Effect of Denosumab on Bone Mineral Density and Markers of Bone Turnover among Postmenopausal Women with Osteoporosis

The aim of this study was to evaluate the effect of denosumab (Dmab) on bone mineral density (BMD) and bone turnover markers after 1 year of treatment. Additionally, the effect of Dmab in bisphosphonate-naïve patients (BP-naïve) compared to patients previously treated with bisphosphonates (BP-prior) was analyzed. This retrospective study included 425 postmenopausal women treated with Dmab for 1 year in clinical practice conditions in specialized centers from Argentina. Participants were also divided according to previous bisphosphonate treatment into BP-naïve and BP-prior. A control group of patients treated with BP not switched to Dmab matched by sex, age, and body mass index was used. Data are expressed as mean ± SEM. After 1 year of treatment with Dmab the bone formation markers total alkaline phosphatase and osteocalcin were significantly decreased (23.36% and 43.97%, resp.), as was the bone resorption marker s-CTX (69.61%). Significant increases in BMD were observed at the lumbar spine, femoral neck, and total hip without differences between BP-naïve and BP-prior. A better BMD response was found in BPprior group compared with BP treated patients not switched to Dmab. Conclusion. Dmab treatment increased BMDand decreased bone turnover markers in the whole group, with similar response in BP-naïve and BP-prior patients. A better BMD response in BP-prior patients versus BP treated patients not switched to Dmab was observed.Facultad de Ciencias Médica

Comparison of sediment transport formulae with monthly 2DH simulation on a sandy beach and on a beach with noneroded sea bed zone

This paper discusses the abilities of numerical models to predict the morphodynamics over loose and rigid beds. In the first part the sediment transport model is presented which solves the bed evolution equation in conjunction with sediment transport formulas. The flow field and the water depth are calculated using the depth-averaged hydrodynamic model TELEMAC-2D developed by Électricité de Franc

Direct numerical simulation of instabilities in a two-dimensional near-critical fluid layer heated from below

International audienceAn analysis of the hydrodynamic stability of a fluid near its near critical point – initially at rest and in thermodynamic equilibrium – is considered in the Rayleigh–Bénard configuration, i.e. heated from below. The geometry is a two-dimensional square cavity and the top and bottom walls are maintained at constant temperatures while the sidewalls are insulated. Owing to the homogeneous thermo-acoustic heating (piston effect), the thermal field exhibits a very specific structure in the vertical direction. A very thin hot thermal boundary layer is formed at the bottom, then a homogeneously heated bulk settles in the core at a lower temperature; at the top, a cooler boundary layer forms in order to continuously match the bulk temperature with the colder temperature of the upper wall. We analyse the stability of the two boundary layers by numerically solving the Navier–Stokes equations appropriate for a van der Waals' gas slightly above its critical point. A finite-volume method is used together with an acoustic filtering procedure. The onset of the instabilities in the two different layers is discussed with respect to the results of the theoretical stability analyses available in the literature and stability diagrams are derived. By accounting for the piston effect the present results can be put within the framework of the stability analysis of Gitterman and Steinberg for a single layer subjected to a uniform, steady temperature gradient

Un outil moléculaire simple et abordable pour identifier les larves de taupins du genre Agriotes

National audienc

Direct numerical simulation of instabilities in a two-dimensional near-critical fluid layer heated from below

International audienceAn analysis of the hydrodynamic stability of a fluid near its near critical point – initially at rest and in thermodynamic equilibrium – is considered in the Rayleigh–Bénard configuration, i.e. heated from below. The geometry is a two-dimensional square cavity and the top and bottom walls are maintained at constant temperatures while the sidewalls are insulated. Owing to the homogeneous thermo-acoustic heating (piston effect), the thermal field exhibits a very specific structure in the vertical direction. A very thin hot thermal boundary layer is formed at the bottom, then a homogeneously heated bulk settles in the core at a lower temperature; at the top, a cooler boundary layer forms in order to continuously match the bulk temperature with the colder temperature of the upper wall. We analyse the stability of the two boundary layers by numerically solving the Navier–Stokes equations appropriate for a van der Waals' gas slightly above its critical point. A finite-volume method is used together with an acoustic filtering procedure. The onset of the instabilities in the two different layers is discussed with respect to the results of the theoretical stability analyses available in the literature and stability diagrams are derived. By accounting for the piston effect the present results can be put within the framework of the stability analysis of Gitterman and Steinberg for a single layer subjected to a uniform, steady temperature gradient

Asociación negativa entre 25-Hidroxi vitamina D y los marcadores inflamatorios en enfermedades reumatológicas

Objective The main purpose of this study was to evaluate serum 25-hydroxyvitamin D (25OHD) levels and its association with in"ammatory markers in patients with rheumatologic diseases (RD). Methods A cross-sectional study in 154 women with RD (rheumatoid arthritis, spondyloarthritis and other connective tissue diseases) and 112 healthy individuals as a control group (CG) was carried out. Results No differences in serum and urine calcium, serum phosphate, and urinary deoxypyridinoline were found. RD group had lower 25OHD and higher PTH compared to CG. RD group had higher C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) compared to CG. The overall mean level of 25OHD (ng/ml) was 26.3±12.0 in the CG and 19.4±6.8 in the RD group (p<0.0001). Moreover, CG had lower percentage of individuals with 25OHD de!ciency compared to RD (29.9% vs 53.2%). The femoral neck BMD was signi!cantly lower in postmenopausal RD women compared to CG. 25OHD levels signi!cantly correlated with ESR and CRP as in"ammatory markers. Age, BMI, presence of RD, and CRP were signi!cantly and negatively associated with 25OHD levels through linear regression analysis. According to univariate logistic regression analysis for 25OHD de!ciency (<20 ng/ml), a signi!cant and negative association with BMI, presence of RD, ESR and CRP were found. Conclusion Patients with RD had lower 25OHD levels than controls and the presence of a RD increases by 2.66 the risk of vitamin D de!ciency. In addition, 25OHD has a negative correlation with ESR and CRP as in"ammatory markers.Fil: Brance, María Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Reumatología y Enfermedades Óseas; ArgentinaFil: Larroudé, María Silvia. Centro de Diagnostico Rossi; ArgentinaFil: Berbotto, Guillermo. Sanatorio Británico de Rosario; ArgentinaFil: Sacnun, Mónica P.. Hospital Provincial de Rosario; ArgentinaFil: Aeschlimann, Carolina. Hospital Provincial de Rosario; ArgentinaFil: Palatnik, M.. Centro de Reumatologia; ArgentinaFil: Chavero, Ignacio. Reumatología y Enfermedades Óseas; ArgentinaFil: Sánchez, Ariel. Centro de Endocrinología; ArgentinaFil: Brun, Lucas Ricardo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentin

Inventory and mapping of Posidonia oceanica reefs of the French Mediterranean coast

International audiencePosidonia oceanicareefs along the French Mediterranean coast were inventoried and mapped using bibliographical data, analysis of aerial photos, images obtained using drone and 3D models. Sixteen previously unreported reefs and another 13 reefs that had been destroyed or disappeared were identified. In all, 75 Posidonia reef structures have were known to exist but today there are only 62 left

Sediment transport formulae for coastal morphodynamic simulation: calculated sediment flux against in situ data

International audienc