High astrometric precision in the calculation of the coordinates of orbiters in the Geo Ring

We present an astrometric method for the calculation of the positions of orbiters in the GEO ring with a high precision, through a rigorous astrometric treatment of observations with a 1-m class telescope, which are part of the CIDA survey of the GEO ring. We compute the distortion pattern to correct for the systematic errors introduced by the optics and electronics of the telescope, resulting in absolute mean errors of 0.16" and 0.12" in right ascension and declination, respectively. These correspond to ˜ 25 m at the mean distance of the GEO ring, and are thus good quality results

Do diabetes and depressed mood affect associations between obesity and quality of life in postmenopause? Results of the KORA-F3 Augsburg population study

<p>Abstract</p> <p>Background</p> <p>To assess associations of obesity with health-related quality of life (HRQL) in postmenopausal women, and whether depressed mood and diabetes moderate these associations.</p> <p>Methods</p> <p>Survey of 983 postmenopausal women aged 35-74, general population, Augsburg region/Germany, 2004/2005. Body weight/height and waist/hip circumference were assessed anthropometrically and classified via BMI ≥ 30 as obese, and WHR ≥ 0.85 as abdominally obese (vs. not). Depressed mood was assessed by the Depression and Exhaustion-(DEEX-)scale, diabetes and postmenopausal status by self-report/medication, and HRQL by the SF-12.</p> <p>Results</p> <p>General linear models revealed negative associations of obesity and abdominal obesity with physical but not mental HRQL. Both forms of excess weight were associated with diabetes but not depressed mood. Moderation depended on the HRQL-domain in question. In non-diabetic women, depressed mood was found to amplify obesity-associated impairment in physical HRQL (mean "obese"-"non-obese" difference given depressed mood: -6.4, p < .001; among those without depressed mood: -2.5, p = .003). Reduced mental HRQL tended to be associated with obesity in diabetic women (mean "obese"-"non-obese" difference: -4.5, p = .073), independent of depressed mood. No interactions pertained to abdominal obesity.</p> <p>Conclusions</p> <p>In postmenopausal women, depressed mood may amplify the negative impact of obesity on physical HRQL, while diabetes may be a precondition for some degree of obesity-related impairments in mental HRQL.</p

The response of Iberian rivers to the North Atlantic Oscillation

In this study we analyzed the influence of the North Atlantic Oscillation (NAO) on the streamflow in 187 sub-basins of the Iberian Peninsula. Monthly and one-month lagged correlations were conducted to assess the spatio-temporal extent of the NAO influence on Iberian river discharges. Analysis of the persistence of the winter NAO throughout the year was also undertaken, together with analysis of streamflow anomalies during positive and negative NAO phases. Moving-window correlation analyses were conducted to assess potential changes in the temporal evolution of the NAO influence on Iberian streamflows. The results show that the NAO has a large impact on surface water resources throughout the Iberian Peninsula during winter, and in the Atlantic watershed during autumn. We showed that water resources management and snowmelt are causing the persistent dependence of streamflows on the previous winter NAO. We found that strongly positive streamflow anomalies occurred during winter, especially in the Atlantic watershed, and provide evidence of non-stationarity and spatial variability in the NAO influence on Iberian water resources

Meeting report: a hard look at the state of enamel research.

The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines (ENAMEL) Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National Institute of Dental and Craniofacial Research (NIDCR). Discussion topics included model organisms, stem cells/cell lines, and tissues/3D cell culture/organoids. Scientists from a number of disciplines, representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field

