135 research outputs found
Development of guidelines for family and non-professional helpers on assisting an older person who is developing cognitive impairment or has dementia: a Delphi expert consensus study
- Author
- A Jorm
- A Ross
- A Ross
- A. F. Jorm
- AH Kingston
- AH Kingston
- AM Byszewski
- B Kitchener
- B. A. Kitchener
- BT Suehs
- C. M. Kelly
- CC Neville
- CD Caron
- CD Caron
- CM Kelly
- CM Kelly
- CM Kelly
- CM Kelly
- D Acosta
- DL Algase
- DM Fick
- E Papastavrou
- E Papastavrou
- F Hasson
- G Hadlaczky
- H Brodaty
- HK Butcher
- J Campbell
- J Francis
- J Lee van der
- JE Gaugler
- JT Tschanz
- K. J. Chalmers
- K. S. Bond
- KS Bond
- KS Bond
- L Etters
- L Hart
- LL Davis
- LN Gitlin
- M Lewis
- M Prince
- Mental Health First Aid Australia
- MJ McClendon
- MJ McClendon
- MY Savundranayagam
- N Carpentier
- NJ Reavley
- R Hébert
- R Schulz
- RL Langlands
- RL Langlands
- RT Woods
- SK Inouye
- Z Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Anorexia nervosa is linked to reduced brain structure in reward and somatosensory regions: a meta-analysis of VBM studies
- Author
- A Boghi
- A Joos
- A Joos
- A Wagner
- American Psychiatric Association
- AR Laird
- AR Laird
- B Suchan
- CA Roberto
- DK Katzman
- DK Katzman
- DK Katzman
- EK Lambe
- F Connan
- F Van den Eynde
- GD Giordano
- HC Friederich
- Helgi B Schiöth
- HT Chui
- J Ashburner
- J Castro-Fornieles
- K Kingston
- LM McCormick
- LN van der Laan
- M Suda
- MR Kohn
- NC Kerem
- NH Golden
- Olga E Titova
- Olof C Hjorth
- PE Turkeltaub
- R Uher
- S Brooks
- S Gaudio
- Samantha J Brooks
- SB Eickhoff
- SJ Brooks
- SJ Brooks
- V Mainz
- VW Swayze 2nd
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Universal health coverage from multiple perspectives: a synthesis of conceptual literature and global debates
- Author
- A Bárcena
- A Dillip
- A Leive
- A Mills
- A Mills
- AE Yamin
- AM Rodney
- B Jacobs
- B Latko
- B Meessen
- C Arnold
- C Victora
- D Holmes
- D McIntyre
- D McIntyre
- D McIntyre
- D McIntyre
- D Stuckler
- D Stuckler
- DB Evans
- DB Evans
- DT Jamison
- E Borgonovi
- FM Knaul
- G Backman
- G Lagomarsino
- G Ooms
- G Rosen
- Gilbert Abotisem Abiiro
- J Frenk
- J Goudge
- J Goudge
- J Kutzin
- J Kutzin
- J Kutzin
- J Macha
- J Rodin
- J Vega
- JC Noronha de
- JD Sachs
- K Xu
- K Xu
- KD Rao
- KS Reddy
- L Forman
- L Garrett
- LA Aday
- LC Chen
- LN Kingston
- M Chan
- M Dekker
- M Marmot
- M McKee
- M Sheikh
- Manuela De Allegri
- ME Kruk
- N Bristol
- N Palmer
- O O’Donnell
- Office of the United Nations High Commissioner for Human Rights WHO
- P Allotey
- R Hammonds
- R Horton
- R Lencucha
- R Moreno-Serra
- R Moreno-Serra
- R Penchansky
- R Wilkinson
- R Yates
- S Cleary
- S Gorin
- S Hickey
- S Young
- SP Silal
- ST Fried
- Sustainable Development Solutions Network
- T Adam
- T Bärnighausen
- T Ensor
- T O’Connell
- T-H Collet
- The Lancet
- The World Bank
- TS Ravindran
- United Nations
- United Nations
- United Nations General Assemby
- United Nations’ General Assembly
- United Nations’ General Assemby
- W Savedoff
- WHO
- WHO
- WHO
- WHO
- WHO World Bank
- WHO World Bank
- World Bank WHO
- World Health Organization
- X Scheil-Adlung
- Y-C Lee
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Background: There is an emerging global consensus on the importance of universal health coverage (UHC), but no unanimity on the conceptual definition and scope of UHC, whether UHC is achievable or not, how to move towards it, common indicators for measuring its progress, and its long-term sustainability. This has resulted in various interpretations of the concept, emanating from different disciplinary perspectives. This paper discusses the various dimensions of UHC emerging from these interpretations and argues for the need to pay attention to the complex interactions across the various components of a health system in the pursuit of UHC as a legal human rights