Some conjectures and results about multizeta values for F_q[t]

In this paper, we explain several conjectures about how a product of two Carlitz-Goss zeta values can be expressed as a F_p-linear combination of Thakur's multizeta values, generalizing the q=2 case dealt by D. Thakur in Relations between multizeta values for F_q[t]. In contrast to the classical sum shuffle, \zeta(a)\zeta(b)=\zeta(a+b)+\zeta(a,b)+\zeta(b,a), the identities we get are much more involved. Hundreds of instances of these conjectures have been proved and we describe the proof method and the evidence.Comment: 10 page

Artists, Aesthetics, and Migrations: Contemporary Visual Arts and Caribbean Diaspora in Miami, Florida.

Artists, Aesthetics, and Migrations: Contemporary Visual Arts and Caribbean Diaspora in Miami, Florida, is an ethnographic study about Miami-based visual artists, and the relationship between Miami and the Caribbean as it is realized visually. Miami is a diasporic city that has been built on the labor and visual culture of the Caribbean, and shaped into a transnational city by its role as a hub of Latin American and Caribbean migration and trade. However, a Caribbean presence is made to be invisible in much of the contemporary visual arts scene. In the political economy of cultural production, artists are rendered in different degrees of visibility based on their social location (e.g. race, gender, class) and suppositions about Caribbean art practice including expectations for “craft” artwork or subject matter (e.g. tropical landscapes). I argue that artists counter these practices by crafting their work to enact performances in the archive; making visible what is often made to seem invisible. While most studies of immigration attend to farm labor, domestic work, and familial relationships, this project turns attention to the field of artistic production. With attention to artists’ work and the socio-geographic terrain of the city, I detail the historic and contemporary relationship between Miami and the Caribbean, and show how artists’ works reflect and produce this experience in several ways: engaging the landscape; rethinking migrations; building practices based on diasporic legacies; and intervening in archives. Although tropes of tropicality attempt to silence the full range of visual realities, the works artists produce are not resigned to be exotic items in collections akin to the cabinets of curiosities of early scientists and explorers. Instead, artists act to render themselves visible. The very existence of the artwork changes the possibilities for how we understand migration and visuality, not only in Miami, but globally.PHDAnthropologyUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/100080/1/lspardo_1.pd

Everolimus Exposure as a Predictor of Toxicity in Renal Cell Cancer Patients in the Adjuvant Setting: Results of a Pharmacokinetic Analysis for SWOG S0931 (EVEREST), a Phase III Study (NCT01120249).

BackgroundS0931 is assessing recurrence-free survival in renal cell carcinoma (RCC) patients randomized to receive everolimus (EVE) versus placebo for one year following nephrectomy. Due to a higher than expected dropout rate, we assessed EVE trough levels in the adjuvant setting to evaluate the relationship between EVE exposure and probability of toxicity.MethodsPatients received 10 mg daily EVE for nine 6-week cycles. Pre-dose whole blood samples were collected pre-cycle 2 and pre-cycle 3 and analyzed for EVE. Patients with pre-cycle 2 and/or pre-cycle 3 EVE results were used in the analysis. Patients were segregated into quartiles (Q) based on EVE levels and logistic regression was used to model the most common adverse event outcomes using EVE trough as a predictor. Hazard and odds ratios were adjusted for age, BMI and performance status.ResultsA total of 467 patients were included in this analysis. Quartiles normalized to an EVE dose of 10 mg/day were < 9.0, 9.0-12.9, 12.9-22.8, and > 22.8 ng/mL, respectively. EVE trough levels increased with increasing age (p < 0.001). Furthermore, EVE trough levels were higher in men than women (19.4 versus 15.4 ng/mL, p = 0.01). Risk of grade 2 + triglycerides was increased in Q2 and Q3 vs Q1 (OR = 2.08; p = 0.02 and OR = 2.63; p = 0.002). Risk of grade 2 + rash was increased in Q2 and Q4 vs Q1 (OR = 2.99; p = 0.01 and OR = 2.90; p = 0.02). There was also an increased risk of any grade 3 + tox in Q2 vs Q1 (OR = 1.71; p = 0.05).ConclusionsWe identified significant gender and age-related differences in EVE trough levels in patients receiving adjuvant treatment for RCC. Furthermore, our analysis identified significant associations between EVE exposure and probability of toxicity

