Technical note: PaleoDataView – a software toolbox for the collection, homogenization and visualization of marine proxy data

We present a software toolbox that allows the efficient collection, management and maintenance of larger paleoceanographic data sets. The program combines a graphical user interface (GUI) with a simple document-based database and functionality for visualization, stratigraphy (visual alignment and radiocarbon calibration), age modelling and efficient ensemble time-series generation to create larger homogenous data compilations. Data can be imported from Excel or text files, are stored locally in netCDF format and can be easily exchanged between collaborating scientists. Within a data collection, data can be imported either to proxy-specific sub-collections or to a multi-proxy (“miscellaneous”) sub-collection that allows the import and management of any downcore data. A single age model is shared among all proxies of a core within a collection. The stand-alone software can be used with Windows and macOS and does not require web access. Installers of the current version for both Windows 10 and macOS including the C++ code can be downloaded from https://www.marum.de/Stefan-Mulitza/PaleoDataView.html (last access: 5 December 2019) along with a detailed user guide

Posaconazole in the management of refractory invasive fungal infections

The rising incidence of invasive fungal infections due to the expanding population of immunocompromised hosts and the increasing prevalence of fungal resistance has led to the need for novel antifungal agents. Posaconazole, a new member of the triazole class has demonstrated in vitro activity against a broad spectrum of fungi and clinical activity against various fungal pathogens, including Aspergillus spp., Candida spp., zygomycetes, and Fusarium spp. To date, posaconazole has been approved for prophylaxis of invasive fungal infections in stem cell transplant recipients with acute graft versus host disease (GVHD) and neutropenic patients receiving intensive induction chemotherapy for acute myelogenous leukemia and myelodys-plastic syndrome. In addition, it has been licensed for use in oropharyngeal candidiasis and for salvage therapy in invasive aspergillosis, fusariosis, coccidioidomycosis, chromoblastomycosis, and mycetoma. Posaconazole is the only azole with activity against zygomycetes and other difficult-to-treat fungi, representing a potential treatment option for refractory invasive mycosis. This article reviews available preclinical and clinical data of posaconazole, focusing on its role in the teatment of refractory invasive fungal infections

Modelling Hourly Particulate Matter (PM10) Concentrations at High Spatial Resolution in Germany Using Land Use Regression and Open Data

Air pollution is a major health risk factor worldwide. Regular short- and long-time exposures to ambient particulate matter (PM) promote various diseases and can lead to premature death. Therefore, in Germany, air quality is assessed continuously at approximately 400 measurement sites. However, knowledge about this intermediate distribution is either unknown or lacks a high spatial–temporal resolution to accurately determine exposure since commonly used chemical transport models are resource intensive. In this study, we present a method that can provide information about the ambient PM concentration for all of Germany at high spatial (100 m × 100 m) and hourly resolutions based on freely available data. To do so we adopted and optimised a method that combined land use regression modelling with a geostatistical interpolation technique using ordinary kriging. The land use regression model was set up based on CORINE (Coordination of Information on the Environment) land cover data and the Germany National Emission Inventory. To test the model’s performance under different conditions, four distinct data sets were used. (1) From a total of 8760 (365 × 24) available h, 1500 were randomly selected. From those, the hourly mean concentrations at all stations (ca. 400) were used to run the model (n = 566,326). The leave-one-out cross-validation resulted in a mean absolute error (MAE) of 7.68 μg m−3 and a root mean square error (RMSE) of 11.20 μg m−3. (2) For a more detailed analysis of how the model performs when an above-average number of high values are modelled, we selected all hourly means from February 2011 (n = 256,606). In February, measured concentrations were much higher than in any other month, leading to a slightly higher MAE of 9.77 μg m−3 and RMSE of 14.36 μg m−3, respectively. (3) To enable better comparability with other studies, the annual mean concentration (n = 413) was modelled with a MAE of 4.82 μg m−3 and a RMSE of 6.08 μg m−3. (4) To verify the model’s capability of predicting the exceedance of the daily mean limit value, daily means were modelled for all days in February (n = 10,845). The exceedances of the daily mean limit value of 50 μg m−3 were predicted correctly in 88.67% of all cases. We show that modelling ambient PM concentrations can be performed at a high spatial–temporal resolution for large areas based on open data, land use regression modelling, and kriging, with overall convincing results. This approach offers new possibilities in the fields of exposure assessment, city planning, and governance since it allows more accurate views of ambient PM concentrations at the spatial–temporal resolution required for such assessments.Peer Reviewe

