Solitary coherent structures in viscoelastic shear flow: computation and mechanism

Starting from stationary bifurcations in Couette-Dean flow, we compute nontrivial stationary solutions in inertialess viscoelastic circular Couette flow. These solutions are strongly localized vortex pairs, exist at arbitrarily large wavelengths, and show hysteresis in the Weissenberg number, similar to experimentally observed ``diwhirl'' patterns. Based on the computed velocity and stress fields, we elucidate a heuristic, fully nonlinear mechanism for these flows. We propose that these localized, fully nonlinear structures comprise fundamental building blocks for complex spatiotemporal dynamics in the flow of elastic liquids.Comment: 5 pages text and 4 figures. Submitted to Physical Review Letter

Exhaled Nitric Oxide in Children with Asthma and Short-Term PM(2.5) Exposure in Seattle

The objective of this study was to evaluate associations between short-term (hourly) exposures to particulate matter with aerodynamic diameters < 2.5 μm (PM(2.5)) and the fractional concentration of nitric oxide in exhaled breath (Fe(NO)) in children with asthma participating in an intensive panel study in Seattle, Washington. The exposure data were collected with tapered element oscillation microbalance (TEOM) PM(2.5) monitors operated by the local air agency at three sites in the Seattle area. Fe(NO) is a marker of airway inflammation and is elevated in individuals with asthma. Previously, we reported that offline measurements of Fe(NO) are associated with 24-hr average PM(2.5) in a panel of 19 children with asthma in Seattle. In the present study using the same children, we used a polynomial distributed lag model to assess the association between hourly lags in PM(2.5) exposure and Fe(NO) levels. Our model controlled for age, ambient NO levels, temperature, relative humidity, and modification by use of inhaled corticosteroids. We found that Fe(NO) was associated with hourly averages of PM(2.5) up to 10–12 hr after exposure. The sum of the coefficients for the lag times associated with PM(2.5) in the distributed lag model was 7.0 ppm Fe(NO). The single-lag-model Fe(NO) effect was 6.9 [95% confidence interval (CI), 3.4 to 10.6 ppb] for a 1-hr lag, 6.3 (95% CI, 2.6 to 9.9 ppb ) for a 4-hr lag, and 0.5 (95% CI, −1.1 to 2.1 ppb) for an 8-hr lag. These data provide new information concerning the lag structure between PM(2.5) exposure and a respiratory health outcome in children with asthma

NGC 346 in the Small Magellanic Cloud. III. Recent Star Formation and Stellar Clustering Properties in the Bright HII Region N 66

In the third part of our photometric study of the star-forming region NGC 346/N~66 and its surrounding field in the Small Magellanic Cloud (SMC), we focus on the large number of low-mass pre-main sequence (PMS) stars revealed by the Hubble Space Telescope Observations with the Advanced Camera for Surveys. We investigate the origin of the observed broadening of the pre-main sequence population in the $V-I$, $V$ CMD. The most likely explanations are either the presence of differential reddening or an age spread among the young stars. Assuming the latter, simulations indicate that we cannot exclude the possibility that stars in NGC 346 might have formed in two distinct events occurring about 10 and 5 Myr ago, respectively. We find that the PMS stars are not homogeneously distributed across NGC 346, but instead are grouped in at least five different clusters. On spatial scales from 0.8$''$ to 8$''$ (0.24 to 2.4 pc at the distance of the SMC) the clustering of the PMS stars as computed by a two-point angular correlation function is self-similar with a power law slope $\gamma \approx -0.3$. The clustering properties are quite similar to Milky Way star forming regions like Orion OB or $\rho$ Oph. Thus molecular cloud fragmentation in the SMC seems to proceed on the same spatial scales as in the Milky Way. This is remarkable given the differences in metallicity and hence dust content between SMC and Milky Way star forming regions.Comment: Accepted for publication in ApJ. 16 pages, 13 (low-resolution) figures, emulateapj.cls LaTeX styl

