stress generated by neutrinos on the propagation of primordial cosmological gravitational waves. The presence of anisotropic stress, like the one generated by free-streaming neutrinos, partially absorbs the gravitational waves (GWs) propagating across the Universe. We find that in the standard case of three neutrino families, 22% of the intensity of the wave is absorbed, in fair agreement with previous studies. We have also calculated the maximum possible amount of damping, corresponding to the case of a flat Universe completely dominated by ultrarelativistic collisionless particles. In this case 43% of the intensity of the wave is absorbed. Finally, we have taken into account the effect of collisions, using a simple form for the collision term parameterized by the mean time between interactions, that allows to go smoothly from the case of a tigthly-coupled fluid to that of a collisionless gas. The dependence of the absorption on the neutrino energy density and on the effectiveness of the interactions opens the interesting possibility of observing spectral features related to particular events in the thermal history of the Universe, like neutrino decoupling and electron-positron annihilation, both occurring at T~1 MeV. GWs entering the horizon at that time will have today a frequency \nu\sim 10^{-9} \Hz, a region that is going to be probed by Pulsar Timing Arrays.Comment: V1: 14 pages, 2 figures. To appear in Gen. Rel. Grav. V2: References Adde

Cosmological implications of a viable non-analytical f(R) model

Power-law corrections (having the exponent strictly between 2 and 3) to the Einstein-Hilbert action yield an extended theory of gravity which is consistent with Solar-System tests and properly reproduces the main phases of the Universe thermal history. We find two distinct constraints for the characteristic length scale of the model: a lower bound from the Solar-System test and an upper bound by requiring the existence of the matter-dominated era. We also show how the extended framework can accommodate the existence of an early de Sitter phase. Within the allowed range of characteristic length scales, the relation between the expansion rate and the energy scale of inflation is modified, yielding a value of the rate several orders of magnitude smaller than in the standard picture. The observational implication of this fact is that a tiny value of the tensor-to-scalar ratio is expected in the extended framework. The suppression of primordial tensor modes also implies that the inflationary scale can be made arbitrarily close to the Planck one according to the current limits. Finally, an analysis of the propagation of gravitational waves on a Robertson-Walker background is addressed.Comment: 10 pages, 5 figure

Gravitational instability of the primordial plasma: anisotropic evolution of structure seeds

We study how the presence of a background magnetic field, of intensity compatible with current observation constraints, affects the linear evolution of cosmological density perturbations at scales below the Hubble radius. The magnetic field provides an additional pressure that can prevent the growth of a given perturbation; however, the magnetic pressure is confined only to the plane orthogonal the field. As a result, the "Jeans length" of the system not only depends on the wavelength of the fluctuation but also on its direction, and the perturbative evolution is anisotropic. We derive this result analytically and back it up with direct numerical integration of the relevant ideal magnetohydrodynamics equations during the matter-dominated era. Before recombination, the kinetic pressure dominates and the perturbations evolve in the standard way, whereas after that time magnetic pressure dominates and we observe the anisotropic evolution. We quantify this effect by estimating the eccentricity $\epsilon$ of a Gaussian perturbation in the coordinate space that was spherically symmetric at recombination. For perturbations at the sub-galactic scale, we find that $\epsilon = 0.7$ at $z=10$ taking the background magnetic field of order $10^{-9}$ gauss.Comment: 11 pages, 5 figures. V2: Added discussion on the role of ambipolar diffusion. Matches version accepted for publication in Physics Letters

On the coupling between spinning particles and cosmological gravitational waves

The influence of spin in a system of classical particles on the propagation of gravitational waves is analyzed in the cosmological context of primordial thermal equilibrium. On a flat Friedmann-Robertson-Walker metric, when the precession is neglected, there is no contribution due to the spin to the distribution function of the particles. Adding a small tensor perturbation to the background metric, we study if a coupling between gravitational waves and spin exists that can modify the evolution of the distribution function, leading to new terms in the anisotropic stress, and then to a new source for gravitational waves. In the chosen gauge, the final result is that, in the absence of other kind of perturbations, there is no coupling between spin and gravitational waves.Comment: 4 pages, to appear in Proceedings of the II Stueckelberg Workshop - Int. J. Mod. Phys.

