Narrativas orais: saberes e fazeres da arquitetura vern?cula na comunidade de S?o Gon?alo do Rio das Pedras (MG) e entorno

A presente pesquisa, Narrativas Orais: saberes e fazeres da arquitetura vern?cula na comunidade de S?o Gon?alo do Rio das Pedras ? (MG) e entorno, desenvolveu-se no ?mbito do programa de p?s-gradua??o interdisciplinar em Estudos Rurais PPGER/UFVJM. O estudo identifica as mem?rias que regem o saber e o fazer em rela??o ao labor, a ocupa??o dos espa?os e principalmente verifica os conhecimentos emp?ricos, acerca do saber local sobre as constru??es de casas, espa?os de trabalho e ranchos. Realizou-se pesquisas bibliogr?ficas, entrevistas por meio de trabalho de campo e observa??es etnogr?ficas com base na metodologia de pesquisa participante, houve levantamento dos conhecimentos presentes na oralidade em rela??o ? arquitetura vern?cula e a maneira como as pessoas se relacionam com suas constru??es, seus h?bitos de constru??es, seus procedimentos e suas reflex?es sobre suas ocupa??es espaciais e vida. Evidenciou-se que h? uma crise do habitar, em que o afastamento da autonomia construtiva tem sido um dos maiores impactos encontrados. Esse afastamento n?o se d? apenas pela escolha dos materiais, mas pela impossibilidade de escolher como habitar. Verifica-se as fun??es ambientais dos espa?os rurais na perspectiva da quest?o da constru??o como um modo de adaptar os materiais locais e sua rela??o com o ambiente. Evidenciaram-se os processos de transforma??o social diante das rela??es estabelecidas frente ao capitalismo, e a urg?ncia por uma ecologia de saberes.Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES)Funda??o de Amparo ? Pesquisa do Estado de Minas Gerais (FAPEMIG)Disserta??o (Mestrado) ? Programa de P?s-Gradua??o em Estudos Rurais, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2018.The present research, Oral Narratives: vernacular architecture knowledge and practices in the community of S?o Gon?alo do Rio das Pedras - (MG) and surroundings, was developed under the interdisciplinary postgraduate program in Rural Studies PPGER / UFVJM. The study identifies the memories that govern the knowledge and the doing in relation to work and the occupation of spaces and it particularly investigates the empirical knowledge the local residents have on the construction of houses, workspaces and ranches. Bibliographical research, fieldwork interviews and ethnographic observations were carried out based on the participant observation, research methodology. A survey was conducted in order to identify participants? oral knowledge regarding vernacular architecture and the way people relate to their constructions, their habits of building, their procedures and their reflections on their spatial occupations and life. It was evidenced that there is a crisis of dwelling and the loss of constructive autonomy has been one of its most critical impacts. This loss is not only due to the limited choice of materials, but also to the impossibility of choosing on how to live. The environmental functions of rural areas have been analyzed in light of construction as a way of adapting local materials and their relation to the environment. The processes of social transformation in the face of established relations with capitalism and the urgent need for an ecology of knowledge were evidenced.La presente investigaci?n, Narrativas orales: saberes y hacer de la arquitectura vern?cula en la comunidad de S?o Gon?alo do Rio das Pedras - (MG) y entorno, se desarroll? en el ?mbito del programa de postgrado interdisciplinario en Estudios Rurales PPGER / UFVJM. El estudio identifica las memorias que rigen el saber y el hacer en relaci?n a la labor, la ocupaci?n de los espacios y principalmente verifica los conocimientos emp?ricos, acerca del saber local sobre las construcciones de casas, espacios de trabajo y ranchos. Se realizaron investigaciones bibliogr?ficas, entrevistas por medio de trabajo de campo y observaciones etnogr?ficas con base en la metodolog?a de investigaci?n participante, hubo levantamiento de los conocimientos presentes en la oralidad en relaci?n a la arquitectura vern?cula y la manera como las personas se relacionan con sus construcciones, sus h?bitos de construcciones, sus procedimientos y sus reflexiones sobre sus ocupaciones espaciales y vida. Se evidenci? que hay una crisis del habitar, en que el alejamiento de la autonom?a constructiva ha sido uno de los mayores impactos encontrados. Este alejamiento no se da s?lo por la elecci?n de los materiales, sino por la imposibilidad de elegir como habitar. Se verifican las funciones ambientales de los espacios rurales en la perspectiva de la cuesti?n de la construcci?n como un modo de adaptar los materiales locales y su relaci?n con el ambiente. Se evidenciaron los procesos de transformaci?n social ante las relaciones establecidas frente al capitalismo, y la urgencia por una ecolog?a de saberes

