Imigrantes brasileiros no Québec: entre integração e mobilidade

Em 1991, a província canadense do Québec conquistou autonomia para definir sua política migratória. O recrutamento e a seleção de imigrantes tornaram-se parte de um processo que, abrindo o Québec ao mundo, preocupou-se também em consolidar a especificidade local diante do Canadá, promovendo o chamado fait français. As políticas de integração os categorizaram como comunidades culturais e minorias visíveis. Definido o Brasil como área de imigração, o fluxo de brasileiros para o Québec aumentou 640% no período 2006-2011 em relação ao quinquênio anterior. Os imigrantes brasileiros mostraram-se reservados diante da definição de uma minoria visível latino-americana e da adesão ao fait français. Ao mesmo tempo, procuraram elementos de aproximação cultural com a sociedade de acolhimento. A análise de percursos migratórios mostrou, ainda, que a obtenção da nacionalidade canadense é um forte componente na aquisição de um capital de mobilidade que, além de facilitar a integração, paradoxalmente, permite novas migrações

Grand Prix des métiers d'art du Québec : Les Amériques

A documentation of the seventh edition of the event: with descriptions of works by 28 Quebec crafts persons from various disciplines; informations on the jury; biographical notes

PARK3 Influences Age at Onset in Parkinson Disease: A Genome Scan in the GenePD Study

Parkinson disease (PD) is a late-onset neurodegenerative disorder. The mean age at onset is 61 years, but the disease can range from juvenile cases to cases in the 8th or 9th decade of life. The parkin gene on chromosome 6q and loci on chromosome 1p35-36 and 1p36 are responsible for some cases of autosomal recessive early-onset parkinsonism, but they do not appear to influence susceptibility or variability of age at onset for idiopathic PD. We have performed a genomewide linkage analysis using variance-component methodology to identify genes influencing age at onset of PD in a population of affected relatives (mainly affected sibling pairs) participating in the GenePD study. Four chromosomal loci showed suggestive evidence of linkage: chromosome 2p (maximum multipoint LOD [MaxLOD] = 2.08), chromosome 9q (MaxLOD = 2.00), chromosome 20 (MaxLOD = 1.82), and chromosome 21 (MaxLOD = 2.21). The 2p and 9q locations that we report here have previously been reported as loci influencing PD affection status. Association between PD age at onset and allele 174 of marker D2S1394, located on 2p13, was observed in the GenePD sample (P=.02). This 174 allele is common to the PD haplotype observed in two families that show linkage to PARK3 and have autosomal dominant PD, which suggests that this allele may be in linkage disequilibrium with a mutation influencing PD susceptibility or age at onset of PD

Discovery of 6‑Phenylpyrimido[4,5‑<i>b</i>][1,4]oxazines as Potent and Selective Acyl CoA:Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors with in Vivo Efficacy in Rodents

The discovery and optimization of a series of acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors based on a pyrimido­[4,5-<i>b</i>]­[1,4]­oxazine scaffold is described. The SAR of a moderately potent HTS hit was investigated resulting in the discovery of phenylcyclohexylacetic acid <b>1</b>, which displayed good DGAT1 inhibitory activity, selectivity, and PK properties. During preclinical toxicity studies a metabolite of <b>1</b> was observed that was responsible for elevating the levels of liver enzymes ALT and AST. Subsequently, analogues were synthesized to preclude the formation of the toxic metabolite. This effort resulted in the discovery of spiroindane <b>42</b>, which displayed significantly improved DGAT1 inhibition compared to <b>1</b>. Spiroindane <b>42</b> was well tolerated in rodents in vivo, demonstrated efficacy in an oral triglyceride uptake study in mice, and had an acceptable safety profile in preclinical toxicity studies