Ideology and the limits of self-interest: System justification motivation and conservative advantages in mass politics

It is commonly assumed that political attitudes are driven by self-interest and that poor people heavily favor policies aimed at redistributing wealth. This assumption fails to explain the popularity of economic conservatism and the degree of support for the capitalist system. Such outcomes are typically explained by the suggestion that most poor people believe they will become rich one day. In a representative sample of low-income Americans, we observed that less than one-fourth were optimistic about their economic prospects. Those respondents who believed that they would become rich one day were no more likely to endorse the legitimacy of the system and no more supportive of conservative ideology or the Republican Party, compared to those who did not believe they would become rich. From a system justification perspective, we propose that people are motivated to defend the social systems on which they depend, and this confers a psychological advantage to conservative ideology. Providing ideological support for the status quo serves epistemic motives to reduce uncertainty, existential motives to reduce threat, and relational motives to share reality with members of mainstream society. We summarize evidence from the United States, Argentina, Lebanon, and other countries bearing on these propositions—including a survey administered shortly before the 2016 U.S. Presidential election—and discuss political implications of system justification motivation.Fil: Jost, John T.. University of New York; Estados UnidosFil: Langer, Melanie. University of New York; Estados UnidosFil: Badaan, Vivienne. University of New York; Estados UnidosFil: Azevedo, Flávio. Universitat Zu Köln; AlemaniaFil: Etchezahar, Edgardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental Dr. Horacio J. A. Rimoldi; ArgentinaFil: Ungaretti, Joaquín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental Dr. Horacio J. A. Rimoldi; ArgentinaFil: Hennes, Erin P.. Purdue University; Estados Unido

SKA Deep Polarization and Cosmic Magnetism

Deep surveys with the SKA1-MID array offer for the first time the opportunity to systematically explore the polarization properties of the microJy source population. Our knowledge of the polarized sky approaching these levels is still very limited. In total intensity the population will be dominated by star-forming and normal galaxies to intermediate redshifts ($z \sim1-2$), and low-luminosity AGN to high redshift. The polarized emission from these objects is a powerful probe of their intrinsic magnetic fields and of their magnetic environments. For redshift of order 1 and above the broad bandwidth of the mid-bands span the Faraday thick and thin regimes allowing study of the intrinsic polarization properties of these objects as well as depolarization from embedded and foreground plasmas. The deep field polarization images will provide Rotation Measures data with very high solid angle density allowing a sensitive statistical analysis of the angular variation of RM on critical arc-minute scales from a magnetic component of Large Scale Structure of the Universe.Comment: 9 pages, 3 figures; to appear as part of 'Cosmic Magnetism' in Proceedings 'Advancing Astrophysics with the SKA (AASKA14)', PoS(AASKA14)11

Functional Groups Accessibility and the Origin of Photoluminescence in N/O‐containing Bottom‐up Carbon Nanodots

Chemical surface functionalization of carbon nanodots (CNDs) offers a valuable opportunity to tailor multifunctionality in these nanocarbons, by engineering the composition of their molecular surface. Therefore, it is important to elucidate the type and amount of CNDs surface functionalization to be able to design their properties accurately. CNDs are often functionalized through amide coupling without validating the degree of surface functionalization. As a measure of surface functionalization, the amounts of primary amines via Kaiser test (KT) or imine reactions of the bare CNDs is often considered. However, this may lead to overestimating the degree of surface functionalization obtained by the pure amide coupling due to different reaction mechanisms and involved intermediates. Herein, four different CNDs prepared by microwave-assisted synthesis from arginine or citric acid with varying amounts of ethylenediamine are presented. We resorted to combining physicochemical methods to provide elemental, structural, and optical information. By that, we developed a method to quantify the degree of surface functionalization by amide coupling and show that the surface functionalization is lower than anticipated. Comparing experimental optical features of the CNDs with different computed model systems enables us to provide a more advanced vision of structure-property relationships in these still elusive nanocarbons

