85 research outputs found
POSaM: a fast, flexible, open-source, inkjet oligonucleotide synthesizer and microarrayer
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2004
- Field of study
DNA arrays are valuable tools in molecular biology laboratories. Their rapid acceptance was aided by the release of plans for a pin-spotting microarrayer by researchers at Stanford. Inkjet microarraying is a flexible, complementary technique that allows the synthesis of arrays of any oligonucleotide sequences de novo. We describe here an open-source inkjet arrayer capable of rapidly producing sets of unique 9,800-feature arrays
Impending U.S. Spending Bust? The Role of Housing Wealth as Borrowing Collateral
- Author
- Alan Greenspan
- Andreas Lehnert
- Ben�tez-Silva
- Daniel H. Cooper
- Erik Hurst
- Erika Morris
- F Juster
- Hanno N Lustig
- Janice C Eberly
- John N Muellbauer
- John Y Campbell
- Jonathan Skinner
- Karl E Case
- Kerwin Charles
- L R Klein
- M A Cambridge
- M I Detroit: Detroit-Livonia-Dearborn
- Mark Lasky
- Michael Lovenheim
- Monika Piazzesi
- Patrick Bajari
- R Kosobud
- Robert Holbrook
- Stephen Zeldes
- Takashi Yamashita
- Tullio Japelli
- Wenli Li
- William H Buiter
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2009
- Field of study
Genome-Wide Association Analysis in Asthma Subjects Identifies SPATS2L as a Novel Bronchodilator Response Gene
- Author
- Bleecker Eugene R.
- Carey Vincent James
- Hanrahan John P.
- Himes Blanca Elena
- Hu Ruoxi
- Irvin Charles G.
- Israel Elliot
- Jiang Xiaofeng
- Klanderman Barbara J.
- Koppelman Gerard H.
- Kubo Michiaki
- Lemanske Robert F.
- Lima John J.
- Litonjua Augusto Ampil
- Lu Quan
- Markezich Amy
- Martinez Fernando D.
- Meyers Deborah A.
- Nakamura Yusuke
- Nieuwenhuis Maartje A. E.
- Panettieri Reynold A.
- Peters Stephen P.
- Postma Dirkje S.
- Senter-Sylvia Jody
- Strunk Robert C.
- Su Jessica Ann Lasky
- Szefler Stanley J.
- Tamari Mayumi
- Tantisira Kelan
- Vonk Judith M.
- Weiss Scott Tillman
- Wu Ann Chen
- Zeiger Robert S.
- Ziniti John
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/07/2012
- Field of study
Bronchodilator response (BDR) is an important asthma phenotype that measures reversibility of airway obstruction by comparing lung function (i.e. FEV1) before and after the administration of a short-acting β2-agonist, the most common rescue medications used for the treatment of asthma. BDR also serves as a test of β2-agonist efficacy. BDR is a complex trait that is partly under genetic control. A genome-wide association study (GWAS) of BDR, quantified as percent change in baseline FEV1 after administration of a β2-agonist, was performed with 1,644 non-Hispanic white asthmatic subjects from six drug clinical trials: CAMP, LOCCS, LODO, a medication trial conducted by Sepracor, CARE, and ACRN. Data for 469,884 single-nucleotide polymorphisms (SNPs) were used to measure the association of SNPs with BDR using a linear regression model, while adjusting for age, sex, and height. Replication of primary P-values was attempted in 501 white subjects from SARP and 550 white subjects from DAG. Experimental evidence supporting the top gene was obtained via siRNA knockdown and Western blotting analyses. The lowest overall combined P-value was 9.7E-07 for SNP rs295137, near the SPATS2L gene. Among subjects in the primary analysis, those with rs295137 TT genotype had a median BDR of 16.0 (IQR = [6.2, 32.4]), while those with CC or TC genotypes had a median BDR of 10.9 (IQR = [5.0, 22.2]). SPATS2L mRNA knockdown resulted in increased β2-adrenergic receptor levels. Our results suggest that SPATS2L may be an important regulator of β2-adrenergic receptor down-regulation and that there is promise in gaining a better understanding of the biological mechanisms of differential response to β2-agonists through GWAS
