301 research outputs found

    Contestations, innovation and change : a case study of a new Western Australian secondary school

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    ABSTRACT\ud This thesis is a case study of the policy contestations associated with the establishment of\ud a new Western Australian government secondary school. State politicians and\ud bureaucrats promoted the school, Ballajura Community College, as fa school for the\ud twenty-first century'. The school opened in 1995 and incorporated the State's first middle\ud school, representing a significant change to the hitherto existing secondary school\ud structure. The thesis provides information on how agents associated with the\ud establishment of a new school navigated the multiple policy agendas against shifting\ud social and political changes. At the time of opening the school the Western Australian\ud government was committed to expanding devolution in schools. This thesis examines\ud how key aspects of the devolution agenda impacted on the planning and establishment of\ud Ballajura Community College.\ud The research provides an 'insider's perspective' of Foundation Principal and\ud utilises a combination of methods including social semiotics, critical discourse analysis\ud and autobiography. Data collection included documentary evidence, interviews with\ud senior policy makers and autobiographical data.\ud While educational research and theory suggests that there is an urgent need to\ud envision new futures for schooling in the twenty-first century, this same research often\ud simplifies the process and does not attend to the multiplicity of variables. This\ud investigation concludes that the design, structure, curriculum development and operation\ud of a new secondary school, in a highly centralised system, is intimately linked to the\ud broader socio-political context and established traditions and practices.\ud This thesis extends the debate on research into school change. It demonstrates\ud that the processes of innovation and change can be neither formulaic nor prescriptive. It\ud raises questions relating to the methods, authority and effects of educational research and\ud argues that educational research for the twenty-first century must broaden its scope to\ud incorporate and legitimise the voice and authority of school leaders and teachers

    Generalized multiresolution analyses with given multiplicity functions

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    Generalized multiresolution analyses are increasing sequences of subspaces of a Hilbert space \H that fail to be multiresolution analyses in the sense of wavelet theory because the core subspace does not have an orthonormal basis generated by a fixed scaling function. Previous authors have studied a multiplicity function mm which, loosely speaking, measures the failure of the GMRA to be an MRA. When the Hilbert space \H is L2(Rn)L^2(\mathbb R^n), the possible multiplicity functions have been characterized by Baggett and Merrill. Here we start with a function mm satisfying a consistency condition which is known to be necessary, and build a GMRA in an abstract Hilbert space with multiplicity function mm.Comment: 16 pages including bibliograph

    DBS Under FCC and International Regulation

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    This Article examines the legal and technological development of DBS in both the domestic and international fora. Part II examines the development of DBS and information policy concerning DBS in the United States. The Article then in part III discusses the international positions of the developed nations, the developing countries, and the Soviet bloc on the DBS issues and reveals the results thus far in the policy debate among these nations and the United States. Part IV concludes the Article with a brief outline of the possibilities for international cooperation to solve the DBS controversy

    Generalized multiresolution analyses with given multiplicity functions

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    Generalized multiresolution analyses are increasing sequences of subspaces of a Hilbert space H that fail to be multiresolution analyses in the sense of wavelet theory because the core subspace does not have an orthonormal basis generated by a fixed scaling function. Previous authors have studied a multiplicity function m which, loosely speaking, measures the failure of the GMRA to be an MRA. When the Hilbert space H is L2(Rn), the possible multiplicity functions have been characterized by Baggett and Merrill. Here we start with a function m satisfying a consistency condition which is known to be necessary, and build a GMRA in an abstract Hilbert space with multiplicity function m

    SILAC-based phosphoproteomics reveals new PP2A-Cdc55-regulated processes in budding

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    Background: Protein phosphatase 2A (PP2A) is a family of conserved serine/threonine phosphatases involved in several essential aspects of cell growth and proliferation. PP2A(Cdc55) phosphatase has been extensively related to cell cycle events in budding yeast; however, few PP2A(Cdc55) substrates have been identified. Here, we performed a quantitative mass spectrometry approach to reveal new substrates of PP2A(Cdc55) phosphatase and new PP2A-related processes in mitotic arrested cells. Results: We identified 62 statistically significant PP2A(Cdc55) substrates involved mainly in actin-cytoskeleton organization. In addition, we validated new PP2A(Cdc55) substrates such as Slk19 and Lte1, involved in early and late anaphase pathways, and Zeo1, a component of the cell wall integrity pathway. Finally, we constructed docking models of Cdc55 and its substrate Mob1. We found that the predominant interface on Cdc55 is mediated by a protruding loop consisting of residues 84-90, thus highlighting the relevance of these aminoacids for substrate interaction. Conclusions: We used phosphoproteomics of Cdc55-deficient cells to uncover new PP2A(Cdc55) substrates and functions in mitosis. As expected, several hyperphosphorylated proteins corresponded to Cdk1-dependent substrates, although other kinases' consensus motifs were also enriched in our dataset, suggesting that PP2A(Cdc55) counteracts and regulates other kinases distinct from Cdk1. Indeed, Pkc1 emerged as a novel node of PP2A(Cdc55) regulation, highlighting a major role of PP2A(Cdc55) in actin cytoskeleton and cytokinesis, gene ontology terms significantly enriched in the PP2A(Cdc55)-dependent phosphoproteome

    Orthotopic liver transplantation for acute and subacute hepatic failure in adults

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    The role of liver transplantation in 29 patients with fulminant and subacute hepatic failure due to a variety of different causes was examined by comparing the outcome and a variety of “hospitalization” variables. Transplanted patients (n = 13) were more likely to survive (p < 0.05), were younger (p < 0.05) and spent more time in the hospital (p < 0.025) than did those who were not transplanted (n = 16). Despite spending a much longer time in the hospital, transplanted patients spent less time in the intensive care unit (p < 0.05) in coma (p < 0.01) and on a respirator (p < 0.01) than did those not transplanted. Most importantly, the survival rate for transplanted patients was significantly improved (p < 0.05) as compared to those not transplanted. We conclude that liver transplantation can be applied successfully to the difficult clinical problem of fulminant and subacute hepatic failure. Copyright © 1987 American Association for the Study of Liver Disease
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