140 research outputs found
The long-time dynamics of two hydrodynamically-coupled swimming cells
Swimming micro-organisms such as bacteria or spermatozoa are typically found
in dense suspensions, and exhibit collective modes of locomotion qualitatively
different from that displayed by isolated cells. In the dilute limit where
fluid-mediated interactions can be treated rigorously, the long-time
hydrodynamics of a collection of cells result from interactions with many other
cells, and as such typically eludes an analytical approach. Here we consider
the only case where such problem can be treated rigorously analytically, namely
when the cells have spatially confined trajectories, such as the spermatozoa of
some marine invertebrates. We consider two spherical cells swimming, when
isolated, with arbitrary circular trajectories, and derive the long-time
kinematics of their relative locomotion. We show that in the dilute limit where
the cells are much further away than their size, and the size of their circular
motion, a separation of time scale occurs between a fast (intrinsic) swimming
time, and a slow time where hydrodynamic interactions lead to change in the
relative position and orientation of the swimmers. We perform a multiple-scale
analysis and derive the effective dynamical system - of dimension two -
describing the long-time behavior of the pair of cells. We show that the system
displays one type of equilibrium, and two types of rotational equilibrium, all
of which are found to be unstable. A detailed mathematical analysis of the
dynamical systems further allows us to show that only two cell-cell behaviors
are possible in the limit of , either the cells are attracted to
each other (possibly monotonically), or they are repelled (possibly
monotonically as well), which we confirm with numerical computations
Ohm's Law for Plasma in General Relativity and Cowling's Theorem
The general-relativistic Ohm's law for a two-component plasma which includes
the gravitomagnetic force terms even in the case of quasi-neutrality has been
derived. The equations that describe the electromagnetic processes in a plasma
surrounding a neutron star are obtained by using the general relativistic form
of Maxwell equations in a geometry of slow rotating gravitational object. In
addition to the general-relativistic effect first discussed by Khanna \&
Camenzind (1996) we predict a mechanism of the generation of azimuthal current
under the general relativistic effect of dragging of inertial frames on radial
current in a plasma around neutron star. The azimuthal current being
proportional to the angular velocity of the dragging of inertial
frames can give valuable contribution on the evolution of the stellar magnetic
field if exceeds (
is the number density of the charged particles, is the conductivity of
plasma). Thus in general relativity a rotating neutron star, embedded in
plasma, can in principle generate axial-symmetric magnetic fields even in
axisymmetry. However, classical Cowling's antidynamo theorem, according to
which a stationary axial-symmetric magnetic field can not be sustained against
ohmic diffusion, has to be hold in the general-relativistic case for the
typical plasma being responsible for the rotating neutron star.Comment: Accepted for publication in Astrophysics & Space Scienc
Forced oscillations in a hydrodynamical accretion disk and QPOs
This is the second of a series of papers aimed to look for an explanation on
the generation of high frequency quasi-periodic oscillations (QPOs) in
accretion disks around neutron star, black hole, and white dwarf binaries. The
model is inspired by the general idea of a resonance mechanism in the accretion
disk oscillations as was already pointed out by Abramowicz & Klu{\'z}niak
(\cite{Abramowicz2001}). In a first paper (P\'etri \cite{Petri2005a}, paper I),
we showed that a rotating misaligned magnetic field of a neutron star gives
rise to some resonances close to the inner edge of the accretion disk. In this
second paper, we suggest that this process does also exist for an asymmetry in
the gravitational potential of the compact object. We prove that the same
physics applies, at least in the linear stage of the response to the
disturbance in the system. This kind of asymmetry is well suited for neutron
stars or white dwarfs possessing an inhomogeneous interior allowing for a
deviation from a perfectly spherically symmetric gravitational field. We show
by a linear analysis that the disk initially in a cylindrically symmetric
stationary state is subject to three kinds of resonances: a corotation
resonance, a Lindblad resonance due to a driven force and a parametric sonance.
The highest kHz QPOs are then interpreted as the orbital frequency of the disk
at locations where the response to the resonances are maximal. It is also found
that strong gravity is not required to excite the resonances.Comment: Accepte
Accretion, Outflows, and Winds of Magnetized Stars
Many types of stars have strong magnetic fields that can dynamically
influence the flow of circumstellar matter. In stars with accretion disks, the
stellar magnetic field can truncate the inner disk and determine the paths that
matter can take to flow onto the star. These paths are different in stars with
different magnetospheres and periods of rotation. External field lines of the
magnetosphere may inflate and produce favorable conditions for outflows from
the disk-magnetosphere boundary. Outflows can be particularly strong in the
propeller regime, wherein a star rotates more rapidly than the inner disk.
