115 research outputs found
First DENIS I-band extragalactic catalog
This paper presents the first I-band photometric catalog of the brightest
galaxies extracted from the Deep Near Infrared Survey of the Southern Sky
(DENIS) An automatic galaxy recognition program has been developed to build
this provisional catalog. The method is based on a discriminating analysis. The
most discriminant parameter to separate galaxies from stars is proved to be the
peak intensity of an object divided by its array. Its efficiency is better than
99%. The nominal accuracy for galaxy coordinates calculated with the Guide Star
Catalog is about 6 arcseconds. The cross-identification with galaxies available
in the Lyon-Meudon Extragalactic DAtabase (LEDA) allows a calibraton of the
I-band photometry with the sample of Mathewson et Al. Thus, the catalog
contains total I-band magnitude, isophotal diameter, axis ratio, position angle
and a rough estimate of the morphological type code for 20260 galaxies. The
internal completeness of this catalog reaches magnitude , with a
photometric accuracy of . 25% of the Southern sky has been
processed in this study.
This quick look analysis allows us to start a radio and spectrographic
follow-up long before the end of the survey.Comment: 13 pages, 17 figures, to appear A&A Supl.
Extragalactic database. VII Reduction of astrophysical parameters
The Lyon-Meudon Extragalactic database (LEDA) gives a free access to the main
astrophysical parameters for more than 100,000 galaxies. The most common names
are compiled allowing users to recover quickly any galaxy. All these measured
astrophysical parameters are first reduced to a common system according to well
defined reduction formulae leading to mean homogeneized parameters. Further,
these parameters are also transformed into corrected parameters from widely
accepted models. For instance, raw 21-cm line widths are transformed into mean
standard widths after correction for instrumental effect and then into maximum
velocity rotation properly corrected for inclination and non-circular velocity.
This paper presents the reduction formulae for each parameter: coordinates,
morphological type and luminosity class, diameter and axis ratio, apparent
magnitude (UBV, IR, HI) and colors, maximum velocity rotation and central
velocity dispersion, radial velocity, mean surface brightness, distance modulus
and absolute magnitude, and group membership. For each of these parameters
intermediate quantities are given: galactic extinction, inclination,
K-correction etc..
All these parameters are available from direct connexion to LEDA (telnet
lmc.univ-lyon1.fr, login: leda, no passwd
OR http://www-obs.univ-lyon1.fr/leda ) and distributed on a standard CD-ROM
(PGC-ROM 1996) by the Observatoire de Lyon via the CNRS (mail to
[email protected]).Comment: 13 pages, 12 figures. The CDROM of the extragalactic database LEDA is
available by mailing to: [email protected]
Calibration of the distance scale from galactic Cepheids: I Calibration based on the GFG sample
New estimates of the distances of 36 nearby galaxies are presented based on
accurate distances of galactic Cepheids obtained by Gieren, Fouque and Gomez
(1998) from the geometrical Barnes-Evans method.
The concept of 'sosie' is applied to extend the distance determination to
extragalactic Cepheids without assuming the linearity of the PL relation. Doing
so, the distance moduli are obtained in a straightforward way.
The correction for extinction is made using two photometric bands (V and I)
according to the principles introduced by Freedman and Madore (1990). Finally,
the statistical bias due to the incompleteness of the sample is corrected
according to the precepts introduced by Teerikorpi (1987) without introducing
any free parameters (except the distance modulus itself in an iterative
scheme).
The final distance moduli depend on the adopted extinction ratio {R_V}/{R_I}
and on the limiting apparent magnitude of the sample. A comparison with the
distance moduli recently published by the Hubble Space Telescope Key Project
(HSTKP) team reveals a fair agreement when the same ratio {R_V}/{R_I} is used
but shows a small discrepancy at large distance.
In order to bypass the uncertainty due to the metallicity effect it is
suggested to consider only galaxies having nearly the same metallicity as the
calibrating Cepheids (i.e. Solar metallicity). The internal uncertainty of the
distances is about 0.1 magnitude but the total uncertainty may reach 0.3
magnitude.Comment: 12 pages, 4 figures, access to a database of extragalactic Cepheids.