Evolution of Multiphase Hot Interstellar Medium in Elliptical Galaxies

We present the results of a variety of simulations concerning the evolution of multiphase (inhomogeneous) hot interstellar medium (ISM) in elliptical galaxies. We assume the gases ejected from stars do not mix globally with the circumferential gas. The ejected gas components evolve separately according to their birth time, position, and origin. We consider cases where supernova remnants (SNRs) mix with local ISM. The components with high metal abundance and/or high density cool and drop out of the hot ISM gas faster than the other components because of their high metal abundance and/or density. This makes the average metal abundance of the hot ISM low. Furthermore, since the metal abundance of mass-loss gas decreases with radius, gas inflow from outer region makes the average metal abundance of the hot ISM smaller than that of mass-loss gas in the inner region. As gas ejection rate of stellar system decreases, mass fraction of mass-loss gas ejected at outer region increases in a galaxy. If the mixing of SNRs is ineffective, our model predicts that observed [Si/Fe] and [Mg/Fe] should decrease towards the galactic center because of strong iron emission by SNRs. In the outer region, where the cooling of time of the ISM is long, the selective cooling is ineffective and most of gas components remain hot. Thus, the metal abundance of the ISM in this region directly reflects that of the gas ejected from stars. Our model shows that supernovae are not effective heating sources in the inner region of elliptical galaxies, because most of the energy released by them radiates. Therefore, cooling flow is established even if the supernova rate is high. Mixing of SNRs with ambient ISM makes the energy transfer between supernova explosion and ambient ISM more effective.Comment: 21 pages (AASTeX), 14 figures, accepted for publication in The Astrophysical Journa

3D Spectrophotometry of Planetary Nebulae in the Bulge of M31

We introduce crowded field integral field (3D) spectrophotometry as a useful technique for the study of resolved stellar populations in nearby galaxies. As a methodological test, we present a pilot study with selected extragalactic planetary nebulae (XPN) in the bulge of M31, demonstrating how 3D spectroscopy is able to improve the limited accuracy of background subtraction which one would normally obtain with classical slit spectroscopy. It is shown that due to the absence of slit effects, 3D is a most suitable technique for spectrophometry. We present spectra and line intensities for 5 XPN in M31, obtained with the MPFS instrument at the Russian 6m BTA, INTEGRAL at the WHT, and with PMAS at the Calar Alto 3.5m Telescope. Using 3D spectra of bright standard stars, we demonstrate that the PSF is sampled with high accuracy, providing a centroiding precision at the milli-arcsec level. Crowded field 3D spectrophotometry and the use of PSF fitting techniques is suggested as the method of choice for a number of similar observational problems, including luminous stars in nearby galaxies, supernovae, QSO host galaxies, gravitationally lensed QSOs, and others.Comment: (1) Astrophysikalisches Institut Potsdam, (2) University of Durham. 18 pages, 11 figures, accepted for publication in Ap

Formulation, Casting, and Evaluation of Paraffin-Based Solid Fuels Containing Energetic and Novel Additives for Hybrid Rockets

This investigation studied the inclusion of various additives to paraffin wax for use in a hybrid rocket motor. Some of the paraffin-based fuels were doped with various percentages of LiAlH4 (up to 10%). Addition of LiAlH4 at 10% was found to increase regression rates between 7 - 10% over baseline paraffin through tests in a gaseous oxygen hybrid rocket motor. Mass burn rates for paraffin grains with 10% LiAlH4 were also higher than those of the baseline paraffin. RDX was also cast into a paraffin sample via a novel casting process which involved dissolving RDX into dimethylformamide (DMF) solvent and then drawing a vacuum on the mixture of paraffin and RDX/DMF in order to evaporate out the DMF. It was found that although all DMF was removed, the process was not conducive to generating small RDX particles. The slow boiling generated an inhomogeneous mixture of paraffin and RDX. It is likely that superheating the DMF to cause rapid boiling would likely reduce RDX particle sizes. In addition to paraffin/LiAlH4 grains, multi-walled carbon nanotubes (MWNT) were cast in paraffin for testing in a hybrid rocket motor, and assorted samples containing a range of MWNT percentages in paraffin were imaged using SEM. The fuel samples showed good distribution of MWNT in the paraffin matrix, but the MWNT were often agglomerated, indicating that a change to the sonication and mixing processes were required to achieve better uniformity and debundled MWNT. Fuel grains with MWNT fuel grains had slightly lower regression rate, likely due to the increased thermal conductivity to the fuel subsurface, reducing the burning surface temperature

Length of the weaning period affects postweaning growth, health, and carcass merit of ranch-direct beef calves weaned during the fall

