Assessing school effects without controlling for prior achievement?

The research findings presented in this paper illustrate how the “value added” of schooling can be assessed empirically using cross-sectional data. Application of the regression-discontinuity approach within a multilevel framework produces both an estimate of the absolute effect of 1 year schooling and an estimate of the variation across schools of this effect. In the study reported here, the approach was applied to both a cross-sectional and a longitudinal dataset. The research findings indicate to what extent different results are produced when cross-sectional as opposed to longitudinal data are analysed

Alzheimer’s disease-associated peptide Aβ₄₂ mobilizes ER Ca²⁺ via InsP₃R-dependent and -independent mechanisms

Dysregulation of Ca2+ homeostasis is considered to contribute to the toxic action of the Alzheimer’s Disease (AD) associated Amyloid β-peptide (Aβ). Ca2+ fluxes across the plasma membrane and release from intracellular stores have both been reported to underlie the Ca2+ fluxes induced by Aβ42. Here, we investigated the contribution of Ca2+ release from the endoplasmic reticulum (ER) to the effects of Aβ42 upon Ca2+ homeostasis and the mechanism by which Aβ42 elicited these effects. Consistent with previous reports, application of soluble oligomeric forms of Aβ42 exhibited Ca2+ mobilizing properties. The Aβ42-stimulated Ca2+ signals persisted in the absence of extracellular Ca2+ indicating a significant contribution of Ca2+ release from the ER Ca2+ store to the generation of these signals. Moreover, inositol 1,4,5-trisphosphate (InsP3) signaling contributed to Aβ42-stimulated Ca2+ release. The Ca2+ mobilizing effect of Aβ42 was also observed when applied to permeabilized cells deficient in InsP3 receptors revealing an additional direct effect of internalized Aβ42 upon the ER, and a mechanism for induction of toxicity by intracellular Aβ42

Spectroscopic confirmation of UV-bright white dwarfs from the Sandage Two-Color Survey of the Galactic Plane

We present spectroscopic observations confirming the identification of hot white dwarfs among UV-bright sources from the Sandage Two-color Survey of the Galactic plane and listed in the Lanning (Lan) catalog of such sources. A subsample of 213 UV bright Lan sources have been identified as candidate white dwarfs based on the detection of a significant proper motion. Spectroscopic observations of 46 candidates with the KPNO 2.1m telescope confirm 30 sources to be hydrogen white dwarfs with subtypes in the DA1-DA6 range, and with one of the stars (Lan 161) having an unresolved M dwarf as a companion. Five more sources are confirmed to be helium white dwarfs, with subtypes from DB3 to DB6. One source (Lan 364) is identified as a DZ 3 white dwarf, with strong lines of calcium. Three more stars are found to have featureless spectra (to within detection limits), and are thus classified as DC white dwarfs. In addition, three sources are found to be hot subdwarfs: Lan 20 and Lan 480 are classified as sdOB, and Lan 432 is classified sdB. The remaining four objects are found to be field F star interlopers. Physical parameters of the DA and DB white dwarfs are derived from model fits.Comment: To appear in the Astronomical Journa

Consequences of divorce-based father absence during childhood for young adult well-being and romantic relationships

Objective: This research explores the implications of father absence due to divorce on young adults' well‐being and romantic relationships. Background: Studies have demonstrated the negative implications of father absence, a common consequence of divorce, on children's development. However, previous research has not systematically compared complete versus partial father absence. Method: Young adults who, as children, experienced complete (n = 38) or partial (n = 41) father absence were compared with 40 participants in a father‐presence control group. Results: Compared with those in the control group, young adults in the partial father‐absence group reported higher psychopathology and maternal overprotection, and lower maternal care, romantic intimacy, commitment, and passion. Under elevated maternal care, the partial‐absence group reported lower dyadic adjustment and consolidated sense of identity. Participants in the complete‐absence group reported higher self‐criticism and maternal overprotection and lower maternal care than controls. Conclusion: Partial father absence might have particularly pernicious consequences for young adults' well‐being. Implications: Clinical and public policy implications are discussed

