Análisis sociológico multivariante de los asegurados en España

La técnica utilizada ha sido el análisis factorial exploratorio que permite una reducción de dimensiones con la consecuente mejora en la interpretación de variables latentes no observadas y que explican la realidad financiera de los encuestados. Esto se hará desde una perspectiva financiera con la intención de detectar aquellas variables que hacen a una persona propensa a contratar un seguro por decisión propia. Una vez identificados los factores, se ha realizado un clúster jerárquico para la agrupación de los encuestados. Finalmente aplicamos técnicas supervisadas para validar la clasificación entre grupos.The technique used has been the Exploratory Factor Analysis (EFA) that allows a reduction of dimensions with the consequent improvement in the interpretation of latent variables not observed and that explain the financial reality of the respondents. This will be done from a financial perspective with the intention of detecting those variables that make a person prone to take out insurance on their own. Once the factors have been elaborated, a hierarchical cluster has been made to identify the financial profiles of the respondents. Finally we applied supervised techniques to validate the classification between groups.Máster Universitario en Ciencias Actuariales y Financiera

Alonso Quijano en el Callejón del Gato: Las ficciones de psycho-killers españolas

The goal of my dissertation is to study the pervasive presence of the psycho-killer in Spanish cultural production of the last two decades. By analyzing selected literary and filmic works, I explore how this character has become a metaphor for the uneasiness caused by the political and socio-cultural changes which took place in Spain from the 1990s onward. However, the adoption of this character is not simply a mimetic process but a reformulation according to literary and cultural traditions such as quixotism and esperpento in order to question the construction of Spanish national identity. The emergence of this figure needs to be examined against the backdrop of the cultural and sociopolitical impact of globalization processes in contemporary Spain and how these processes shape new constructions of national identity. Apart from this, the psycho-killer is a radically individualistic figure that arises as a result of the skepticism and the disenchantment caused by the failures of the young Spanish democracy

Tácticas químicas para controlar a interacción de sistemas sintéticos con ácidos nucleicos

Esta tese describe o deseño e síntese de tres sistemas diferentes, capaces de interactuar e recoñecer secuencias específicas de ácidos nucleicos. Na primeira parte, sintetizáronse análogos funcionais da oncoproteína MYC e o seu dominante negativo OMOMYC, así como derivados marcados con fluoróforos. Usáronse dúas estratexias alternativas que implican unha ou dúas ligazóns químicas nativas, obténdose moi bos rendementos. Estas miniproteínas terapeuticamente relevantes, son capaces de dimerizar e recoñecer o suco maior do E-ADN, ademais de internalizarse eficientemente en células vivas. A segunda parte describe a síntese de sistemas conmutables capaces de interactuar específicamente co suco menor de secuencias de ADN ricas en A / T dun xeito reversible e controlable externamente. No último capítulo obtivéronse, nun único paso, oligómeros fluorescentes de bisbenzamidina, que mostraron afinidades moi altas para diferentes combinacións de pares de bases A / T inseríndose no suco menor de ADN

Planta acuícola en mar abierto

Traballo fin de mestrado (UDC.EPS). Enxeñaría naval e oceánic

Petrolero de crudo de 280.000 TPM

Traballo fin de grao (UDC.EPS). Propulsión e servizos do buque. Curso 2013/201

A chemical approach for the synthesis of the DNA-binding domain of the oncoprotein MYC

