Effect of a Pay-As-You-Drive charge on the adoption of lower carbon vehicles

It is now becoming clear that the ACEA voluntary agreement for reducing CO2 emissions from new cars to 140g/km by 2008 is unlikely to be met. Beyond this, delivering a target of 120g/km by 2012 also looks improbable. As pressure for mandatory regulation grows, for a limited time there remains an opportunity to increase the effectiveness of existing consumer price signals to encourage the adoption of lower carbon vehicles. This study uses a new approach to designing an effective low carbon taxation regime with the aim of persuading UK consumers to purchase more fuel-efficient and lowcarbon cars (defined as ≤100gCO2/km). This approach starts by identifying the most accessible attitudinal levers with which to modify (automotive) consumer behaviour. This achieved, a taxation system is then devised to influence attitudes and behaviour to maximum effect. In this way, the ‘attitude-action’ gap is bridged, exploiting the most efficient links between tax policy, consumer attitudes, car purchasing behaviour and carbon impact. By focusing on (private car) consumer understanding, knowledge and reception of price signals, the research investigates the effect of transferring 50% of the Fuel Excise Duty (FED) tax burden to a new graduated Pay-As-You-Drive (PAYD) distance charge based on vehicle CO2 emissions, replacing the existing ‘A’ to ‘G’ graduated Vehicle Excise Duty (VED). In addition, the distance charge differentials are re-scaled such that lower carbon cars pay less per mile that they do under the current tax system (higher carbon cars are charged proportionately more). The results of modelling changes in consumer behaviour indicate that by introducing a PAYD charge based on an annual cost gradient of £10 (€15/$18) for each additional vehicle gCO2/km, consumers increasingly opt to purchase lower carbon cars such that total annual carbon emissions are reduced by 0.3-0.5 MtC, and the proportion of Band ‘A’ cars increases by an additional 2.2$2520) in the annual variable cost differential between the least and most polluting units. With a PAYD charge based on an annual cost gradient of £14 (€21/$26) for each additional gCO2/km, total annual carbon emissions are reduced by 0.6-1.0 MtC, and the proportion of Band ‘A’ cars increases by 6.2$3529). Interestingly, both scenarios only lead to a marginal reduction in mobility (1%-2%) as measured by total car miles travelled. The interpretation is that private motorists continue to drive to the same extent as under the existing system, but do so in more fuel-efficient (lower carbon) cars. The modelling also predicts an increase in annual UK road taxation revenue of £4.4-£7.8 billion (€6.5-€11.4/$8.1-$14.3 billion), which, the authors suggest, could be used to purchase carbon-offsets and/or fund capital grants for Band A cars, so reinforcing the PAYD scheme. The research does not model possible secondary effects of changes in driving habits resulting from the increased transparency of motoring costs, but the extension of these types of elastic effects would be straightforward to include in future work

Calibration of Computational Models with Categorical Parameters and Correlated Outputs via Bayesian Smoothing Spline ANOVA

It has become commonplace to use complex computer models to predict outcomes in regions where data does not exist. Typically these models need to be calibrated and validated using some experimental data, which often consists of multiple correlated outcomes. In addition, some of the model parameters may be categorical in nature, such as a pointer variable to alternate models (or submodels) for some of the physics of the system. Here we present a general approach for calibration in such situations where an emulator of the computationally demanding models and a discrepancy term from the model to reality are represented within a Bayesian Smoothing Spline (BSS) ANOVA framework. The BSS-ANOVA framework has several advantages over the traditional Gaussian Process, including ease of handling categorical inputs and correlated outputs, and improved computational efficiency. Finally this framework is then applied to the problem that motivated its design; a calibration of a computational fluid dynamics model of a bubbling fluidized which is used as an absorber in a CO2 capture system

Effects of Litter on Aquatic Macrophyte Germination and Growth

In Arkansas, during seasonal drought periods, lake water levels drop leaving exposed mudflats which are primary sites for seedling establishment. Commonly, these exposed mudflats are partially covered with decomposing litter from previous stands of aquatic plants. In this study, aqueous leachates from the litter of four macrophytes, Eleocharis quadrangulata, Justicia americana, Polygonum lapathifolium, and Potamogeton nodosus, were used to test for chemical interference with germination and seedling growth. Only Justicia americana leachate was found to affect the growth of several of the test species. The potential for chemical interference by Justicia litter was evaluated further using extracts of acidified leachate. Resulting bioassays demonstrated significant effects on growth but not on seed germination. Bioassays of chromatographically separated fractions again revealed significant effects on seedling growth. These results suggest that interference by Justicia americana leachate on growth of seedlings is in part allelochemic