Multiple Sclerosis Patient Management During the COVID-19 Pandemic: Practical Recommendations From the Portuguese Multiple Sclerosis Study Group (GEEM)

The spread of the COVID-19 pandemic has imposed significant challenges on healthcare provision, requiring changes in the conventional patient management, particularly in chronic diseases like multiple sclerosis (MS). To increase patient safety and reduce the risk of infection, while ensuring an appropriate and regular follow-up, tele-medicine gained prominence as a valid alternative to face-to-face appointments. However, the urgency of the implementation and the lack of experience in most MS centers led to "ad hoc" and extremely diverse approaches, which now merit to be standardized and refined. Indeed, while tele-consultation cannot fully replace face-to-face visits, it certainly can, and will, be incorporated as part of the routine care of MS patients in the near future. Bearing this in mind, the Portuguese Multiple Sclerosis Study Group (GEEM) has developed a set of recommendations for the usage of tele-medicine in the management of MS patients, both during the pandemic and in the future. The consensus was obtained through a two-step modified Delphi methodology, resulting in 15 recommendations, which are detailed in the manuscript.info:eu-repo/semantics/publishedVersio

Gene Expression Profiling in Gastric Mucosa from Helicobacter pylori-Infected and Uninfected Patients Undergoing Chronic Superficial Gastritis

Helicobacter pylori infection reprograms host gene expression and influences various cellular processes, which have been investigated by cDNA microarray using in vitro culture cells and in vivo gastric biopsies from patients of the Chronic Abdominal Complaint. To further explore the effects of H. pylori infection on host gene expression, we have collected the gastric antral mucosa samples from 6 untreated patients with gastroscopic and pathologic confirmation of chronic superficial gastritis. Among them three patients were infected by H. pylori and the other three patients were not. These samples were analyzed by a microarray chip which contains 14,112 cloned cDNAs, and microarray data were analyzed via BRB ArrayTools software and Ingenuity Pathways Analysis (IPA) website. The results showed 34 genes of 38 differentially expressed genes regulated by H. pylori infection had been annotated. The annotated genes were involved in protein metabolism, inflammatory and immunological reaction, signal transduction, gene transcription, trace element metabolism, and so on. The 82% of these genes (28/34) were categorized in three molecular interaction networks involved in gene expression, cancer progress, antigen presentation and inflammatory response. The expression data of the array hybridization was confirmed by quantitative real-time PCR assays. Taken together, these data indicated that H. pylori infection could alter cellular gene expression processes, escape host defense mechanism, increase inflammatory and immune responses, activate NF-κB and Wnt/β-catenin signaling pathway, disturb metal ion homeostasis, and induce carcinogenesis. All of these might help to explain H. pylori pathogenic mechanism and the gastroduodenal pathogenesis induced by H. pylori infection

A Systematic Review of Dynamometry and its Role in Hand Trauma Assessment

The dynamometer was developed by American neurologists and came into general use in the late 19th century. It is still used in various ways as a diagnostic and prognostic tool in clinical settings. In this systematic review we assessed in detail the different uses of dynamometry, its reliability, different dynamometers used and the influence of rater experience by bringing together and evaluating all published literature in this field. It was found that dynamometry is applied in a wide range of medical conditions. Furthermore, the great majority of studies reported acceptable to high reliability of dynamometry. Jamar mechanical dynamometer was used most often in the studies reviewed. There were mixed results concerning the effect of rater experience. The factors influencing the results of dynamometry were identified as age, gender, body weight, grip strength, BMI, non/dominant hand, assessing upper/lower limbs, rater and patient’s strength and the distance from the joint where the dynamometer is placed. This review provides an understanding of the relevance and significance of dynamometry which should serve as a starting point to guide its use in hand trauma assessment. On the basis of our findings, we suggest that hand dynamometry has a great potential, and could be used more often in clinical practice

Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection

BACKGROUND Clostridium difficile is the most common cause of infectious diarrhea in hospitalized patients. Recurrences are common after antibiotic therapy. Actoxumab and bezlotoxumab are human monoclonal antibodies against C. difficile toxins A and B, respectively. METHODS We conducted two double-blind, randomized, placebo-controlled, phase 3 trials, MODIFY I and MODIFY II, involving 2655 adults receiving oral standard-of-care antibiotics for primary or recurrent C. difficile infection. Participants received an infusion of bezlotoxumab (10 mg per kilogram of body weight), actoxumab plus bezlotoxumab (10 mg per kilogram each), or placebo; actoxumab alone (10 mg per kilogram) was given in MODIFY I but discontinued after a planned interim analysis. The primary end point was recurrent infection (new episode after initial clinical cure) within 12 weeks after infusion in the modified intention-to-treat population. RESULTS In both trials, the rate of recurrent C. difficile infection was significantly lower with bezlotoxumab alone than with placebo (MODIFY I: 17% [67 of 386] vs. 28% [109 of 395]; adjusted difference, −10.1 percentage points; 95% confidence interval [CI], −15.9 to −4.3; P<0.001; MODIFY II: 16% [62 of 395] vs. 26% [97 of 378]; adjusted difference, −9.9 percentage points; 95% CI, −15.5 to −4.3; P<0.001) and was significantly lower with actoxumab plus bezlotoxumab than with placebo (MODIFY I: 16% [61 of 383] vs. 28% [109 of 395]; adjusted difference, −11.6 percentage points; 95% CI, −17.4 to −5.9; P<0.001; MODIFY II: 15% [58 of 390] vs. 26% [97 of 378]; adjusted difference, −10.7 percentage points; 95% CI, −16.4 to −5.1; P<0.001). In prespecified subgroup analyses (combined data set), rates of recurrent infection were lower in both groups that received bezlotoxumab than in the placebo group in subpopulations at high risk for recurrent infection or for an adverse outcome. The rates of initial clinical cure were 80% with bezlotoxumab alone, 73% with actoxumab plus bezlotoxumab, and 80% with placebo; the rates of sustained cure (initial clinical cure without recurrent infection in 12 weeks) were 64%, 58%, and 54%, respectively. The rates of adverse events were similar among these groups; the most common events were diarrhea and nausea. CONCLUSIONS Among participants receiving antibiotic treatment for primary or recurrent C. difficile infection, bezlotoxumab was associated with a substantially lower rate of recurrent infection than placebo and had a safety profile similar to that of placebo. The addition of actoxumab did not improve efficacy. (Funded by Merck; MODIFY I and MODIFY II ClinicalTrials.gov numbers, NCT01241552 and NCT01513239.

Narrativas orais: saberes e fazeres da arquitetura vern?cula na comunidade de S?o Gon?alo do Rio das Pedras (MG) e entorno