Astronomy & Astrophysics (in press) 200
Selective Inactivity of Pyrazinamide against Tuberculosis in C3HeB/FeJ Mice Is Best Explained by Neutral pH of Caseum
Pyrazinamide (PZA) is one of only two sterilizing drugs in the first-line antituberculosis regimen. Its activity is strongly pH dependent; the MIC changes by several orders of magnitude over a range of pH values that may be encountered in various in vivo compartments. We recently reported selective inactivity of PZA in a subset of C3HeB/FeJ mice with large caseous lung lesions. In the present study, we evaluated whether such inactivity was explained by poor penetration of PZA into such lesions or selection of drug-resistant mutants. Despite demonstrating similar dose-proportional PZA exposures in plasma, epithelial lining fluid, and lung lesions, no dose response was observed in a subset of C3HeB/FeJ mice with the highest CFU burden. Although PZA-resistant mutants eventually replaced the susceptible bacilli in BALB/c mice and in C3HeB/FeJ mice with low total CFU burdens, they never exceeded 1% of the total population in nonresponding C3HeB/FeJ mice. The selective inactivity of PZA in large caseous lesions of C3HeB/FeJ mice is best explained by the neutral pH of liquefying caseum
Calibration of the distance scale from galactic Cepheids:II Use of the HIPPARCOS calibration
New estimate of the distances of 36 nearby galaxies is presented. It is based
on the calibration of the V- and I-band Period-Lumi- nosity relations for
galactic Cepheids measured by the HIPPARCOS mission. The distance moduli are
obtained in a classical way. The statistical bias due to the incompleteness of
the sample is corrected according to the precepts introduced by Teerikorpi
(1987).
We adopt a constant slope (the one obtained with LMC Cepheids). The
correction for incompleteness bias introduce an uncertainty which depends on
each galaxy. On the mean, this uncertainty is small (0.04 mag) but it may reach
0.3 mag. We show that the un- certainty due to the correction of the extinction
is small (propably less than 0.05 mag.). The correlation between the
metallicity and the morphological type of the host galaxy sug- gests us to
reduce the application to spiral galaxies in order to bypass the problem of
metallicity. We suspect that the adopted PL slopes are not valid for all
morphological types of galaxies. This may induce a mean systematic shift of 0.1
mag on distance moduli.
A comparison with the distance moduli recently published by Freedman et al.
(2001) shows there is a reasonably good agreement with our distance moduli.Comment: Accepted for Astron & Astrophys. (2002) Cepheid database available at
ftp://www-obs.univ-lyon1.fr via anonymous ftp. Directory:
pub/base/CEPHEIDES.tar.g
Osteoprotegerin in Exosome-Like Vesicles from Human Cultured Tubular Cells and Urine
Urinary exosomes have been proposed as potential diagnostic tools. TNF superfamily cytokines and receptors may be
present in exosomes and are expressed by proximal tubular cells. We have now studied the expression of selected TNF
superfamily proteins in exosome-like vesicles from cultured human proximal tubular cells and human urine and have
identified additional proteins in these vesicles by LC-MS/MS proteomics. Human proximal tubular cells constitutively
released exosome-like vesicles that did not contain the TNF superfamily cytokines TRAIL or TWEAK. However, exosome-like
vesicles contained osteoprotegerin (OPG), a TNF receptor superfamily protein, as assessed by Western blot, ELISA or
selected reaction monitoring by nLC-(QQQ)MS/MS. Twenty-one additional proteins were identified in tubular cell exosomelike
vesicles, including one (vitamin D binding protein) that had not been previously reported in exosome-like vesicles.
Twelve were extracellular matrix proteins, including the basement membrane proteins type IV collagen, nidogen-1, agrin
and fibulin-1. Urine from chronic kidney disease patients contained a higher amount of exosomal protein and exosomal
OPG than urine from healthy volunteers. Specifically OPG was increased in autosomal dominant polycystic kidney disease
urinary exosome-like vesicles and expressed by cystic epithelium in vivo. In conclusion, OPG is present in exosome-like
vesicles secreted by proximal tubular epithelial cells and isolated from Chronic Kidney Disease urine.This work was supported by grants from the Instituto de Salud Carlos III (ISCIIIRETIC REDINREN RD06/0016, RD12/0021, PI11/01854, PI10/00072 PI09/
00641 and PS09/00447); Comunidad de Madrid (Fibroteam S2010/BMD-2321, S2010/BMD-2378); Sociedad Española de NefrologÍa; European Network (HEALTH
F2-2008-200647); DIALOK European project LSHB-CT-2007-036644; Fundacion Lilly and IRSIN/FRIAT to JE; Programa Intensificación Actividad Investigadora (ISCIII/
Agencia Laín-Entralgo/CM) to AO; Instituto de Salud Carlos III (FIS PI11/01401, CP09/00229); and Fundación Conchita Rábago de Jiménez DÍaz to GAL. The funders
had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscrip
Limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials
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