Fabrication and deterministic transfer of high quality quantum emitter in hexagonal boron nitride

Color centers in solid state crystals have become a frequently used system for single photon generation, advancing the development of integrated photonic devices for quantum optics and quantum communication applications. In particular, defects hosted by two-dimensional (2D) hexagonal boron nitride (hBN) are a promising candidate for next-generation single photon sources, due to its chemical and thermal robustness and high brightness at room temperature. The 2D crystal lattice of hBN allows for a high extraction efficiency and easy integration into photonic circuits. Here we develop plasma etching techniques with subsequent high temperature annealing to reliably create defects. We show how different fabrication parameters influence the defect formation probability and the emitter brightness. A full optical characterization reveals the higher quality of the created quantum emitters, represented by a narrow spectrum, short excited state lifetime and high single photon purity. We also investigated the photostability on short and very long timescales. We utilize a wet chemically-assisted transfer process to reliably transfer the single photon sources onto arbitrary substrates, demonstrating the feasibility for the integration into scalable photonic quantum information processing networks.Comment: revised versio

Model-Based Design of Growth-Attenuated Viruses

Live-virus vaccines activate both humoral and cell-mediated immunity, require only a single boosting, and generally provide longer immune protection than killed or subunit vaccines. However, growth of live-virus vaccines must be attenuated to minimize their potential pathogenic effects, and mechanisms of attenuation by conventional serial-transfer viral adaptation are not well-understood. New methods of attenuation based on rational engineering of viral genomes may offer a potentially greater control if one can link defined genetic modifications to changes in virus growth. To begin to establish such links between genotype and growth phenotype, we developed a computer model for the intracellular growth of vesicular stomatitis virus (VSV), a well-studied, nonsegmented, negative-stranded RNA virus. Our model incorporated established regulatory mechanisms of VSV while integrating key wild-type infection steps: hijacking of host resources, transcription, translation, and replication, followed by assembly and release of progeny VSV particles. Generalization of the wild-type model to allow for genome rearrangements matched the experimentally observed attenuation ranking for recombinant VSV strains that altered the genome position of their nucleocapsid gene. Finally, our simulations captured previously reported experimental results showing how altering the positions of other VSV genes has the potential to attenuate the VSV growth while overexpressing the immunogenic VSV surface glycoprotein. Such models will facilitate the engineering of new live-virus vaccines by linking genomic manipulations to controlled changes in virus gene-expression and growth

Space-compatible cavity-enhanced single-photon generation with hexagonal boron nitride

Sources of pure and indistinguishable single-photons are critical for near-future optical quantum technologies. Recently, color centers hosted by two-dimensional hexagonal boron nitride (hBN) have emerged as a promising platform for high luminosity room temperature single-photon sources. Despite the brightness of the emitters, the spectrum is rather broad and the single-photon purity is not sufficient for practical quantum information processing. Here, we report integration of such a quantum emitter hosted by hBN into a tunable optical microcavity. A small mode volume of the order of $\lambda^3$ allows us to Purcell enhance the fluorescence, with the observed excited state lifetime shortening. The cavity significantly narrows the spectrum and improves the single-photon purity by suppression of off-resonant noise. We explore practical applications by evaluating the performance of our single-photon source for quantum key distribution and quantum computing. The complete device is compact and implemented on a picoclass satellite platform, enabling future low-cost satellite-based long-distance quantum networks

Advanced burning stages and fate of 8-10 Mo stars

The stellar mass range 8<M/Mo<12 corresponds to the most massive AGB stars and the most numerous massive stars. It is host to a variety of supernova progenitors and is therefore very important for galactic chemical evolution and stellar population studies. In this paper, we study the transition from super-AGB star to massive star and find that a propagating neon-oxygen burning shell is common to both the most massive electron capture supernova (EC-SN) progenitors and the lowest mass iron-core collapse supernova (FeCCSN) progenitors. Of the models that ignite neon burning off-center, the 9.5Mo model would evolve to an FeCCSN after the neon-burning shell propagates to the center, as in previous studies. The neon-burning shell in the 8.8Mo model, however, fails to reach the center as the URCA process and an extended (0.6 Mo) region of low Ye (0.48) in the outer part of the core begin to dominate the late evolution; the model evolves to an EC-SN. This is the first study to follow the most massive EC-SN progenitors to collapse, representing an evolutionary path to EC-SN in addition to that from SAGB stars undergoing thermal pulses. We also present models of an 8.75Mo super-AGB star through its entire thermal pulse phase until electron captures on 20Ne begin at its center and of a 12Mo star up to the iron core collapse. We discuss key uncertainties and how the different pathways to collapse affect the pre-supernova structure. Finally, we compare our results to the observed neutron star mass distribution.Comment: 20 pages, 14 figures, 1 table. Submitted to ApJ 2013 February 19; accepted 2013 June