Dopamine : a versatile player in development, regeneration and disease

The dopamine neurotransmitter is present in all multicellular organisms. In the brain, the dopaminergic system orchestrates reward-motivation pathways and is involved in the control of voluntary movements and endocrine hormone secretion. Dysfunction of dopamine signalling may lead to pathological conditions such as Parkinson’s disease, where dopaminergic neurons of the midbrain degenerate. Moreover, modulation of dopamine receptor signalling influences tumour growth. The aim of this work was to explore the regeneration capacity of the dopaminergic system in the vertebrate brain and to test whether dopamine may control the growth of brain tumours. To this end we performed two sets of studies. Initially, we investigated the development and regeneration of the dopaminergic system in newts, which are aquatic salamanders capable of complete regeneration of the dopaminergic system in the brain. Thereafter, we investigated how dopaminergic ligands impinge specifically on brain tumour cells. In paper I, we screened a library of dopaminergic ligands for their ability to stimulate or to inhibit glioblastoma cell growth and survival. We identified the dopamine receptor 2 antagonist, trifluoperazine, as an inhibitor of glioblastoma growth. We also showed that susceptibility to trifluoperazine correlates with the dopamine receptor expression profile of the investigated glioblastoma cell lines. We concluded that dopamine receptor signalling pathways are promising targets for pharmacological interventions to inhibit glioblastoma growth. In paper II, we characterized the cellular basis of brain development and stereotyped behaviour in two regeneration model salamander species. These data provide insight into the maturation of neural stem cells that are found in the adult salamander brain. Furthermore, we showed how lesioning of the dopaminergic innervation affects neurogenesis in the forebrain and behavioural performance. This study provides a new evolutionary perspective on the genesis and dynamics of brain cells in the salamander brain, including dopaminergic cells. In paper III, we developed a tissue clearing method, CUBICe, to extend our study of dopaminergic neurite outgrowth during development as well as regeneration. We demonstrated that CUBICe is compatible for high resolution imaging of whole salamander brains. It is also a faster and more robust method, which allows to maintain a better sample integrity of embryonic brains in general, compared to Advanced CUBIC and Advanced CLARITY. In addition, using CUBICe we achieved tracing of genetically marked cells with neurite outgrowth of over 3600 µm. Ultimately, we showed that our method is ideal for tracing genetically marked dopaminergic cells in the salamander brain and for quantifying dopaminergic neurite density and regeneration in whole brain regions. In summary, this thesis provides insight into the versatile role of dopamine in both normal and pathological conditions of the vertebrate brain, as well as offers innovative tools for studying the regeneration of the dopaminergic system

Classifying Privacy and Verifiability Requirements for Electronic Voting

Abstract: Voter privacy and verifiability are fundamental security concepts for elec-tronic voting. Existing literature on electronic voting provides many definitions and interpretations of these concepts, both informal and formal. While the informal defini-tions are often vague and imprecise, the formal definitions tend to be very complex and restricted in their scope as they are usually tailored for specific scenarios. Moreover, some of the existing interpretations are contradictory. This paper provides informal, yet precise definitions of anonymity, receipt-freeness and coercion-resistance and identifies different levels of individual and universal veri-fiability. The overarching goal of this paper is to investigate which levels are conceiv-able for implementing these requirements in e-voting systems for elections of different significance (for instance political elections vs. elections in associations).

Energy density and weight change in a long-term weight-loss trial

<p>Abstract</p> <p>Background</p> <p>Health risks linked to obesity and the difficulty most have in achieving weight loss underscore the importance of identifying dietary factors that contribute to successful weight loss.</p> <p>Methods</p> <p>This study examined the association between change in dietary energy density and weight loss over time. Subjects were 213 men and women with BMI of 30–39 kg/m²and without chronic illness enrolled in 2004 in a randomized trial evaluating behavioral treatments for long-term weight loss. Subjects completed a 62-item food frequency questionnaire at baseline and at 6, 12, and 18 months.</p> <p>Results</p> <p>Pearson correlations between BMI and energy density (kcals/g of solid food) at baseline were not significantly different from zero (r = -0.02, p = 0.84). In a longitudinal analysis, change in energy density was strongly related to change in BMI. The estimated β for change in BMI (kg/m²) of those in the quartile representing greatest decrease in energy density at 18 months compared to those in the quartile with the least was -1.95 (p = 0.006). The association was especially strong in the first six months (estimated β = -1.43), the period with greatest weight loss (mean change in BMI = -2.50 kg/m²from 0–6 months <it>vs. </it>0.23 kg/m²from 12–18 months) and the greatest contrast with respect to change in energy density.</p> <p>Conclusion</p> <p>Decreased energy density predicted weight loss in this 18 month weight loss study. These findings may have important implications for individual dietary advice and public health policies targeting weight control in the general population</p