Submitted by Nivaldo Melo ([email protected]) on 2019-08-12T12:23:01Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) mayan_maharishi_faria_ladeira_amancio.pdf: 8121484 bytes, checksum: 7c03230139377de52a0d9d2fe2356ec3 (MD5)Approved for entry into archive by Jos? Henrique Henrique ([email protected]) on 2019-08-12T18:12:02Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) mayan_maharishi_faria_ladeira_amancio.pdf: 8121484 bytes, checksum: 7c03230139377de52a0d9d2fe2356ec3 (MD5)Made available in DSpace on 2019-08-12T18:12:02Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) mayan_maharishi_faria_ladeira_amancio.pdf: 8121484 bytes, checksum: 7c03230139377de52a0d9d2fe2356ec3 (MD5) Previous issue date: 2018Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES)Funda??o de Amparo ? Pesquisa do Estado de Minas Gerais (FAPEMIG)A presente pesquisa, Narrativas Orais: saberes e fazeres da arquitetura vern?cula na comunidade de S?o Gon?alo do Rio das Pedras ? (MG) e entorno, desenvolveu-se no ?mbito do programa de p?s-gradua??o interdisciplinar em Estudos Rurais PPGER/UFVJM. O estudo identifica as mem?rias que regem o saber e o fazer em rela??o ao labor, a ocupa??o dos espa?os e principalmente verifica os conhecimentos emp?ricos, acerca do saber local sobre as constru??es de casas, espa?os de trabalho e ranchos. Realizou-se pesquisas bibliogr?ficas, entrevistas por meio de trabalho de campo e observa??es etnogr?ficas com base na metodologia de pesquisa participante, houve levantamento dos conhecimentos presentes na oralidade em rela??o ? arquitetura vern?cula e a maneira como as pessoas se relacionam com suas constru??es, seus h?bitos de constru??es, seus procedimentos e suas reflex?es sobre suas ocupa??es espaciais e vida. Evidenciou-se que h? uma crise do habitar, em que o afastamento da autonomia construtiva tem sido um dos maiores impactos encontrados. Esse afastamento n?o se d? apenas pela escolha dos materiais, mas pela impossibilidade de escolher como habitar. Verifica-se as fun??es ambientais dos espa?os rurais na perspectiva da quest?o da constru??o como um modo de adaptar os materiais locais e sua rela??o com o ambiente. Evidenciaram-se os processos de transforma??o social diante das rela??es estabelecidas frente ao capitalismo, e a urg?ncia por uma ecologia de saberes.Disserta??o (Mestrado) ? Programa de P?s-Gradua??o em Estudos Rurais, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2018.The present research, Oral Narratives: vernacular architecture knowledge and practices in the community of S?o Gon?alo do Rio das Pedras - (MG) and surroundings, was developed under the interdisciplinary postgraduate program in Rural Studies PPGER / UFVJM. The study identifies the memories that govern the knowledge and the doing in relation to work and the occupation of spaces and it particularly investigates the empirical knowledge the local residents have on the construction of houses, workspaces and ranches. Bibliographical research, fieldwork interviews and ethnographic observations were carried out based on the participant observation, research methodology. A survey was conducted in order to identify participants? oral knowledge regarding vernacular architecture and the way people relate to their constructions, their habits of building, their procedures and their reflections on their spatial occupations and life. It was evidenced that there is a crisis of dwelling and the loss of constructive autonomy has been one of its most critical impacts. This loss is not only due to the limited choice of materials, but also to the impossibility of choosing on how to live. The environmental functions of rural areas have been analyzed in light of construction as a way of adapting local materials and their relation to the environment. The processes of social transformation in the face of established relations with capitalism and the urgent need for an ecology of knowledge were evidenced.La presente investigaci?n, Narrativas orales: saberes y hacer de la arquitectura vern?cula en la comunidad de S?o Gon?alo do Rio das Pedras - (MG) y entorno, se desarroll? en el ?mbito del programa de postgrado interdisciplinario en Estudios Rurales PPGER / UFVJM. El estudio identifica las memorias que rigen el saber y el hacer en relaci?n a la labor, la ocupaci?n de los espacios y principalmente verifica los conocimientos emp?ricos, acerca del saber local sobre las construcciones de casas, espacios de trabajo y ranchos. Se realizaron investigaciones bibliogr?ficas, entrevistas por medio de trabajo de campo y observaciones etnogr?ficas con base en la metodolog?a de investigaci?n participante, hubo levantamiento de los conocimientos presentes en la oralidad en relaci?n a la arquitectura vern?cula y la manera como las personas se relacionan con sus construcciones, sus h?bitos de construcciones, sus procedimientos y sus reflexiones sobre sus ocupaciones espaciales y vida. Se evidenci? que hay una crisis del habitar, en que el alejamiento de la autonom?a constructiva ha sido uno de los mayores impactos encontrados. Este alejamiento no se da s?lo por la elecci?n de los materiales, sino por la imposibilidad de elegir como habitar. Se verifican las funciones ambientales de los espacios rurales en la perspectiva de la cuesti?n de la construcci?n como un modo de adaptar los materiales locales y su relaci?n con el ambiente. Se evidenciaron los procesos de transformaci?n social ante las relaciones establecidas frente al capitalismo, y la urgencia por una ecolog?a de saberes