Mode excitation by turbulent convection in rotating stars. I. Effect of uniform rotation

We focus on the influence of the Coriolis acceleration on the stochastic excitation of oscillation modes in convective regions of rotating stars. Our aim is to estimate the asymmetry between excitation rates of prograde and retrograde modes. We extend the formalism derived for obtaining stellar $p$- and $g$-mode amplitudes (Samadi & Goupil 2001, Belkacem et al. 2008) to include the effect of the Coriolis acceleration. We then study the special case of uniform rotation for slowly rotating stars by performing a perturbative analysis. This allows us to consider the cases of the Sun and the CoRoT target HD 49933. We find that, in the subsonic regime, the influence of rotation as a direct contribution to mode driving is negligible in front of the Reynolds stress contribution. In slow rotators, the indirect effect of the modification of the eigenfunctions on mode excitation is investigated by performing a perturbative analysis of the excitation rates. It turns out that the excitation of solar $p$ modes is affected by rotation with excitation rates asymmetries between prograde and retrograde modes of the order of several percents. Solar low-order $g$ modes are also affected by uniform rotation and their excitation rates asymmetries are found to reach up to 10 %. The CoRoT target HD 49933 is rotating faster than the Sun ($\Omega / \Omega_\odot \approx 8$) and we show that the resulting excitation rates asymmetry is about 10 % for the excitation rates of $p$ modes. We have then demonstrated that $p$ and $g$ mode excitation rates are modified by uniform rotation through the Coriolis acceleration. Study of the effect of differential rotation is dedicated to a forthcoming paper.Comment: 9 pages, 4 figures, accepted in A&

Kaposi's Sarcoma Associated-Herpes Virus (KSHV) Seroprevalence in Pregnant Women in South Africa

<p>Abstract</p> <p>Background</p> <p>Factors previously associated with Kaposi's sarcoma-associated herpesvirus (KSHV) transmission in Africa include sexual, familial, and proximity to river water. We measured the seroprevalence of KSHV in relation to HIV, syphilis, and demographic factors among pregnant women attending public antenatal clinics in the Gauteng province of South Africa.</p> <p>Methods</p> <p>We tested for antibodies to KSHV lytic K8.1 and latent Orf73 antigens in 1740 pregnant women attending antenatal clinics who contributed blood to the "National HIV and Syphilis Sero-Prevalence Survey - South Africa, 2001". Information on HIV and syphilis serology, age, education, residential area, gravidity, and parity was anonymously linked to evaluate risk factors for KSHV seropositivity. Clinics were grouped by municipality regions and their proximity to the two main river catchments defined.</p> <p>Results</p> <p>KSHV seropositivity (reactive to either lytic K8.1 and latent Orf73) was nearly twice that of HIV (44.6% vs. 23.1%). HIV and syphilis seropositivity was 12.7% and 14.9% in women without KSHV, and 36.1% and 19.9% respectively in those with KSHV. Women who are KSHV seropositive were 4 times more likely to be HIV positive than those who were KSHV seronegative (AOR 4.1 95%CI: 3.4 - 5.7). Although, women with HIV infection were more likely to be syphilis seropositive (AOR 1.8 95%CI: 1.3 - 2.4), no association between KSHV and syphilis seropositivity was observed. Those with higher levels of education had lower levels of KSHV seropositivity compared to those with lower education levels. KSHV seropositivity showed a heterogeneous pattern of prevalence in some localities.</p> <p>Conclusions</p> <p>The association between KSHV and HIV seropositivity and a lack of common association with syphilis, suggests that KSHV transmission may involve geographical and cultural factors other than sexual transmission.</p

