1,485 research outputs found
Comprehensive User Engagement Sites (CUES) in Philadelphia: A Constructive Proposal
This paper is a study about Philadelphia’s comprehensive user engagement sites (CUESs) as the authors address and examine issues related to the upcoming implementation of a CUES while seeking solutions for its disputed questions and plans. Beginning with the federal drug schedules, the authors visit some of the medical and public health issues vis-à -vis safe injection facilities (SIFs). Insite, a successful Canadian SIF, has been thoroughly researched as it represents a paradigm for which a Philadelphia CUES can expand upon. Also, the existing criticisms against SIFs are revisited while critically unpackaged and responded to in favor of the establishment. In the main section, the authors propose the layout and services of the upcoming CUES, much of which would be in congruent to Vancouver’s Insite. On the other hand, the CUES would be distinct from Insite, as the authors emphasize, in that it will offer an information center run by individuals in recovery and place additional emphasis on early education for young healthcare professionals by providing them a platform to work at the site. The paper will also briefly investigate the implementation of a CUES site under an ethical scope of the Harm Reduction Theory. Lastly, the authors recommend some strategic plans that the Philadelphia City government may consider employing at this crucial stage
Exact results on spin dynamics and multiple quantum dynamics in alternating spin-1/2 chains with XY-Hamiltonian at high temperatures
We extend the picture of a transfer of nuclear spin-1/2 polarization along a
homogeneous one-dimensional chain with the XY-Hamiltonian to the inhomogeneous
chain with alternating nearest neighbour couplings and alternating Larmor
frequencies. To this end, we calculate exactly the spectrum of the spin-1/2
XY-Hamiltonian of the alternating chain with an odd number of sites. The exact
spectrum of the XY-Hamiltonian is also applied to study the multiple quantum
(MQ) NMR dynamics of the alternating spin-1/2 chain. MQ NMR spectra are shown
to have the MQ coherences of zero and second orders just as in the case
of a homogeneous chain. The intensities of the MQ coherences are calculated.Comment: 10 pages, 4 figure
On parameters of the Levi-Civita solution
The Levi-Civita (LC) solution is matched to a cylindrical shell of an
anisotropic fluid. The fluid satisfies the energy conditions when the mass
parameter is in the range . The mass per unit
length of the shell is given explicitly in terms of , which has a
finite maximum. The relevance of the results to the non-existence of horizons
in the LC solution and to gauge cosmic strings is pointed out.Comment: Latex, no figure
Algorithm engineering for optimal alignment of protein structure distance matrices
Protein structural alignment is an important problem in computational
biology. In this paper, we present first successes on provably optimal pairwise
alignment of protein inter-residue distance matrices, using the popular Dali
scoring function. We introduce the structural alignment problem formally, which
enables us to express a variety of scoring functions used in previous work as
special cases in a unified framework. Further, we propose the first
mathematical model for computing optimal structural alignments based on dense
inter-residue distance matrices. We therefore reformulate the problem as a
special graph problem and give a tight integer linear programming model. We
then present algorithm engineering techniques to handle the huge integer linear
programs of real-life distance matrix alignment problems. Applying these
techniques, we can compute provably optimal Dali alignments for the very first
time
Universality in fully developed turbulence
We extend the numerical simulations of She et al. [Phys.\ Rev.\ Lett.\ 70,
3251 (1993)] of highly turbulent flow with Taylor-Reynolds number
up to , employing a reduced wave
vector set method (introduced earlier) to approximately solve the Navier-Stokes
equation. First, also for these extremely high Reynolds numbers ,
the energy spectra as well as the higher moments -- when scaled by the spectral
intensity at the wave number of peak dissipation -- can be described by
{\it one universal} function of for all . Second, the ISR
scaling exponents of this universal function are in agreement with
the 1941 Kolmogorov theory (the better, the large is), as is the
dependence of . Only around viscous damping leads to
slight energy pileup in the spectra, as in the experimental data (bottleneck
phenomenon).Comment: 14 pages, Latex, 5 figures (on request), 3 tables, submitted to Phys.
Rev.
