Mobile radio propagation prediction using ray tracing methods

The basic problem is to solve the two-dimensional scalar Helmholtz equation for a point source (the antenna) situated in the vicinity of an array of scatterers (such as the houses and any other relevant objects in 1 square km of urban environment). The wavelength is a few centimeters and the houses a few metres across, so there are three disparate length scales in the problem. The question posed by BT concerned ray counting on the assumptions that: (i) rays were subject to a reflection coefficient of about 0.5 when bouncing off a house wall and (ii) that diffraction at corners reduced their energy by 90%. The quantity of particular interest was the number of rays that need to be accounted for at any particular point in order for those neglected to only contribute 10% of the field at that point; a secondary question concerned the use of rays to predict regions where the field was less than 1% of that in the region directly illuminated by the antenna. The progress made in answering these two questions is described in the next two sections and possibly useful representations of the solution of the Helmholtz equations in terms other than rays are given in the final section

Repurposing of the fasciolicide triclabendazole to treat infections caused by staphylococcus spp. and vancomycin-resistant enterococci

One approach to combat the increasing incidence of multidrug-resistant (MDR) bacterial pathogens involves repurposing existing compounds with known safety and development pathways as new antibacterial classes with potentially novel mechanisms of action. Here, triclabendazole (TCBZ), a drug originally developed to treat Fasciola hepatica (liver fluke) in sheep and cattle, and later in humans, was evaluated as an antibacterial alone or in combination with sub-inhibitory concentrations of polymyxin B (PMB) against clinical isolates and reference strains of key Gram-positive and Gram-negative bacteria. We show for the first time that in vitro, TCBZ selectively kills methicillin-sensitive and methicillin-resistant Staphylococcus aureus and Staphylococcus pseudintermedius at a minimum inhibitory concentration (MIC) range of 2–4 µg/mL, and vancomycin-resistant enterococci at a MIC range of 4–8 µg/mL. TCBZ also inhibited key Gram-negative bacteria in the presence of sub-inhibitory concentrations of PMB, returning MIC₉₀ values of 1 µg/mL for Escherichia coli, 8 µg/mL for Klebsiella pneumoniae, 2 µg/mL for Acinetobacter baumannii and 4 µg/mL for Pseudomonasaeruginosa. Interestingly, TCBZ was found to be bacteriostatic against intracellular S. aureus but bactericidal against intracellular S. pseudintermedius. Additionally, TCBZ’s favourable pharmacokinetic (PK) and pharmacodynamic (PD) profile was further explored by in vivo safety and efficacy studies using a bioluminescent mouse model of S. aureus sepsis. We show that repeated four-hourly oral treatment of mice with 50 mg/kg TCBZ after systemic S. aureus challenge resulted in a significant reduction in S. aureus populations in the blood to 18 h post-infection (compared to untreated mice) but did not clear the bacterial infection from the bloodstream, consistent with in vivo bacteriostatic activity. These results indicate that additional pharmaceutical development of TCBZ may enhance its PK/PD, allowing it to be an appropriate candidate for the treatment of serious MDR bacterial pathogensHongfei Pi, Abiodun D. Ogunniyi, Bhumi Savaliya, Hang Thi Nguyen, Stephen W. Page, Ernest Lacey, Henrietta Venter and Darren J. Trot

Effects of momentum conservation on the analysis of anisotropic flow

We present a general method for taking into account correlations due to momentum conservation in the analysis of anisotropic flow, either by using the two-particle correlation method or the standard flow vector method. In the latter, the correlation between the particle and the flow vector is either corrected through a redefinition (shift) of the flow vector, or subtracted explicitly from the observed flow coefficient. In addition, momentum conservation contributes to the reaction plane resolution. Momentum conservation mostly affects the first harmonic in azimuthal distributions, i.e., directed flow. It also modifies higher harmonics, for instance elliptic flow, when they are measured with respect to a first harmonic event plane such as one determined with the standard transverse momentum method. Our method is illustrated by application to NA49 data on pion directed flow.Comment: RevTeX 4, 10 pages, 1 eps figure. Version accepted for publication in Phys Rev

Optical Spectra of SNR Candidates in NGC 300

We present moderate-resolution (<5A) long-slit optical spectra of 51 nebular objects in the nearby Sculptor Group galaxy NGC 300 obtained with the 2.3 meter Advanced Technology Telescope at Siding Spring Observatory, Australia. Adopting the criterion of [SII]/Ha>=0.4 to confirm supernova remnants (SNRs) from optical spectra, we find that of 28 objects previously proposed as SNRs from optical observations, 22 meet this criterion with six showing [SII]/Ha of less than 0.4. Of 27 objects suggested as SNRs from radio data, four are associated with the 28 previously proposed SNRs. Of these four, three (included in the 22 above) meet the criterion. In all, 22 of the 51 nebular objects meet the [SII]/Ha criterion as SNRs while the nature of the remaining 29 objects remains undetermined by these observations.Comment: Accepted for publication in Astrophysics & Space Scienc