Bovine respiratory disease (BRD) is the most economically devastating feedlot disease. Risk factors associated with incidence of BRD include (1) stress associated with maternal separation, (2) stress associated with introduction to an unfamiliar environment, (3) poor intake associated with introduction of novel feedstuffs into the animal\u27s diet, (4) exposure to novel pathogens upon transport to a feeding facility and commingling with unfamiliar cattle, (5) inappropriately administered respiratory disease vaccination programs, and (6) poor response to respiratory disease vaccination programs. Management practices that are collectively referred to as preconditioning are thought to minimize damage to the beef carcass from the BRD complex. Preconditioning management reduces the aforementioned risk factors for respiratory disease by (1) using a relatively long ranch-of-origin weaning period following maternal separation, (2) exposing calves to concentrate-type feedstuffs, and (3) producing heightened resistance to respiratory disease-causing organisms through a preweaning vaccination program. The effectiveness of such programs for preserving animal performance is highly touted by certain segments of the beef industry. Ranch-of-origin weaning periods of up to 60 days are suggested for preconditioning beef calves prior to sale; however, optimal length of the ranch-of-origin weaning period has not been determined experimentally. The objective of this study was to test the validity of beef industry assumptions about appropriate length of ranch-of-origin weaning periods for calves aged 160 to 220 days and weaned during the fall

Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures.

Copy number alteration (CNA) profiling of human tumors has revealed recurrent patterns of DNA amplifications and deletions across diverse cancer types. These patterns are suggestive of conserved selection pressures during tumor evolution but cannot be fully explained by known oncogenes and tumor suppressor genes. Using a pan-cancer analysis of CNA data from patient tumors and experimental systems, here we show that principal component analysis-defined CNA signatures are predictive of glycolytic phenotypes, including 18F-fluorodeoxy-glucose (FDG) avidity of patient tumors, and increased proliferation. The primary CNA signature is enriched for p53 mutations and is associated with glycolysis through coordinate amplification of glycolytic genes and other cancer-linked metabolic enzymes. A pan-cancer and cross-species comparison of CNAs highlighted 26 consistently altered DNA regions, containing 11 enzymes in the glycolysis pathway in addition to known cancer-driving genes. Furthermore, exogenous expression of hexokinase and enolase enzymes in an experimental immortalization system altered the subsequent copy number status of the corresponding endogenous loci, supporting the hypothesis that these metabolic genes act as drivers within the conserved CNA amplification regions. Taken together, these results demonstrate that metabolic stress acts as a selective pressure underlying the recurrent CNAs observed in human tumors, and further cast genomic instability as an enabling event in tumorigenesis and metabolic evolution

Asymmetric WIMP dark matter

In existing dark matter models with global symmetries the relic abundance of dark matter is either equal to that of anti-dark matter (thermal WIMP), or vastly larger, with essentially no remaining anti-dark matter (asymmetric dark matter). By exploring the consequences of a primordial asymmetry on the coupled dark matter and anti-dark matter Boltzmann equations we find large regions of parameter space that interpolate between these two extremes. Interestingly, this new asymmetric WIMP framework can accommodate a wide range of dark matter masses and annihilation cross sections. The present-day dark matter population is typically asymmetric, but only weakly so, such that indirect signals of dark matter annihilation are not completely suppressed. We apply our results to existing models, noting that upcoming direct detection experiments will constrain a large region of the relevant parameter space.Comment: 32 pages, 6 figures, updated references, updated XENON100 bounds, typo in figure caption correcte

The early-type galaxies NGC 1407 and NGC 1400 - II: star formation and chemical evolutionary history

We present a possible star formation and chemical evolutionary history for two early-type galaxies NGC 1407 and NGC 1400. They are the two brightest galaxies of the NGC 1407 (or Eridanus-A) group, one of the 60 groups studied as part of the Group Evolution Multi-wavelength Study (GEMS). Our analysis is based on new high signal-to-noise spatially resolved integrated spectra obtained at the ESO 3.6m telescope, out to 0.6 (NGC 1407) and 1.3 (NGC 1400) effective radii. Using Lick/IDS indices we estimate luminosity-weighted ages, metallicities and $\alpha$-element abundance ratios. Colour radial distributions from HST/ACS and Subaru Suprime-Cam multi-band wide-field imaging are compared to colours predicted from spectroscopically determinated ages and metallicities using single stellar population models. The galaxies formed over half of their mass in a single short-lived burst of star formation (> 100 M(sun)/year) at redshift z>5. This likely involved an outside-in mechanism with supernova-driven galactic winds, as suggested by the flatness of the alpha-element radial profiles and the strong negative metallicity gradients. Our results support the predictions of the revised version of the monolithic collapse model for galaxy formation and evolution. We speculate that, since formation the galaxies have evolved quiescently and that we are witnessing the first infall of NGC 1400 in the group.Comment: 14 pages, 9 tables, 6 figures, Accepted for publication in MNRA