SonicSpray: a technique to reconfigure permeable mid-air displays

Permeable, mid-air displays, such as those using fog or water mist are limited by our ability to shape and control the aerosol and deal with two major issues: (1) the size and complexity of the system, and (2) the creation of laminar flow, to retain display quality. Here we present SonicSpray, a technique using ultrasonic Bessel beams to create reconfigurable mid-air displays. We build a prototype from low-cost, off-the-shelf parts. We explore the potential and limitations of SonicSpray to create and redirect laminar flows of fog. We demonstrate a working prototype that precisely controls laminar aerosols through only 6x6 ultrasound transducers array. We describe the implementation steps to build the device, verify the control and projection algorithm for the display, and evaluate its performance. We finally report our exploration of several useful applications, in learning, entertainment and arts

Challenging situations in partial nephrectomy

© 2016 IJS Publishing Group Ltd Although most partial nephrectomies are performed as primary procedures in the elective or semi-imperative setting on kidneys with relatively normal anatomy, this is not always the case. The indications for partial nephrectomy continue to expand and it is becoming particularly relevant in patients with single functioning kidneys, poor kidney function, anatomical anomalies and hereditary syndromes predisposing to multiple kidney cancers, such as Von Hippel-Lindau syndrome. These, along with previous abdominal su rgery, pose surgical challenges. In this article we offer advice as to how to tackle these unusual situations. An ability to master the whole range of indications will allow the modern upper renal tract surgeon to offer partial nephrectomy to a wider range of patients.Link_to_subscribed_fulltex

Simplified Bioprinting-Based 3D Cell Culture Infection Models for Virus Detection

Studies of virus–host interactions in vitro may be hindered by biological characteristics of conventional monolayer cell cultures that differ from in vivo infection. Three-dimensional (3D) cell cultures show more in vivo-like characteristics and may represent a promising alternative for characterisation of infections. In this study, we established easy-to-handle cell culture platforms based on bioprinted 3D matrices for virus detection and characterisation. Different cell types were cultivated on these matrices and characterised for tissue-like growth characteristics regarding cell morphology and polarisation. Cells developed an in vivo-like morphology and long-term cultivation was possible on the matrices. Cell cultures were infected with viruses which differed in host range, tissue tropism, cytopathogenicity, and genomic organisation and virus morphology. Infections were characterised on molecular and imaging level. The transparent matrix substance allowed easy optical monitoring of cells and infection even via live-cell microscopy. In conclusion, we established an enhanced, standardised, easy-to-handle bioprinted 3D-cell culture system. The infection models are suitable for sensitive monitoring and characterisation of virus–host interactions and replication of different viruses under physiologically relevant conditions. Individual cell culture models can further be combined to a multicellular array. This generates a potent diagnostic tool for propagation and characterisation of viruses from diagnostic samples.Peer Reviewe

Stress, Task, and Relationship Orientations Across German and Vietnamese Cultures

Cultural background and context can be an important predictor of a manager’s behavior, stress and leadership orientation. This paper examines the stress, task, and relationship orientations of people in the high-context culture of Vietnam and in the low-context culture of Germany. As a result of the analysis of 420 responses, some significant differences were found between the two samples. It appears that Vietnamese have higher scores on task, relationship and stress orientations than German respondents. While gender is a significant factor in stress perceptions, it did not demonstrate any differences in the task and relationship orientations of these respondents. In this paper, literature on German and Vietnamese cultures is presented along with practical application, suggestions and implications for future studies.Key words: Culture; Germany; Leadership; Relationships; Stress perception; Tasks; Vietna

Space Qualification of Ultrafast Laser-Written Integrated Waveguide Optics

Satellite-based quantum technologies represent a possible route for extending the achievable range of quantum communication, allowing the construction of worldwide quantum networks without quantum repeaters. In space missions, however, the volume available for the instrumentation is limited, and footprint is a crucial specification of the devices that can be employed. Integrated optics could be highly beneficial in this sense, as it allows for the miniaturization of different functionalities in small and monolithic photonic circuits. This article reports on qualification of waveguides fabricated in glass by femtosecond laser micromachining for their use in a low Earth orbit space environment. In particular, different laser-written integrated devices, such as straight waveguides, directional couplers, and Mach-Zehnder interferometers, are exposed to suitable proton and γ-ray irradiation. This experiment shows that no significant changes have been induced to their characteristics and performances by the radiation exposure. These results, combined with the high compatibility of laser-written optical circuits to quantum communication applications, pave the way for the use of laser-written integrated photonic components in future satellite missions

Changes in BMI before and during economic development and subsequent risk of cardiovascular disease and total mortality: A 35-year follow-up study in China

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