The genetic determinants of recurrent somatic mutations in 43,693 blood genomes
- Author
- Abecasis Goncalo R
- Albert Christine
- Arnett Donna K
- Barnes Kathleen C
- Becker Lewis C
- Bick Alexander G
- Bis Joshua C
- Blackwell Thomas W
- Blangero John
- Boerwinkle Eric
- Bowden Donald W
- Brody Jennifer A
- Broome Jai G
- Cade Brian E
- Chami Nathalie
- Chen Yii-Der Ida
- Chen Zhanghua
- Cho Michael H
- Correa Adolfo
- Curran Joanne E
- Custer Brian S
- Darbar Dawood
- de Andrade Mariza
- DeMeo Dawn L
- Desai Pinkal
- Duggirala Ravindranath
- Fornage Myriam
- Freedman Barry I
- Gao Yan
- Gauderman W. James
- Gilliland Frank D
- Grammer Leslie
- Gu C. Charles
- Gui Hongsheng
- Guo Xiuqing
- He Jiang
- Heckbert Susan R
- Irvin Marguerite R
- Jaiswal Siddhartha
- Johnsen Jill M
- Johnson Andrew D
- Kang Hyun M
- Kaplan Robert
- Kardia Sharon
- Kenny Eimear E
- Konkle Barbara A
- Kooperberg Charles
- Kumar Rajesh
- Lasky-Su Jessica
- Laurie Cecelia A
- Lee Wen-Jane
- Lewis Joshua P
- Li Xingnan
- Loos Ruth J. F
- Manichaikul Ani W
- Mathias Rasika
- McGarvey Stephen
- Meyers Deborah A
- Natarajan Pradeep
- O\u27Connell Jeffrey R
- Ortega Victor
- Palmer Nicholette D
- Psaty Bruce M
- Qiao Dandi
- Raffield Laura M
- Redline Susan
- Reiner Alexander P
- Rich Stephen S
- Roden Dan
- Rotter Jerome I
- Schleimer Robert P
- Shoemaker M. Benjamin
- Shuldiner Alan R
- Silverman Edwin K
- Smith Albert V
- Smith Nicholas L
- Taylor Kent D
- Tiwari Hemant
- Vasan Ramachandran S
- Weinstock Joshua S
- Weiss Scott T
- Wheeler Marsha M
- Wiggins Kerri L
- Williams Keoki L
- Xiao Shujie
- Yanek Lisa R
- Yun Jeong H
- Publication venue
- Henry Ford Health Scholarly Commons
- Publication date
- 28/04/2023
- Field of study
Nononcogenic somatic mutations are thought to be uncommon and inconsequential. To test this, we analyzed 43,693 National Heart, Lung and Blood Institute Trans-Omics for Precision Medicine blood whole genomes from 37 cohorts and identified 7131 non-missense somatic mutations that are recurrently mutated in at least 50 individuals. These recurrent non-missense somatic mutations (RNMSMs) are not clearly explained by other clonal phenomena such as clonal hematopoiesis. RNMSM prevalence increased with age, with an average 50-year-old having 27 RNMSMs. Inherited germline variation associated with RNMSM acquisition. These variants were found in genes involved in adaptive immune function, proinflammatory cytokine production, and lymphoid lineage commitment. In addition, the presence of eight specific RNMSMs associated with blood cell traits at effect sizes comparable to Mendelian genetic mutations. Overall, we found that somatic mutations in blood are an unexpectedly common phenomenon with ancestry-specific determinants and human health consequences
Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed
- Author
- Abecasis Goncalo
- Armanios Mary
- Arnett Donna K
- Arvanitis Marios
- Ashley-Koch Allison E
- Aslibekyan Stella
- Auer Paul L
- Aviv Abraham
- Barnes Kathleen C
- Barwick Lucas
- Battle Alexis
- Becker Lewis C
- Bis Joshua C
- Blackwell Thomas W
- Blangero John
- Bleecker Eugene R
- Boerwinkle Eric
- Bowden Donald W
- Brody Jennifer A
- Burchard Esteban G
- Cade Brian E
- Celedón Juan C
- Chang Yen Pei C
- Chen Yii-Der Ida
- Chen Zhanghua
- Cho Michael H
- Conomos Matthew P
- Correa Adolfo
- Cox Nancy J
- Cupples L Adrienne
- Curran Joanne E
- Custer Brian
- Darbar Dawood
- Daya Michelle
- de Andrade Mariza
- de las Fuentes Lisa
- Deka Ranjan
- DeMeo Dawn L
- Ellinor Patrick T
- Eng Celeste
- Fingerlin Tasha E.