Impact of Ozone-initiated Terpene Chemistry on Indoor Air Quality and Human Health

The ECA Report no. 26 on ¿Ozone-Initiated Chemistry and Its impact on Indoor Air Quality and Human Health¿ summarises the current state-of-the-art concerning indoor air pollution and health due to chemical reactions occurring indoors makes recommendation for research priorities for the future. More sepcifically, a state-of-the-art review on the scientific evidence concerning ozone-initiated terpene chemistry and related human health effects is given along with measurements methods so far developed to monitor the concentration of the key reactants ozone and terpene and finally a risk assessment methodology for indoor ozone-initiated terpene chemistry is described.JRC.I.5-Physical and chemical exposure

Radioluminescent nanoparticles for radiation-controlled release of drugs

The present work demonstrates a novel concept for intratumoral chemo-radio combination therapy for locally advanced solid tumors. For some locally advanced tumors, chemoradiation is currently standard of care. This combination treatment can cause acute and long term toxicity that can limit its use in older patients or those with multiple medical comorbidities. Intratumoral chemotherapy has the potential to address the problem of systemic toxicity that conventional chemotherapy suffers, and may, in our view, be a better strategy for treating certain locally advanced tumors. The present study proposes how intratumoral chemoradiation can be best implemented. The enabling concept is the use of a new chemotherapeutic formulation in which chemotherapy drugs (e.g., paclitaxel (PTX)) are co-encapsulated with radioluminecsnt nanoparticles (e.g., CaWO4 (CWO) nanoparticles (NPs)) within protective capsules formed by biocompatible/biodegradable polymers (e.g., poly(ethylene glycol)-poly(lactic acid) or PEG-PLA). This drug-loaded polymer-encapsulated radioluminescent nanoparticle system can be locally injected in solution form into the patient's tumor before the patient receives normal radiotherapy (e.g., 30–40 fractions of 2–3 Gy daily X-ray dose delivered over several weeks for locally advanced head and neck tumors). Under X-ray irradiation, the radioluminescent nanoparticles produce UV-A light that has a radio-sensitizing effect. These co-encapsulated radioluminescent nanoparticles also enable radiation-triggered release of chemo drugs from the polymer coating layer. The non-toxic nature (absence of dark toxicity) of this drug-loaded polymer-encapsulated radioluminescent nanoparticle (“PEG-PLA/CWO/PTX”) formulation was confirmed by the MTT assay in cancer cell cultures. A clonogenic cell survival assay confirmed that these drug-loaded polymer-encapsulated radioluminescent nanoparticles significantly enhance the cancer cell killing effect of radiation therapy. In vivo study validated the efficacy of PEG-PLA/CWO/PTX-based intratumoral chemo-radio therapy in mouse tumor xenografts (in terms of tumor response and mouse survival). Results of a small-scale NP biodistribution (BD) study demonstrate that PEG-PLA/CWO/PTX NPs remained at the tumor sites for a long period of time (> 1 month) following direct intratumoral administration. A multi-compartmental pharmacokinetic model (with rate constants estimated from in vitro experiments) predicts that this radiation-controlled drug release technology enables significant improvements in the level and duration of drug availability within the tumor (throughout the typical length of radiation treatment, i.e., > 1 month) over conventional delivery systems (e.g., PEG-PLA micelles with no co-encapsulated CaWO4, or an organic liquid, e.g., a 50:50 mixture of Cremophor EL and ethanol, as in Taxol), while it is capable of maintaining the systemic level of the chemo drug far below the toxic threshold limit over the entire treatment period. This technology thus has the potential to offer a new therapeutic option that has not previously been available for patients excluded from conventional chemoradiation protocols