ICPBR-Working Group Risks posed by dusts: overview of the area and recommendations

Background: In 2008 the poisoning of about 12000 bee colonies was reported from Germany. These poisonings were caused by the drift of dust particles containing the insecticidal substance clothianidin following the seeding of maize seeds, inadequately treated with the insecticide Poncho Pro. Results: Investigations were done on the dust load contained in seed packages of different crops, on the experimental abrasion of dust from treated seeds using the Heubach-Dustmeter as well as on the actual dust drift during the sowing operation of treated seeds with different machinery under field conditions. Resistance to abrasion of treated seeds and subsequent dust drift during sowing operations differ significantly between crops, coating recipes and facilities. Furthermore dust drift depends on particle size, sowing technology as well as on environmental conditions (e.g. wind speed, soil humidity). Conclusions: The drift of dust from treated seeds may pose a risk to honeybees, which needs to be appropriately considered within the authorization process of pesticides. The total quantity of abraded dust as well as the actual emission of dust during the sowing operation can be significantly reduced by technical means (e.g. coating recipe and facility equipment, deflector technology) and by additional mitigation measures (e.g. maximum wind speed). Keywords: honeybee, poisoning, risk, seed treatment, dust, drif

Identification of Yeast and Human 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAr) Transporters

International audienc

Prothrombotic Hemostasis Disturbances in Patients with Severe COVID-19:Individual daily data

This data article accompanies the manuscript entitled: "Prothrombotic Disturbances of hemostasis of Patients with Severe COVID-19: a Prospective Longitudinal Observational Cohort Study" submitted to by the same authors. We report temporal changes of plasma levels of an extended set of laboratory parameters during the ICU stay of the 21 COVID-19 patients included in the monocentre cohort: CRP, platelet count, prothrombin time; Clauss fibrinogen and clotting factors II, V and VIII levels, D-dimers, antithrombin activity, protein C, free protein S, total and free tissue factor pathway inhibitor, PAI-1 levels, von Willebrand factor antigen and activity, ADAMTS-13 (plasma levels); and of two integrative tests of coagulation (thrombin generation with ST Genesia) and fibrinolysis (global fibrinolytic capacity - GFC). Regarding hemostasis, we used double-centrifuged frozen citrated plasma prospectively collected after daily performance of usual coagulation tests. Demographic and clinical characteristics of patients and thrombotic and hemorrhagic complications were also collected from patient's electronic medical reports

Pathologies related to abnormal deposits in dermatology : a physico-chemical approach

Although numerous pathologies are associated with abnormal skin deposits, these remain poorly described, as accurate characterization continues to present a challenge for dermatologists. Their submicrometer size as well as their diverse chemistry require various characterization tools. We aim to exemplify characterization of endogenous and exogenous skin deposits in some selected skin diseases using different physico-chemical techniques. We begin with a presentation of selected dis-eases associated with skin deposits. We then present those of our results which show their variety of structure, location and chemical composition, obtained with various tools: Field Emission Scanning Electron Microscopy coupled with Energy Dispersive X-ray Spectroscopy, X-ray fluorescence, vibra-tional spectroscopies, as well as techniques specific to synchrotron radiation. Our results constitute a real opportunity to improve diagnosis, and to understand the pathogenesis of many skin diseases, and opportunities for therapeutic intervention.Peer reviewe