- Fornage Myriam
- Freedman Barry I
- Garrett Melanie E
- Gelb Bruce D.
- Gilliland Frank D
- Gladwin Mark T
- Gogarten Stephanie M.
- Gui Hongsheng
- Guo Xiuqing
- He Jiang
- Heavner Benjamin
- Heckbert Susan R
- Hidalgo Bertha A
- Hou Lifang
- Hwang Shih-Jen
- Irvin Marguerite R
- Islam Talat
- Iyer Kruthika R
- Jain Deepti
- Johnsen Jill M
- Johnson W Craig
- Kaab Stefan
- Kaplan Robert
- Kardia Sharon LR
- Keener Rebecca
- Kelly Shannon
- Kenny Eimear E
- Keramati Ali
- Konkle Barbara A
- Kooperberg Charles
- Kumar Rajesh
- Lane John
- Launer Lenore
- Laurie Cathy C
- Laurie Cecelia A
- Lee Jiwon
- Levin Albert M
- Levy Daniel
- Liu Chunyu
- Liu Simin
- Loos Ruth JF
- Mak Angel CY
- Mathias Rasika A
- McGarvey Stephen T
- McHugh Caitlin P
- Meyers Deborah A
- Miller-Fleming Tyne W
- Minster Ryan L
- Mitchell Braxton D
- Montgomery Courtney G
- Moscati Arden
- Naseri Take
- Nekhai Sergei
- Nickerson Deborah A
- North Kari E
- Nouraie Mehdi
- O’Connell Jeff
- Palmer Nicholette D
- Pankratz Nathan
- Peralta Juan M
- Perry James A
- Peyser Patricia A
- Psaty Bruce M
- Raby Benjamin A
- Rafaels Nicholas
- Raffield Laura M
- Redline Susan
- Reiner Alexander P
- Reupena Muagututi’a Sefuiva
- Rich Stephen S
- Roden Daniel
- Rotter Jerome I
- Ruczinski Ingo
- Sabino Ester C
- Schwartz David A.
- Sciurba Frank
- Seidman Christine
- Sheu Wayne H-H
- Shoemaker M. Benjamin
- Silverman Edwin K
- Sinner Moritz F
- Smith Albert V
- Smith Jennifer A
- Smith Nicholas L
- Su Jessica Lasky
- Taub Margaret A
- Taylor James G
- Taylor Kent D
- Telen Marilyn J
- Thornton Timothy
- Tiwari Hemant K
- Tracy Russell P
- Vasan Ramachandran S
- Weeks Daniel E
- Weinstock Joshua S
- Weiss Scott T
- Wen Fayun
- Wheeler Marsha M
- White Marquitta J
- Wiggins Kerri L
- Williams L. Keoki
- Wilson James G
- Yanek Lisa R
- Yang Ivana V
- Zhang Yingze
- Zhao Wei
- Publication venue
- Henry Ford Health Scholarly Commons
- Publication date
- 12/01/2022
- Field of study
Genetic studies on telomere length are important for understanding age-related diseases. Prior GWAS for leukocyte TL have been limited to European and Asian populations. Here, we report the first sequencing-based association study for TL across ancestrally-diverse individuals (European, African, Asian and Hispanic/Latino) from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program. We used whole genome sequencing (WGS) of whole blood for variant genotype calling and the bioinformatic estimation of telomere length in n=109,122 individuals. We identified 59 sentinel variants (p-value OBFC1indicated the independent signals colocalized with cell-type specific eQTLs for OBFC1 (STN1). Using a multi-variant gene-based approach, we identified two genes newly implicated in telomere length, DCLRE1B (SNM1B) and PARN. In PheWAS, we demonstrated our TL polygenic trait scores (PTS) were associated with increased risk of cancer-related phenotypes
SNAPSHOT USA 2019 : a coordinated national camera trap survey of the United States
- Author
- Allen Maximilian L
- Alston Jesse M
- Andy Katherine E
- Anhalt-Depies Christine
- Appel Cara L
- Barnick Kelsey A
- Barthelmess Erika L
- Barton Brandon T
- Baruzzi Carolina
- Bebko Alexandra J