CB6 87. Sustitución valvular aórtica en octogenarios

IntroducciónEn las últimas décadas, la población mayor de 80 años que requiere una cirugía por estenosis aórtica degenerativa ha aumentado sustancialmente.Material y métodosSe compararon los resultados a corto y medio plazo de la sustitución valvular aórtica convencional (SVAo) en estenosis aórtica degenerativa en pacientes mayores y menores de 80 años intervenidos en nuestro centro entre abril de 2004 y diciembre de 2008. Los predictores de mortalidad y eventos adversos mayores cardio y cerebrovasculares (MACCE) en el postoperatorio y el seguimiento se determinaron por análisis multivariante.ResultadosCuatrocientos cincuenta y un pacientes fueron incluidos; 94 (20,8%) eran mayores de 80 años. La cirugía cardíaca previa (odds ratio [OR]: 4,08; p=0,047), la insuficiencia renal (OR: 6,75; p < 0,001), la cirugía coronaria concomitante (OR: 2,57; p=0,034), el sexo femenino (OR: 2,49; p=0,047) y la hipertensión pulmonar grave (OR: 3,68; p=0,024) fueron predictores independientes de mortalidad hospitalaria. En el seguimiento, la edad (hazard ratio [HR]: 2,24; p=0,02), la vasculopatía periférica (HR: 5,1; p < 0,001) e hipertensión arterial (HTA) (HR: 5,2; p=0,025) fueron predictores independientes de mortalidad tardía. Sólo la vasculopatía periférica (HR: 3,55; p=0,014) e HTA (HR: 8,24; p=0,04) fueron predictores independientes de mortalidad cardíaca tardía. La insuficiencia renal (OR: 2,57; p=0,005), hipertensión pulmonar grave (OR: 3,49; p=0,005) y cirugía coronaria asociada (OR: 2,49; p=0,002) fueron predictores independientes de MACCE postoperatorios. Diabetes mellitus (HR: 2,03; p=0,033) y vasculopatía periférica (HR: 2,3; p=0,041) predijeron una mayor incidencia de MACCE en el seguimiento.ConclusionesLa edad mayor de 80 años no empeora el pronóstico a corto y medio plazo tras la SVAo por estenosis aórtica grave degenerativa

Risk-taking attitudes of people who seek health care: An exploratory approach through lottery games using generalized estimating equations

Background: The characterization of the risk-taking attitude of individuals may be useful for planning health care interventions. It has been attempted to study expressions of risk-taking attitude and evaluate characteristics of a standard lottery game in a population that seeks health care to elicit these attitudes. Methods: Multicentric cross-sectional study. Demographic and socioe-conomic characteristics, quality of life (EuroQol-5D), and health risk behaviors were collected from 662 users of 23 health centers selected by random sampling. Risk-taking attitude was evaluated by means of a self-evaluation scale and two lotteries games (L1 and L2; L2 included the possibility of economic losses). Generalized estimating equations (GEE) explicative models were used to evaluate the variability of risk-taking attitude. Results: Nineteen percent out of interviewed people (CI95%: 15.6-22.6%) expressed a high risk appetite, but only 10.0% (CI95% 7.0 to 13.0) were classified as risk-seeking by L2. It was found association between increased risk appetite and having a better perception of health status (0.110. CI95%: 0.007-0.212) or a higher income (0.010. CI95%: 0.017-0.123) or smoking status (0.059. CI95%: 0.004-0.114). Being Spanish was associated with lower risk appetite (-0.105. CI95%: -0.005 -0.205), as being over 65 (-0.031. CI95%:- 0.061- -0.001) or a woman (-0.038. CI95%:-0.064- -0.012). The intraclass correlation coefficient for self-evaluation scale was 0.511 (95% CI: 0.372 to 0.629), 0.571 (95% CI: 0.441-0.678) for L1 and 0.349 (95% CI: 0.186-0.493) for L2. Conclusions: People who seek health care express certain inclination to risk, but this feature is attenuated when methodologies involving losses are used. Risk appetite seems greater in young people, males, people with better health, or more income, and in immigrants. Lottery games such as the proposed ones are a simple and useful tool to estimate individuals'' inclination to risk

STIM1 R304W in mice causes subgingival hair growth and an increased fraction of trabecular bone

Calcium signaling plays a central role in bone development and homeostasis. Store operated calcium entry (SOCE) is an important calcium influx pathway mediated by calcium release activated calcium (CRAC) channels in the plasma membrane. Stromal interaction molecule 1 (STIM1) is an endoplasmic reticulum calcium sensing protein important for SOCE. We generated a mouse model expressing the STIM1 R304W mutation, causing Stormorken syndrome in humans. Stim1R304W/R304W mice showed perinatal lethality, and the only three animals that survived into adulthood presented with reduced growth, low body weight, and thoracic kyphosis. Radiographs revealed a reduced number of ribs in the Stim1R304W/R304W mice. Microcomputed tomography data revealed decreased cortical bone thickness and increased trabecular bone volume fraction in Stim1R304W/R304W mice, which had thinner and more compact bone compared to wild type mice. The Stim1R304W/+ mice showed an intermediate phenotype. Histological analyses showed that the Stim1R304W/R304W mice had abnormal bone architecture, with markedly increased number of trabeculae and reduced bone marrow cavity. Homozygous mice showed STIM1 positive osteocytes and osteoblasts. These findings highlight the critical role of the gain-of-function (GoF) STIM1 R304W protein in skeletal development and homeostasis in mice. Furthermore, the novel feature of bilateral subgingival hair growth on the lower incisors in the Stim1R304W/R304W mice and 25 % of the heterozygous mice indicate that the GoF STIM1 R304W protein also induces an abnormal epithelial cell fate