Inferring Update Sequences in Boolean Gene Regulatory Networks

International audienceThis paper employs mathematical programming and mixed integer linear programming techniques for solving a problem arising in the study of geneticregulatory networks. More precisely, we solve the inverse problem consisting in the determination of the sequence of updates in the digraph representingthe gene regulatory network (GRN) of Arabidopsis thaliana in such a way that the generated gene activity is as close as possible to the observed data

Inferring Parameters in Genetic Regulatory Networks

International audienceWe formulate and solve the problem of determining the arc weights in a Genetic Regulatory Network (GRN) so that it presents observed states at given development stages

Inferring Parameters in Genetic Regulatory Networks

International audienceWe formulate and solve the problem of determining the arc weights in a Genetic Regulatory Network (GRN) so that it presents observed states at given development stages

Nonrandom distribution and frequencies of genomic and EST-derived microsatellite markers in rice, wheat, and barley

BACKGROUND: Earlier comparative maps between the genomes of rice (Oryza sativa L.), barley (Hordeum vulgare L.) and wheat (Triticum aestivum L.) were linkage maps based on cDNA-RFLP markers. The low number of polymorphic RFLP markers has limited the development of dense genetic maps in wheat and the number of available anchor points in comparative maps. Higher density comparative maps using PCR-based anchor markers are necessary to better estimate the conservation of colinearity among cereal genomes. The purposes of this study were to characterize the proportion of transcribed DNA sequences containing simple sequence repeats (SSR or microsatellites) by length and motif for wheat, barley and rice and to determine in-silico rice genome locations for primer sets developed for wheat and barley Expressed Sequence Tags. RESULTS: The proportions of SSR types (di-, tri-, tetra-, and penta-nucleotide repeats) and motifs varied with the length of the SSRs within and among the three species, with trinucleotide SSRs being the most frequent. Distributions of genomic microsatellites (gSSRs), EST-derived microsatellites (EST-SSRs), and transcribed regions in the contiguous sequence of rice chromosome 1 were highly correlated. More than 13,000 primer pairs were developed for use by the cereal research community as potential markers in wheat, barley and rice. CONCLUSION: Trinucleotide SSRs were the most common type in each of the species; however, the relative proportions of SSR types and motifs differed among rice, wheat, and barley. Genomic microsatellites were found to be primarily located in gene-rich regions of the rice genome. Microsatellite markers derived from the use of non-redundant EST-SSRs are an economic and efficient alternative to RFLP for comparative mapping in cereals

Resumen de los autos sobre adjudicación del Curato de Villanueva de Muñeca a D. Francisco del Valle y Liébana : principiados en el Provisorato de León y concluidos en el Supremo Tribunal de la Rota de la Nunciatura Apostólica

Marcas: Sello de la Biblioteca Provincial de LeónCopia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-2010Enc. hol

European cancer mortality predictions for the year 2015: does lung cancer have the highest death rate in EU women?

Total cancer mortality rates in the EU are predicted to fall 7.5% in men and 6% in women between 2009 and 2015. However, due to population aging, total number of cancer deaths will rise to 1 359 100. Cancer mortality outlook for 2015 remains favourable, except for pancreas in both sexes and female lung that is predicted to overtake breast becoming the female cancer with the highest rate (14.24/100 000

Inferring Parameters in Genetic Regulatory Networks

International audienceWe formulate and solve the problem of determining the arc weights in a Genetic Regulatory Network (GRN) so that it presents observed states at given development stages

Comparación de los efects de dos programas de entrenameinto sobre la fuerza activa y reactiva en un grupo de baloncesto y otro fisicamente activo

87 páginas : gráficasThe present investigative work exposes the basics of the training of the explosive force, looking for the improvement of the vertical jump by means of two training methods, one focused on the reactive force for young athletes of fifteen years of basketball and the second one focused on active force in gym machines for adults between 18 and 20 years of the Bodytech gym. Initial checks were made by means of valuation tests for the vertical jump, then two specific training programs were created for each of the groups, programs that last for 12 weeks. The number of participants was a total of 14 people, all men, with an age range between 15 and 20 years; for the controls of the tests carried out, 2 more were executed apart from the initial one, the second one had its moment in week 6 of the program and the third one at the end of week number 12. There was a significant improvement in the vertical jump and body composition except for the lean mass of the basketball group. After a comparison between both training methods, a greater progress was found in the reactive force method demonstrated in a 1.71% development in the jump improvement for the basketball group and 1.57% for the team that worked in the gym.El presente trabajo investigativo expone los fundamentos del entrenamiento de la fuerza explosiva, buscando la mejora del salto vertical por medio de dos métodos de entrenamiento, uno enfocado en la fuerza reactiva para deportistas jóvenes de quince años de baloncesto y el segundo enfocado en fuerza activa realizados en máquinas de gimnasio para adultos entre 18 y 20 años del gimnasio Bodytech. Se realizaron controles iniciales por medio de pruebas valorativas para el salto vertical, a continuación, se crearon dos programas de entrenamiento específico para cada uno de los grupos, programas que tienen una duración de 12 semanas. La cantidad de participantes fue un total de 14 personas, todos hombres, con un rango de edad entre 15 y 20 años; para los controles de las pruebas realizadas, se ejecutaron 2 más aparte de la inicial, el segundo tuvo su momento en la semana 6 del programa y el tercero al finalizar durante la semana número 12. Allí se encontró una mejora significativa en el salto vertical y la composición corporal a excepción de la masa magra del grupo de baloncesto. Luego de una comparación entre ambos métodos de entrenamiento, se encontró un mayor progreso en el método de fuerza reactiva demostrado en un 1,71% de desarrollo en la mejora del salto para el grupo de baloncesto y 1,57% para el equipo que trabajo en gimnasio.Incluye bibliografíaPregradoProfesional en Ciencias del Deport

LA FUSIÓN CARULLA-VIVERO, ¿CREÓ VALOR?

El presente trabajo busca determinar si la fusión de las empresas Carulla-Vivero ocurrida en el año 2000 generó valor. Para esto, se estudia el conceptode valor, posteriormente se explica el estudio de caso como metodología deinvestigación para concluir con la exposición del caso mismo de la fusión, ysu resultado. Una vez realizado el análisis de las dos empresas, se hace unacomparación y una valoración por dos metodologías ampliamente aceptadas:los métodos Economic Value Added (EVA) - Weighted Average Cost of Capital(WACC) y Flujo de Caja Histórico, con lo cual se explora en su interior la fusióny se explican los resultados obtenidos en ella. Finalmente, se hace una seriede observaciones, conclusiones y recomendaciones sobre la fusión, asícomo de la metodología del estudio de caso, para el abordaje de temas de laadministración