Risque dû à la consommation des boissons rafraichissantes sans alcool édulcorées

L’objectif de la présente étude est d’estimer la qualité chimique et microbiologique des différents types de boissons rafraichissantes sans alcool (BRSA) commercialisées dans la région de Djelfa. Les résultats obtenus montrent que 36.66% des échantillons sont non conformes à la réglementation Algérienne. 23.33% sont relatives à la qualité chimique (dépassement des doses de la saccharine pour 20% des échantillons et présence d’un édulcorant non autorisé, le cyclamate dans un seul échantillon) et 13.33% relatives à la qualité microbiologique (dû principalement à la flore fongique, plus particulièrement aux levures et secondairement aux coliformes). Quatre classes sont issues de la classification hiérarchique et confirment l’analyse en composante principale; ces classes ne se distinguent que pour les paramètres acésulfame K et aspartame.Mots-clés: édulcorants, CLHP, BRSA, contrôle de qualité, Djelfa.Risque result of sweaters refreshing soft drinks without alcohol consumption The aim of this study is predict chemical and microbiological quality of different type of refreshing soft drinks without alcohol (BRSA) marketed in Djelfa city. The result obtained has proved that 36.66% of samples are no conforming of Algerian regulation. 23.33% are concerning a chemical quality (the exceed of the doses of saccharin for 20% of samples and presence of a Sweetener no permit, the cyclamate in one sample) and 13.33% related to microbiological quality (to resist especially of fungal flore, more specific of yeast and secondarily of coliform). Four cases are resulted of the hierarchic classification and proved the analysis of principal compound; those classes no distinct that for acesulfam K and aspartam permanents.Keywords: sweeteners, HPLC, BRSA, quality control, Djelfa

A STUDY OF THE SOL-GEL TRANSITION OF POLYACRYLAMIDE SOLUTIONS BY STATIC LIGHT SCATTERING

Abstract A gelation process in polyacrylamide solutions is studied by static light scattering measurements at different concentrations and different scattering angles. By examining the temporal variation of the light scattered intensity I(t) from the samples undergoing the transition, we find that at the first stage of gelation, the scattered intensity is a linear function of time and the formed aggregates are linear chains. After this initial period, a crossover occurs; the aggregates become branched and their mass grows as a power law in time. At this stage, the total scattered intensity is well described by the dynamic droplets aggregation model. The analysis of the data shows that the gelation process is governed by an irreversible aggregation limited by reaction and characterized by a fractal dimension D f = 2.1 and a polydispersion coefficient τ = 1.5

Synchronous Primary Tumors of the Kidney and Pancreas: Case Report

The simultaneous presence of primary carcinomas in the same patient is uncommon and synchronous primary tumors involving the kidney and pancreas are extremely rare. There are a few reports in the English literature of synchronous primary malignancies of the kidney and pancreas. We present a 62-year-old man who had weight loss of 9 kg and epigastric pain. Findings showed a Furhman grade II renal papillary carcinoma confined to the kidney and a synchronous well differentiated pancreatic ductal adenocarcinoma.Key Words: Synchronous double cancer, renal cell carcinoma, pancreatic carcinom

Multicomponent and 1,3-dipolar cycloaddition synthesis of triazole- and isoxazole-acridinedione/xanthenedione heterocyclic hybrids: cytotoxic effects on human cancer cells

A new series of diverse 1,2,3-triazole-acridinedione/xanthenedione and 1,2-isoxazole-acridinedione/xanthenedione heterocyclic hybrids have been synthesized via 1,3-dipolar coupling reaction of N/O-substituted-acridinedione-alkyne or O-substituted-xanthenedione-alkyne substrates with various aromatic azides or oximes. In all cases, the cycloaddition is totally regioselective. The chemical structures of the synthesized compounds are determined using 2D NMR and are further confirmed by single-crystal X-ray diffraction analysis. Preliminary in vitro cytotoxic assays on two human breast cancer cell lines (MDA-MB-231, T47-D) and one prostate cancer cell line (PC3) are performed on some selected compounds. The most active O-1,2,3-triazole-xanthenedione hybrid displays the best cytotoxicity effects with IC50 ≤ 20 μM in breast cancer and IC50 = 10 μM in prostate cancer cell lines.publishe

A step-by-step synthesis of triazole-benzimidazole-chalcone hybrids: Anticancer activity in human cells+

