Are the Models for Type Ia Supernova Progenitors Consistent with the Properties of Supernova Remnants?

We explore the relationship between the models for progenitor systems of Type Ia supernovae and the properties of the supernova remnants that evolve after the explosion. Most models for Type Ia progenitors in the single degenerate scenario predict substantial outflows during the presupernova evolution. Expanding on previous work, we estimate the imprint of these outflows on the structure of the circumstellar medium at the time of the supernova explosion, and the effect that this modified circumstellar medium has on the evolution of the ensuing supernova remnant. We compare our simulations with the observational properties of known Type Ia supernova remnants in the Galaxy (Kepler, Tycho, SN 1006), the Large Magellanic Cloud (0509-67.5, 0519-69.0, N103B), and M31 (SN 1885). We find that optically thick outflows from the white dwarf surface (sometimes known as accretion winds) with velocities above 200 km/s excavate large low-density cavities around the progenitors. Such large cavities are incompatible with the dynamics of the forward shock and the X-ray emission from the shocked ejecta in all the Type Ia remnants that we have examined.Comment: To appear in ApJ. 17 pages, 10 figures, emulateap

The young stellar population of NGC 4214 as observed with HST. II. Results

We present the results of a detailed UV-optical study of the nearby dwarf starburst galaxy NGC 4214 using multifilter HST/WFPC2+STIS photometry. The stellar extinction is found to be quite patchy, with some areas having values of E(4405-5495)< 0.1 mag and others, associated with star forming regions, much more heavily obscured, a result which is consistent with previous studies of the nebular extinction. We determined the ratio of blue-to-red supergiants and found it to be consistent with theoretical models for the metallicity of the SMC. The stellar IMF of the field in the range 20-100 solar masses is found to be steeper than Salpeter. A number of massive clusters and associations with ages between a few and 200 million years are detected and their properties are discussed.Comment: 49 pages, 12 figures, 6 table

Current-Induced Step Bending Instability on Vicinal Surfaces

We model an apparent instability seen in recent experiments on current induced step bunching on Si(111) surfaces using a generalized 2D BCF model, where adatoms have a diffusion bias parallel to the step edges and there is an attachment barrier at the step edge. We find a new linear instability with novel step patterns. Monte Carlo simulations on a solid-on-solid model are used to study the instability beyond the linear regime.Comment: 4 pages, 4 figure

Validity, practical utility, and reliability of the activPAL in preschool children

&lt;p&gt;Purpose: With the increasing global prevalence of childhood obesity, it is important to have appropriate measurement tools for investigating factors (e.g. sedentary time) contributing to positive energy balance in early childhood. For pre-school children, single unit monitors such as the activPALTM are promising. However, validation is required as activity patterns differ from adults.&lt;/p&gt; &lt;p&gt;Methods: Thirty pre-school children participated in a validation study. Children were videoed for one hour undertaking usual nursery activity while wearing an activPALTM. Video (criterion method) was analyzed on a second-by-second basis to categorise posture and activity. This was compared with the corresponding activPALTM output. In a subsequent sub-study investigating practical utility and reliability, 20 children wore an activPALTM for seven consecutive 24-hour periods.&lt;/p&gt; &lt;p&gt;Results: A total of 97,750 seconds of direct observation from 30 children were categorized as sit/lie (46%), stand (35%), walk (16%); with 3% of time in nonsit/lie/upright postures (e.g. crawl/crouch/kneel-up). Sensitivity for the overall total time matched seconds detected as activPALTM ‘sit/lie’ was 86.7%, specificity 97.1%, and positive predictive value (PPV) 96.3%. For individual children, the median (interquartile range) sensitivity for activPALTM sit/lie was 92.8% (76.1-97.4), specificity 97.3% (94.9-99.2), PPV 97.0% (91.5-99.1). The activPALTM underestimated total time spent sitting (mean difference -4.4%, p&#60;0.01), and overestimated time standing (mean difference 7.1%, p&#60;0.01). There was no difference in overall % time categorised as ‘walk’ (p=0.2). The monitors were well tolerated by children during a seven day period of free-living activity. In the reliability study, at least five days of monitoring were required to obtain an intraclass correlation coefficient of ≥0.8 for time spent sit/lie according to activPALTM output.&lt;/p&gt; &lt;p&gt;Conclusion: The activPAL had acceptable validity, practical utility, and reliability for the measurement of posture and activity during freeliving activities in pre-school children.&lt;/p&gt

An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors

Current anticancer chemotherapy relies on a limited set of in vitro or indirect prognostic markers of tumor response to available drugs. A more accurate analysis of drug sensitivity would involve studying tumor response in vivo. To this end, we have developed an implantable device that can perform drug sensitivity testing of several anticancer agents simultaneously inside the living tumor. The device contained reservoirs that released microdoses of single agents or drug combinations into spatially distinct regions of the tumor. The local drug concentrations were chosen to be representative of concentrations achieved during systemic treatment. Local efficacy and drug concentration profiles were evaluated for each drug or drug combination on the device, and the local efficacy was confirmed to be a predictor of systemic efficacy in vivo for multiple drugs and tumor models. Currently, up to 16 individual drugs or combinations can be assessed independently, without systemic drug exposure, through minimally invasive biopsy of a small region of a single tumor. This assay takes into consideration physiologic effects that contribute to drug response by allowing drugs to interact with the living tumor in its native microenvironment. Because these effects are crucial to predicting drug response, we envision that these devices will help identify optimal drug therapy before systemic treatment is initiated and could improve drug response prediction beyond the biomarkers and in vitro and ex vivo studies used today. These devices may also be used in clinical drug development to safely gather efficacy data on new compounds before pharmacological optimization.National Cancer Institute (U.S.) (Innovative Molecular Analysis Technologies Program R21-CA177391)Kibur Medical, Inc

The Star Formation Rate in the Reionization Era as Indicated by Gamma-ray Bursts

High-redshift gamma-ray bursts (GRBs) offer an extraordinary opportunity to study aspects of the early Universe, including the cosmic star formation rate (SFR). Motivated by the two recent highest-z GRBs, GRB 080913 at z = 6.7 and GRB 090423 at z = 8.1, and more than four years of Swift observations, we first confirm that the GRB rate does not trace the SFR in an unbiased way. Correcting for this, we find that the implied SFR to beyond z = 8 is consistent with LBG-based measurements after accounting for unseen galaxies at the faint end of the UV luminosity function. We show that this provides support for the integrated star formation in the range 6 < z < 8 to have been alone sufficient to reionize the Universe.Comment: 4 pages, 4 figures; modified to match version accepted for publication in ApJ Letter

The structure and evolution of quasi-stars

The existence of bright quasars at high redshifts implies that supermassive black holes were able to form in the early Universe. Though a number of mechanisms to achieve this have been proposed, none yet stands out. A recent suggestion is the formation of quasi-stars, initially stellar-mass black holes accreting from hydrostatic giant-like envelopes of gas, formed from the monolithic collapse of pre-galactic gas clouds. In this work, we modify the Cambridge STARS stellar evolution package to construct detailed models of the evolution of these objects. We find that, in all of our models, the black hole inside the envelope is able to reach slightly more than one-tenth of the total mass of the system before hydrostatic equilibrium breaks down. This breakdown occurs after a few million years of evolution. We show that the mechanism which causes the hydrostatic evolution to end is present in polytropic models. We also show that the solutions are highly sensitive to the size of the inner boundary radius and that no physical solutions exist if the inner boundary is chosen to be less than about 0.3 of the Bondi radius.Comment: 12 pages, 11 figures. Published in MNRAS. Very belatedly updated to (more closely) match published versio