issue. Discussion: The literature presents UHC as a multi-dimensional concept, operationalized in terms of universal population coverage, universal financial protection, and universal access to quality health care, anchored on the basis of health care as an international legal obligation grounded in international human rights laws. As a legal concept, UHC implies the existence of a legal framework that mandates national governments to provide health care to all residents while compelling the international community to support poor nations in implementing this right. As a humanitarian social concept, UHC aims at achieving universal population coverage by enrolling all residents into health-related social security systems and securing equitable entitlements to the benefits from the health system for all. As a health economics concept, UHC guarantees financial protection by providing a shield against the catastrophic and impoverishing consequences of out-of-pocket expenditure, through the implementation of pooled prepaid financing systems. As a public health concept, UHC has attracted several controversies regarding which services should be covered: comprehensive services vs. minimum basic package, and priority disease-specific interventions vs. primary health care. Summary: As a multi-dimensional concept, grounded in international human rights laws, the move towards UHC in LMICs requires all states to effectively recognize the right to health in their national constitutions. It also requires a human rights-focused integrated approach to health service delivery that recognizes the health system as a complex phenomenon with interlinked functional units whose effective interaction are essential to reach the equilibrium called UHC
Extra-Intestinal Manifestations of Familial Adenomatous Polyposis
- Author
- A Devic
- A Hansmann
- A Kartheuser
- AC Lockhart
- AJ Sigurdson
- AK Gurbuz
- AL Knudsen
- André P. van Beek
- Annemieke Roos
- AR Latchford
- B Seket
- BA Hirschman
- BR Rood
- C Bulow
- C Gupta
- CJ Stewart
- D Schweinitz von
- D Thomas
- DS Cooper
- E Papini
- EG Meir Van
- EI Traboulsi
- EJ Gardner
- EJ Gardner
- Emma J. Groen
- EW Naylor
- F Beuschlein
- F Cetta
- F Cetta
- F Cetta
- F Cetta
- F Maire
- F Paraf
- FM Giardiello
- FM Giardiello
- FM Giardiello
- FM Giardiello
- Friso L. Muntinghe
- G Ozuner
- GL Alexander
- HF Vasen
- HF Vasen
- HJ Jarvinen
- HW Crail
- I Heiskanen
- J Bjork
- J Bjork
- J Le Borgne
- J Turcot
- Jakob de Vries
- Jan H. Kleibeuker
- JC Healy
- JE Kingston
- JF Gebert
- JM Church
- JM Schnater
- JMG Wilson
- JS Wu
- K Chelaifa
- K Kubo
- KB Kaplan
- KH Goss
- KP Nugent
- L Bertario
- L Bertario
- L Ramaglia
- LJ Hughes
- LK Su
- LN Pho
- M Peifer
- M Phillips
- M Seki
- MA Wijn
- Max J. H. Witjes
- MC Frates
- MC Gallagher
- MF Herrera
- MH Nieuwenhuis
- MI Canto
- ML Bisgaard
- MM Grumbach
- MT Ballo
- N Yamakita
- NJ Sturt
- NR Schneider
- NS Fearnhead
- P Galiatsatos
- P Marchesa
- PJ Pines Corrales
- R Chetty
- R Fodde
- R Fodde
- R Valanzano
- RA Komorowski
- RM Reynolds
- RO Plail
- Roelien H. Enting
- RP Sanders
- RR Lonser
- S Aretz
- S Bulow
- S Bulow
- S Wakatsuki
- SB Middleton
- SK Clark
- SK Clark
- SR Hamilton
- T Iwama
- T Iwama
- T Matsumoto
- T Sudo
- T Takeuchi
- TA Painter
- TG Smith
- Thera P. Links
- TP Links
- VE Kimonis
- WH Marshall
- WK Hirota
- Z Traill
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2008
- Field of study