Immunogenicity and tolerability of an MF59-adjuvanted, egg-derived, A/H1N1 pandemic influenza vaccine in children 6-35 months of age

Background: Vaccines against pandemic A/H1N1 influenza should provide protective immunity in children, because they are at greater risk of disease than adults. This study was conducted to identify the optimal dose of an MF59 (R)-adjuvanted, egg-derived, A/H1N1 influenza vaccine for young children. Methods: Children 6-11 months (N = 144) and 12-35 months (N = 186) of age received vaccine formulations containing either 3.75 mu g antigen with half the standard dose of MF59 or 7.5 mu g antigen with a standard dose of MF59, or a nonadjuvanted formulation containing 15 mu g antigen (children 12-35 months only). Participants were given 2 primary vaccine doses 3 weeks apart, followed by 1 booster dose of MF59-adjuvanted seasonal influenza vaccine 1 year later. Immunogenicity was assessed by hemagglutination inhibition and microneutralization assays. Results: All vaccine formulations were highly immunogenic and met all 3 European licensure criteria after 2 doses. MF59-adjuvanted vaccines met all licensure criteria after 1 dose in both age cohorts, while nonadjuvanted vaccine did not meet all criteria after 1 dose in children 12-35 months. A single booster dose was highly immunogenic, and stable antibody persistence was observed in response to all vaccines. All vaccines were well tolerated. Conclusions: In this study, a single dose of 3.75 mu g antigen with half the standard dose of MF59 was shown to be optimal, providing adequate levels of immediate and long-term antibodies in pediatric subjects 6-35 months of age. These data demonstrated that MF59 adjuvant allowed for reduced antigen content and promoted significant long-term antibody persistence in children, with a satisfactory safety profile

Mercury Dispersion through Streams Draining The Mt. Amiata District, Southern Tuscany, Italy

Abstract The Mt. Amiata area hosts the 3 rd largest Hg district in the world, overlapping with a present-day geothermal system that is exploited for energy production. Mining activity ceased in 1980; remediation of mining areas was only partial, and is still under way. A significant transport of mercury is documented in the streams draining the district. By far the largest output occurs to the southeast in the Paglia River catchment; this river is tributary of Tiber River, the largest river of central Italy. A much smaller transport occurs to the north, in the Orcia-Ombrone catchment. Most transport is in particulate form; mercury is temporarily stored in stream and overbank sediments, and can be significantly mobilized and redistributed by extreme events such as flash floods. Transfer to the biosphere and food chain is not negligible, as some fish in Paglia and Tiber Rivers show Hg contents that may be harmful for human consumption. The overall output from the Monte Amiata district represents a significant contribution to the Mediterranean Sea budget of this metal

Refining Rates of Active Crustal Deformation in the Upper Plate of Subduction Zones, Implied by Geological and Geodetic Data: The E-Dipping West Crati Fault, Southern Italy

