Associations of self-reported physical activity types and levels with quality of life, depression symptoms, and mortality in hemodialysis patients: The DOPPS

pre-printBackground and objectives Physical activity has been associated with better health status in diverse populations, but the association in patients on maintenance hemodialysis is less established. Patient-reported physical activities and associations with mortality, health-related quality of life, and depression symptoms in patients on maintenance hemodialysis in 12 countries were examined. Design, setting, participants, &measurements In total, 5763 patients enrolled in phase 4 of the Dialysis Outcomes and Practice Patterns Study (2009-2011) were classified into five aerobic physical activity categories (never/rarely active to very active) and by muscle strength/flexibility activity using the Rapid Assessment of Physical Activity questionnaire. The Kidney Disease Quality of Life scale was used for health-related quality of life. The Center for Epidemiologic Studies Depression scale was used for depression symptoms. Linear regression was used for associations of physical activity with health-related quality of life and depression symptoms scores. Cox regression was used for association of physical activity with mortality. Results The median (interquartile range) of follow-up was 1.6 (0.9-2.5) years; 29% of patients were classified as never/rarely active, 20% of patients were classified as very active, and 20.5% of patients reported strength/ flexibility activities. Percentages of very active patients were greater in clinics offering exercise programs.Aerobic activity, but not strength/flexibility activity, was associated positively with health-related quality of life and inversely with depression symptoms and mortality (adjusted hazard ratio of death for very active versus never/rarely active, 0.60; 95%confidence interval, 0.47 to 0.77). Similar associations with aerobic activity were observed in strata of age, sex, time on dialysis, and diabetes status. Conclusions The findings are consistent with the health benefits of aerobic physical activity for patients on maintenance hemodialysis. Greater physical activity was observed in facilities providing exercise programs, suggesting a possible opportunity for improving patient outcomes

Rosuvastatin and vascular dysfunction markers in pulmonary arterial hypertension: a placebo-controlled study

We investigated whether chronic rosuvastatin administration could improve the abnormalities of the circulating levels of vascular dysfunction markers in pulmonary arterial hypertension (PAH). Sixty patients, aged 13 to 60 years, with idiopathic (N = 14) or congenital heart disease-associated PAH (N = 46) were equally but randomly assigned to rosuvastatin treatment (10 mg a day, orally) or placebo for 6 months in a blind fashion. Plasma levels of P-selectin, tissue-plasminogen activator and its inhibitor as well as von Willebrand factor antigen were measured by enzyme-linked immunoassay before and after 1, 3, and 6 months of treatment. Baseline levels of biomarkers were elevated (68, 16, 45 and 46% increase relative to controls, for P-selectin, von Willebrand factor antigen, tissue-plasminogen activator and its inhibitor, respectively; P < 0.001). P-selectin values at baseline, 1, 3, and 6 months were 39.9 ± 18.5, 37.6 ± 14.6, 34.8 ± 14.6, and 35.4 ± 13.9 ng/mL, respectively, for the rosuvastatin group and 45.7 ± 26.8, 48.0 ± 26.9, 48.1 ± 25.7, and 45.7 ± 25.6 ng/mL for the placebo group. The P-selectin level was lower in the rosuvastatin group compared with placebo throughout treatment (P = 0.037, general linear model). A trend was observed towards a decrease in tissue-plasminogen activator in the statin group (16% reduction, P = 0.094), with no significant changes in the other markers. Since P-selectin is crucial in inflammation and thrombosis, its reduction by rosuvastatin is potentially relevant in the pathophysiological scenario of PAH.FAPES

An artificial immune system for fuzzy-rule induction in data mining

This work proposes a classification-rule discovery algorithm integrating artificial immune systems and fuzzy systems. The algorithm consists of two parts: a sequential covering procedure and a rule evolution procedure. Each antibody (candidate solution) corresponds to a classification rule. The classification of new examples (antigens) considers not only the fitness of a fuzzy rule based on the entire training set, but also the affinity between the rule and the new example. This affinity must be greater than a threshold in order for the fuzzy rule to be activated, and it is proposed an adaptive procedure for computing this threshold for each rule. This paper reports results for the proposed algorithm in several data sets. Results are analyzed with respect to both predictive accuracy and rule set simplicity, and are compared with C4.5rules, a very popular data mining algorithm

String-Loop Corrected Magnetic Black Holes

We discuss the form of the string-loop-corrected effective action obtained by compactification of the heterotic string theory on the manifold $K3\times T^2$ or on its orbifold limit and the loop-corrected magnetic black hole solutions of the equations of motion. Effective 4D theory has N=2 local supersymmetry. Using the string-loop-corrected prepotential of the N=2 supersymmetric theory, which receives corrections only from the string world sheets of torus topology, we calculate the loop corrections to the tree-level gauge couplings and solve the loop-corrected equations of motion. At the string-tree level, the effective gauge couplings decrease at small distances from the origin, and in this region string-loop corrections to the gauge couplings become important. A possibility of smearing the singularity of the tree-level supersymmetric solution with partially broken supersymmetry by quantum corrections is discussed.Comment: Improved version. Mixing of the dilaton with other moduli properly taken into account. Explanatory notes adde

