Can Undergraduate Artists With No Training in Forensic Art Produce Accurate Age Progressions?

When children go missing and remain missing for long periods of time, authorities sometimes retain forensic artists to age progress the last known picture to provide an estimate of the current appearance. In the present research, undergraduate artists with no training in forensic art were asked to age progress images of children to an adult appearance. Similarity of age progressions produced by undergraduate artists were as similar to the corresponding targets as were age progressions produced by practicing forensic artists. However, age progressions produced by undergraduate artists were rated as being more similar to description matched foils than were the age progressions produced by professional forensic artists, suggesting that professionally produced age progressions might be more useful. Results suggest that untrained individual have sufficient knowledge of facial growth to produce age progressions that are somewhat similar to their corresponding targets

Revised NODDI model for diffusion MRI data with multiple b-tensor encodings

This work proposes a revision of the NODDI model to relate brain tissue microstructure to the new generation of diffusion MRI data with multiple b-tensor encodings. NODDI was developed originally for conventional multi-shell diffusion data acquired with linear tensor encoding (LTE). While adequate for LTE data, it has been shown to be incompatible with data using spherical tensor encoding (STE). We embed a different set of assumptions in NODDI, while retaining the tortuosity constraint, to accommodate both LTE and STE data. Experiments with human data with multiple b-tensor encodings confirm the efficacy of the revision

Blood and cerebrospinal fluid neurofilament light differentially detect neurodegeneration in early Alzheimer's disease

Cerebrospinal fluid (CSF) neurofilament light (NfL) concentration has reproducibly been shown to reflect neurodegeneration in brain disorders, including Alzheimer’s disease (AD). NfL concentration in blood correlates with the corresponding CSF levels, but few studies have directly compared the reliability of these 2 markers in sporadic AD. Herein, we measured plasma and CSF concentrations of NfL in 478 cognitively unimpaired (CU) subjects, 227 patients with mild cognitive impairment, and 113 patients with AD dementia. We found that the concentration of NfL in CSF, but not in plasma, was increased in response to Ab pathology in CU subjects. Both CSF and plasma NfL concentrations were increased in patients with mild cognitive impairment and AD dementia. Furthermore, only NfL in CSF was associated with reduced white matter microstructure in CU subjects. Finally, in a transgenic mouse model of AD, CSF NfL increased before serum NfL in response to the development of Ab pathology. In conclusion, NfL in CSF may be a more reliable biomarker of neurodegeneration than NfL in blood in preclinical sporadic AD

Facial stereotypes and perceived mental illness

It is well established that we carry stereotypes that impact on human perception and behaviour (e.g. G.W. Allport, “The nature of prejudice”. Reading, MA: Addison-Wesley, 1954). Here, we investigate the possibility that we hold a stereotype for a face indicating that its owner may have a mental illness. A three-stage face-perception experiment suggested the presence of such a stereotype. Participants first rated 200 synthetic male faces from the EvoFIT facial-composite system for perceived mental illness (PMI). These faces were used to create a computer-based rating scale that was used by a second sample of participants to make a set of faces appear mentally ill. There was evidence to suggest that the faces that participants identified using the PMI scale differed along this dimension (although not entirely as expected). In the final stage of the study, another set of synthetic faces were created by artificially increasing and decreasing levels along the scale. Participants were asked to rate these items for PMI and for six criminal types. It was found that participants assigned higher PMI ratings (cf. veridical) for items with inflated PMI (although there was no reliable difference in ratings between veridical faces and faces with decreased PMI). Implications of the findings are discussed

Parental reference photos do not always improve the accuracy of forensic age progressions

During long-term missing children cases, forensic artists construct age-progressions to estimate the child’s current appearance. It is commonly believed that incorporating information about the child’s biological relatives is critical in accurately estimating the child’s current appearance. However, some evidence suggests that predicting appearance based on inheritance of features may be error prone. The present studies examine whether age-progressions constructed with the aid of a biological reference photos led to better recognition than those constructed without a biological reference. We also investigated whether there would be any variation depending on the age-range of the age-progressions. Eight professional forensic artists created age-progressions based upon photographs provided by each of our eight targets. Half of their age progressions with the aid of parental reference photos and half without parental reference photos. Furthermore, half were age-progressed across a longer age-range (5-20 years) and half covered a shorter age-range (12-20 years). In Experiment 1 similarity scores were higher over shorter age-ranges. Further, across longer age-ranges age-progressions created with the aid of a parental reference were lower than those without a reference. In Experiment 2 recognition performance was higher across shorter age-ranges. Additionally, across longer age-ranges age-progressions created with the aid of a parental reference were recognized worse than those without a reference. These results suggest that in long-term missing person cases, forensic artists may benefit from not relying on biological references. Finally, consistent with previous research (e.g. Lampinen et al., 2012) age-progressions provided no benefit over using outdated photographs

Characterization of clastic sedimentary enviroments by clustering algorithm and several statistical approaches — case study, Sava Depression in Northern Croatia