Inflation, cold dark matter, and the central density problem

A problem with high central densities in dark halos has arisen in the context of LCDM cosmologies with scale-invariant initial power spectra. Although n=1 is often justified by appealing to the inflation scenario, inflationary models with mild deviations from scale-invariance are not uncommon and models with significant running of the spectral index are plausible. Even mild deviations from scale-invariance can be important because halo collapse times and densities depend on the relative amount of small-scale power. We choose several popular models of inflation and work out the ramifications for galaxy central densities. For each model, we calculate its COBE-normalized power spectrum and deduce the implied halo densities using a semi-analytic method calibrated against N-body simulations. We compare our predictions to a sample of dark matter-dominated galaxies using a non-parametric measure of the density. While standard n=1, LCDM halos are overdense by a factor of 6, several of our example inflation+CDM models predict halo densities well within the range preferred by observations. We also show how the presence of massive (0.5 eV) neutrinos may help to alleviate the central density problem even with n=1. We conclude that galaxy central densities may not be as problematic for the CDM paradigm as is sometimes assumed: rather than telling us something about the nature of the dark matter, galaxy rotation curves may be telling us something about inflation and/or neutrinos. An important test of this idea will be an eventual consensus on the value of sigma_8, the rms overdensity on the scale 8 h^-1 Mpc. Our successful models have values of sigma_8 approximately 0.75, which is within the range of recent determinations. Finally, models with n>1 (or sigma_8 > 1) are highly disfavored.Comment: 13 pages, 6 figures. Minor changes made to reflect referee's Comments, error in Eq. (18) corrected, references updated and corrected, conclusions unchanged. Version accepted for publication in Phys. Rev. D, scheduled for 15 August 200

On the spin distributions of Λ\LambdaCDM haloes

We used merger trees realizations, predicted by the extended Press-Schechter theory, in order to study the growth of angular momentum of dark matter haloes. Our results showed that: 1) The spin parameter $\lambda'$ resulting from the above method, is an increasing function of the present day mass of the halo. The mean value of $\lambda'$ varies from 0.0343 to 0.0484 for haloes with present day masses in the range of $10^9\mathrm{h}^{-1}M_{\odot}$ to $10^{14}\mathrm{h}^{-1}M_{\odot}$. 2)The distribution of $\lambda'$ is close to a log-normal, but, as it is already found in the results of N-body simulations, the match is not satisfactory at the tails of the distribution. A new analytical formula that approximates the results much more satisfactorily is presented. 3) The distribution of the values of $\lambda'$ depends only weakly on the redshift. 4) The spin parameter of an halo depends on the number of recent major mergers. Specifically the spin parameter is an increasing function of this number.Comment: 10 pages, 8 figure

On the reliability of merger-trees and the mass growth histories of dark matter haloes

We have used merger trees realizations to study the formation of dark matter haloes. The construction of merger-trees is based on three different pictures about the formation of structures in the Universe. These pictures include: the spherical collapse (SC), the ellipsoidal collapse (EC) and the non-radial collapse (NR). The reliability of merger-trees has been examined comparing their predictions related to the distribution of the number of progenitors, as well as the distribution of formation times, with the predictions of analytical relations. The comparison yields a very satisfactory agreement. Subsequently, >.........Comment: A&SS Accepte

Proximity effect at superconducting Sn-Bi2Se3 interface

We have investigated the conductance spectra of Sn-Bi2Se3 interface junctions down to 250 mK and in different magnetic fields. A number of conductance anomalies were observed below the superconducting transition temperature of Sn, including a small gap different from that of Sn, and a zero-bias conductance peak growing up at lower temperatures. We discussed the possible origins of the smaller gap and the zero-bias conductance peak. These phenomena support that a proximity-effect-induced chiral superconducting phase is formed at the interface between the superconducting Sn and the strong spin-orbit coupling material Bi2Se3.Comment: 7 pages, 8 figure

Centrality Dependence of the High p_T Charged Hadron Suppression in Au+Au collisions at sqrt(s_NN) = 130 GeV

PHENIX has measured the centrality dependence of charged hadron p_T spectra from central Au+Au collisions at sqrt(s_NN)=130 GeV. The truncated mean p_T decreases with centrality for p_T > 2 GeV/c, indicating an apparent reduction of the contribution from hard scattering to high p_T hadron production. For central collisions the yield at high p_T is shown to be suppressed compared to binary nucleon-nucleon collision scaling of p+p data. This suppression is monotonically increasing with centrality, but most of the change occurs below 30% centrality, i.e. for collisions with less than about 140 participating nucleons. The observed p_T and centrality dependence is consistent with the particle production predicted by models including hard scattering and subsequent energy loss of the scattered partons in the dense matter created in the collisions.Comment: 7 pages text, LaTeX, 6 figures, 2 tables, 307 authors, resubmitted to Phys. Lett. B. Revised to address referee concerns. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are publicly available at http://www.phenix.bnl.gov/phenix/WWW/run/phenix/papers.htm

Heavy Quarks and Heavy Quarkonia as Tests of Thermalization

We present here a brief summary of new results on heavy quarks and heavy quarkonia from the PHENIX experiment as presented at the "Quark Gluon Plasma Thermalization" Workshop in Vienna, Austria in August 2005, directly following the International Quark Matter Conference in Hungary.Comment: 8 pages, 5 figures, Quark Gluon Plasma Thermalization Workshop (Vienna August 2005) Proceeding