Outflows may also form at the disk-magnetosphere boundary of slowly rotating
stars, if the magnetosphere is compressed by the accreting matter. In isolated,
strongly magnetized stars, the magnetic field can influence formation and/or
propagation of stellar wind outflows. Winds from low-mass, solar-type stars may
be either thermally or magnetically driven, while winds from massive, luminous
O and B type stars are radiatively driven. In all of these cases, the magnetic
field influences matter flow from the stars and determines many observational
properties. In this chapter we review recent studies of accretion, outflows,
and winds of magnetized stars with a focus on three main topics: (1) accretion
onto magnetized stars; (2) outflows from the disk-magnetosphere boundary; and
(3) winds from isolated massive magnetized stars. We show results obtained from
global magnetohydrodynamic simulations and, in a number of cases compare global
simulations with observations.Comment: 60 pages, 44 figure
Practicing Imperfect Forgiveness
Forgiveness is typically regarded as a good thing - even a virtue - but acts of forgiveness can vary widely in value, depending on their context and motivation. Faced with this variation, philosophers have tended to reinforce everyday concepts of forgiveness with strict sets of conditions, creating ideals or paradigms of forgiveness. These are meant to distinguish good or praiseworthy instances of forgiveness from problematic instances and, in particular, to protect the self-respect of would-be forgivers. But paradigmatic forgiveness is problematic for a number of reasons, including its inattention to forgiveness as a gendered trait. We can account for the values and the risks associated with forgiving far better if we treat it as a moral practice and not an ideal
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab
This is the final version. Available on open access from Nature Research via the DOI in this recordData availability:
The study protocol including the statistical analysis plan is available at https://www.clarityibd.org/. Individual participant de-identified data that underlie the results reported in this article will be available immediately after publication for a period of 5 years. Due to the sensitive nature of the data, this will be made available to investigators whose proposed use of the data has been approved by an independent review committee. Analyses will be restricted to the aims in the approved proposal. Proposals should be directed to [email protected]. To gain access data requestors will need to sign a data access agreement. Data from the Virus Watch study is currently being archived on the Office of National Statistics Secure Research Service and will be available shortly. Source data are provided with this paper in the Source Data file. Source data are provided with this paper.Code availability:
Statistical analyses were undertaken in R 4.1.2 (R Foundation for Statistical Computing, Vienna, Austria. Code has been made available at: https://github.com/exeteribd/clarityibd-public.Anti tumour necrosis factor (anti-TNF) drugs increase the risk of serious respiratory infection and impair protective immunity following pneumococcal and influenza vaccination. Here we report SARS-CoV-2 vaccine-induced immune responses and breakthrough infections in patients with inflammatory bowel disease, who are treated either with the anti-TNF antibody, infliximab, or with vedolizumab targeting a gut-specific anti-integrin that does not impair systemic immunity. Geometric mean [SD] anti-S RBD antibody concentrations are lower and half-lives shorter in patients treated with infliximab than vedolizumab, following two doses of BNT162b2 (566.7 U/mL [6.2] vs 4555.3 U/mL [5.4], p <0.0001; 26.8 days [95% CI 26.2 - 27.5] vs 47.6 days [45.5 - 49.8], p <0.0001); similar results are also observed with ChAdOx1 nCoV-19 vaccination (184.7 U/mL [5.0] vs 784.0 U/mL [3.5], p <0.0001; 35.9 days [34.9 - 36.8] vs 58.0 days [55.0 - 61.3], p value < 0.0001). One fifth of patients fail to mount a T cell response in both treatment groups. Breakthrough SARS-CoV-2 infections are more frequent (5.8% (201/3441) vs 3.9% (66/1682), p = 0.0039) in patients treated with infliximab than vedolizumab, and the risk of breakthrough SARS-CoV-2 infection is predicted by peak anti-S RBD antibody concentration after two vaccine doses. Irrespective of the treatments, higher, more sustained antibody levels are observed in patients with a history of SARS-CoV-2 infection prior to vaccination. Our results thus suggest that adapted vaccination schedules may be required to induce immunity in at-risk, anti-TNF-treated patients
Relativistic Laser-Matter Interaction and Relativistic Laboratory Astrophysics
The paper is devoted to the prospects of using the laser radiation
interaction with plasmas in the laboratory relativistic astrophysics context.
We discuss the dimensionless parameters characterizing the processes in the
laser and astrophysical plasmas and emphasize a similarity between the laser
and astrophysical plasmas in the ultrarelativistic energy limit. In particular,
we address basic mechanisms of the charged particle acceleration, the
collisionless shock wave and magnetic reconnection and vortex dynamics
properties relevant to the problem of ultrarelativistic particle acceleration.Comment: 58 pages, 19 figure
- …