- Belant Jerrold L
- Benson John F
- Bergquist Amelia M
- Beyer Dean E
- Bogan Daniel A
- Bontrager Helen
- Brandt LaRoy S E
- Bresnan Claire
- Brooke Jarred M
- Burr Jessica C
- Carter Neil H
- Chrysafis Petros
- Cincotta Connor
- Clark Darren
- Cliché Rachel
- Compton Justin A
- Coster Stephanie S
- Cove Michael V
- Crockett Seth C
- Crupi Anthony P
- Darracq Andrea K
- Davis Daniel
- Davis Miranda L
- DeGregorio Brett A
- Durbin Caleb
- Dykstra Adrienne
- Edelman Andrew J
- Ellison Caroline N
- Evans Bryn E
- Facka Aaron N
- Fantle-Lepczyk Jean E
- Favreau Jorie
- Fisher-Reid M Caitlin
- Flaherty Elizabeth A
- Forrester Tavis
- Fowler Melinda
- Frerichs Taylor
- Fritts Sarah
- Fuller Todd
- Gay Mandy
- Gerber Brian D
- Giery Sean T
- Gompper Matthew E
- Gray Morgan
- Green Austin M
- Hagen Robert H
- Halbur Michelle
- Hammerich Steven
- Hansen Christopher P
- Harris Nyeema C
- Hawkins Melissa T R
- Hernandez Cristian J
- Hernández-Yáñez Haydée
- Herrera Daniel J
- Hess George
- Higdon Summer D
- Horan Robert V
- Hubbard Tru
- Iannarilli Fabiola
- Jachowski David S
- Jaspers Kodi Jo
- Jensen Alex J
- Jordan Mark J
- Kautz Todd M
- Kays Roland
- Kilborn Jillian
- King Sean M
- Klann Renee
- Knowles Travis W
- Kuhn Kellie M
- Kuprewicz Erin K
- Lafferty Diana J R
- LaPoint Scott
- Lashley Marcus A
- Lasky Monica
- Lathrop Richard G
- Lee Thomas E
- Lepczyk Christopher A
- Leslie Matthew S
- Lesmeister Damon B
- Linnell Mark A
- Long Robert A
- Lonsinger Robert C
- MacCombie Kelly Anne
- Maher Sean P
- Marks Sharyn B
- Mason David S
- McShea William J
- Millspaugh Joshua J
- Mortelliti Alessio
- Nagy Christopher
- Nasrallah Sophie L
- Neiswenter Sean A
- Nelson Carrie
- O'Mara M Teague
- O'Neill Brian J
- Parsons Arielle W
- Pelletier Robert
- Pendergast Mary
- Price Melissa R
- Rega-Brodsky Christine C
- Remine Kathryn R
- Rentz Michael S
- Revord Ronald S
- Risch Derek R
- Roemer Gary W
- Romero Andrea
- Rota Christopher
- Rowe Helen
- Russell Katarina
- Ruthven Chip
- Sands Joshua
- Schalk Christopher M
- Schipper Jan
- Schmitz Noel
- Scognamillo Daniel G
- Sevin Jennifer
- Shamon Hila
- Sirén Alexej P K
- Solberg Jaylin N
- Sperry Jinelle H
- Sprague Tiffany
- Stenglein Jennifer L
- Studds Colin E
- Sutherland Chris
- Tellez Chelsey
- Thompson Weston C
- Tleimat Jaquelyn
- Trout Edward
- van der Merwe Marius
- Vanek John P
- Warren Paige
- Wasdin Joanne R
- Webb Stephen L
- Wehr Nathaniel H
- Weiss Katherine C B
- Wells Brenna
- Whipple Laura S
- Whittier Christopher A
- Williamson Jacque
- Zhao Jennifer Y
- Zimova Marketa
- Zorn Adam
- Şekercioğlu Çağan H
- Publication venue
- 'Wiley'
- Publication date
- 01/06/2021
- Field of study
This article is protected by copyright. All rights reserved.With the accelerating pace of global change, it is imperative that we obtain rapid inventories of the status and distribution of wildlife for ecological inferences and conservation planning. To address this challenge, we launched the SNAPSHOT USA project, a collaborative survey of terrestrial wildlife populations using camera traps across the United States. For our first annual survey, we compiled data across all 50 states during a 14-week period (17 August - 24 