4,658 research outputs found
Digital Transformation of Education in China: A Review Against the Backdrop of the 2024 World Digital Education Conference
The flourishing digital technologies are impacting intensively on all facets of education development. How to promote the digital transformation of education by leveraging emerging digital technologies has become a highly concerning topic among educational researchers throughout the world. The Chinese government organized the 2024 World Digital Education Conference in Shanghai on January 30-31 to advance the digital transformation in education. The conference summarized China’s achievements in digital education and laid out a vision for building an international exchange and cooperation platform for global digital education development. This article is a review of China’s explorations and experiments in the digital transformation of education
The ciliary GTPase Arl13b regulates cell migration and cell cycle progression
Acknowledgments We acknowledge Prof. Tamara Caspary from Emory University for kindly providing the cell lines, Linda Duncan from the University of Aberdeen Ian Fraser Cytometry Center for help with flow cytometry. MP was funded by the Scottish Universities Life Science Alliance (SULSA) and the University of Aberdeen. Funding This work was supported by grants from British Council China (Sino-UK higher Education for PhD studies) to YD and CM, The Carnegie Trust for the Universities of Scotland (70190) and The NHS Grampian Endowment Funds (14/09) to BL, and National Natural Science Foundation of China (31528011) to BL and YD.Peer reviewedPostprin
tdCoxSNN: Time-Dependent Cox Survival Neural Network for Continuous-time Dynamic Prediction
The aim of dynamic prediction is to provide individualized risk predictions
over time, which are updated as new data become available. In pursuit of
constructing a dynamic prediction model for a progressive eye disorder,
age-related macular degeneration (AMD), we propose a time-dependent Cox
survival neural network (tdCoxSNN) to predict its progression using
longitudinal fundus images. tdCoxSNN builds upon the time-dependent Cox model
by utilizing a neural network to capture the non-linear effect of
time-dependent covariates on the survival outcome. Moreover, by concurrently
integrating a convolutional neural network (CNN) with the survival network,
tdCoxSNN can directly take longitudinal images as input. We evaluate and
compare our proposed method with joint modeling and landmarking approaches
through extensive simulations. We applied the proposed approach to two real
datasets. One is a large AMD study, the Age-Related Eye Disease Study (AREDS),
in which more than 50,000 fundus images were captured over a period of 12 years
for more than 4,000 participants. Another is a public dataset of the primary
biliary cirrhosis (PBC) disease, where multiple lab tests were longitudinally
collected to predict the time-to-liver transplant. Our approach demonstrates
commendable predictive performance in both simulation studies and the analysis
of the two real datasets
Baryon-Baryon Potentials on the Lattice
The interaction of spatially extended heavy baryons is investigated in the
framework of lattice QCD with dynamical quarks. It is shown that the expected
dipole forces have a very short range and that the baryon-antibaryon
interaction is more attractive than the baryon-baryon interaction. Sea quarks
play a minor important role.Comment: 8 pages, uuencoded postscript file; Physics Letters B, in pres
The Expression and Roles of Nde1 and Ndel1 in the Adult Mammalian Central Nervous System
Open Access funded by Wellcome Trust Under a Creative Commons license Acknowledgments We thank Prof Angelo Sementilli, Department of Pathology, Universidade Metropolitana de Santos, SP, Brazil, for the human sample collection. This study is funded by Scottish Universities Life Sciences Alliance (HR07019 to S. Shen and C.D. McCaig), Medical Research Scotland (384 FRG to B. Lang, United Kingdom), Tenovus Scotland (G12/25 to B. Lang), Sino-UK Higher Education Research Partnership for PhD Studies (C.D. McCaig and Y.Q. Ding) and Wellcome Trust (WT081633MA-NCE to P.J.A. McCaffery, United Kingdom).Peer reviewedPublisher PD
Neurochemical characterization of pERK-expressing spinal neurons in histamine-induced itch
