Scaffolding problem-based learning with CSCL tools

Small-group medical problem-based learning (PBL) was a pioneering form of collaborative learning at the university level. It has traditionally been delivered in face-to-face text-based format. With the advancement of computer technology and progress in CSCL, educational researchers are now exploring how to design digitally-implemented scaffolding tools to facilitate medical PBL. The "deteriorating patient" (DP) role play was created as a medical simulation that extends traditional PBL and can be implemented digitally. We present a case study of classroom usage of the DP role play that examines teacher scaffolding of PBL under two conditions: using a traditional whiteboard (TW) and using an interactive whiteboard (IW). The introduction of the IW technology changed the way that the teacher scaffolded the learning. The IW showed the teacher all the information shared within the various subgroups of a class, broadening the basis for informed classroom scaffolding. The visual records of IW usage demonstrated what students understood and reduced the need to structure the task. This allowed more time for engaging students in challenging situations by increasing the complexity of the problem. Although appropriate scaffolding is still based on the teacher's domain knowledge and pedagogy experience, technology can help by expanding the scaffolding choices that an instructor can make in a medical training context. © 2010 The Author(s).published_or_final_versionSpringer Open Choice, 01 Dec 201

The formation of the eccentric-orbit millisecond pulsar J1903+0327 and the origin of single millisecond pulsars

The millisecond pulsar J1903+0327 is accompanied by an ordinary G-dwarf star in an unusually wide ($P_{\rm orb} \simeq 95.2$\,days) and eccentric ($e \simeq 0.44$) orbit. The standard model for producing MSPs fails to explain the orbital characteristics of this extraordinary binary, and alternative binary models are unable to explain the observables. We present a triple-star model for producing MSPs in relatively wide eccentric binaries with a normal (main-sequence) stellar companion. We start from a stable triple system consisting of a Low-Mass X-ray Binary (LMXB) with an orbital period of at least 1 day, accompanied by a G-dwarf in a wide and possibly eccentric orbit. Variations in the initial conditions naturally provide a satisfactory explanation for the unexplained triple component in the eclipsing soft X-ray transient 4U~2129+47 or the cataclysmic variable EC 19314-5915. The best explanation for J1903, however, results from the expansion of the orbit of the LMXB, driven by the mass transfer from the evolving donor star to its neutron star companion, which causes the triple eventually to becomes dynamically unstable. Using numerical computations we show that, depending on the precise system configuration at the moment the triple becomes dynamically unstable, the ejection of each of the three components is possible. If the donor star of the LMXB is ejected, a system resembling J1903, will result. If the neutron star is ejected, a single MSP results. This model therefore also provides a straightforward mechanism for forming single MSP in the Galactic disk. We conclude that the Galaxy contains some 30--300 binaries with characteristics similar to J1903, and about an order of magnitude fewer single millisecond pulsars produced with the proposed triple scenario.Comment: ApJ accepted for publicatio

Heavy Ion Physics at the LHC with the ATLAS Detector

The ATLAS detector at CERN will provide a high-resolution longitudinally-segmented calorimeter and precision tracking for the upcoming study of heavy ion collisions at the LHC (sqrt(s_NN)=5520 GeV). The calorimeter covers |eta|<5 with both electromagnetic and hadronic sections, while the inner detector spectrometer covers |eta|<2.5. ATLAS will study a full range of observables necessary to characterize the hot and dense matter formed at the LHC. Global measurements (particle multiplicities, collective flow) will provide access into its thermodynamic and hydrodynamic properties. Measuring complete jets out to 100's of GeV will allow detailed studies of energy loss and its effect on jets. Quarkonia will provide a handle on deconfinement mechanisms. ATLAS will also study the structure of the nucleon and nucleus using forward physics probes and ultraperipheral collisions, both enabled by segmented Zero Degree Calorimeters.Comment: 9 pages, 8 figures, submitted to the Proceedings of Quark Matter 2006, Shanghai, China, November 14-20, 200

Quark Matter 2006: high-pT and jets

An overview of new experimental results on high-\pT{} particle production and jets in heavy ion collisions from the Quark Matter 2006 conference is presented.Comment: Presented at Quark Matter 200

The Mid-Infrared Instrument for the James Webb Space Telescope, V: Predicted Performance of the MIRI Coronagraphs

The imaging channel on the Mid-Infrared Instrument (MIRI) is equipped with four coronagraphs that provide high contrast imaging capabilities for studying faint point sources and extended emission that would otherwise be overwhelmed by a bright point-source in its vicinity. Such bright sources might include stars that are orbited by exoplanets and circumstellar material, mass-loss envelopes around post-main-sequence stars, the near-nuclear environments in active galaxies, and the host galaxies of distant quasars. This paper describes the coronagraphic observing modes of MIRI, as well as performance estimates based on measurements of the MIRI flight model during cryo-vacuum testing. A brief outline of coronagraphic operations is also provided. Finally, simulated MIRI coronagraphic observations of a few astronomical targets are presented for illustration

Rational optimization of tolC as a powerful dual selectable marker for genome engineering

Selection has been invaluable for genetic manipulation, although counter-selection has historically exhibited limited robustness and convenience. TolC, an outer membrane pore involved in transmembrane transport in E. coli, has been implemented as a selectable/counter-selectable marker, but counter-selection escape frequency using colicin E1 precludes using tolC for inefficient genetic manipulations and/or with large libraries. Here, we leveraged unbiased deep sequencing of 96 independent lineages exhibiting counter-selection escape to identify loss-of-function mutations, which offered mechanistic insight and guided strain engineering to reduce counter-selection escape frequency by ∼40-fold. We fundamentally improved the tolC counter-selection by supplementing a second agent, vancomycin, which reduces counter-selection escape by 425-fold, compared colicin E1 alone. Combining these improvements in a mismatch repair proficient strain reduced counter-selection escape frequency by 1.3E6-fold in total, making tolC counter-selection as effective as most selectable markers, and adding a valuable tool to the genome editing toolbox. These improvements permitted us to perform stable and continuous rounds of selection/counter-selection using tolC, enabling replacement of 10 alleles without requiring genotypic screening for the first time. Finally, we combined these advances to create an optimized E. coli strain for genome engineering that is ∼10-fold more efficient at achieving allelic diversity than previous best practices

Search for positively charged strangelets and other related results with E864 at the AGS

We report on the latest results in the search for positively charged strangelets from E864's 96/97 run at the AGS with sensitivity of about $8\times 10^{-9}$ per central collision. This contribution also contains new results of a search for highly charged strangelets with $Z=+3$. Production of light nuclei, such as $^6He$ and $^6Li$, is presented as well. Measurements of yields of these rarely produced isotopes near midrapidity will help constrain the production levels of strangelets via coalescence. E864 also measures antiproton production which includes decays from antihyperons. Comparisons with antiproton yields measured by E878 as a function of centrality indicate a large antihyperon-to-antiproton ratio in central collisions.Comment: 8 pages, 4 figures; Talk at SQM'98, Padova, Italy (July 20-24th, 1998