November of 2019). We sampled wildlife at 1509 camera trap sites from 110 camera trap arrays covering 12 different ecoregions across four development zones. This effort resulted in 166,036 unique detections of 83 species of mammals and 17 species of birds. All images were processed through the Smithsonian's eMammal camera trap data repository and included an expert review phase to ensure taxonomic accuracy of data, resulting in each picture being reviewed at least twice. The results represent a timely and standardized camera trap survey of the USA. All of the 2019 survey data are made available herein. We are currently repeating surveys in fall 2020, opening up the opportunity to other institutions and cooperators to expand coverage of all the urban-wild gradients and ecophysiographic regions of the country. Future data will be available as the database is updated at eMammal.si.edu/snapshot-usa, as well as future data paper submissions. These data will be useful for local and macroecological research including the examination of community assembly, effects of environmental and anthropogenic landscape variables, effects of fragmentation and extinction debt dynamics, as well as species-specific population dynamics and conservation action plans. There are no copyright restrictions; please cite this paper when using the data for publication.Publisher PDFPeer reviewe
Genetic diversity fuels gene discovery for tobacco and alcohol use
- Author
- Addison Clifton
- Akiyama Masato
- Albert Christine M.
- Aliev Fazil
- Alonso Alvaro
- Arnett Donna K.
- Ashley-Koch Allison E.
- Ashrani Aneel A.
- Barnes Kathleen C.
- Barr R. Graham
- Bartz Traci M.
- Batini Chiara
- Becker Diane M.
- Benjamin Emelia J.
- Bergen Andrew W.
- Bielak Lawrence F.
- Bierut Laura J.
- Bis Joshua C.
- Bjornsdottir Gyda
- Blangero John
- Bleecker Eugene R.
- Boardman Jason D.
- Boerwinkle Eric
- Boomsma Dorret I.
- Boorgula Meher Preethi
- Bowden Donald W.
- Brody Jennifer A.
- Cade Brian E.
- Chasman Daniel I.
- Chavan Sameer
- Chen Fang
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Iona
- Cho Michael H.
- Choquet Hélène
- Cole John W.
- Cornelis Marilyn C.
- Cucca Francesco
- Curran Joanne E.
- David Sean P.
- de Andrade Mariza
- Dick Danielle M.
- Docherty Anna R.
- Duggirala Ravindranath
- Eaton Charles B.
- Ehringer Marissa A.
- Esko Tõnu
- Faul Jessica D.
- Fiorillo Edoardo
- Fornage Myriam
- Freedman Barry I.
- Gabrielsen Maiken E.
- Gagliano Taliun Sarah A.
- Gao Shuang
- Garrett Melanie E.
- Gharib Sina A.
- Gieger Christian
- Gillespie Nathan
- Glahn David C.
- Gordon Scott D.
- Gu Charles C.
- Gu Dongfeng
- Gudbjartsson Daniel F.
- Guo Xiuqing
- Haessler Jeffrey
- Hall Michael E.
- Haller Toomas
- Hancock Dana B.
- Harris Kathleen Mullan
- He Jiang
- Herd Pamela
- Hewitt John K.
- Hickie Ian
- Hidalgo Bertha
- Hokanson John E.
- Hopfer Christian
- Hottenga JoukeJan
- Hou Lifang
- Huang Hongyan
- Hung Yi-Jen
- Hunter David J.
- Hveem Kristian
- Hwang Shih-Jen
- Hwu Chii-Min
- Iacono William
- Irvin Marguerite R.
- Jang Seon-Kyeong
- Jee Yon Ho
- Jiang Bibo
- Jiang Yu
- Johnson Eric O.
- Joo Yoonjung Y.
- Jorgenson Eric
- Justice Anne E.
- Kamatani Yoichiro
- Kaplan Robert C.
