Situación actual de la COX-2 en oncología veterinaria

La enzima prostaglandina G/H sintetasa, también conocida como ciclooxigenasa (COX), controla la síntesis de prostaglandinas a partir del acido araquidónico. Se reconocen fundamentalmente dos isoformas de esta enzima que son denominadas COX-I y COX2. En la actualidad sabemos que un importante número de tumores sobrexpresan (sobreexpresan) la COX-2, mientras que esto no sucede en los tejidos normales de los cuales proceden. Este artículo pretende actualizar la información referente a la COX-2 y su implicación en oncología veterinaria

Demixing and orientational ordering in mixtures of rectangular particles

Using scaled-particle theory for binary mixtures of two-dimensional hard particles with rotational freedom, we analyse the stability of nematic phases and the demixing phase behaviour of a variety of mixtures, focussing on cases where at least one of the components consists of hard rectangles or hard squares. A pure fluid of hard rectangles may exhibit, aside from the usual uniaxial nematic phase, an additional (tetratic) oriented phase, possessing two directors, which is the analogue of the biaxial or cubatic phases in three- dimensional fluids. There is computer simulation evidence that the tetratic phase might be stable with respect to phases with spatial order for rectangles with low aspect ratios. As hard rectangles are mixed with other particles not possessing stable tetratic order by themselves, the tetratic phase is destabilised, via a first- or second-order phase transition, to uniaxial nematic or isotropic phases; for hard rectangles of low aspect ratio tetratic order persists in a relatively large range of volume fractions. The order of these transitions depends on the particle geometry, dimensions and thermodynamic conditions of the mixture. The second component of the mixture has been chosen to be hard discs or disco-rectangles, the geometry of which is different from that of rectangles, leading to packing frustration and demixing behaviour, or simply rectangles of different aspect ratio. These mixtures may be good candidates for observing thermodynamically stable tetratic phases in monolayers of hard particles. Finally, demixing between fluid (isotropic--tetratic or tetratic--tetratic) phases is seen to occur in mixtures of hard squares of different sizes when the size ratio is sufficiently large.Comment: 27 pages, 9 figure

Mathematical and Anthropological Analysis of Northern Luzon Funeral Textile

The study presents a mathematical analysis and provides an anthropological perspective of the funeral textile of the indigenous communities in northern Luzon, Philippines. In particular, a symmetry analysis is performed, based on principles of group theory and transformation geometry, on the various repeating patterns found in funeral garments and blankets. Results show that particular frieze groups and plane crystallographic groups are favored due to choice of motifs which are reflective of cultural beliefs and funeral traditions, as well as weaving style and methodology. The results of the analysis point to the depth of mathematics present in the work of the weaver, who is able to arrive at meaningful geometric designs without formal training in mathematics. This study contributes directly to the branch of mathematics pertaining to mathematical crystallography in art and cultural heritage which deals, among others, with the use of group theoretic methods and tools in mathematical crystallography to understand the mathematics in artworks arising from various cultures all over the world. It provides further data and analysis to the growing body of literature that uses symmetry to enhance interpretation of culture from the artistic style of its artifacts

A Systematic Search for High Surface Brightness Giant Arcs in a Sloan Digital Sky Survey Cluster Sample

We present the results of a search for gravitationally-lensed giant arcs conducted on a sample of 825 SDSS galaxy clusters. Both a visual inspection of the images and an automated search were performed and no arcs were found. This result is used to set an upper limit on the arc probability per cluster. We present selection functions for our survey, in the form of arc detection efficiency curves plotted as functions of arc parameters, both for the visual inspection and the automated search. The selection function is such that we are sensitive only to long, high surface brightness arcs with g-band surface brightness mu_g 10. Our upper limits on the arc probability are compatible with previous arc searches. Lastly, we report on a serendipitous discovery of a giant arc in the SDSS data, known inside the SDSS Collaboration as Hall's arc.Comment: 34 pages,8 Fig. Accepted ApJ:Jan-200

Indirect Off-Axis Holography for Antenna Metrology

Phase acquisition in antenna measurement, especially at millimeter- and submillimeter-wave frequencies, is an expensive and challenging task. The need of a steady phase reference demands not only a very stable source but unvarying temperature conditions and strong positioning accuracy requirements. Indirect off-axis holography is an interferometric technique that allows for characterization of an unknown field by means of a simple filtering process of the hologram or intensity interference pattern in the spectral domain, provided that the reference field, employed to interfere with the unknown field, is known in amplitude and phase. This technique can be used to avoid the effect of the errors related to the phase acquisition and to further develop new efficient and robust techniques capable of phase retrieval from amplitude-only acquisitions allowing for cost and complexity reduction of the measurement setup. A short review of the state-of-the-art in antenna metrology is presented in this chapter, as well as a description of conventional indirect off-axis techniques applied to this field. Last sections are devoted to the description of novel measurement techniques developed by the authors in order to overcome the main limitations of the conventional methods

Isolated spin qubits in SiC with a high-fidelity infrared spin-to-photon interface

The divacancies in SiC are a family of paramagnetic defects that show promise for quantum communication technologies due to their long-lived electron spin coherence and their optical addressability at near-telecom wavelengths. Nonetheless, a mechanism for high-fidelity spin-to-photon conversion, which is a crucial prerequisite for such technologies, has not yet been demonstrated. Here we demonstrate a high-fidelity spin-to-photon interface in isolated divacancies in epitaxial films of 3C-SiC and 4H-SiC. Our data show that divacancies in 4H-SiC have minimal undesirable spin-mixing, and that the optical linewidths in our current sample are already similar to those of recent remote entanglement demonstrations in other systems. Moreover, we find that 3C-SiC divacancies have millisecond Hahn-echo spin coherence time, which is among the longest measured in a naturally isotopic solid. The presence of defects with these properties in a commercial semiconductor that can be heteroepitaxially grown as a thin film on shows promise for future quantum networks based on SiC defects.Comment: 26 pages, 4 figure

Completeness of classical spin models and universal quantum computation

We study mappings between distinct classical spin systems that leave the partition function invariant. As recently shown in [Phys. Rev. Lett. 100, 110501 (2008)], the partition function of the 2D square lattice Ising model in the presence of an inhomogeneous magnetic field, can specialize to the partition function of any Ising system on an arbitrary graph. In this sense the 2D Ising model is said to be "complete". However, in order to obtain the above result, the coupling strengths on the 2D lattice must assume complex values, and thus do not allow for a physical interpretation. Here we show how a complete model with real -and, hence, "physical"- couplings can be obtained if the 3D Ising model is considered. We furthermore show how to map general q-state systems with possibly many-body interactions to the 2D Ising model with complex parameters, and give completeness results for these models with real parameters. We also demonstrate that the computational overhead in these constructions is in all relevant cases polynomial. These results are proved by invoking a recently found cross-connection between statistical mechanics and quantum information theory, where partition functions are expressed as quantum mechanical amplitudes. Within this framework, there exists a natural correspondence between many-body quantum states that allow universal quantum computation via local measurements only, and complete classical spin systems.Comment: 43 pages, 28 figure