This is the peer reviewed version of the following article: Calo-Lapido, R., Penas, C., Jiménez-Balsa, A., Vázquez, M. E., Mascareñas, J. L. (2019), A chemical approach for the synthesis of the DNA-binding domain of the oncoprotein MYC. Org. Biomol. Chem., 17: 6748-6752, which has been published in final form at https://doi.org/10.1039/C9OB01209E. This article may be used for non-commercial purposes in accordance with RSC Terms and Conditions for Use of Self-Archived VersionsWe describe the first chemical synthesis of a functional mutant of the DNA binding domain of the oncoprotein MYC, using two alternative strategies which involve either one or two Native Chemical Ligations (NCLs). Both routes allowed the efficient synthesis of a miniprotein which is capable of heterodimerizing with MAX, and replicate the DNA binding of the native protein. The versatility of the reported synthetic approach enabled the straightforward preparation of MYC and Omomyc analogues, as well as fluorescently labeled derivativesFinancial support from the MINECO (CTQ2015-70698-R and SAF2016-76689-R, orfeo-cinqa CTQ2016-81797-REDC), Xunta de Galicia (2015-CP082, ED431C 2017/19, ED431B 2018/04, Centro singular de investigación de Galicia accreditation 2016–2019, ED431G/09), the European Union (European Regional Development Fund - ERDF), Fundación AECC (IDEAS197VAZQ), and the European Research Council (Advanced Grant No. 340055) is acknowledged. R. C. L. thanks Xunta de Galicia and the European Social Fund for her fellowship. A. J. B. thanks Xunta de Galicia for his post-doctoral fellowshipS

Selective pressures explain differences in flower color among Gentiana lutea Populations

Flower color variation among plant populations might reflect adaptation to local conditions such as the interacting animal community. In the northwest Iberian Peninsula, flower color of Gentiana lutea varies longitudinally among populations, ranging from orange to yellow. We explored whether flower color is locally adapted and the role of pollinators and seed predators as agents of selection by analyzing the influence of flower color on (i) pollinator visitation rate and (ii) escape from seed predation and (iii) by testing whether differences in pollinator communities correlate with flower color variation across populations. Finally, (iv) we investigated whether variation in selective pressures explains flower color variation among 12 G. lutea populations. Flower color influenced pollinator visits and differences in flower color among populations were related to variation in pollinator communities. Selective pressures on flower color vary among populations and explain part of flower color differences among populations of G. lutea. We conclude that flower color in G. lutea is locally adapted and that pollinators play a role in this adaptation.This work was financed by the Plan Nacional de I + D + I (2008-2011), CGL2009-08959 Ministerio de Ciencia. T.V. was supported by a PhD grant from the Plan Galego de Investigación e Crecemento 2011/2015 (Plan I2C), Consellería de Educación e Ordenación Universitaria e InnovaciónS

Water sports could contribute to the translocation of ranaviruses

[EN] Ranaviruses have been identified as the cause of explosive disease outbreaks in amphibians worldwide and can be transmitted between hosts both via direct and indirect contact, in which humans might contribute to the translocation of contaminated material. The aim of this study was to evaluate the possible role of water sports in the human translocation of ranavirus, Batrachochytrium dendrobatidis (Bd), and B. salamandrivorans (Bsal). A total of 234 boats were sampled during the spring Spanish Canoe Championship which took place in Pontillón de Castro, a reservoir with a history of ranavirosis, in May 2017. Boats were tested for the presence of ranavirus and Batrachochytrium spp. DNA, using quantitative real-time polymerase chain reaction techniques (qPCR). A total of 22 swabs (22/234, 9.40%) yielded qPCR-positive results for Ranavirus DNA while Bd or Bsal were not detected in any of the samples. We provide the first evidence that human-related water sports could be a source of ranavirus contamination, providing justification for public disinfecting stations in key areas where human traffic from water sports is high.SITis study was partially funded by the Principado de Asturias, PCTI 2018–2020 (GRUPIN: IDI2018-000237) and FEDER. We thank Benjamin Rabanal from the Laboratorio de Técnicas Instrumentales, University of León, for Batrachochytrium spp. PCR analysis, and Frank Pasmans’ Lab for kindly providing Bd and Bsal DNA controls

Canonical DNA minor groove insertion of bisbenzamidine-Ru(ii) complexes with chiral selectivity

We report the first Ru(ii) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis-benzamidine minor groove DNA-binding agent with a ruthenium(ii) complex. Importantly, one of the enantiomers (Δ-[Ru(bpy)2b4bpy]2+, Δ-4Ru) shows a considerably higher DNA affinity than the parent organic ligand and the other enantiomer, particularly for the AATT sequence, while the other enantiomer preferentially targets long AAATTT sites with overall lower affinity. Finally, we demonstrate that the photophysical properties of these new binders can be exploited for DNA cleavage using visible light