La formation à l’enseignement des professeurs d’université : un aperçu

Dans nos universités, la perspective de l’embauche d’un nombre important de professeurs débutants offre l’occasion idéale de revoir les structures existantes de formation et de soutien à ces novices peu préparés aux exigences de leur métaprofession. Or, depuis trois décennies, des formations ont été mises en place et leur analyse montre qu’aux années où régnait le modèle additif ont succédé les années du modèle transformatif, conçu dans une perspective de formation continue et collaborative, élargi à la dimension professionnelle. Une exploration non exhaustive du site internet de 48 universités et de leurs centres de formation permet d’offrir un aperçu de la formation des professeurs d’université de plusieurs pays.In our universities, the prospect of hiring a significant number of new professors offers an ideal opportunity to revisit the existing training and support structures for these novices, little prepared to face the demands of their metaprofession. Training programs have been in place for three decades and analysis shows that the transformative model, developed from a perspective of continuing and collaborative education and expanded to the professional dimension, has replaced the previous additive model. A preliminary exploration of Internet sites of 48 universities and their training centres provides an overview of the training of university professors in a number of countries.En nuestras universidades, la perspectiva de contratar a un número importante de profesores principiantes ofrece una oportunidad ideal de volver a considerar las estructuras existentes de formación y de apoyo a estos nuevos profesores, poco preparados a las exigencias de su metaprofesión. Ahora bien, desde hace tres décadas, algunas formaciones fueron implementadas y su análisis muestra que a la época del modelo aditivo, sucedió la época del modelo transformativo, elaborado en una perspectiva de formación continua y de colaboración, extendido a la dimensión profesional. Una exploración no exhaustiva del sitio Internet de 48 universidades y de sus centros de formación proporciona un vistazo de la formación de los profesores de universidad en varios países

Cobimetinib in Pediatric and Young Adult Patients with Relapsed or Refractory Solid Tumors (iMATRIX-cobi): A Multicenter, Phase I/II Study

Cobimetinib; Pediatrics; Refractory Solid TumorsCobimetinib; Pediatria; Tumors sòlids refractarisCobimetinib; Pediatría; Tumores sólidos refractariosBackground: The MAPK pathway is an emerging target across a number of adult and pediatric tumors. Targeting the downstream effector of MAPK, MEK1, is a proposed strategy to control the growth of MAPK-dependent tumors. Objective: iMATRIX-cobi assessed the safety, pharmacokinetics, and anti-tumor activity of cobimetinib, a highly selective MEK inhibitor, in children and young adults with relapsed/refractory solid tumors. Patients and methods: This multicenter Phase I/II study enrolled patients aged 6 months to < 30 years with solid tumors with known/expected MAPK pathway involvement. Patients received cobimetinib tablet or suspension formulation on Days 1-21 of a 28-day cycle. Dose escalation followed a rolling 6 design. The primary endpoint was safety; secondary endpoints were pharmacokinetics and anti-tumor activity. Results: Of 56 enrolled patients (median age 9 years [range 3-29]), 18 received cobimetinib tablets and 38 cobimetinib suspension. Most common diagnoses were low-grade glioma (LGG; n = 32, including n = 12 in the expansion cohort) and plexiform neurofibroma within neurofibromatosis type 1 (n = 12). Six patients (11 %) experienced dose-limiting toxicities (including five ocular toxicity events), which established a pediatric recommended Phase II dose (RP2D) of 0.8 mg/kg tablet and 1.0 mg/kg suspension. Most frequently reported treatment-related adverse events were gastrointestinal and skin disorders. Steady state mean exposure (Cmax, AUC0-24) of cobimetinib at the RP2D (1.0 mg/kg suspension) was ~ 50 % lower than in adults receiving the approved 60 mg/day dose. Overall response rate was 5.4 % (3/56; all partial responses in patients with LGG). Conclusions: The safety profile of cobimetinib in pediatrics was similar to that reported in adults. Clinical activity was observed in LGG patients with known/suspected MAPK pathway activation. Cobimetinib combination regimens may be required to improve response rates in this pediatric population

