Truncated Hilbert space approach to the 2d ϕ4\phi^{4} theory

We apply the massive analogue of the truncated conformal space approach to study the two dimensional $\phi^{4}$ theory in finite volume. We focus on the broken phase and determine the finite size spectrum of the model numerically. We interpret the results in terms of the Bethe-Yang spectrum, from which we extract the infinite volume masses and scattering matrices for various couplings. We compare these results against semiclassical analysis and perturbation theory. We also analyze the critical point of the model and confirm that it is in the Ising universality class.Comment: pdflatex, 35 pages with 29 pdf figures. Binary program is also attached, run on linux as: phi4 config.dat, v2: typos corrected, comparison to other works and references added, vacuum splitting analysis corrected, comparison to sine-Gordon TCSA added, v3: improved numerics, analysis on excited kink added, critical point investigate

Plasma proteome analysis of patients with type 1 diabetes with diabetic nephropathy

<p>Abstract</p> <p>Background</p> <p>As part of a clinical proteomics program focused on diabetes and its complications we are looking for new and better protein biomarkers for diabetic nephropathy. The search for new and better biomarkers for diabetic nephropathy has, with a few exceptions, previously focused on either hypothesis-driven studies or urinary based investigations. To date only two studies have investigated the proteome of blood in search for new biomarkers, and these studies were conducted in sera from patients with type 2 diabetes. This is the first reported in depth proteomic study where plasma from type 1 diabetic patients was investigated with the goal of finding improved candidate biomarkers to predict diabetic nephropathy. In order to reach lower concentration proteins in plasma a pre-fractionation step, either hexapeptide bead-based libraries or anion exchange chromatography, was performed prior to surface enhanced laser desorption/ionization time-of-flight mass spectrometry analysis.</p> <p>Results</p> <p>Proteomic analysis of plasma from a cross-sectional cohort of 123 type 1 diabetic patients previously diagnosed as normoalbuminuric, microalbuminuric or macroalbuminuric, gave rise to 290 peaks clusters of which 16 were selected as the most promising biomarker candidates based on statistical performance, including independent component analysis. Four of the peaks that were discovered have been identified as transthyretin, apolipoprotein A1, apolipoprotein C1 and cystatin C. Several yet unidentified proteins discovered by this novel approach appear to have more potential as biomarkers for diabetic nephropathy.</p> <p>Conclusion</p> <p>These results demonstrate the capacity of proteomic analysis of plasma, by confirming the presence of known biomarkers as well as revealing new biomarkers for diabetic nephropathy in plasma in type 1 diabetic patients.</p

Dissolved Inorganic Geogenic Phosphorus Load to a Groundwater-Fed Lake: Implications of Terrestrial Phosphorus Cycling by Groundwater

The general perception has long been that lake eutrophication is driven by anthropogenic sources of phosphorus (P) and that P is immobile in the subsurface and in aquifers. Combined investigation of the current water and P budgets of a 70 ha lake (Nørresø, Fyn, Denmark) in a clayey till-dominated landscape and of the lake’s Holocene trophic history demonstrates a potential significance of geogenic (natural) groundwater-borne P. Nørresø receives water from nine streams, a groundwater-fed spring located on a small island, and precipitation. The lake loses water by evaporation and via a single outlet. Monthly measurements of stream, spring, and outlet discharge, and of tracers in the form of temperature, δ18O and δ2H of water, and water chemistry were conducted. The tracers indicated that the lake receives groundwater from an underlying regional confined glaciofluvial sand aquifer via the spring and one of the streams. In addition, the lake receives a direct groundwater input (estimated as the water balance residual) via the lake bed, as supported by the artesian conditions of underlying strata observed in piezometers installed along the lake shore and in wells tapping the regional confined aquifer. The groundwater in the regional confined aquifer was anoxic, ferrous, and contained 4–5 µmol/L dissolved inorganic orthophosphate (DIP). Altogether, the data indicated that groundwater contributes from 64% of the water-borne external DIP loading to the lake, and up to 90% if the DIP concentration of the spring, as representative for the average DIP of the regional confined aquifer, is assigned to the estimated groundwater input. In support, paleolimnological data retrieved from sediment cores indicated that Nørresø was never P-poor, even before the introduction of agriculture at 6000 years before present. Accordingly, groundwater-borne geogenic phosphorus can have an important influence on the trophic state of recipient surface water ecosystems, and groundwater-borne P can be a potentially important component of the terrestrial P cycle