2,679 research outputs found
Prostaglandin E2-like activity of 20:3n-9 platelet lipoxygenase end-product
Abstract5,8,11-Icosatrienoic acid (20:3n-9), a fatty acid associated with platelet hyperactivity, was oxygenated by platelet lipoxygenase. The end-product of this pathway was purified by high-performance liquid chromatography (HPLC) and characterized as 12-hydroxy-5,8,10-icosatrienoic acid [12-OH-20:3(5,8,10)] by capillary gas-liquid mass spectrometry. When tested upon platelet aggregation, 12-OH-20:3(5,8,10) exhibited a biphasic effect. At low concentrations (below 5 × 10−7 M) it potentiated aggregation but inhibited it at higher levels, a pattern similar to that obtained with prostaglandin E2. However, since the amounts of 12-OH-20:3(5,8,10) generated under thrombin stimulation are in the range of concentrations with potentiating effects, it seems that the 12-OH derivative is responsible for the hyperaggrebility of 20: 3n-9-rich platelets
The inner circumstellar disk of the UX Ori star V1026 Sco
The UX Ori type variables (named after the prototype of their class) are
intermediate-mass pre-main sequence objects. One of the most likely causes of
their variability is the obscuration of the central star by orbiting dust
clouds. We investigate the structure of the circumstellar environment of the
UX~Ori star V1026 Sco (HD 142666) and test whether the disk inclination is
large enough to explain the UX Ori variability. We observed the object in the
low-resolution mode of the near-infrared interferometric VLTI/AMBER instrument
and derived H- and K-band visibilities and closure phases. We modeled our AMBER
observations, published Keck Interferometer observations, archival MIDI/VLTI
visibilities, and the spectral energy distribution using geometric and
temperature-gradient models. Employing a geometric inclined-ring disk model, we
find a ring radius of 0.15 +- 0.06 AU in the H band and 0.18 +- 0.06 AU in the
K band. The best-fit temperature-gradient model consists of a star and two
concentric, ring-shaped disks. The inner disk has a temperature of
1257^{+133}_{-53} K at the inner rim and extends from 0.19 +- 0.01 AU to 0.23
+- 0.02 AU. The outer disk begins at 1.35^{+0.19}_{-0.20} AU and has an inner
temperature of 334^{+35}_{-17} K. The derived inclination of
48.6^{+2.9}_{-3.6}deg approximately agrees with the inclination derived with
the geometric model (49 +- 5deg in the K band and 50 +- 11deg in the H band).
The position angle of the fitted geometric and temperature-gradient models are
163 +- 9deg (K band; 179 +- 17deg in the H band) and 169.3^{+4.2}_{-6.7}deg,
respectively. The narrow width of the inner ring-shaped model disk and the disk
gap might be an indication for a puffed-up inner rim shadowing outer parts of
the disk. The intermediate inclination of ~50deg is consistent with models of
UX Ori objects where dust clouds in the inclined disk obscure the central star
Dark-bright mixing of interband transitions in symmetric semiconductor quantum dots
In photoluminescence spectra of symmetric [111] grown GaAs/AlGaAs quantum
dots in longitudinal magnetic fields applied along the growth axis we observe
in addition to the expected bright states also nominally dark transitions for
both charged and neutral excitons. We uncover a strongly non-monotonous, sign
changing field dependence of the bright neutral exciton splitting resulting
from the interplay between exchange and Zeeman effects. Our theory shows
quantitatively that these surprising experimental results are due to
magnetic-field-induced \pm 3/2 heavy-hole mixing, an inherent property of
systems with C_3v point-group symmetry.Comment: 5 pages, 3 figure
Atmospheric parameters and chemical properties of red giants in the CoRoT asteroseismology fields
A precise characterisation of the red giants in the seismology fields of the
CoRoT satellite is a prerequisite for further in-depth seismic modelling.