- Kaprio Jaakko
- Kardia Sharon L. R.
- Keller Matthew C.
- Kelly Tanika N.
- Khunsriraksakul Chachrit
- Kooperberg Charles
- Korhonen Tellervo
- Kraft Peter
- Krauter Kenneth
- Kuusisto Johanna
- Laakso Markku
- Lasky-Su Jessica
- Lee James J.
- Lee Wen-Jane
- Levy Daniel
- Li Kevin
- Li Liming
- Li Yuqing
- Lin Kuang
- Lind Penelope A.
- Liu Chunyu
- Liu Dajiang J.
- Liu Mengzhen
- Lloyd-Jones Donald M.
- Lutz Sharon M.
- Ma Jiantao
- Manichaikul Ani
- Martin Nicholas G.
- Mathur Ravi
- Matoba Nana
- McArdle Patrick F.
- McGue Matt
- McQueen Matthew B.
- Medland Sarah E.
- Metspalu Andres
- Meyers Deborah A.
- Millwood Iona Y.
- Mitchell Braxton D.
- Mohlke Karen L.
- Moll Matthew
- Montasser May E.
- Morrison Alanna C.
- Mulas Antonella
- Munafò Marcus R.
- Mägi Reedik
- Nielsen Jonas B.
- North Kari E.
- Oelsner Elizabeth C.
- Okada Yukinori
- Orrù Valeria
- Otto Jacqueline M.
- Palmer Nicholette D.
- Palviainen Teemu
- Pandit Anita
- Park S. Lani
- Peters Annette
- Peters Ulrike
- Peyser Patricia A.
- Polderman Tinca J. C.
- Rafaels Nicholas
- Redline Susan
- Reed Robert M.
- Reiner Alex P.
- Rice John P.
- Rich Stephen S.
- Richmond Nicole E.
- Roan Carol
- Rotter Jerome I.
- Rueschman Michael N.
- Runarsdottir Valgerdur
- Saccone Nancy L.
- Saunders Gretchen R. B.
- Schwartz David A.
- Shadyab Aladdin H.
- Shi Jingchunzi
- Shringarpure Suyash S.
- Sicinski Kamil
- Silva Lilian Fernandes
- Skogholt Anne Heidi
- Smith Jennifer A.
- Smith Nicholas L.
- Sotoodehnia Nona
- Stallings Michael C.
- Stefansson Hreinn
- Stefansson Kari
- Stitzel Jerry A.
- Sun Xiao
- Syed Moin
- Tal-Singer Ruth
- Taylor Amy E.
- Taylor Kent D.
- Telen Marilyn J.
- Thai Khanh K.
- Thorgeirsson Thorgeir E.
- Tiwari Hemant
- Turman Constance
- Tyrfingsson Thorarinn
- Vrieze Scott
- Wall Tamara L.
- Walters Robin G.
- Wang Chen
- Wang Xingyan
- Weir David R.
- Weiss Scott T.
- White Wendy B.
- Whitfield John B.
- Wiggins Kerri L.
- Willemsen Gonneke
- Willer Cristen J.
- Winsvold Bendik S.
- Xu Huichun
- Yanek Lisa R.
- Yin Jie
- Young Kendra A.
- Young Kristin L.
- Yu Bing
- Zhao Wei
- Zhou Wei
- Zuccolo Luisa
- Zöllner Sebastian
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury(1-4). These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries(5). Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in sample size and genetic diversity improved locus identification and fine-mapping resolution, and that a large majority of the 3,823 associated variants (from 2,143 loci) showed consistent effect sizes across ancestry dimensions. However, polygenic risk scores developed in one ancestry performed poorly in others, highlighting the continued need to increase sample sizes of diverse ancestries to realize any potential benefit of polygenic prediction.Peer reviewe
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L.
- Arif Shaikh Md
- Aritomi N.
- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Attadio Francesca
- Aubin Florian
- AVALLONE Guerino
- Azrad D.
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Baier Jeremy
- Baiotti Luca
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
- Barayoga J. C.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Dániel
- Bartoletti A. M.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
- Basti Andrea
- Bates D. E.
- Bawaj Mateusz
- Baxi P.
- Bayley Joseph
- Baylor Amanda
- Baynard II. P. A.
