4D Printing of origami structures for minimally invasive surgeries using functional scaffold

Origami structures have attracted attention in biomedical applications due to their ability to develop surgical tools that can be expanded from a minimal volume to a larger and functional device. On the other hand, four-dimensional (4D) printing is an emerging technology, which involves 3D printing of smart materials that can respond to external stimuli such as heat. This short communication introduces the proof of concept of merging origami and 4D printing technologies to develop minimally invasive delivery of functional biomedical scaffolds with high shape recovery. The shape-memory effect (SME) of the PLA filament and the origami designs were also assessed in terms of deformability and recovery rate. The results showed that herringbone tessellation origami structure combined with internal natural cancellous bone core satisfies the design requirement of foldable scaffolds. The substantial and consistent SME of the 4D printed herringbone tessellation origami, which exhibited 96% recovery compared to 61% for PLA filament, was the most significant discovery of this paper. The experiments demonstrated how the use of 4D printing in situ with origami structures could achieve reliable and repeatable results, therefore conclusively proving how 4D printing of origami structures can be applied to biomedical scaffolds

Rayleigh and depinning instabilities of forced liquid ridges on heterogeneous substrates

Depinning of two-dimensional liquid ridges and three-dimensional drops on an inclined substrate is studied within the lubrication approximation. The structures are pinned to wetting heterogeneities arising from variations of the strength of the short-range polar contribution to the disjoining pressure. The case of a periodic array of hydrophobic stripes transverse to the slope is studied in detail using a combination of direct numerical simulation and branch-following techniques. Under appropriate conditions the ridges may either depin and slide downslope as the slope is increased, or first breakup into drops via a transverse instability, prior to depinning. The different transition scenarios are examined together with the stability properties of the different possible states of the system.Comment: Physics synopsis link: http://physics.aps.org/synopsis-for/10.1103/PhysRevE.83.01630

Late-onset bloodstream infection and perturbed maturation of the gastrointestinal microbiota in premature infants

Late-onset bloodstream infection (LO-BSI) is a common complication of prematurity, and lack of timely diagnosis and treatment can have life-threatening consequences. We sought to identify clinical characteristics and microbial signatures in the gastrointestinal microbiota preceding diagnosis of LO-BSI in premature infants.Daily faecal samples and clinical data were collected over two years from 369 premature neonates (<32 weeks gestation). We analysed samples from 22 neonates who developed LO-BSI and 44 matched control infants. Next-generation sequencing of 16S rRNA gene regions amplified by PCR from total faecal DNA was used to characterise the microbiota of faecal samples preceding diagnosis from infants with LO-BSI and controls. Culture of selected samples was undertaken, and bacterial isolates identified using MALDI-TOF. Antibiograms from bloodstream and faecal isolates were compared to explore strain similarity.From the week prior to diagnosis, infants with LO-BSI had higher proportions of faecal aerobes/facultative anaerobes compared to controls. Risk factors for LO-BSI were identified by multivariate analysis. Enterobacteriaceal sepsis was associated with antecedent multiple lines, low birth weight and a faecal microbiota with prominent Enterobacteriaceae. Staphylococcal sepsis was associated with Staphylococcus OTU faecal over-abundance, and the number of days prior to diagnosis of mechanical ventilation and of the presence of centrally-placed lines. In 12 cases, the antibiogram of the bloodstream isolate matched that of a component of the faecal microbiota in the sample collected closest to diagnosis.The gastrointestinal tract is an important reservoir for LO-BSI organisms, pathogens translocating across the epithelial barrier. LO-BSI is associated with an aberrant microbiota, with abundant staphylococci and Enterobacteriaceae and a failure to mature towards predominance of obligate anaerobes

Sensing with magnetic dipolar resonances in semiconductor nanospheres

In this work we propose two novel sensing principles of detection that exploit the magnetic dipolar Mie resonance in high-refractiveindex dielectric nanospheres. In particular, we theoretically investigate the spectral evolution of the extinction and scattering cross sections of these nanospheres as a function of the refractive index of the external medium (next). Unlike resonances in plasmonic nanospheres, the spectral position of magnetic resonances in high-refractive-index nanospheres barely shifts as next changes. Nevertheless, there is a drastic reduction in the extinction cross section of the nanospheres when next increases, especially in the magnetic dipolar spectral region, which is accompanied with remarkable variations in the radiation patterns. Thanks to these changes, we propose two new sensing parameters, which are based on the detection of: i) the intensity variations in the transmitted or backscattered radiation by the dielectric nanospheres at the magnetic dipole resonant frequency, and ii) the changes in the radiation pattern at the frequency that satisfies Kerker's condition of near-zero forward radiation. To optimize the sensitivity, we consider several semiconductor materials and particles sizes. © 2013 Optical Society of America.B.G.-C. acknowledges support from the JAE-Doc program of the Spanish Council of Research (CSIC). This research has been funded by Ministerio de Ciencia e Innovación, through grants: Consolider NanoLight (CSD2007-00046), FIS2009-13430-C02, as well as by the Comunidad de Madrid (Microseres-CM, S2009/TIC-1476).Peer Reviewe

Modulation of finger photoplethysmographic traces during forced respiration: venous blood in motion?

Photoplethysmographic (PPG) signals were recorded from the fingers of 10 healthy volunteers during forced respiratory inspiration. The aim of this pilot study was to assess the effect of negative airway pressure on the blood volumes within the tissue bed of the finger, and the resultant modulation of PPG signals. The acquired signals were analysed and oxygen saturations estimated from the frequency spectra in the cardiac and respiratory frequency ranges. Assuming that respiratory modulation affects blood volumes in veins to a greater extent than in arteries, the local venous oxygen saturation was estimated. Estimated venous oxygen saturation was found to be 3.1% (±4.2%) lower than the estimated arterial saturation

Adaptive phase estimation is more accurate than non-adaptive phase estimation for continuous beams of light

We consider the task of estimating the randomly fluctuating phase of a continuous-wave beam of light. Using the theory of quantum parameter estimation, we show that this can be done more accurately when feedback is used (adaptive phase estimation) than by any scheme not involving feedback (non-adaptive phase estimation) in which the beam is measured as it arrives at the detector. Such schemes not involving feedback include all those based on heterodyne detection or instantaneous canonical phase measurements. We also demonstrate that the superior accuracy adaptive phase estimation is present in a regime conducive to observing it experimentally.Comment: 15 pages, 9 figures, submitted to PR