Aménagement d’une salle des employés au Département de pharmacie du Centre hospitalier de l’Université de Montréal (projet ESPACE)

Objectif : Aménager une salle des employés multifonctionnelle au sein du Département de pharmacie du Centre hospitalier de l’Université de Montréal et en évaluer l’influence sur le bonheur au travail et le sentiment d’appartenance des employés envers le département. Description de la problématique : Les employés ont accès à une salle à manger comprenant un nombre restreint de places assises et qui peut s’avérer bruyante. Certains employés ont exprimé le besoin de disposer d’une nouvelle salle principalement destinée au repos et à la tenue d’activités diverses. Résolution de la problématique : Un sondage préintervention a été envoyé à l’ensemble des membres du département pour évaluer les besoins relatifs à l’aménagement des lieux (taux de réponse de 31 %). En réponse aux commentaires reçus, un local de 28 mètres carrés a été choisi. Certains bureaux ont dû être relocalisés et du mobilier inutilisé provenant de l’Hôtel-Dieu de Montréal a servi à aménager le nouvel espace. Les employés ont pu profiter des lieux avant de répondre aux sondages à cinq et 40 semaines après l'intervention (taux de réponse de 20 % et de 26 %). Cette nouvelle salle a eu une influence modeste sur le bonheur au travail (4,9–5,8/10) et le sentiment d’appartenance (4,2–4,4/10) des employés. Conclusion : Les deux sondages post-intervention ont montré que l’influence réelle de cette salle s’est révélée moins grande que ce qui avait été anticipé. La principale barrière à son utilisation a été le manque d’activités organisées. Abstract Objective: To create a multifunctional employee lounge in the Centre hospitalier de l’Université de Montréal’s pharmacy department and to assess its impact on employees’ workplace happiness and on their sense of belonging to the department. Problem description: Employees have access to a dining room with limited seating capacity and which can be noisy. Some employees have expressed the need for a new room to be used primarily for resting and conducting various activities. Problem resolution: A pre-intervention survey was sent to all department staff to assess space planning needs (31% response rate). In response to the comments received, an area measuring 28 m2 was chosen. Certain offices had to be relocated, and unutilized furniture from the Hôtel-Dieu de Montréal was used to furnish the new room. The employees were able to use the lounge for 5 and 40 weeks before completing the post-intervention surveys (response rates of 20% and 26%). The new lounge had a modest impact on workplace happiness (4.9-5.8/10) and on their sense of belonging (4.2-4.4/10). Conclusion: The two post-intervention surveys showed that the lounge’s actual impact was less than anticipated. The main barrier to its use was the lack of organized activities

: (Introduction du dossier “La régulation du genre dans la coexistence des niveaux de droit : regards croisés Europe-Canada / The Regulation of Gender in the Co-Existence of Levels of Law: Conversations between Europe and Canada”)

International audienc

: (Introduction du dossier “La régulation du genre dans la coexistence des niveaux de droit : regards croisés Europe-Canada / The Regulation of Gender in the Co-Existence of Levels of Law: Conversations between Europe and Canada”)

International audienc

A propos des rapports sociaux de sexe. Parcours épistémologiques

International audienc

Understanding the Barriers to Pediatric Oncologist Engagement and Accrual to Clinical Trials in National Cancer Institute-Designated Community Oncology Research Programs.

