96 research outputs found
Collider limits on new physics within micrOMEGAs4.3
Results from the LHC put severe constraints on models of new physics. This
includes constraints on the Higgs sector from the precise measurement of the
mass and couplings of the 125GeV Higgs boson, as well as limits from searches
for other new particles. We present the procedure to use these constraints in
micrOMEGAs by interfacing it to the external codes Lilith, HiggsSignals,
HiggsBounds and SModelS. A few dedicated modules are also provided. With these
new features, micrOMEGAs_4.3 provides a generic framework for evaluating dark
matter observables together with collider and non-collider constraints.Comment: 23 page
First update of the living European guideline (EuroGuiDerm) on atopic eczema
First update of the living European guideline (EuroGuiDerm) on atopic eczem
Exploiting Ligand-Protein Conjugates to Monitor Ligand-Receptor Interactions
We introduce three assays for analyzing ligand-receptor interactions based on the specific conjugation of ligands to SNAP-tag fusion proteins. Conjugation of ligands to different SNAP-tag fusions permits the validation of suspected interactions in cell extracts and fixed cells as well as the establishment of high-throughput assays. The different assays allow the analysis of strong and weak interactions. Conversion of ligands into SNAP-tag substrates thus provides access to a powerful toolbox for the analysis of their interactions with proteins
Les Houches 2015: Physics at TeV colliders - new physics working group report
We present the activities of the 'New Physics' working group for the 'Physics
at TeV Colliders' workshop (Les Houches, France, 1-19 June, 2015). Our report
includes new physics studies connected with the Higgs boson and its properties,
direct search strategies, reinterpretation of the LHC results in the building
of viable models and new computational tool developments. Important signatures
for searches for natural new physics at the LHC and new assessments of the
interplay between direct dark matter searches and the LHC are also considered.Comment: Proceedings of the New Physics Working Group of the 2015 Les Houches
Workshop, Physics at TeV Colliders, Les Houches 1-19 June 2015. 197 page
The impact of transposable element activity on therapeutically relevant human stem cells
Human stem cells harbor significant potential for basic and clinical translational research as well as regenerative
medicine. Currently ~ 3000 adult and ~ 30 pluripotent stem cell-based, interventional clinical trials are ongoing
worldwide, and numbers are increasing continuously. Although stem cells are promising cell sources to treat a
wide range of human diseases, there are also concerns regarding potential risks associated with their clinical use,
including genomic instability and tumorigenesis concerns. Thus, a deeper understanding of the factors and
molecular mechanisms contributing to stem cell genome stability are a prerequisite to harnessing their therapeutic
potential for degenerative diseases. Chemical and physical factors are known to influence the stability of stem cell
genomes, together with random mutations and Copy Number Variants (CNVs) that accumulated in cultured human
stem cells. Here we review the activity of endogenous transposable elements (TEs) in human multipotent and
pluripotent stem cells, and the consequences of their mobility for genomic integrity and host gene expression. We
describe transcriptional and post-transcriptional mechanisms antagonizing the spread of TEs in the human genome,
and highlight those that are more prevalent in multipotent and pluripotent stem cells. Notably, TEs do not only
represent a source of mutations/CNVs in genomes, but are also often harnessed as tools to engineer the stem cell
genome; thus, we also describe and discuss the most widely applied transposon-based tools and highlight the
most relevant areas of their biomedical applications in stem cells. Taken together, this review will contribute to the
assessment of the risk that endogenous TE activity and the application of genetically engineered TEs constitute for
the biosafety of stem cells to be used for substitutive and regenerative cell therapiesS.R.H. and P.T.R. are funded by the Government of Spain (MINECO, RYC-2016-
21395 and SAF2015â71589-P [S.R.H.]; PEJ-2014-A-31985 and SAF2015â71589-
P [P.T.R.]). GGS is supported by a grant from the Ministry of Health of the
Federal Republic of Germany (FKZ2518FSB403)
P3HT-Based Solar Cells: Structural Properties and Photovoltaic Performance
Each year we are bombarded with B.Sc. and Ph.D. applications from students that want to improve the world. They have learned that their future depends on changing the type of fuel we use and that solar energy is our future. The hope and energy of these young people will transform future energy technologies, but it will not happen quickly. Organic photovoltaic devices are easy to sketch, but the materials, processing steps, and ways of measuring the properties of the materials are very complicated. It is not trivial to make a systematic measurement that will change the way other research groups think or practice. In approaching this chapter, we thought about what a new researcher would need to know about organic photovoltaic devices and materials in order to have a good start in the subject. Then, we simplified that to focus on what a new researcher would need to know about poly-3-hexylthiophene:phenyl-C61-butyric acid methyl ester blends (P3HT: PCBM) to make research progress with these materials. This chapter is by no means authoritative or a compendium of all things on P3HT:PCBM. We have selected to explain how the sample fabrication techniques lead to control of morphology and structural features and how these morphological features have specific optical and electronic consequences for organic photovoltaic device applications
SModelS - Interpreting LHC searches for new
International audienc
Interpretation of SUSY searches with simplified models
International audienc
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