- Bazzan M.
- Bedakihale V. M.
- Beirnaert Freija
- Bejger Michał
- Belardinelli Daniele
- Bell Angus
- Benedetto V.
- Benoit William
- Bentley Joe
- Bera Sayantani
- Berbel Marina
- Bergamin Fabio
- Berger Beverly
- Bernuzzi Sebastiano
- Beroiz Martin
- Berry Christopher P. L.
- Bersanetti Diego
- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
- Bevins Nathaniel
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- Yamamura S.
- Yamazaki Ryo
- Yan S.
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- Yarbrough Zach
- Yasui H.
- Yeh S. -W.
- Yelikar A. B.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuan S.
- Yuzurihara Hirotaka
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- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badalyan A.
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Baltus Grégory
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
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- Barber J.
- Barish B. C.
- Barker D.
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- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
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- Barta Dániel
- Barthelmy S. D.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
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- Bécsy Bence
- C. Utina Andrei
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- Cagnoli Gianpietro
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- Capocasa Eleonora
- Capote E.
- Carapella G.
- Carbognani F.
- Carlassara M.
- Carlin Julian
- Carolina Silva Oliveira Ana
- Carpinelli Massimo
- Carter Jonathan
- Carullo Gregorio
- Casentini C.
- Castaldi G.
- Castro-Lucas S. Y.
- Caudill S.
- Cavaglia Marco
- Cavalieri Roberto
- Cella Giancarlo
- Cerdá-Durán Pablo
- Cesarini Elisabetta
- Chaibi W.
- Chalathadka Subrahmanya Shreevathsa
- Chan C.
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- Chan W. L.
- Chandra K.
- Chang I. P.
- Chang R. -J.
- Chang W.
- Chanial Pierre
- Chao Shiuh
- Chapman-Bird Christian
- Charlton E. L.
- Charlton Philip
- CHASSANDE-MOTTIN Eric
- Chastain L.
- Chatterjee Chayan
- Chatterjee Debarati
- Chatterjee Deep
- Chaturvedi M.
- Chaty Sylvain
- Chatziioannou Katerina
- Chen A.
- Chen A. H. -Y.
- Chen Dan
- Chen H.
- Chen Hsin-Yu
- Chen Junxin
- Chen K. H.
- Chen X.
- Chen Y.
- Chen Y. -R.
- Cheng H.
- Chessa Piero
- Chia H. Y.
- Chiadini Francesco
- Chiang C.
- Chiarini G.
- Chiba A.
- Chiba R.
- Chierici R.
- Chincarini Andrea
- Chiofalo M. L.
- Chiummo Antonino
- Chou C.
- Choudhary Sunil
- Christensen Nelson
- Chua Sheon S. Y.
- Chun Lung Chan Juno
- Chung K. W.
- Ciani Giacomo
- Ciecieląg Paweł
- Cieślar Marek
- Cifaldi M.
- Ciobanu A. A.
- Ciolfi Riccardo
- Clara F.
- Clark James
- Clarke Teagan
- Clasey Essick Reed
- Claudio Diaz Mario
- Clearwater P.
- Clesse S.
- Cleva F.
- Coccia E.
- Codazzo Elena
- Cohadon Pierre-François
- Colleoni Marta
- Collette C. G.
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- Colombo Alberto
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- Concetta Tringali Maria
- Conti Livia
- Cooper Sam
- Corbitt Thomas
- Cordero-Carrión Isabel
- Corezzi S.
- Cornish Neil
- Corsi Alessandra
- Cortese Stefano
- Costa C. A.
- Cottingham R.
- Coughlin Michael
- Couineaux A.
- Coulon J. -P.
- Countryman S. T.
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- Cousins Bryce
- Couvares Peter
- Coward D. M.
- Cowart M. J.
- Cowburn B. D.
- Coyne Dennis
- Coyne Robert
- Craig K.
- Creighton Jolien
- Creighton T. D.
- Criswell Alexander
- Crockett-Gray J. C. G.
- Croquette Michaël
- Crouch R.
- Crowder S. G.
- Cudell Jean-René
- Cullen T. J.
- Cumming Alan
- Cuoco E.
- Curyło M.
