Doubles and Negatives are Positive (in Self-Assembly)

In the abstract Tile Assembly Model (aTAM), the phenomenon of cooperation occurs when the attachment of a new tile to a growing assembly requires it to bind to more than one tile already in the assembly. Often referred to as ``temperature-2'' systems, those which employ cooperation are known to be quite powerful (i.e. they are computationally universal and can build an enormous variety of shapes and structures). Conversely, aTAM systems which do not enforce cooperative behavior, a.k.a. ``temperature-1'' systems, are conjectured to be relatively very weak, likely to be unable to perform complex computations or algorithmically direct the process of self-assembly. Nonetheless, a variety of models based on slight modifications to the aTAM have been developed in which temperature-1 systems are in fact capable of Turing universal computation through a restricted notion of cooperation. Despite that power, though, several of those models have previously been proven to be unable to perform or simulate the stronger form of cooperation exhibited by temperature-2 aTAM systems. In this paper, we first prove that another model in which temperature-1 systems are computationally universal, namely the restricted glue TAM (rgTAM) in which tiles are allowed to have edges which exhibit repulsive forces, is also unable to simulate the strongly cooperative behavior of the temperature-2 aTAM. We then show that by combining the properties of two such models, the Dupled Tile Assembly Model (DTAM) and the rgTAM into the DrgTAM, we derive a model which is actually more powerful at temperature-1 than the aTAM at temperature-2. Specifically, the DrgTAM, at temperature-1, can simulate any aTAM system of any temperature, and it also contains systems which cannot be simulated by any system in the aTAM

The effect on melanoma risk of genes previously associated with telomere length.

Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10(-9), two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk.This is the final version of the article. It first appeared from Oxford University Press via http://dx.doi.org/10.1093/jnci/dju26

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Absence of linkage of Noonan syndrome to the neurofibromatosis type 1 locus.

Eleven families with Noonan syndrome in either two or three generations have been identified. Following the reports of subjects with features of both Noonan syndrome and neurofibromatosis type 1, these pedigrees have been studied using a number of probes at the neurofibromatosis type 1 locus (17q11). A significantly negative lod score was obtained with the intragenic probe NF1-C2, suggesting that the genes for Noonan syndrome and neurofibromatosis type 1 are not contiguous

Disinfectants prepared in a hospital pharmacy: assessment of their microbiological purity and antimicrobial effectivenes

The microbial contamination and antimicrobial effectiveness of seven topical disinfectants prepared at the hospital pharmacy were studied. These products were controlled throughout storage and use. The manufacturing routine investigated was able to deliver larger batch sizes and quality products that allowed increased storage time. The formulations chosen by the pharmacists were effective against bacteria for their intended uses. For chloramine only, loss of effectiveness required reduced storage time. No significant modification in the microbial quality of these products was observed during use in our hospital.Journal ArticleSCOPUS: ar.jFLWNAinfo:eu-repo/semantics/publishe