Novel series of triazole-benzimidazole-chalcone hybrid compounds have been synthesized via click chemistry, between different azide derivatives and substituted benzimidazole terminal alkynes bearing a chalcone moiety. The starting alkynes are prepared via base-catalysed nitrogen alkylation of pre-synthetized benzimidazole-chalcone substrates. All the intermediates as well as the final products are fully characterized by 1D and 2D NMR and mass spectrometry techniques. HMBC correlations permits the identification of a unique 1,4-disubstitued triazole-benzimidazole-chalcone isomer. Evaluation of the anti-proliferative potential in breast and prostate cancer cell lines showed that the presence of chloro substituents at the chalcone ring of the triazole-benzimidazole-chalcone skeleton enhanced the cytotoxic effects. The benzyl group linked to the 1,2,3-triazole moiety provides more antiproliferative potential.publishe

Microtubule-associated protein 6 mediates neuronal connectivity through Semaphorin 3E-dependent signalling for axonal growth.

Structural microtubule associated proteins (MAPs) stabilize microtubules, a property that was thought to be essential for development, maintenance and function of neuronal circuits. However, deletion of the structural MAPs in mice does not lead to major neurodevelopment defects. Here we demonstrate a role for MAP6 in brain wiring that is independent of microtubule binding. We find that MAP6 deletion disrupts brain connectivity and is associated with a lack of post-commissural fornix fibres. MAP6 contributes to fornix development by regulating axonal elongation induced by Semaphorin 3E. We show that MAP6 acts downstream of receptor activation through a mechanism that requires a proline-rich domain distinct from its microtubule-stabilizing domains. We also show that MAP6 directly binds to SH3 domain proteins known to be involved in neurite extension and semaphorin function. We conclude that MAP6 is critical to interface guidance molecules with intracellular signalling effectors during the development of cerebral axon tracts

Taurine: a potential marker of apoptosis in gliomas

New cancer therapies are being developed that trigger tumour apoptosis and an in vivo method of apoptotic detection and early treatment response would be of great value. Magnetic resonance spectroscopy (MRS) can determine the tumour biochemical profile in vivo, and we have investigated whether a specific spectroscopic signature exists for apoptosis in human astrocytomas. High-resolution magic angle spinning (HRMAS) 1H MRS provided detailed 1H spectra of brain tumour biopsies for direct correlation with histopathology. Metabolites, mobile lipids and macromolecules were quantified from presaturation HRMAS 1H spectra acquired from 41 biopsies of grades II (n=8), III (n=3) and IV (n=30) astrocytomas. Subsequently, TUNEL and H&E staining provided quantification of apoptosis, cell density and necrosis. Taurine was found to significantly correlate with apoptotic cell density (TUNEL) in both non-necrotic (R=0.727, P=0.003) and necrotic (R=0.626, P=0.0005) biopsies. However, the ca 2.8 p.p.m. polyunsaturated fatty acid peak, observed in other studies as a marker of apoptosis, correlated only in non-necrotic biopsies (R=0.705, P<0.005). We suggest that the taurine 1H MRS signal in astrocytomas may be a robust apoptotic biomarker that is independent of tumour necrotic status

Yearly Performance of Low-Enthalpy Parabolic Trough Collectors in MENA Region According to Different Sun-Tracking Strategies

International audienceSolar parabolic trough collector (PTC) is a very popular system in solar concentration technology, which is widely used for electric production and heat generation in industrial processes. In this paper, a validated mathematical model has been proposed to evaluate the performance of low-enthalpy PTC in five sites of the MENA region: Ouarzazate (Morocco), Gafsa (Tunisia), Jeddah (Saudi Arabia), Amman (Jordan) and Aswane (Egypt). A MATLAB program was developed to simulate the hourly thermal performance of the PTC under fluctuating climatic conditions. A particular attention has been given to the effect of the sun-tracking technique on the collector's performance. The model validation was carried out in two phases: first, by comparison with the results generated by the System Advisor Model software, and second by comparison with experimental data. In both cases, a very close agreement is obtained. The results have shown clearly that the tracking technique, climate and season of the year have a significant impact on the PTC performance. The best site for implementing such technologies was found to be Ouarzazate (Morocco) with a useful annual energy generation potential varying from 104.85 to 154.57 MWh. On December 24, the PTC operating in Ouarzazate using 0.2 kg/s mass flow rate, the outlet water temperature can achieve a maximum temperature of 70 °C using the full-tracking and N-S tracking techniques, while the outlet temperature does not exceed 46.5 °C using the E-W tracking. This temperature can reach 82 °C on July 07, by using the full-tracking and E-W tracking modes. From a general aspect, it was also concluded that the optimal cost-effective tracking strategy for the annual heat generation is the E-W polar tracking one independently of the geographical location. \textcopyright 2017 Elsevier Lt