Perfect-fluid cylinders and walls - sources for the Levi-Civita space-time
The diagonal metric tensor whose components are functions of one spatial
coordinate is considered. Einstein's field equations for a perfect-fluid source
are reduced to quadratures once a generating function, equal to the product of
two of the metric components, is chosen. The solutions are either static fluid
cylinders or walls depending on whether or not one of the spatial coordinates
is periodic. Cylinder and wall sources are generated and matched to the vacuum
(Levi--Civita) space--time. A match to a cylinder source is achieved for
-\frac{1}{2}<\si<\frac{1}{2}, where \si is the mass per unit length in the
Newtonian limit \si\to 0, and a match to a wall source is possible for
|\si|>\frac{1}{2}, this case being without a Newtonian limit; the positive
(negative) values of \si correspond to a positive (negative) fluid density.
The range of \si for which a source has previously been matched to the
Levi--Civita metric is 0\leq\si<\frac{1}{2} for a cylinder source.Comment: 22 pages, LaTeX, one included figure. Revised version: three
(non-perfect-fluid) interior solutions are added, one of which falsifies the
original conjecture in Sec. 4, and the circular geodesics of the Levi-Civita
space-time are discussed in a footnot
Elastic turbulence in curvilinear flows of polymer solutions
Following our first report (A. Groisman and V. Steinberg, \sl Nature , 53 (2000)) we present an extended account of experimental observations of
elasticity induced turbulence in three different systems: a swirling flow
between two plates, a Couette-Taylor (CT) flow between two cylinders, and a
flow in a curvilinear channel (Dean flow). All three set-ups had high ratio of
width of the region available for flow to radius of curvature of the
streamlines. The experiments were carried out with dilute solutions of high
molecular weight polyacrylamide in concentrated sugar syrups. High polymer
relaxation time and solution viscosity ensured prevalence of non-linear elastic
effects over inertial non-linearity, and development of purely elastic
instabilities at low Reynolds number (Re) in all three flows. Above the elastic
instability threshold, flows in all three systems exhibit features of developed
turbulence. Those include: (i)randomly fluctuating fluid motion excited in a
broad range of spatial and temporal scales; (ii) significant increase in the
rates of momentum and mass transfer (compared to those expected for a steady
flow with a smooth velocity profile). Phenomenology, driving mechanisms, and
parameter dependence of the elastic turbulence are compared with those of the
conventional high Re hydrodynamic turbulence in Newtonian fluids.Comment: 23 pages, 26 figure
The ArgoNeuT Detector in the NuMI Low-Energy beam line at Fermilab
The ArgoNeuT liquid argon time projection chamber has collected thousands of
neutrino and antineutrino events during an extended run period in the NuMI
beam-line at Fermilab. This paper focuses on the main aspects of the detector
layout and related technical features, including the cryogenic equipment, time
projection chamber, read-out electronics, and off-line data treatment. The
detector commissioning phase, physics run, and first neutrino event displays
are also reported. The characterization of the main working parameters of the
detector during data-taking, the ionization electron drift velocity and
lifetime in liquid argon, as obtained from through-going muon data complete the
present report.Comment: 43 pages, 27 figures, 5 tables - update referenc
Imputation of KIR Types from SNP Variation Data.
Large population studies of immune system genes are essential for characterizing their role in diseases, including autoimmune conditions. Of key interest are a group of genes encoding the killer cell immunoglobulin-like receptors (KIRs), which have known and hypothesized roles in autoimmune diseases, resistance to viruses, reproductive conditions, and cancer. These genes are highly polymorphic, which makes typing expensive and time consuming. Consequently, despite their importance, KIRs have been little studied in large cohorts. Statistical imputation methods developed for other complex loci (e.g., human leukocyte antigen [HLA]) on the basis of SNP data provide an inexpensive high-throughput alternative to direct laboratory typing of these loci and have enabled important findings and insights for many diseases. We present KIR∗IMP, a method for imputation of KIR copy number. We show that KIR∗IMP is highly accurate and thus allows the study of KIRs in large cohorts and enables detailed investigation of the role of KIRs in human disease.This work was supported by the Australian National Health and Medical Research Council (NHMRC), Career Development Fellowship ID 1053756 (S.L.); by a Victorian Life Sciences Computation Initiative (VLSCI) grant number VR0240 on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government, Australia (S.L.); by the UK Multiple Sclerosis Society, grant 894/08 (S.S.); and by the Wellcome Trust and the MRC with partial funding from the National Institute of Health Cambridge Biomedical Research Centre (J.T., J.A.T.). Research at the Murdoch Childrens Research Institute was supported by the Victorian Government's Operational Infrastructure Support Program.This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.ajhg.2015.09.00
- …