Designing Attentive Information Dashboards

Information dashboards are a critical capability in contemporary business intelligence and analytics systems. Despite their strong potential to support better decision-making, the massive amount of information they provide challenges users performing data exploration tasks. Accordingly, dashboard users face difficulties in managing their limited attentional resources when processing the presented information on dashboards. Also, studies have shown that the amount of concentrated time humans can spend on a task has dramatically decreased in recent years; thus, there is a need for designing user interfaces that support users attention management. In this design science research project, we propose attentive information dashboards that provide individualized visual attention feedback (VAF) as an innovative artifact to solve this problem. We articulate theoretically grounded design principles and instantiate a software artifact leveraging users eye movement data in real time to provide individualized VAF. We evaluated the instantiated artifact in a controlled lab experiment with 92 participants. The results from analyzing users eye movement after receiving individualized VAF reveal that our proposed design has a positive effect on users attentional resource allocation, attention shift rate, and attentional resource management. We contribute a system architecture for attentive information dashboards that support data exploration and two theoretically grounded design principles that provide prescriptive knowledge on how to provide individualized VAF. Practitioners can leverage the prescriptive knowledge derived from our research to design innovative systems that support users information processing by managing their limited attentional resources

Organizational culture, leadership style and effectiveness: A case study of middle eastern construction clients

During the last few decades, organizational effectiveness has received a great deal of attention in many industrial sectors. As a result, a variety of models have been formulated which measure organizational performance. In the construction industry, two factors have subsequently captured the imagination and interest of researchers and practitioners alike: the culture of the organization and the leadership style of project managers. This focus places a requirement upon construction organizations to recognize and understand their organizational culture, and equally, to clearly communicate it to their employees as part of their capitalist drive of constantly improving performance, productivity and profit. Traditional ways of conducting construction business require a sound understanding of the technical and managerial demands of executing projects, which in turn, places an increased emphasis upon the management and leadership competencies of individual project managers. The purpose of the research is to explore the relationship between organizational culture, authentic leadership style and effectiveness within the context of a case study investigation centred on Middle Eastern construction clients and their project managers. The outcomes of the investigation, which include the presentation of an explanatory model, indicate that organizational culture is directly and positively related to performance and effectiveness, while project managers' leadership style has an indirect relationship to effectiveness. A strong organizational culture is therefore deemed critical to organizational performance

Developing a novel tool to assess the ability to self-administer medication - A systematic evaluation of patients' video recordings in the ABLYMED study

Background: Older people often experience medication management problems due to multimorbidity, polypharmacy and medication complexity. There is often a large gap between patients' self-reported and actual abilities to handle the self -administration of their medication. Here we report on the development and evaluation of a new tool to assess the ability of non-demented hospitalized patients to self-administer medication in different dosage forms. To this end, we video-recorded the patients' medication management performance and implemented a novel assessment scheme, which was applied by several independent raters.Methods: Sixty-seven in-patients > 70 years of age and regularly taking > 5 different drugs autonomously of the ABLYMED study agreed to the video recording of their medication management performance with five different dosage forms. All raters underwent a training and applied a standardized assessment form and written guide with rating rules for evaluation. In a pilot phase, video recordings of three patients were rated by 19 raters (15 medical students, two expert raters to determine a reference standard, and two main raters who later rated the total sample). In the rating phase, based on the ratings obtained from the two main raters, we determined interrater (assessed every section of 20 patients as agreement between the raters at one point of time) and intrarater (assessed as consistency within each rater across three points of time) agreement by intraclass correlation analysis.Results: In the pilot phase we obtained an overall sufficient agreement pattern, with an adjustment of the rating rules for patches. In the rating phase we achieved satisfactory agreement between the two raters (interrater reliability) and across different points of time (intrarater reliability). For two dosage forms (eye-drops and pen), rater training needed to be repeated to reach satisfactory levels.Discussion: Our novel rating procedure was found to be objective, valid and reproducible, given appropriate training of the raters. Our findings are an important part of a larger research project to implement a novel assessment for the ability to self-administer medication in different dosage forms. Further, they can support the development of patient trainings to improve medication management and secure independent living.Paul-Kuth Foundatio

Volumetry improves the assessment of the vestibular aqueduct size in inner ear malformation