A plasma generator utilizing the high intensity ASTROMAG magnets

The magnet configuration for the proposed particle astrophysics magnet facility (ASTROMAG) on the space station includes a cusp magnetic field with an intensity of a few tesla. With these large magnets (or others) located in the outer ionosphere, many quite interesting and unique plasma physics experiments become possible. First there are studies utilizing the magnet alone to examine the supersonic, sub-Alfvenic interaction with the ambient medium; the scale length for the magnet perturbation is approx. 20 m. The magnetic field geometry when combined with the Earth's and their relative motion will give rise to a host of plasma phenomena: ring nulls, x-points, ion-acoustic and lower-hybrid shocks, electron heating (possible shuttle glow without a surface) launching of Alfvenwaves, etc. Second, active experiments are possible for a controlled study of fundamental plasma phenomena. A controlled variable species plasma can be made by using an RF ion source; use of two soft iron rings placed about the line cusp would give an adequate resonance zone (ECH or ICH) and a confining volume suitable for gas efficiency. The emanating plasma can be used to study free expansion of plasma along and across field lines (polar wind), plasma flows around the space platform, turbulent mixing in the wake region, long wavelength spectrum of convecting modes, plasma-dust interactions, etc

Organizing the innovation process : complementarities in innovation networking

This paper contributes to the developing literature on complementarities in organizational design. We test for the existence of complementarities in the use of external networking between stages of the innovation process in a sample of UK and German manufacturing plants. Our evidence suggests some differences between the UK and Germany in terms of the optimal combination of innovation activities in which to implement external networking. Broadly, there is more evidence of complementarities in the case of Germany, with the exception of the product engineering stage. By contrast, the UK exhibits generally strong evidence of substitutability in external networking in different stages, except between the identification of new products and product design and development stages. These findings suggest that previous studies indicating strong complementarity between internal and external knowledge sources have provided only part of the picture of the strategic dilemmas facing firms

Corticotropinoma as a Component of Carney Complex.

Known germline gene abnormalities cause one-fifth of the pituitary adenomas in children and adolescents, but, in contrast with other pituitary tumor types, the genetic causes of corticotropinomas are largely unknown. In this study, we report a case of Cushing disease (CD) due to a loss-of-function mutation in PRKAR1A, providing evidence for association of this gene with a corticotropinoma. A 15-year-old male presenting with hypercortisolemia was diagnosed with CD. Remission was achieved after surgical resection of a corticotropin (ACTH)-producing pituitary microadenoma, but recurrence 3 years later prompted reoperation and radiotherapy. Five years after the original diagnosis, the patient developed ACTH-independent Cushing syndrome, and a diagnosis of primary pigmented nodular adrenocortical disease was confirmed. A PRKAR1A mutation (c.671delG, p.G225Afs*16) was detected in a germline DNA sample from the patient, which displayed loss of heterozygosity in the corticotropinoma. No other germline or somatic mutations of interest were found. As corticotropinomas are not a known component of Carney complex (CNC), we performed loss of heterozygosity and messenger RNA stability studies in the patient's tissues, and analyzed the effect of Prkar1a silencing on AtT-20/D16v-F2 mouse corticotropinoma cells. No PRKAR1A defects were found among 97 other pediatric CD patients studied. Our clinical case and experimental data support a role for PRKAR1A in the pathogenesis of a corticotroph cell tumor. This is a molecularly confirmed report of a corticotropinoma presenting in association with CNC. We conclude that germline PRKAR1A mutations are a novel, albeit apparently infrequent, cause of CD

White Blood, Black Gold: The Commodification of Wild Rubber in the Bolivian Amazon, 1870-1920

The Bolivian rubber boom thrived during the 1880 and 1920 decades throughout the Amazonian fluvial network (Madre de Dios, Beni, Purús, Madeira and Beni rivers). The economic potential of rubber quickly became a decisive phenomenon in the social history of Eastern Bolivia, linked with the definitive ocupation of marginal territories, new interethnic relations, national and international migration, taxation, property entitlement, the foundation of cities, the rise of nationalism, the struggle to settle republican frontiers and a novel regional opening to global economy. The boom also encouraged substantial developments in cartography, hidrography, botanics and ethnology. Our goal is to describe the singularities of the rubber-tapping industry in Bolivia and to analyse the representations of “nature” held by rubber tappers of the period: there was indeed a modernist discourse based on the usual ideas of "progress" and "civilization" of the industry opposed to the "wildness", "savagery" and "barbarism" massively attributed to Amazonia, and also a generalized notion of the jungle as a "desert land" open to opportunities for the self-made man. In retrospect, these discourses can certainly reveal a lack of “ecological awareness”. However, a closer analysis of historical sources also shows the existence of voices that were more nuanced and reflexive, and in some cases even dared to point out the limits of extractivism –not only in "ecological" terms but also in reference to the life of the indigenous and creole populations involved in the rubber boom

A Randomized, Double-Blinded, Phase II Trial of Gemcitabine and Nab-Paclitaxel Plus Apatorsen or Placebo in Patients with Metastatic Pancreatic Cancer: The RAINIER Trial.