The rheological and fracture properties of Gouda cheese

The rheological and fracture behaviour of Gouda cheese was studied. Methods for determining these properties of visco-elastic materials are described. Application of the theory of fracture mechanics, after modification and expansion, to visco-elastic materials with a low or no yield stress is discussed. For such materials, of which Gouda cheese is an example, the flow properties greatly affect the fracture behaviour.From the effect of variation in composition (fat, water, NaCl and Ca content, pH) and maturation on the behaviour of Gouda cheese, it may be concluded that this cheese may be considered as a composite material. Fat particles act as a filler in a swollen protein matrix. The amount of fat and the rigidity of the fat particles affect the rigidity of the cheese. Factors like pH, water and NaCl content, that change the properties of the protein matrix, clearly affect the -rheological and fracture behaviour, e.g. the rigidity and the shortness, of the cheese. The trends of these changes on the protein matrix are similar to those on rennet and acid skimmilk gels under various conditions .As an example of the importance of the experimental results for cheese manufacturing, the relation between the pH of cheese and eye or slit formation was studied

The value-added of primary schools: what is it really measuring?

This paper compares the official value-added scores in 2005 for all primary schools in three adjacent LEAs in England with the raw-score Key Stage 2 results for the same schools. The correlation coefficient for the raw- and value-added scores of these 457 schools is around +0.75. Scatterplots show that there are no low attaining schools with average or higher value-added, and no high attaining schools with below average value-added. At least some of the remaining scatter is explained by the small size of some schools. Although some relationship between these measures is to be expected – so that schools adding considerable value would tend to have high examination outcome scores – the relationship shown is too strong for this explanation to be considered sufficient. Value-added analysis is intended to remove the link between a schools’ intake scores and their raw-score outcomes at KS2. It should lead to an estimate of the differential progress made by pupils, assessed between schools. In fact, however, the relationship between value-added and raw scores is of the same size as the original relationship between intake scores and raw-scores that the value-added is intended to overcome. Therefore, however appealing the calculation of value-added figures is, their development is still at the stage where they are not ready to move from being a research tool to an instrument of judgement on schools. Such figures may mislead parents, governors and teachers and, even more importantly, they are being used in England by OFSTED to pre-determine the results of school inspections

Mapping human serum induced gene networks as a basis for the creation of biomimetic periosteum for bone repair

The periosteum is a highly vascularised, collagen-rich tissue that plays a crucial role in directing bone repair. This is orchestrated primarily by its resident progenitor cell population. Indeed, preservation of periosteum integrity is critical for bone healing. Cells extracted from the periosteum retain their osteochondrogenic properties and as such are a promising basis for tissue engineering strategies for the repair of bone defects. However, the culture expansion conditions, and the way in which the cells are reintroduced to the defect site are critical aspects of successful translation. Indeed, expansion in human serum and implantation on biomimetic materials has previously been shown to improve in vivo bone formation. As such, this study aimed to develop a protocol to allow for the expansion of human periosteum derived cells (hPDCs) in a biomimetic periosteal-like environment. The expansion conditions were defined through the investigation of the bioactive cues involved in augmenting hPDC proliferative and multipotency characteristics, based on transcriptomic analysis of cells cultured in human serum. Master regulators of transcriptional networks were identified and an optimised periosteal derived-growth factor cocktail (PD-GFC; containing β-Estradiol, FGF2, TNFα, TGFβ, IGF-1 and PDGF-BB) was generated. Expansion of hPDCs in PD-GFC resulted in serum mimicry with regards to the cell morphology, proliferative capacity and chondrogenic differentiation. When incorporated into a 3D collagen-type-1 matrix and cultured in PD-GFC, the hPDCs migrated to the surface that represented the matrix topography of the periosteum cambium layer. Furthermore, gene expression analysis revealed a downregulated Wnt and TGFβ signature and an upregulation of CREB, which may indicate the hPDCs are recreating their progenitor cell signature. This study highlights the first stage in the development of a biomimetic periosteum which may have applications in bone repair