Position statement: Pre-hospital rapid sequence intubation

The Professional Board for Emergency Care at the Health Professions Council of South Africa (HPCSA) has approved pre-hospital rapid sequence intubation (RSI) as part of the scope of practice for registered emergency care practitioners (ECPs). RSI is an advanced airway management process that facilitates endotracheal intubation in adults and children. Features of this technique include pre-oxygenation, rapid pharmacological induction of unconsciousness, and neuromuscular blockade to enable the placement of an endotracheal tube. RSI has become widespread as the procedure of choice for definitive airway management by pre- and in-hospital emergency care personnel worldwide. In the emergency department setting, RSI is superior to intubation with deep sedation, a technique not incorporating pharmacological paralysis as part of the intubation sequence. For this reason, the implementation of RSI in the pre-hospital environment is supported, provided that it is practised within an appropriate framework of clinical governance

Preparing for and managing change: Climate adaptation for biodiversity and ecosystems

The emerging field of climate-change adaptation has experienced a dramatic increase in attention as the impacts of climate change on biodiversity and ecosystems have become more evident. Preparing for and addressing these changes are now prominent themes in conservation and natural resource policy and practice. Adaptation increasingly is viewed as a way of managing change, rather than just maintaining existing conditions. There is also increasing recognition of the need not only to adjust management strategies in light of climate shifts, but to reassess and, as needed, modify underlying conservation goals. Major advances in the development of climate-adaptation principles, strategies, and planning processes have occurred over the past few years, although implementation of adaptation plans continues to lag. With ecosystems expected to undergo continuing climate-mediated changes for years to come, adaptation can best be thought of as an ongoing process, rather than as a fixed endpoint. © The Ecological Society of America

Masivukeni: Development of a Multimedia Based Antiretroviral Therapy Adherence Intervention for Counselors and Patients in South Africa

Effective medical treatment for HIV/AIDS requires patients’ optimal adherence to antiretroviral therapy (ART). In resource-constrained settings, lack of adequate standardized counseling for patients on ART remains a significant barrier to adherence. Masivukeni (“Let’s Wake Up” in Xhosa) is an innovative multimedia-based intervention designed to help people living with HIV in resource-limited settings achieve and maintain high levels of ART adherence. Adapted from a couples-based intervention tested in the United States (US), Masivukeni was developed through community-based participatory research with US and South African partners and informed by Ewart’s Social Action Theory. Innovative computer-based multimedia strategies were used to translate a labor- and training-intensive intervention into one that could be readily and widely used by lay counselors with relatively little training with low-literacy patients. In this paper, we describe the foundations of this new intervention, the process of its development, and the evidence of its high acceptability and feasibility

Protocol for the development of guidance for stakeholder engagement in health and healthcare guideline development and implementation

Stakeholder engagement has become widely accepted as a necessary component of guideline development and implementation. While frameworks for developing guidelines express the need for those potentially affected by guideline recommendations to be involved in their development, there is a lack of consensus on how this should be done in practice. Further, there is a lack of guidance on how to equitably and meaningfully engage multiple stakeholders. We aim to develop guidance for the meaningful and equitable engagement of multiple stakeholders in guideline development and implementation. METHODS: This will be a multi-stage project. The first stage is to conduct a series of four systematic reviews. These will (1) describe existing guidance and methods for stakeholder engagement in guideline development and implementation, (2) characterize barriers and facilitators to stakeholder engagement in guideline development and implementation, (3) explore the impact of stakeholder engagement on guideline development and implementation, and (4) identify issues related to conflicts of interest when engaging multiple stakeholders in guideline development and implementation. DISCUSSION: We will collaborate with our multiple and diverse stakeholders to develop guidance for multi-stakeholder engagement in guideline development and implementation. We will use the results of the systematic reviews to develop a candidate list of draft guidance recommendations and will seek broad feedback on the draft guidance via an online survey of guideline developers and external stakeholders. An invited group of representatives from all stakeholder groups will discuss the results of the survey at a consensus meeting which will inform the development of the final guidance papers. Our overall goal is to improve the development of guidelines through meaningful and equitable multi-stakeholder engagement, and subsequently to improve health outcomes and reduce inequities in health