Lessons learnedThe addition of the heat shock protein 27 (Hsp27)-targeting antisense oligonucleotide, apatorsen, to a standard first-line chemotherapy regimen did not result in improved survival in unselected patients with metastatic pancreatic cancer.Findings from this trial hint at the possible prognostic and predictive value of serum Hsp27 that may warrant further investigation.BackgroundThis randomized, double-blinded, phase II trial evaluated the efficacy of gemcitabine/nab-paclitaxel plus either apatorsen, an antisense oligonucleotide targeting heat shock protein 27 (Hsp27) mRNA, or placebo in patients with metastatic pancreatic cancer.MethodsPatients were randomized 1:1 to Arm A (gemcitabine/nab-paclitaxel plus apatorsen) or Arm B (gemcitabine/nab-paclitaxel plus placebo). Treatment was administered in 28-day cycles, with restaging every 2 cycles, until progression or intolerable toxicity. Serum Hsp27 levels were analyzed at baseline and on treatment. The primary endpoint was overall survival (OS).ResultsOne hundred thirty-two patients were enrolled, 66 per arm. Cytopenias and fatigue were the most frequent grade 3/4 treatment-related adverse events for both arms. Median progression-free survival (PFS) and OS were 2.7 and 5.3 months, respectively, for arm A, and 3.8 and 6.9 months, respectively, for arm B. Objective response rate was 18% for both arms. Patients with high serum level of Hsp27 represented a poor-prognosis subgroup who may have derived modest benefit from addition of apatorsen.ConclusionAddition of apatorsen to chemotherapy does not improve outcomes in unselected patients with metastatic pancreatic cancer in the first-line setting, although a trend toward prolonged PFS and OS in patients with high baseline serum Hsp27 suggests this therapy may warrant further evaluation in this subgroup

Altered prostanoid production by fibroblasts cultured from the lungs of human subjects with idiopathic pulmonary fibrosis

BACKGROUND: Prostanoids are known to participate in the process of fibrogenesis. Because lung fibroblasts produce prostanoids and are believed to play a central role in the pathogenesis of idiopathic pulmonary fibrosis (IPF), we hypothesized that fibroblasts (HF) cultured from the lungs of patients with IPF (HF-IPF) have an altered balance between profibrotic (thromboxane [TX]A(2)) and antifibrotic (prostacyclin [PGI(2)]) prostaglandins (PGs) when compared with normal human lung fibroblasts (HF-NL). METHODS: We measured inducible cyclooxygenase (COX)-2 gene and protein expression, and a profile of prostanoids at baseline and after IL-1β stimulation. RESULTS: In both HF-IPF and HF-NL COX-2 expression was undetectable at baseline, but was significantly upregulated by IL-1β. PGE(2) was the predominant COX product in IL-1β-stimulated cells with no significant difference between HF-IPF and HF-NL (28.35 [9.09–89.09] vs. 17.12 [8.58–29.33] ng/10(6) cells/30 min, respectively; P = 0.25). TXB(2) (the stable metabolite of TXA(2)) production was significantly higher in IL-1β-stimulated HF-IPF compared to HF-NL (1.92 [1.27–2.57] vs. 0.61 [0.21–1.64] ng/10(6) cells/30 min, respectively; P = 0.007) and the ratio of PGI(2) (as measured by its stable metabolite 6-keto-PGF(1α)) to TXB(2) was significantly lower at baseline in HF-IPF (0.08 [0.04–0.52] vs. 0.12 [0.11–0.89] in HF-NL; P = 0.028) and with IL-1β stimulation (0.24 [0.05–1.53] vs. 1.08 [0.51–3.79] in HF-NL; P = 0.09). CONCLUSION: An alteration in the balance of profibrotic and antifibrotic PGs in HF-IPF may play a role in the pathogeneses of IPF

Recent Legal Literature

Reeves: A Treatise on speacial Subjects of the Law of Real Property; Miller: The Data of Jurisprudence; American State Reports, Vols. 96, 97, 98.; Flanders: An Exposition of the Constitution of the United States; Mikell: Cases on Criminal Law; Longsdorf (ed.): Current Law, a complete Encyclopedia of New Law; Harris: A Treatise on American Advocacy; Edgington: The Monroe Doctrin