We investigate crustal deformation within the upper plate of the Ionian Subduction Zone (ISZ) at different time scales by (i) refining geodetic rates of crustal extension from continuous Global Navigation Satellite System (GNSS) measurements and (ii) mapping sequence of Late Quaternary raised marine terraces tectonically deformed by the West Crati normal fault, in northern Calabria. This region experienced damaging earthquakes in 1184 (M 6.75) and 1854 (M 6.3), possibly on the E-dipping West Crati fault (WCF) which, however, is not unanimously considered to be a seismogenic source. We report geodetic measurements of extension and strain rates across the strike of the E dipping WCF and throughout the northern Calabria obtained by using velocities from 18 permanent GNSS stations with a series length longer than 4.5 years. These results suggest that crustal extension may be seismically accommodated in this region by a few normal faults. Furthermore, by applying a synchronous correlation approach, we refine the chronology of understudied tectonically deformed palaeoshorelines mapped on the footwall and along the strike of the WCF, facilitating calculation of the associated fault-controlled uplift rates. Raised Late Quaternary palaeoshorelines are preserved on the footwall of the WCF indicating that “regional” uplift, likely related to the deformation associated either with the subduction or mantle upwelling processes, is affected by local footwall uplift. We show that GIS-based elevations of Late Quaternary palaeoshorelines, as well as temporally constant uplift rates, vary along the strike of the WCF, implying normal faulting activity through time. This suggests that (i) the fault slip rate governing seismic hazard has also been constant over the Late Quaternary, over multiple earthquake cycles, and (ii) our geodetically derived fault throw rate for the WCF is likely a more than reasonable value to be used over longer time scales for an improved seismic hazard assessment. Overall, we emphasize the importance of mapping crustal deformation within the upper plate above subduction zones to avoid unreliable interpretations relating to the mechanism controlling regional uplift

Bipolar disorder in late life: clinical characteristics in a sample of older adults admitted for manic episode

BACKGROUND: Although manic episodes in older adults are not rare, little published data exist on late-life manic episodes. Resistance to treatment and concomitant neurological lesions are frequent correlates of elderly mania. The aim of this study was to investigate the prevalence of hospitalizations due to mania in patients older than 64 years through a period of 5 years in an Italian public psychiatric ward. Moreover, we aimed at describing clinical presentation of elderly manic episodes. METHODS: A retrospective chart review was conducted in order to describe clinical presentation of 20 elderly patients hospitalized for manic episode; moreover, we compared age at onset, the presence of family history for mood disorders, psychosis and irritability between the elderly group and a matched group of 20 younger manic inpatients. RESULTS: Seven percent of the whole inpatient elderly people suffered from mania. Half of those patients had a mood disorder age at onset after 50 years and 5 patients were at their first manic episode. Geriatric- and adulthood mania showed similar clinical presentation but younger people had more frequently a mood disorders family history. CONCLUSION: Half of our older manic inpatients consisted of "classic" bipolar patients with an extension of clinical manifestations into later life; the other half of our sample was heterogeneous, even though it was not possible to identify clearly which patients may have had vascular lesions related to the onset of mania

Therapeutic Implications of Mesenchymal Stem Cells in Liver Injury

Mesenchymal stem cells (MSCs), represent an attractive tool for the establishment of a successful stem-cell-based therapy of liver diseases. A number of different mechanisms contribute to the therapeutic effects exerted by MSCs, since these cells can differentiate into functional hepatic cells and can also produce a series of growth factors and cytokines able to suppress inflammatory responses, reduce hepatocyte apoptosis, regress liver fibrosis, and enhance hepatocyte functionality. To date, the infusion of MSCs or MSC-conditioned medium has shown encouraging results in the treatment of fulminant hepatic failure and in end-stage liver disease in experimental settings. However, some issues under debate hamper the use of MSCs in clinical trials. This paper summarizes the biological relevance of MSCs and the potential benefits and risks that can result from translating the MSC research to the treatment of liver diseases

HIV-1 Tat-induced diarrhea is improved by the PPARalpha agonist, palmitoylethanolamide, by suppressing the activation of enteric glia

Diarrhea is a severe complication in HIV-1-infected patients with Trans-activator of transcription (HIV-1 Tat) protein being recognized as a major underlying cause. Beside its direct enterotoxic effects, Tat protein has been recently shown to affect enteric glial cell (EGC) activity. EGCs regulate intestinal inflammatory responses by secreting pro-inflammatory molecules; nonetheless, they might also release immune-regulatory factors, as palmytoilethanolamide (PEA), which exerts anti-inflammatory effects by activating PPARα receptors. We aimed at clarifying whether EGCs are involved in HIV-1 Tat-induced diarrhea and if PEA exerts antidiarrheal activity