Objectives: Enlarged vestibular aqueduct (EVA) is a common finding associated with inner ear malformations (IEM). However, uniform radiologic definitions for EVA are missing and various 2D-measurement methods to define EVA have been reported. This study evaluates VA volume in different types of IEM and compares 3D-reconstructed VA volume to 2D-measurements. Methods: A total of 98 high-resolution CT (HRCT) data sets from temporal bones were analyzed (56 with IEM; [cochlear hypoplasia (CH; n = 18), incomplete partition type I (IPI; n = 12) and type II (IPII; n = 11) and EVA (n = 15)]; 42 controls). VA diameter was measured in axial images. VA volume was analyzed by software-based, semi-automatic segmentation and 3D-reconstruction. Differences in VA volume between the groups and associations between VA volume and VA diameter were assessed. Inter-rater-reliability (IRR) was assessed using the intra-class-correlation-coefficient (ICC). Results: Larger VA volumes were found in IEM compared to controls. Significant differences in VA volume between patients with EVA and controls (p < 0.001) as well as between IPII and controls (p < 0.001) were found. VA diameter at the midpoint (VA midpoint) and at the operculum (VA operculum) correlated to VA volume in IPI (VA midpoint: r = 0.78, VA operculum: r = 0.91), in CH (VA midpoint: r = 0.59, VA operculum: r = 0.61), in EVA (VA midpoint: r = 0.55, VA operculum: r = 0.66) and in controls (VA midpoint: r = 0.36, VA operculum: r = 0.42). The highest IRR was found for VA volume (ICC = 0.90). Conclusions: The VA diameter may be an insufficient estimate of VA volume, since (1) measurement of VA diameter does not reliably correlate with VA volume and (2) VA diameter shows a lower IRR than VA volume. 3D-reconstruction and VA volumetry may add information in diagnosing EVA in cases with or without additional IEM. Keywords: 3D segmentation; Cochlear malformation; Diagnosis; Inner ear malformation; Volum

Detection of Spirocerca lupi and an unknown Trichinella-like nematode in raccoon (Procyon lotor).

The raccoon Procyon lotor (Carnivora: Procyonidae) is an invasive species of growing importance for the introduction of alien pathogens or as additional hosts for autochthonous pathogens in Europe, including zoonotic parasites. As the population is steadily increasing and outcompeting the red fox (Vulpes vulpes) in Germany, the consumption of raccoon meat raises concerns about pathogens they may transmit. Therefore the presence of Trichinella larvae was here investigated in muscle samples (n = 904) of raccoons from northern Germany. No Trichinella larvae were found, thus confirming the general low occurrence of this parasite in Germany. However, Spirocerca lupi (n = 12) and an unidentified Trichinella-like nematode (n = 1) were accidently detected in the examined samples. The first is not a zoonotic parasite but has a high veterinary relevance as it can cause severe diseases in dogs. It is the first documented autochthonous infection of this nematode in Germany. The larvae of an unidentified Trichinella-like nematode were found in high abundance in all examined muscles of one raccoon, though they could not be identified to species level. Histological investigation revealed intramuscular cystic structures. This is the largest study investigating muscular parasites of raccoons in Europe so far, which suggests that this invasive animal species is infected by S. lupi and by a yet unknown Trichinella -like parasite

Internal auditory canal volume in normal and malformed inner ears

Purpose: A narrow bony internal auditory canal (IAC) may be associated with a hypoplastic cochlear nerve and poorer hearing performances after cochlear implantation. However, definitions for a narrow IAC vary widely and commonly, qualitative grading or two-dimensional measures are used to characterize a narrow IAC. We aimed to refine the definition of a narrow IAC by determining IAC volume in both control patients and patients with inner ear malformations (IEMs). Methods: In this multicentric study, we included high-resolution CT (HRCT) scans of 128 temporal bones (85 with IEMs: cochlear aplasia, n = 11; common cavity, n = 2; cochlear hypoplasia type, n = 19; incomplete partition type I/III, n = 8/8; Mondini malformation, n = 16; enlarged vestibular aqueduct syndrome, n = 19; 45 controls). The IAC diameter was measured in the axial plane and the IAC volume was measured by semi-automatic segmentation and three-dimensional reconstruction. Results: In controls, the mean IAC diameter was 5.5 mm (SD 1.1 mm) and the mean IAC volume was 175.3 mm3 (SD 52.6 mm3). Statistically significant differences in IAC volumes were found in cochlear aplasia (68.3 mm3, p < 0.0001), IPI (107.4 mm3, p = 0.04), and IPIII (277.5 mm3, p = 0.0004 mm3). Inter-rater reliability was higher in IAC volume than in IAC diameter (intraclass correlation coefficient 0.92 vs. 0.77). Conclusions: Volumetric measurement of IAC in cases of IEMs reduces measurement variability and may add to classifying IEMs. Since a hypoplastic IAC can be associated with a hypoplastic cochlear nerve and sensorineural hearing loss, radiologic assessment of the IAC is crucial in patients with severe sensorineural hearing loss undergoing cochlear implantation. Keywords: 3D segmentation; Cochlear malformation; Diagnosis; Inner ear malformation; Internal auditory canal; Volum