Familial adenomatous polyposis (FAP) is an autosomal dominantly inherited disorder, which results from a germ line mutation in the APC (adenomatous polyposis coli) gene. FAP is characterized by the formation of hundreds to thousands of colorectal adenomatous polyps. Although the development of colorectal cancer stands out as the most prevalent complication, FAP is a multisystem disorder of growth. This means, it is comparable to other diseases such as the MEN syndromes, Von Hippel-Lindau disease and neurofibromatosis. However, the incidence of many of its clinical features is much lower. Therefore, a specialized multidisciplinary approach to optimize health care—common for other disorders—is not usually taken for FAP patients. Thus, clinicians that care for and counsel members of high-risk families should have familiarity with all the extra-intestinal manifestations of this syndrome. FAP-related complications, for which medical attention is essential, are not rare and their estimated lifetime risk presumably exceeds 30%. Affected individuals can develop thyroid and pancreatic cancer, hepatoblastomas, CNS tumors (especially medulloblastomas), and various benign tumors such as adrenal adenomas, osteomas, desmoid tumors and dental abnormalities. Due to improved longevity, as a result of better prevention of colorectal cancer, the risk of these clinical problems will further increase
Advances in estrogen receptor biology: prospects for improvements in targeted breast cancer therapy
- Author
- A Buzdar
- A Buzdar
- A Takeshita
- A Warnmark
- AB Grey
- AB Grey
- AC Pike
- AC Pike
- AJ Horlein
- AJ Morrison
- AK Shiau
- AM Brzozowski
- AM Simeone
- AU Buzdar
- AU Buzdar
- B Fisher
- B Fisher
- B Kristensen
- B Saville
- BA Stoll
- BD Darimont
- BG Rowan
- C Chang
- C McMahon
- C Morris
- CK Glass
- CK Osborne
- CK Osborne
- CK Tang
- CL Smith
- CL Smith
- CM Klinge
- CS Suen
- CW Wong
- D Burakov
- D Chen
- D Chen
- D Chen
- D Moras
- DA Cameron
- DA Cameron
- DJ Mangelsdorf
- DJ Slamon
- DM Heery
- DR Spigel
- E Neuman
- E Nishihara
- E Pukkala
- Early Breast Cancer Trialists' Collaborative Group
- EP Gelmann
- EV Jensen
- G Bunone
- G Redeuilh
- GG Kuiper
- Group EBCTC
- Group EBCTC
- GT Beatson
- H Chen
- H Cho
- H Endoh
- H Hong
- H Li
- H Mouridsen
- H Ueda
- H Zhang
- HJ Huang
- HJ List
- HP Koeffler
- I Girault
- I Tcherepanova
- J Bonneterre
- J Cuzick
- J DiRenzo
- J Font de Mora
- J Lamb
- J Torchia
- J Xu
- J Xu
- JA Fontana
- JA Fontana
- JA Katzenellenbogen
- JD Chen
- JG Klijn
- JG Klijn
- JG Klijn
- JH Segars
- JJ Rusthoven
- JJ Voegel
- JM Hall
- JM Hall
- JN Ingle
- JP Aumais
- K Holli
- K Jepsen
- K Paech
- KJ Lauritsen
- L Johansson
- L Ko
- L Wickerham
- LN Wei
- M Baum
- M Beato
- M Dutertre
- M Fan
- M Kaufmann
- M Watanabe
- MG Curtis
- MG Rosenfeld
- MM Montano
- MY Farhat
- N Wolmark
- P Bortman
- P Dombernowsky
- P Puigserver
- P Webb
- P Webb
- PB Joel
- PE Budtz
- PH Driggers
- PJ Kushner
- PJ Kushner
- PS Danielian
- PS Jones
- R Gusterson
- R Janknecht
- R Nahta
- RB Buchanan
- RB Clarke
- RB Lanz
- RE Kingston
- RK Vadlamudi
- RM Lavinsky
- RM Zwijsen
- RR Love
- RR Perry
- RT Turner
- S Ait-Si-Ali
- S Bautista
- S Green
- S Kato
- S Kousteni
- S Misiti
- S Mosselman
- S Oesterreich
- S Sommer
- SA Fuqua
- SA Onate
- SJ Jubelirer
- SL Anzick
- SM Aronica
- SR Cummings
- SR Johnston
- T Fornander
- T Matsuda
- T Saarto
- T Sakamoto
- T Simoncini
- U Veronesi
- V Kumar
- V Speirs
- VC Jordan
- VC Jordan
- VC Jordan
- VJ Assikis
- VV Ogryzko
- VV Ogryzko
- W Shao
- XJ Yang
- Y Shang
- Y Shang
- YK Kang
- YZ Liu
- Z Li
- Z Wang
- Publication venue
- BioMed Central
- Publication date
- 07/11/2003
- Field of study
Estrogen receptor (ER) has a crucial role in normal breast development and is expressed in the most common breast cancer subtypes. Importantly, its expression is very highly predictive for response to endocrine therapy. Current endocrine therapies for ER-positive breast cancers target ER function at multiple levels. These include targeting the level of estrogen, blocking estrogen action at the ER, and decreasing ER levels. However, the ultimate effectiveness of therapy is limited by either intrinsic or acquired resistance. Identifying the factors and pathways responsible for sensitivity and resistance remains a challenge in improving the treatment of breast cancer. With a better understanding of coordinated action of ER, its coregulatory factors, and the influence of other intracellular signaling cascades, improvements in breast cancer therapy are emerging
Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Abusleme Hoffman AC
- Acharya BS
- Adam Bourdarios C
- Adamczyk L
- Adamek L
- Addepalli SV
- Addison MJ
- Adelman J
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agaras MN
- Agarwala J
- Aggarwal A
- Agheorghiesei C
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ahuja S
- Ai X
- Aielli G
- Aikot A
- Ait Tamlihat M
- Aitbenchikh B
- Aizenberg I
- Akbiyik M
- Akimov AV
- Akiyama D
- Akolkar NN
- Al Khoury K
- Alberghi GL
- Albert J
- Albicocco P
- Albouy GL
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi F
- Algren M
- Alhroob M
- Ali B
- Ali HMJ
- Ali S
- Alibocus SW
- Aliev M
- Alimonti G
- Alkakhi W
- Allaire C
- Allbrooke BMM
- Allen JF
- Allendes Flores CA
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alvarez Estevez M
- Alvarez Fernandez A
- Alves Cardoso M
- Alviggi MG
- Aly M
- Amaral Coutinho Y
- Ambler A
- Amelung C
- Amerl M
- Ames CG
- Amidei D
- Amor Dos Santos SP
- Amos KR
- Ananiev V
- Anastopoulos C
- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Anulli F
- Aoki M
- Aoki T
- Aparisi Pozo JA
- Aparo MA
- Aperio Bella L
- Appelt C
- Apyan A
- Aranzabal N
- Arcangeletti C
- Arce ATH
- Arena E
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Arnaez O
- Arnold H
- Artoni G
- Asada H
- Asai K
- Asai S
- Asbah NA
- Assamagan K
- Astalos R
- Atashi S
- Atkin RJ
- Atkinson M
- Atmani H
- Atmasiddha PA
- Augsten K
- Auricchio S
- Auriol AD
- Austrup VA
- Avolio G
- Axiotis K
- Azuelos G
- Babal D
- Bachacou H
- Bachas K
- Bachiu A
- Backman F
- Badea A
- Bagnaia P
- Bahmani M
- Bailey AJ
- Bailey VR
- Baines JT
- Baines L
- Bakalis C
- Baker OK
- Bakos E
- Bakshi Gupta D
- Balakrishnan V
- Balasubramanian R
- Baldin EM
- Balek P
- Ballabene E
- Balli F
- Baltes LM
- Balunas WK
- Balz J
- Banas E
- Bandieramonte M
- Bandyopadhyay A
- Bansal S
- Barak L
- Barakat M
- Barberio EL
- Barberis D
- Barbero M
- Barel MZ
- Barends KN
- Barillari T
- Barisits M-S
- Barklow T
- Baron Moreno DA
- Baron P
- Baroncelli A
- Barone G
- Barr AJ
- Barr JD
- Barranco Navarro L
- Barreiro Guimarães da Costa J
- Barreiro F
- Barron U
- Barros Teixeira MG
- Barsov S
- Bartels F
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- Barton AE
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- Basan A
- Baselga M
- Bassalat A
- Basso MJ
- Basson CR
- Bates RL
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- Batley JR
- Batool B
- Battaglia M
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- Bauer M
- Bauer P
- Bazzano Hurrell LT
- Beacham JB
- Beau T
- Beauchemin PH
- Becherer F
- Bechtle P
- Beck HP
- Becker K
- Becot C
- Beddall AJ
- Bednyakov VA
- Bee CP
- Beemster LJ
- Beermann TA
- Begalli M
- Begel M
- Behera A
- Behr JK
- Beirer JF
- Beisiegel F
- Belfkir M
- Bella G
- Bellagamba L
- Bellerive A
- Bellos P
- Beloborodov K
- Belyaev NL
- Benchekroun D
- Bendebba F
- Benhammou Y
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Bergeaas Kuutmann E
- Berger N
- Bergmann B
- Beringer J
- Bernardi G
- Bernius C
- Bernlochner FU
- Bernon F
- Berry T
- Berta P
- Berthold A
- Bertram IA
- Bethke S
- Betti A
- Bevan AJ
- Bhamjee M
- Bhatta S
- Bhattacharya DS
- Bhattarai P
- Bhopatkar VS
- Bi R
- Bianchi RM
- Bianco G
- Biebel O
- Bielski R
- Biglietti M
- Billoud TRV
- Bindi M
- Bingul A
- Bini C
- Biondini A
- Birch-sykes CJ
- Bird GA
- Birman M
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- Biryukov S
- Bisanz T
- Bisceglie E
- Biswal JP
- Biswas D
- Bitadze A
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- Bloch I
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- Blumenthal J
- Bobbink GJ
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- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bokan P