Date of Acceptance: 08/07/2015 Acknowledgements This work was supported by grants from the Ministry of Science and Technology of China (2012CB966904, 2011CB51005), National Natural Science Foundation of China (31271182, 81200692, 91232724, 81200933, 81101026), Shanghai Natural Science Foundation (12ZR1434300), Key Specialty Construction Project of Pudong Health Bureau of Shanghai (PWZz2013-17), Shenzhen Key Laboratory for Molecular Biology of Neural Development (ZDSY20120617112838879), Fundamental Research Funds for the Central Universities (1500219072) and Sino-UK Higher Education Research Partnership for PhD Studies.Peer reviewedPublisher PD
Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice
Acknowledgements We thank Miss Jia-Yin and Miss Yu-Ling Sun for their help in breading the mice. Funding This work was supported by grants from the National Natural Science Foundation of China (81200933 to N.-N. Song; 81200692 to L. Chen; 81101026 to Y. Huang; 31528011 to B. Lang; 81221001, 91232724 and 81571332 to Y-Q. Ding), Zhejiang Province Natural Science Foundation of China (LQ13C090004 to C. Zhang), China Postdoctoral Science Foundation (2016 M591714 to C.-C. Qi), and the Fundamental Research Funds for the Central Universities (2013KJ049).Peer reviewedPublisher PD
Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug Interactions
Organic anion transporting polypeptide (OATP) 1B1 mediates the hepatic uptake of many drugs including lipid-lowering statins. Decreased OATP1B1 transport activity is often associated with increased systemic exposure of statins and statin-induced myopathy. Antimalarial drug chloroquine (CQ) is also used for long-term treatment of rheumatoid arthritis and systemic lupus erythematosus. CQ is lysosomotropic and inhibits protein degradation in lysosomes. The current studies were designed to determine the effects of CQ on OATP1B1 protein degradation, OATP1B1-mediated transport in OATP1B1-overexpressing cell line, and statin uptake in human sandwich-cultured hepatocytes (SCH). Treatment with lysosome inhibitor CQ increased OATP1B1 total protein levels in HEK293-OATP1B1 cells and in human SCH as determined by OATP1B1 immunoblot. In HEK293-FLAG-tagged OATP1B1 stable cell line, co-immunofluorescence staining indicated that intracellular FLAG-OATP1B1 is colocalized with lysosomal associated membrane glycoprotein (LAMP)-2, a marker protein of late endosome/lysosome. Enlarged LAMP-2-positive vacuoles with FLAG-OATP1B1 protein retained inside were readily detected in CQ-treated cells, consistent with blocking lysosomal degradation of OATP1B1 by CQ. In HEK293-OATP1B1 cells, without pre-incubation, CQ concentrations up to 100 μM did not affect OATP1B1-mediated [3H]E217G accumulation. However, pre-incubation with CQ at clinically relevant concentration(s) significantly decreased [3H]E217G and [3H]pitavastatin accumulation in HEK293-OATP1B1 cells and [3H]pitavastatin accumulation in human SCH. CQ pretreatment (25 μM, 2 h) resulted in ∼1.9-fold decrease in Vmax without affecting Km of OATP1B1-mediated [3H]E217G transport in HEK293-OATP1B1 cells. Pretreatment with monensin and bafilomycin A1, which also have lysosome inhibition activity, significantly decreased OATP1B1-mediated transport in HEK293-OATP1B1 cells. Pharmacoepidemiologic studies using data from the U.S. Food and Drug Administration Adverse Event Reporting System indicated that CQ plus pitavastatin, rosuvastatin, and pravastatin, which are minimally metabolized by the cytochrome P450 enzymes, led to higher myopathy risk than these statins alone. In summary, the present studies report novel findings that lysosome is involved in degradation of OATP1B1 protein and that pre-incubation with lysosomotropic drug CQ downregulates OATP1B1 transport activity. Our in vitro data in combination with pharmacoepidemiologic studies support that CQ has potential to cause OATP-mediated drug–drug interactions
Orbital Currents in Underdoped Cuprates
Orbital currents, either fluctuating or static, have emerged as promising
candidates for a description of the pseudogap state in underdoped cuprates. I
shall review the evolution of these ideas and describe some experiments which
have been proposed to test the existence of orbital currents.Comment: 6 pages; Proceedings of the SNS 2001 Conferenc
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