EXPERIMENTAL VALIDATION OF A COMPUTATIONAL PROGRAM FOR SIMULATING HYBRID SOLAR AND GAS WATER HEATING SYSTEMS

This work presents the methodology and results of the validation of a computer program for the simulation of water heating systems combining solar energy and gas. Two experimental systems, named series and parallel, were assembled. These systems have the same components, differing on how they are connected. All the components were individually characterized and their parameters determined. Simulations of the behavior of the thermal tank, gas heater and solar collector were performed and confronted to experimental data. The results show that the simulation program “AQUESOLGAS” can accurately describe the behavior of water heating systems with solar energy and gas

An evaluation framework for event detection using a morphological model of acoustic scenes

This paper introduces a model of environmental acoustic scenes which adopts a morphological approach by ab-stracting temporal structures of acoustic scenes. To demonstrate its potential, this model is employed to evaluate the performance of a large set of acoustic events detection systems. This model allows us to explicitly control key morphological aspects of the acoustic scene and isolate their impact on the performance of the system under evaluation. Thus, more information can be gained on the behavior of evaluated systems, providing guidance for further improvements. The proposed model is validated using submitted systems from the IEEE DCASE Challenge; results indicate that the proposed scheme is able to successfully build datasets useful for evaluating some aspects the performance of event detection systems, more particularly their robustness to new listening conditions and the increasing level of background sounds.Research project partly funded by ANR-11-JS03-005-01

EXPERIMENTAL VALIDATION OF A COMPUTATIONAL PROGRAM FOR SIMULATING HYBRID SOLAR AND GAS WATER HEATING SYSTEMS

This work presents the methodology and results of the validation of a computer program for the simulation of water heating systems combining solar energy and gas. Two experimental systems, named series and parallel, were assembled. These systems have the same components, differing on how they are connected. All the components were individually characterized and their parameters determined. Simulations of the behavior of the thermal tank, gas heater and solar collector were performed and confronted to experimental data. The results show that the simulation program “AQUESOLGAS” can accurately describe the behavior of water heating systems with solar energy and gas

Numerical simulations of compressible Rayleigh-Taylor turbulence in stratified fluids

We present results from numerical simulations of Rayleigh-Taylor turbulence, performed using a recently proposed lattice Boltzmann method able to describe consistently a thermal compressible flow subject to an external forcing. The method allowed us to study the system both in the nearly-Boussinesq and strongly compressible regimes. Moreover, we show that when the stratification is important, the presence of the adiabatic gradient causes the arrest of the mixing process.Comment: 15 pages, 11 figures. Proceedings of II Conference on Turbulent Mixing and Beyond (TMB-2009

A morphological model for simulating acoustic scenes and its application to sound event detection

This paper introduces a model for simulating environmental acoustic scenes that abstracts temporal structures from audio recordings. This model allows us to explicitly control key morphological aspects of the acoustic scene and to isolate their impact on the performance of the system under evaluation. Thus, more information can be gained on the behavior of an evaluated system, providing guidance for further improvements. To demonstrate its potential, this model is employed to evaluate the performance of nine state of the art sound event detection systems submitted to the IEEE DCASE 2013 Challenge. Results indicate that the proposed scheme is able to successfully build datasets useful for evaluating important aspects of the performance of sound event detection systems, such as their robustness to new recording conditions and to varying levels of background audio.This paper introduces a model for simulating environmental acoustic scenes that abstracts temporal structures from audio recordings. This model allows us to explicitly control key morphological aspects of the acoustic scene and to isolate their impact on the performance of the system under evaluation. Thus, more information can be gained on the behavior of an evaluated system, providing guidance for further improvements. To demonstrate its potential, this model is employed to evaluate the performance of nine state of the art sound event detection systems submitted to the IEEE DCASE 2013 Challenge. Results indicate that the proposed scheme is able to successfully build datasets useful for evaluating important aspects of the performance of sound event detection systems, such as their robustness to new recording conditions and to varying levels of background audio

Production, characterization, and antigen specificity of recombinant 62-71-3, a candidate monoclonal antibody for rabies prophylaxis in humans

Rabies kills many people throughout the developing world every year. The murine monoclonal antibody (mAb) 62-71-3 was recently identified for its potential application in rabies postexposure prophylaxis (PEP). The purpose here was to establish a plant-based production system for a chimeric mouse-human version of mAb 62-71-3, to characterize the recombinant antibody and investigate at a molecular level its interaction with rabies virus glycoprotein. Chimeric 62-71-3 was successfully expressed in Nicotiana benthamiana. Glycosylation was analyzed by mass spectroscopy; functionality was confirmed by antigen ELISA, as well as rabies and pseudotype virus neutralization. Epitope characterization was performed using pseudotype virus expressing mutagenized rabies glycoproteins. Purified mAb demonstrated potent viral neutralization at 500 IU/mg. A critical role for antigenic site I of the glycoprotein, as well as for two specific amino acid residues (K226 and G229) within site I, was identified with regard to mAb 62-71-3 neutralization. Pseudotype viruses expressing glycoprotein from lyssaviruses known not to be neutralized by this antibody were the controls. The results provide the molecular rationale for developing 62-71-3 mAb for rabies PEP; they also establish the basis for developing an inexpensive plant-based antibody product to benefit low-income families in developing countries.—Both, L., van Dolleweerd, C., Wright, E., Banyard, A. C., Bulmer-Thomas, B., Selden, D., Altmann, F., Fooks, A. R., Ma, J. K.-C. Production, characterization, and antigen specificity of recombinant 62-71-3, a candidate monoclonal antibody for rabies prophylaxis in humans

Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk.

It has recently been suggested that the low-frequency c.136-14_136-13insC variant in high-mobility group A1 (HMGA1) may strongly contribute to insulin resistance and type 2 diabetes risk. In our study, we attempted to confirm that HMGA1 is a novel type 2 diabetes locus in French Caucasians. The gene was sequenced in 368 type 2 diabetic case subjects with a family history of type 2 diabetes and 372 normoglycemic control subjects without a family history of type 2 diabetes. None of the 41 genetic variations identified were associated with type 2 diabetes. The lack of association between the c.136-14_136-13insC variant and type 2 diabetes was confirmed in an independent French group of 4,538 case subjects and 4,015 control subjects and in a large meta-analysis of 16,605 case subjects and 46,179 control subjects. Finally, this variant had no effects on metabolic traits and was not involved in variations of HMGA1 and insulin receptor (INSR) expressions. The c.136-14_136-13insC variant was not associated with type 2 diabetes in individuals of European descent. Our study emphasizes the need to analyze a large number of subjects to reliably assess the association of low-frequency variants with the disease