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- Bomben M
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- Boonekamp M
- Booth CD
- Borbély AG
- Bordulev IS
- Borecka-Bielska HM
- Borgna LS
- Borissov G
- Bortoletto D
- Boscherini D
- Bosman M
- Bossio Sola JD
- Bouaouda K
- Bouchhar N
- Boudreau J
- Bouhova-Thacker EV
- Boumediene D
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- Boveia A
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- Boye D
- Boyko IR
- Bracinik J
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- Brandt G
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- Brau B
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- Brener R
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- Brenner R
- Bressler S
- Britton D
- Britzger D
- Brock I
- Brooijmans G
- Brooks WK
- Brost E
- Brown LM
- Bruce LE
- Bruckler TL
- Bruckman de Renstrom PA
- Bruni A
- Bruni G
- Bruschi M
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- Brüers B
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- Buat Q
- Buchin D
- Buckley AG
- Bulekov O
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- Burgard CD
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- Burr JTP
- Burton CD
- Burzynski JC
- Busch EL
- Bussey PJ
- Butler JM
- Buttar CM
- Butterworth JM
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- Buxo Vazquez CJ
- Buzykaev AR
- Büscher V
- Cabrera Urbán S
- Cadamuro L
- Caforio D
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- Cairo VMM
- Cakir O
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- Calafiura P
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- Callea G
- Caloba LP
- Calvet D
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- Calvet TP
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- Camacho Toro R
- Camarda S
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- Camarri P
- Camerlingo MT
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- Camincher C
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- Camplani A
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- Canesse A
- Cantero J
- Cao Y
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- Carbone A
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- Cardenas JCJ
- Cardillo F
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- Carlino G
- Carlotto JI
- Carlson BT
- Carlson EM
- Carminati L
- Carnelli A
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- Carrio Argos F
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- Carter JWS
- Carter TM
- Casado MP
- Caspar M
- Castiglia EG
- Castillo Garcia L
- Castillo Gimenez V
- Castillo FL
- Castro NF
- Catinaccio A
- Catmore JR
- Cavaliere V
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- Cavasinni V
- Cekmecelioglu YC
- Celebi E
- Celli F
- Centonze MS
- Cepaitis V
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- Cetin SA
- Chadi Z
- Chakraborty D
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- Chan WY
- Chapman JD
- Chapon E
- Chargeishvili B
- Charlton DG
- Charman TP
- Chatterjee M
- Chauhan C
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chen A
- Chen B
- Chen B
- Chen H
- Chen H
- Chen J
- Chen J
- Chen M
- Chen S
- Chen SJ
- Chen X
- Chen X
- Chen Y
- Cheng CL
- Cheng HC
- Cheong S
- Cheplakov A
- Cheremushkina E
- Cherepanova E
- Cherkaoui El Moursli R
- Cheu E
- Cheung K
- Chevalier L
- Chiarella V
- Chiarelli G
- Chiedde N
- Chiodini G
- Chisholm AS
- Chitan A
- Chitishvili M
- Chizhov MV
- Choi K
- Chomont AR
- Chou Y
- Chow EYS
- Chowdhury T
- Chu KL
- Chu MC
- Chu X
- Chudoba J
- Chwastowski JJ
- Cieri D
- Ciesla KM
- Cindro V
- Ciocio A
- Cirotto F
- Citron ZH
- Citterio M
- Ciubotaru DA
- Ciungu BM
- Clark A
- Clark PJ
- Clavijo Columbie JM
- Clawson SE
- Clement C
- Clercx J
- Coadou Y
- Cobal M
- Coccaro A
- Coelho Barrue RF
- Coelho Lopes De Sa R
- Coelli S
- Cohen H
- Coimbra AEC
- Cole B
- Collot J