Portuguese twitter dataset on COVID-19

Over the last two years, the COVID-19 pandemic has affected hundreds of millions of people around the world. As in many crises, people turn to social media platforms, like Twitter, to communicate and share information. Twitter datasets have been used over the years in many research studies to extract valuable information. Therefore, several large COVID- 19 Twitter datasets have been released over the last two years. However, none of these datasets contains only Portuguese Tweets, despite the Portuguese Language being reported as one of the top five languages used on Twitter. In this paper, we present the first large-scale Portuguese COVID-19 Twitter dataset. The dataset contains over 19 million Tweets spanning 2020 and 2021, allowing the entire pandemic to be analyzed. We also conducted a sentiment analysis on the dataset and correlated the various spikes in Tweet count and sentiment scores to various news articles and government announcements in Portugal and Brazil. The dataset is available at: https://github.com/bioinformaticsua/ Portuguese-Covid19-DatasetThis work was supported by FCT – Fundaçãoo para a Ciência e Tecnologia within project DSAIPA/AI/0088/2020.info:eu-repo/semantics/publishedVersio

A Comment on Quantum Distribution Functions and the OSV Conjecture

Using the attractor mechanism and the relation between the quantization of $H^{3}(M)$ and topological strings on a Calabi Yau threefold $M$ we define a map from BPS black holes into coherent states. This map allows us to represent the Bekenstein-Hawking-Wald entropy as a quantum distribution function on the phase space $H^{3}(M)$. This distribution function is a mixed Husimi/anti-Husimi distribution corresponding to the different normal ordering prescriptions for the string coupling and deviations of the complex structure moduli. From the integral representation of this distribution function in terms of the Wigner distribution we recover the Ooguri-Strominger-Vafa (OSV) conjecture in the region "at infinity" of the complex structure moduli space. The physical meaning of the OSV corrections are briefly discussed in this limit.Comment: 27 pages. v2:reference and footnote adde

Genetic characterization of Toxoplasma gondii isolates from pigs intended for human consumption in Brazil

AbstractThis study genetically Toxoplasma gondii isolates obtained from pigs intended for human consumption in northeastern Brazil; multilocus PCR-RFLP and sequencing techniques were utilized. Bioassays were conducted using the brain and tongue of 20 pig heads purchased at butcher shops in the city of Ilheus, Bahia, Brazil. Overall, 11 T. gondii isolates designated TgPgBr06-16 were identified. Application of multilocus PCR-RFLP with seven molecular markers (SAG1, SAG2, SAG3, BTUB, C22-8, PK1 and Apico) identified six different genotypes. Isolates TgPgBr 06, 08, 11, 12, 14 and 15 were indistinguishable by this technique, forming a single genotype; the remaining isolates were characterized as distinct genotypes. However, when five genetic markers (SAG1, SAG2, SAG3, BTUB and c22-8) were employed in multilocus PCR-sequencing, all eleven strains of T. gondii were shown to be different. All isolates differed from Type I, II and III clonal genotypes using both genotyping techniques. These results demonstrate that the multilocus PCR-RFLP assay underestimated the true diversity of the T. gondii population in this study. Thus, DNA sequencing is the preferred technique to infer the genetic diversity and population structure of T. gondii strains from Brazil. Moreover, it is necessary to develop new molecular markers to group and characterize atypical T. gondii isolates from South America

Seven new microendemic species of Brachycephalus (Anura:Brachycephalidae) from southern Brazil

Brachycephalus (Anura: Brachycephalidae) is a remarkable genus of miniaturized frogs of the Brazilian Atlantic Rainforest. Many of its species are highly endemic to cloud forests, being found only on one or a few mountaintops. Such level of microendemism might be caused by their climatic tolerance to a narrow set of environmental conditions found only in montane regions. This restriction severely limits the chance of discovery of new species, given the difficulty of exploring these inaccessible habitats. Following extensive fieldwork in montane areas of the southern portion of the Atlantic Rainforest, in this study we describe seven new species of Brachycephalus from the states of Paraná and Santa Catarina, southern Brazil. These species can be distinguished from one another based on coloration and the level of rugosity of the skin in different parts of their body. These discoveries increase considerably the number of described species of Brachycephalus in southern Brazil

Black hole partition functions and duality

The macroscopic entropy and the attractor equations for BPS black holes in four-dimensional N=2 supergravity theories follow from a variational principle for a certain `entropy function'. We present this function in the presence of R^2-interactions and non-holomorphic corrections. The variational principle identifies the entropy as a Legendre transform and this motivates the definition of various partition functions corresponding to different ensembles and a hierarchy of corresponding duality invariant inverse Laplace integral representations for the microscopic degeneracies. Whenever the microscopic degeneracies are known the partition functions can be evaluated directly. This is the case for N=4 heterotic CHL black holes, where we demonstrate that the partition functions are consistent with the results obtained on the macroscopic side for black holes that have a non-vanishing classical area. In this way we confirm the presence of a measure in the duality invariant inverse Laplace integrals. Most, but not all, of these results are obtained in the context of semiclassical approximations. For black holes whose area vanishes classically, there remain discrepancies at the semiclassical level and beyond, the nature of which is not fully understood at present.Comment: 36 pages, Late

Geometric Transition as a Change of Polarization

Taking the results of hep-th/0702110 we study the Dijkgraaf-Vafa open/closed topological string duality by considering the wavefunction behavior of the partition function. We find that the geometric transition associated with the duality can be seen as a change of polarization.Comment: 20 page