150 research outputs found
The attentional boost effect and perceptual degradation: Assessing the influence of attention on recognition memory
Supplementary material
The Supplementary material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fpsyg.
2022.1024498/full#supplementary-materialFunding
Financial support for this study was provided by a Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant awarded to BM (RGPIN-2019-07021) and open access to the published study was supported by funds from Goethe Universitaet awarded to JO.Researchers have suggested that the recognition memory effects resulting from two separate attentional manipulations—attentional boost and perceptual degradation—may share a common cause; namely a transient up-regulation of attention at the time of encoding that leads to enhanced memory performance at the time of retrieval. Prior research has demonstrated that inducing two similar transient shifts of attention simultaneously produces redundant performance in memory. In the present study, we sought to evaluate the combined influence of the attentional boost and perceptual degradation on recognition memory. If these two effects share a common cause, then we ought to observe a redundancy in memory performance, such that these two factors interact. Yet, across four experiments we fail to observe such a redundancy in recognition memory. We evaluate these results using the limited resource model of attention and speculate on how combining transient shifts of attention may produce redundant memory performance in the one case, but non-redundant performance in the other case.Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant awarded to BM (RGPIN-2019-07021)Open access to the published study was supported by funds from Goethe Universitae
A panel of genes methylated with high frequency in colorectal cancer
Background:
The development of colorectal cancer (CRC) is accompanied by extensive epigenetic changes, including frequent regional hypermethylation particularly of gene promoter regions. Specific genes, including SEPT9, VIM1 and TMEFF2 become methylated in a high fraction of cancers and diagnostic assays for detection of cancer-derived methylated DNA sequences in blood and/or fecal samples are being developed. There is considerable potential for the development of new DNA methylation biomarkers or panels to improve the sensitivity and specificity of current cancer detection tests. Methods:
Combined epigenomic methods - activation of gene expression in CRC cell lines following DNA demethylating treatment, and two novel methods of genome-wide methylation assessment - were used to identify candidate genes methylated in a high fraction of CRCs. Multiplexed amplicon sequencing of PCR products from bisulfite-treated DNA of matched CRC and non-neoplastic tissue as well as healthy donor peripheral blood was performed using Roche 454 sequencing. Levels of DNA methylation in colorectal tissues and blood were determined by quantitative methylation specific PCR (qMSP). Results:
Combined analyses identified 42 candidate genes for evaluation as DNA methylation biomarkers. DNA methylation profiles of 24 of these genes were characterised by multiplexed bisulfite-sequencing in ten matched tumor/normal tissue samples; differential methylation in CRC was confirmed for 23 of these genes. qMSP assays were developed for 32 genes, including 15 of the sequenced genes, and used to quantify methylation in tumor, adenoma and non-neoplastic colorectal tissue and from healthy donor peripheral blood. 24 of the 32 genes were methylated in \u3e50% of neoplastic samples, including 11 genes that were methylated in 80% or more CRCs and a similar fraction of adenomas. Conclusions:
This study has characterised a panel of 23 genes that show elevated DNA methylation in \u3e50% of CRC tissue relative to non-neoplastic tissue. Six of these genes (SOX21, SLC6A15, NPY, GRASP, ST8SIA1 and ZSCAN18) show very low methylation in non-neoplastic colorectal tissue and are candidate biomarkers for stool-based assays, while 11 genes (BCAT1, COL4A2, DLX5, FGF5, FOXF1, FOXI2, GRASP, IKZF1, IRF4, SDC2 and SOX21) have very low methylation in peripheral blood DNA and are suitable for further evaluation as blood-based diagnostic markers
Growth of Long Range Forward-Backward Multiplicity Correlations with Centrality in Au+Au Collisions at = 200 GeV
Forward-backward multiplicity correlation strengths have been measured with
the STAR detector for Au+Au and collisions at =
200 GeV. Strong short and long range correlations (LRC) are seen in central
Au+Au collisions. The magnitude of these correlations decrease with decreasing
centrality until only short range correlations are observed in peripheral Au+Au
collisions. Both the Dual Parton Model (DPM) and the Color Glass Condensate
(CGC) predict the existence of the long range correlations. In the DPM the
fluctuation in the number of elementary (parton) inelastic collisions produces
the LRC. In the CGC longitudinal color flux tubes generate the LRC. The data is
in qualitative agreement with the predictions from the DPM and indicates the
presence of multiple parton interactions.Comment: 6 pages, 3 figures The abstract has been slightly modifie
Spin alignment measurements of the and vector mesons at RHIC
We present the first spin alignment measurements for the and
vector mesons produced at mid-rapidity with transverse momenta up
to 5 GeV/c at = 200 GeV at RHIC. The diagonal spin density
matrix elements with respect to the reaction plane in Au+Au collisions are
= 0.32 0.04 (stat) 0.09 (syst) for the
( GeV/c) and = 0.34 0.02 (stat) 0.03
(syst) for the ( GeV/c), and are constant with transverse
momentum and collision centrality. The data are consistent with the unpolarized
expectation of 1/3 and thus no evidence is found for the transfer of the
orbital angular momentum of the colliding system to the vector meson spins.