PurposeClinical trial participation leads to progress in cancer care. Principal investigators (PIs) and clinical research associates (CRAs) play key roles in the provision and maintenance of clinical trial portfolios at their sites. Previous studies have evaluated the educational and resource needs of adult oncology providers, but nothing to date has focused on providers of pediatric oncology care. We aimed to identify the educational needs and clinical trial participation barriers at National Cancer Institute Community Oncology Research Program (NCORP) Children's Oncology Group (COG) sites to improve the quality of site investigator engagement.MethodsQuality improvement surveys of pediatric clinical research staff at NCORP sites were performed. The first was a web-based inquiry of NCORP COG PIs and lead CRAs to assess their general understanding of NCORP organizational structure and needs. The second survey of COG PIs was conducted by one-on-one telephone interviews aimed at identifying specific barriers to physician engagement and patient enrollment in clinical trial research.ResultsThe majority of NCORP COG PIs and CRAs (63%) reported an incomplete understanding of NCORP structure, with approximately half expressing interest in developing stronger collaborations and engagement. Most NCORP COG PIs reported at least one shared barrier to clinical trial enrollment (78%), with inadequate protected time and research support (39% each) being the most frequently cited barriers.ConclusionsContributions to pediatric cancer clinical research at COG NCORP sites could be enhanced through improved education, resources, and time allocation

Understanding the Barriers to Pediatric Oncologist Engagement and Accrual to Clinical Trials in National Cancer Institute-Designated Community Oncology Research Programs.

PurposeClinical trial participation leads to progress in cancer care. Principal investigators (PIs) and clinical research associates (CRAs) play key roles in the provision and maintenance of clinical trial portfolios at their sites. Previous studies have evaluated the educational and resource needs of adult oncology providers, but nothing to date has focused on providers of pediatric oncology care. We aimed to identify the educational needs and clinical trial participation barriers at National Cancer Institute Community Oncology Research Program (NCORP) Children's Oncology Group (COG) sites to improve the quality of site investigator engagement.MethodsQuality improvement surveys of pediatric clinical research staff at NCORP sites were performed. The first was a web-based inquiry of NCORP COG PIs and lead CRAs to assess their general understanding of NCORP organizational structure and needs. The second survey of COG PIs was conducted by one-on-one telephone interviews aimed at identifying specific barriers to physician engagement and patient enrollment in clinical trial research.ResultsThe majority of NCORP COG PIs and CRAs (63%) reported an incomplete understanding of NCORP structure, with approximately half expressing interest in developing stronger collaborations and engagement. Most NCORP COG PIs reported at least one shared barrier to clinical trial enrollment (78%), with inadequate protected time and research support (39% each) being the most frequently cited barriers.ConclusionsContributions to pediatric cancer clinical research at COG NCORP sites could be enhanced through improved education, resources, and time allocation

New Look at RSV Infection: Tissue Clearing and 3D Imaging of the Entire Mouse Lung at Cellular Resolution

International audienceThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC B

Translating the Symptom Screening in Pediatrics Tool (SSPedi) into Argentinian Spanish for paediatric patients receiving cancer treatments, and evaluating understandability and cultural relevance in a multiple-phase descriptive study

Objectives To translate a symptom screening tool developed for paediatric patients receiving cancer therapies called Symptom Screening in Pediatrics Tool (SSPedi) into Argentinian Spanish and to evaluate the understandability and cultural relevance of the translated version of SSPedi among children with cancer and paediatric haematopoietic stem cell transplant (HSCT) recipients.Methods We conducted a multiphase, descriptive study to translate SSPedi into Argentinian Spanish. Using two translators, forward and backward translations were performed. The translated version was evaluated by Spanish-speaking paediatric patients 8–18 years of age receiving cancer treatments in two centres in Argentina and El Salvador.Primary and secondary outcome measures The primary outcome was patient self-reported difficulty with understanding of the SSPedi instructions and each symptom using a 5-point Likert scale. Secondary outcomes were incorrect understanding of the SSPedi instructions, symptoms and response scale determined by cognitive interviews with the patients and rated using a 4-point Likert scale. Cultural relevance was assessed qualitatively.Results There were 30 children enrolled and included in cognitive interviews; 16 lived in Argentina and 14 lived in El Salvador. The most common types of Spanish spoken were Central American (17, 57%) followed by South American (10, 33%) and Castilian (3, 10%). No changes to Argentinian Spanish SSPedi were required based on the outcomes or qualitative comments. No issues with cultural relevance were identified by any of the respondents.Conclusions We translated and finalised Argentinian Spanish SSPedi. Future research will focus on its use to describe bothersome symptoms by Argentinian Spanish-speaking children