Academic-Community Partnerships: Effectiveness Evaluated Beyond the Ivory Walls

Community-based participatory research (CBPR) has furthered our understanding of the working principles required for academic-community partnerships to address persistent public health problems. However, little is known about how effective these partnerships have been in eliminating or reducing community-based public health issues. To contribute to the literature in this area, the authors conducted a survey of U.S. schools and programs in public health and community groups working with these academic partners to: (1) identify the most common local public health issues addressed; (2) examine the characteristics of the partnership and the actual or perceived benefits and challenges for each partner; (3) assess the perceived effectiveness of the partnership and their evaluation techniques; and (4) analyze the intent to continue or dissolve the partnership and the associated factors that influence this decision. The authors provide recommendations that can improve the development, functioning, and effectiveness of academic-community collaborations aimed at addressing a variety of public health concerns

Academic-Community Partnerships Effectiveness Evaluated Beyond the Ivory Walls

Community-based participatory research (CBPR) has furthered our understanding of the working principles required for academic-community partnerships to address persistent public health problems. However, little is known about how effective these partnerships have been in eliminating or reducing community-based public health issues. To contribute to the literature in this area, the authors conducted a survey of U.S. schools and programs in public health and community groups working with these academic partners to: (1) identify the most common local public health issues addressed; (2) examine the characteristics of the partnership and the actual or perceived benefits and challenges for each partner; (3) assess the perceived effectiveness of the partnership and their evaluation techniques; and (4) analyze the intent to continue or dissolve the partnership and the associated factors that influence this decision. The authors provide recommendations that can improve the development, functioning, and effectiveness of academic-community collaborations aimed at addressing a variety of public health concerns

Disorders of sex development : insights from targeted gene sequencing of a large international patient cohort

Background: Disorders of sex development (DSD) are congenital conditions in which chromosomal, gonadal, or phenotypic sex is atypical. Clinical management of DSD is often difficult and currently only 13% of patients receive an accurate clinical genetic diagnosis. To address this we have developed a massively parallel sequencing targeted DSD gene panel which allows us to sequence all 64 known diagnostic DSD genes and candidate genes simultaneously. Results: We analyzed DNA from the largest reported international cohort of patients with DSD (278 patients with 46, XY DSD and 48 with 46, XX DSD). Our targeted gene panel compares favorably with other sequencing platforms. We found a total of 28 diagnostic genes that are implicated in DSD, highlighting the genetic spectrum of this disorder. Sequencing revealed 93 previously unreported DSD gene variants. Overall, we identified a likely genetic diagnosis in 43% of patients with 46, XY DSD. In patients with 46, XY disorders of androgen synthesis and action the genetic diagnosis rate reached 60%. Surprisingly, little difference in diagnostic rate was observed between singletons and trios. In many cases our findings are informative as to the likely cause of the DSD, which will facilitate clinical management. Conclusions: Our massively parallel sequencing targeted DSD gene panel represents an economical means of improving the genetic diagnostic capability for patients affected by DSD. Implementation of this panel in a large cohort of patients has expanded our understanding of the underlying genetic etiology of DSD. The inclusion of research candidate genes also provides an invaluable resource for future identification of novel genes

Mammal responses to global changes in human activity vary by trophic group and landscape

Wildlife must adapt to human presence to survive in the Anthropocene, so it is critical to understand species responses to humans in different contexts. We used camera trapping as a lens to view mammal responses to changes in human activity during the COVID-19 pandemic. Across 163 species sampled in 102 projects around the world, changes in the amount and timing of animal activity varied widely. Under higher human activity, mammals were less active in undeveloped areas but unexpectedly more active in developed areas while exhibiting greater nocturnality. Carnivores were most sensitive, showing the strongest decreases in activity and greatest increases in nocturnality. Wildlife managers must consider how habituation and uneven sensitivity across species may cause fundamental differences in human–wildlife interactions along gradients of human influence.Peer reviewe

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo

Job Sharing in Australia: Possibilities, Problems and Strategies

This paper defines job sharing and explores its potential benefits. An overview of its origins and growth in Australia and overseas is followed by discussion of management issues. Organisational issues concern aspects of planning, implementation and operation. Issues for job sharers include finding an appropriate job share partner, maintenance of the job sharing relationship, protection of voluntary participation and preservation of pro rata benefits and other working conditions. A process for facilitating effective liaison between management, job sharers and trade unions is proposed. Job sharing is uncommon in Australia but may assist workers to balance work and family responsibilities or pursue interests outside work while avoiding many disadvantages of precarious work. For employers, it may facilitate retention of valued staff, reduce turnover, enhance recruiting or reduce staff costs. These propositions have not been rigorously tested, however, and avenues for future research are therefore explored

HIGH RESOLUTION SPECTROSCOPY OF CH2F2CH_{2}F_{2} IN THE 3 μ\mum REGION. THE 2vg BAND AT 2839cm−12839 cm^{-1}.

$^{(1)}$M. Carlotti, G.D. Nivellini, F. Tullini, and B. Carli, J. Mol. Spectrosc. 132, 158-165 (1988) $^{(2)}$M. N. Deo, R. D'Cunha, and A. Weber, analysis reported at the 1994 Columbus meeting, paper RH08Author Institution: Molecular Physics Division, National Institute of Standards and TechnologyThe infrared absorption spectrum of methylene fluoride ($CH_{2}F_{2}$) has been recorded at a spectral resolution of $0.004 cm^{-1}$ in the region from 2700 to $3300 cm^{-1}$ with the BOMEM DA3.002 Fourier transform spectrometer at NIST. The 2vg band, centered at $2838.6 cm^{-1}$, has been analyzed in detail and the analyses of the $v_{1}$ and $(v_{2}+v_{8})$ bands at $2948 cm^{-1}$ and $2943 cm^{-1}$, respectively, are underway. The 2vg band is quite perturbed, but using the non- and only slightly perturbed transitions it has been possible to obtain a least squares fit using the Watson A-reduction Hamiltonian. The ground state constants were constrained to the values reported by Carlotti, $et al.^{(1)}$ 1159 transitions with J and K values ranging up to 44 and 22, respectively, were used in the fit. The resulting upper state constants reproduce the experimental data (the non- and only slightly perturbed transitions) with a standard deviation of $0.00034 cm^{-1}$. Full use of all observed transitions will require the inclusion of x,y-type Coriolis interaction with the $v_{6}$ $fundamental^{(2)}$ and a z-type Coriolis transitions coupling with the $v_{2}+v_{8}$ combination band. Work on these bands is in progress