Spin alignments for and in Au+Au collisions were also measured
with respect to the particle's production plane. The result,
= 0.41 0.02 (stat) 0.04 (syst), is consistent with that in p+p
collisions, = 0.39 0.03 (stat) 0.06 (syst), also
measured in this work. The measurements thus constrain the possible size of
polarization phenomena in the production dynamics of vector mesons.Comment: 7 pages, 4 figures. fig.1 updated; one more reference added, one typo
corrected, published in PRC.77.06190
System-Size Independence of Directed Flow Measured at the BNL Relativistic Heavy-Ion Collider
We measure directed flow (ν_1) for charged particles in Au+Au and Cu+Cu collisions at √S_(NN)=200 and 62.4 GeV, as a function of pseudorapidity (η), transverse momentum (p_t), and collision centrality, based on data from the STAR experiment. We find that the directed flow depends on the incident energy but, contrary to all available model implementations, not on the size of the colliding system at a given centrality. We extend the validity of the limiting fragmentation concept to ν_1 in different collision systems, and investigate possible explanations for the observed sign change in ν_1(p_t)
Measurements of meson production in relativistic heavy-ion collisions at RHIC
We present results for the measurement of meson production via its
charged kaon decay channel in Au+Au collisions at
, 130, and 200 GeV, and in and +Au collisions
at GeV from the STAR experiment at the BNL Relativistic
Heavy Ion Collider (RHIC). The midrapidity () meson transverse
momentum () spectra in central Au+Au collisions are found to be well
described by a single exponential distribution. On the other hand, the
spectra from , +Au and peripheral Au+Au collisions show power-law tails
at intermediate and high and are described better by Levy
distributions. The constant yield ratio vs beam species, collision
centrality and colliding energy is in contradiction with expectations from
models having kaon coalescence as the dominant mechanism for production
at RHIC. The yield ratio as a function of is consistent
with a model based on the recombination of thermal quarks up to GeV/, but disagrees at higher transverse momenta. The measured nuclear
modification factor, , for the meson increases above unity at
intermediate , similar to that for pions and protons, while is
suppressed due to the energy loss effect in central Au+Au collisions. Number of
constituent quark scaling of both and for the meson
with respect to other hadrons in Au+Au collisions at =200 GeV
at intermediate is observed. These observations support quark
coalescence as being the dominant mechanism of hadronization in the
intermediate region at RHIC.Comment: 22 pages, 21 figures, 4 table
Longitudinal double-spin asymmetry for inclusive jet production in p+p collisions at sqrt(s)=200 GeV
We report a new STAR measurement of the longitudinal double-spin asymmetry
A_LL for inclusive jet production at mid-rapidity in polarized p+p collisions
at a center-of-mass energy of sqrt(s) = 200 GeV. The data, which cover jet
transverse momenta 5 < p_T < 30 GeV/c, are substantially more precise than
previous measurements. They provide significant new constraints on the gluon
spin contribution to the nucleon spin through the comparison to predictions
derived from one global fit of polarized deep-inelastic scattering
measurements.Comment: 7 pages, 4 figures + 1 tabl
Systematic Measurements of Identified Particle Spectra in pp, d+Au and Au+Au Collisions from STAR
Identified charged particle spectra of , , and
\pbar at mid-rapidity () measured by the \dedx method in the
STAR-TPC are reported for and d+Au collisions at \snn = 200 GeV and for
Au+Au collisions at 62.4 GeV, 130 GeV, and 200 GeV. ... [Shortened for arXiv
list. Full abstract in manuscript.]Comment: 58 pages, 46 figures, 37 table
Hadronic resonance production in +Au collisions at = 200 GeV at RHIC
We present the first measurements of the , (892),
(1232), (1385), and (1520) resonances in +Au
collisions at = 200 GeV, reconstructed via their hadronic
decay channels using the STAR detector at RHIC. The masses and widths of these
resonances are studied as a function of transverse momentum (). We observe
that the resonance spectra follow a generalized scaling law with the transverse
mass (). The of , , and . The , ,
, , and ratios in
+Au collisions are compared to the measurements in minimum bias
interactions, where we observe that both measurements are comparable. The
nuclear modification factors () of the , , and
scale with the number of binary collisions () for 1.2 GeV/.Comment: STAR Collaboration. Submitted to PR
Identified baryon and meson distributions at large transverse momenta from Au+Au collisions at GeV
Transverse momentum spectra of , and up to 12 GeV/c
at mid-rapidity in centrality selected Au+Au collisions at GeV are presented. In central Au+Au collisions, both and
show significant suppression with respect to binary scaling at
4 GeV/c. Protons and anti-protons are less suppressed than
, in the range 1.5 6 GeV/c. The and
ratios show at most a weak dependence and no significant
centrality dependence. The ratios in central Au+Au collisions approach
the values in p+p and d+Au collisions at 5 GeV/c. The results at high
indicate that the partonic sources of , and have
similar energy loss when traversing the nuclear medium.Comment: 6 pages, 4 figure
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