- Cusinato Marco
- D'Angelo Beatrice
- D'Antonio S.
- d'Emilio V.
- D'Onofrio Luca
- D'Urso D.
- Dabadie P.
- Dal Canton Tito
- DALL'OSSO Simone
- Danilishin Stefan
- Danzmann K.
- Darroch K. E.
- Darsow-Fromm Christian
- Dartez L. P.
- Dasgupta A.
- Datta Sayantani
- Dattilo V.
- Daumas A.
- Dave I.
- Davenport A.
- Davier M.
- Davis Derek
- Davis Michael C.
- Daw Edward
- Dax Maximilian
- De Laurentis Martina
- De Lillo Federico
- de Lluc Planas Maria
- De Marco F.
- De Matteis F.
- De Pietri Roberto
- De Rosa Rosario
- de rossi camilla
- De Simone R.
- de Souza Melo S. Assis
- Deenadayalan M.
- Degallaix Jerome
- Del Pozzo W.
- Delfavero Vera
- Dell'Aquila Daniele
- Deléglise Samuel
- Demos N.
- Dent Thomas
- Depasse Antoine
- Dhurandhar S.
- Di Fiore L.
- Di Fronzo Chiara
- di giovanni Fabrizio
- Di Giovanni M.
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- Yeung T. Y.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
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- Zeeshan M.
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- Zendri J. -P.
- Zevin Michael
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- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
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- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
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- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
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- Verma B.
- Verma P.
- Verma Yogesh
- Vermeulen Sander M.
- Veske Doğa
- Vetrano F.
- Veutro A.
- Vibhute Ajay
- Viceré Andrea
- Vidyant S.
- Viets Aaron
- Vijaykumar Aditya
- Vilkha A.
- Villa-Ortega Verónica
- Vincent Erin
- Vinet J. -Y.
- Viret S.
- Virgo Collaboration
- Virtuoso Andrea
- Vitale Salvatore
- Vocca H.
- Voigt Daniel
- von Reis E. R. G.
- von Wrangel J. S. A.
- Vyatchanin Sergey P.
- Wade L. E.
- Wade Madeline
- Wagner Katelyn
- Walet R. C.
- Walker M.
- Wallace G. S.
- Wallace L.
- Wang Haoyu
- Wang J. Z.
- Wang W. H.
- Wang Z.
- Waratkar Gaurav
- Ward R. L.
- Warner J.
- Was Michal
- Washimi Tatsuki
- Washington N. Y.
- Watarai D.
- Wayt K. E.
- Weaver B.
- Weaving C. R.
- Webster S. A.
- Weinert M.
- Weinstein Alan J.
- Weiss R.
- Weizmann Kiendrebeogo R.
- Weller C. M.
- Weller Robert
- Wellmann F.
- Wen L.
- Wette Karl
- Weßels P.
- Whelan John
- White D. D.
- Whiting Bernard F.
- Whittle Chris
- Wildberger J. B.
- Wilk O. S.
- Wilken Dennis
- Willetts K.
- Williams Daniel
- Williams Michael J.
- Williams N. S.
- Willis Joshua
- Willke Benno
- Wils Milan
- Wipf C. C.
- Woan Graham
- Woehler J.
- Wofford Jared
- Wolfe N. E.
- Won Lee Hyung
- Won Seo Jin
- Wong D.
- Wong Henry T.
- Wright J. L.
- Wright Mick
- Wu Chien-Ming
- Wu David S.
- Wu Hsun-Chung
- Wysocki Daniel
- Xiao Liting
- Xu Victoria
- Xu Yumeng
- Yaala M. Ben
- Yadav Nikesh
- Yakovlev Alexey
- Yamamoto Hiroaki
- Yamamoto Kazuhiro
- Yamamoto M.
- Yamamoto Takahiro
- Yamamoto Takahiro S.
- Yamamura S.
- Yamazaki Ryo
- Yan S.
- Yan T.
- Yang F.
- Yang Fengwei
- Yang Kate Z.
- Yang L. -C.
- Yang Yi
- Yarbrough Zach
- Yeh S. -W.
- Yelikar A. B.
- Yeung S. M. C.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zeoli M.
- Zerrad M.
- Zevin Michael
- Zhang A. C.
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
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