High-resolution FEROS and HARPS spectra were obtained as part of the
ground-based follow-up campaigns for 19 targets holding great asteroseismic
potential. These data are used to accurately estimate their fundamental
parameters and the abundances of 16 chemical species in a self-consistent
manner. Some powerful probes of mixing are investigated (the Li and CNO
abundances, as well as the carbon isotopic ratio in a few cases). The
information provided by the spectroscopic and seismic data is combined to
provide more accurate physical parameters and abundances. The stars in our
sample follow the general abundance trends as a function of the metallicity
observed in stars of the Galactic disk. After an allowance is made for the
chemical evolution of the interstellar medium, the observational signature of
internal mixing phenomena is revealed through the detection at the stellar
surface of the products of the CN cycle. A contamination by NeNa-cycled
material in the most massive stars is also discussed. With the asteroseismic
constraints, these data will pave the way for a detailed theoretical
investigation of the physical processes responsible for the transport of
chemical elements in evolved, low- and intermediate-mass stars.Comment: Accepted for publication in A&A, 25 pages, 13 colour figures (revised
version after language editing
Evaluation of POSSUM for Patients Undergoing Pancreatoduodenectomy
Comparison of operative morbidity rates after pancreatoduodenectomy between units may be misleading because it does not take into account the physiological variable of the condition of the patients. The aim of the present study was to evaluate the Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity (POSSUM) for pancreatoduodenectomy patients and to look for risk factors associated with morbidity in a high-volume center. Between January 1993 and April 2006, 652 patients underwent a pancreatoduodenectomy, 502 of them for malignant disease. POSSUM performance was evaluated by assessing the "goodness-of-fit" with the linear analysis method. Overall, 332 of the 652 patients (50.9%) had one or more complication after pancreatoduodenectomy, and 9 patients (1.4%) died. POSSUM had a significant lack of fit using goodness-of-fit analysis. In multivariate analysis, one statistically significant factor associated with morbidity and not incorporated in POSSUM (P < 0.05) was identified: ampulla of Vater adenocarcinoma (OR = 1.73, 95% CI: 1.07-2.80). Overall, there is a lack of calibration of POSSUM among patients who undergo pancreatoduodenectom
Models of red giants in the CoRoT asteroseismology fields combining asteroseismic and spectroscopic constraints
Context. The availability of asteroseismic constraints for a large sample of
red giant stars from the CoRoT and Kepler missions paves the way for various
statistical studies of the seismic properties of stellar populations.
Aims. We use the first detailed spectroscopic study of 19 CoRoT red-giant
stars (Morel et al 2014) to compare theoretical stellar evolution models to
observations of the open cluster NGC 6633 and field stars.
Methods. In order to explore the effects of rotation-induced mixing and
thermohaline instability, we compare surface abundances of carbon isotopic
ratio and lithium with stellar evolution predictions. These chemicals are
sensitive to extra-mixing on the red-giant branch.
Results. We estimate mass, radius, and distance for each star using the
seismic constraints. We note that the Hipparcos and seismic distances are
different. However, the uncertainties are such that this may not be
significant. Although the seismic distances for the cluster members are self
consistent they are somewhat larger than the Hipparcos distance. This is an
issue that should be considered elsewhere. Models including thermohaline
instability and rotation-induced mixing, together with the seismically
determined masses can explain the chemical properties of red-giants targets.
However, with this sample of stars we cannot perform stringent tests of the
current stellar models. Tighter constraints on the physics of the models would
require the measurement of the core and surface rotation rates, and of the
period spacing of gravity-dominated mixed modes. A larger number of stars with
longer times series, as provided by Kepler or expected with Plato, would help
for ensemble asteroseismology.Comment: Accepted 03/05/201
Studying complex interventions : reflections from the FEMHealth project on evaluating fee exemption policies in West Africa and Morocco
Peer reviewedPublisher PD
<sup>18</sup>F-FDG-PET/CT to Detect Pathological Complete Response After Neoadjuvant Treatment in Patients with Cancer of the Esophagus or Gastroesophageal Junction:Accuracy and Long-Term Implications
Purpose : The curative strategy for patients with esophageal cancer without distant metastases consists of esophagectomy with preceding chemo(radio)therapy (CRT). In 10–40% of patients treated with CRT, no viable tumor is detectable in the resection specimen (pathological complete response (pCR)). This study aims to define the clinical outcomes of patients with a pCR and to assess the accuracy of post-CRT FDG-PET/CT in the detection of a pCR. Methods: Four hundred sixty-three patients with cancer of the esophagus or gastroesophageal junction who underwent esophageal resection after CRT between 1994 and 2013 were included. Patients were categorized as pathological complete responders or noncomplete responders. Standardized uptake value (SUV) ratios of 135 post-CRT FDG-PET/CTs were calculated and compared with the pathological findings in the corresponding resection specimens. Results: Of the 463 included patients, 85 (18.4%) patients had a pCR. During follow-up, 25 (29.4%) of these 85 patients developed recurrent disease. Both 5-year disease-free survival (5y-DFS) and 5-year overall survival (5y-OS) were significantly higher in complete responders compared to noncomplete responders (5y-DFS 69.6% vs. 44.2%; P = 0.001 and 5y-OS 66.5% vs. 43.7%; P = 0.001). Not pCR, but only pN0 was identified as an independent predictor of (disease-free) survival. Conclusion: Patients with a pCR have a higher probability of survival compared to noncomplete responders. One third of patients with a pCR do develop recurrent disease, and pCR can therefore not be equated with cure. FDG-PET/CT was inaccurate to predict pCR and therefore cannot be used as a sole diagnostic tool to predict pCR after CRT for esophageal cancer.</p
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