Abstract This study demonstrates a method to identify and characterize some facies of turbiditic depositional environments. The study area is a hydrocarbon field in the Sava Depression (Northern Croatia). Its Upper Miocene reservoirs have been proved to represent a lacustrine turbidite system. In the workflow, first an unsupervised neural network was applied as clustering method for two sandstone reservoirs. The elements of the input vectors were the basic petrophysical parameters. In the second step autocorrelation surfaces were used to reveal the hidden anisotropy of the grid. This anisotropy is supposed to identify the main continuity directions in the geometrical analyses of sandstone bodies. Finally, in the description of clusters several parametric and nonparametric statistics were used to characterize the identified facies. Obtained results correspond to the previously published interpretation of those reservoir facies

Optimal In Silico Target Gene Deletion through Nonlinear Programming for Genetic Engineering

Optimal selection of multiple regulatory genes, known as targets, for deletion to enhance or suppress the activities of downstream genes or metabolites is an important problem in genetic engineering. Such problems become more feasible to address in silico due to the availability of more realistic dynamical system models of gene regulatory and metabolic networks. The goal of the computational problem is to search for a subset of genes to knock out so that the activity of a downstream gene or a metabolite is optimized.Based on discrete dynamical system modeling of gene regulatory networks, an integer programming problem is formulated for the optimal in silico target gene deletion problem. In the first result, the integer programming problem is proved to be NP-hard and equivalent to a nonlinear programming problem. In the second result, a heuristic algorithm, called GKONP, is designed to approximate the optimal solution, involving an approach to prune insignificant terms in the objective function, and the parallel differential evolution algorithm. In the third result, the effectiveness of the GKONP algorithm is demonstrated by applying it to a discrete dynamical system model of the yeast pheromone pathways. The empirical accuracy and time efficiency are assessed in comparison to an optimal, but exhaustive search strategy.Although the in silico target gene deletion problem has enormous potential applications in genetic engineering, one must overcome the computational challenge due to its NP-hardness. The presented solution, which has been demonstrated to approximate the optimal solution in a practical amount of time, is among the few that address the computational challenge. In the experiment on the yeast pheromone pathways, the identified best subset of genes for deletion showed advantage over genes that were selected empirically. Once validated in vivo, the optimal target genes are expected to achieve higher genetic engineering effectiveness than a trial-and-error procedure

Acceptance of near-natural greenspace management relates to ecological and socio-cultural assigned values among European urbanites

Grasslands are widespread elements of urban greenspace providing recreational, psychological and aesthetic benefits to city residents. Two urban grassland types of contrasting management dominate urban greenspaces: frequently mown, species-poor short-cut lawns and less intensively managed, near-natural tall-grass meadows. The higher conservation value of tall-grass meadows makes management interventions such as converting short-cut lawns into tall-grass meadows a promising tool for urban biodiversity conservation. The societal success of such interventions, however, depends on identifying the values urban residents assign to different types of urban grasslands, and how these values translate to attitudes towards greenspace management. Using 2027 questionnaires across 19 European cities, we identify the assigned values that correlate with people's personal greenspace use and their preferences for different types of urban grasslands to determine how these values relate to the agreement with a scenario of converting 50 of their cities� short-cut lawns into tall-grass meadows. We found that most people assigned nature-related values, such as wildness, to tall-grass meadows and utility-related values, such as recreation, to short-cut lawns. Positive value associations of wildness and species richness with tall-grass meadows, and social and nature-related greenspace activities, positively correlated with agreeing to convert short-cut lawns into tall-grass meadows. Conversely, disapproval of lawn conversion correlated with positive value associations of cleanliness and recreation potential with short-cut lawns. Here, people using greenspaces for nature-related activities were outstandingly positive about lawn conversion. The results show that the plurality of values assigned to different types of urban grasslands should be considered in urban greenspace planning. For example, tall-grass meadows could be managed to also accommodate the values associated with short-cut lawns, such as tidiness and recreation potential, to support their societal acceptance

HIV-1 Superinfection in the Antiretroviral Therapy Era: Are Seroconcordant Sexual Partners at Risk?

Acquisition of more than one strain of human immunodeficiency virus type 1 (HIV-1) has been reported to occur both during and after primary infection, but the risks and repercussions of dual and superinfection are incompletely understood. In this study, we evaluated a longitudinal cohort of chronically HIV-infected men who were sexual partners to determine if individuals acquired their partners' viral strains.Our cohort of HIV-positive men consisted of 8 couples that identified themselves as long-term sexual partners. Viral sequences were isolated from each subject and analyzed using phylogenetic methods. In addition, strain-specific PCR allowed us to search for partners' viruses present at low levels. Finally, we used computational algorithms to evaluate for recombination between partners' viral strains.All couples had at least one factor associated with increased risk for acquisition of new HIV strains during the study, including detectable plasma viral load, sexually transmitted infections, and unprotected sex. One subject was dually HIV-1 infected, but neither strain corresponded to that of his partner. Three couples' sequences formed monophyletic clusters at the entry visit, with phylogenetic analysis suggesting that one member of the couple had acquired an HIV strain from his identified partner or that both had acquired it from the same source outside their partnership. The 5 remaining couples initially displayed no evidence of dual infection, using phylogenetic analysis and strain-specific PCR. However, in 1 of these couples, further analysis revealed recombinant viral strains with segments of viral genomes in one subject that may have derived from the enrolled partner. Thus, chronically HIV-1 infected individuals may become superinfected with additional HIV strains from their seroconcordant sexual partners. In some cases, HIV-1 superinfection may become apparent when recombinant viral strains are detected