- Conde Muiño P
- Connell MP
- Connell SH
- Connelly IA
- Conroy EI
- Conventi F
- Cooke HG
- Cooper-Sarkar AM
- Cordeiro Oudot Choi A
- Cormier F
- Corpe LD
- Corradi M
- Corriveau F
- Cortes-Gonzalez A
- Costa MJ
- Costanza F
- Costanzo D
- Cote BM
- Cowan G
- Cranmer K
- Cremonini D
- Crescioli F
- Cristinziani M
- Cristoforetti M
- Croft V
- Crosby JE
- Crosetti G
- Crépé-Renaudin S
- Cueto A
- Cuhadar Donszelmann T
- Cui H
- Cui Z
- Cunningham WR
- Curcio F
- Czodrowski P
- Czurylo MM
- Da Cunha Sargedas De Sousa MJ
- Da Fonseca Pinto JV
- Da Via C
- Dabrowski W
- Dado T
- Dahbi S
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- Zhemchugov A
- Zheng J
- Zheng K
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- Zhulanov V
- Zimine NI
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- Ziolkowski M
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- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 01/04/2024
- Field of study
This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fb−1 of proton-proton collision data recorded at a centre-of-mass energy of √s = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations
Combination of searches for heavy spin-1 resonances using 139 fb−1 of proton-proton collision data at s = 13 TeV with the ATLAS detector
- Author
- Aad G
- Aakvaag E
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboelela M
- Aboulhorma A
- Abramowicz H
- Abreu H
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- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 19/04/2024
- Field of study
A combination of searches for new heavy spin-1 resonances decaying into different pairings of W, Z, or Higgs bosons, as well as directly into leptons or quarks, is presented. The data sample used corresponds to 139 fb−1 of proton-proton collisions at
= 13 TeV collected during 2015–2018 with the ATLAS detector at the CERN Large Hadron Collider. Analyses selecting quark pairs (qq, bb,
, and tb) or third-generation leptons (τν and ττ) are included in this kind of combination for the first time. A simplified model predicting a spin-1 heavy vector-boson triplet is used. Cross-section limits are set at the 95% confidence level and are compared with predictions for the benchmark model. These limits are also expressed in terms of constraints on couplings of the heavy vector-boson triplet to quarks, leptons, and the Higgs boson. The complementarity of the various analyses increases the sensitivity to new physics, and the resulting constraints are stronger than those from any individual analysis considered. The data exclude a heavy vector-boson triplet with mass below 5.8 TeV in a weakly coupled scenario, below 4.4 TeV in a strongly coupled scenario, and up to 1.5 TeV in the case of production via vector-boson fusion
Vitamin A derivatives in the prevention and treatment of human cancer.
- Author
- Abels JC
- Abrahm J
- Alberts DS
- Alfthan O
- Arlin ZA
- Behzadian MA
- Belisario JC
- Bertram JS
- Besa EC
- Besa EC
- Bichler E
- Bollag W
- Bollag W
- Burge-Bottenbley A
- Cassidy J
- Chapekar MS
- Clark RE
- Clark RE
- Claudy AL
- Cope FO
- Cordero AA
- Daenen S
- Di Silverio F
- Edelson Y
- Elias PM
- Evard JP
- Fitzpatrick JE
- Flynn PJ
- Fontana JA
- Gold E
- Gold EJ
- Goodman G
- Graham V
- Greenberg BR
- Grunberg SM
- Grupper CH
- Guilhou JJ
- Haydey RP
- Hong WK
- Hong WK
- Huang CC
- Hunziker T
- Ippolito F
- Jablonska S
- Jacobs C
- Jenkinson HA
- Jetten AM
- Jetten AM
- Jetten AM
- Kanerva LO
- Kerndrup G
- Kessler JF
- Kingston T
- Koch HF
- Koch HF
- Kolonel LN
- Komiyama S
- Kowalzick L
- Legha SS
- Levine N
- Levine N
- Lie SO
- Lippman SM
- Lippman SM
- Lippman SM
- Lippman SM
- Lippman SM
- Lippman SM
- Lippman SM
- Lotan R
- Lotan R
- Lotan R
- Lutzner MA
- Mahrle G
- Markowska J
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- Meyskens FL
- Meyskens FL
- Meyskens FL
- Meyskens FL
- Meyskens FL
- Michalek AM
- Misset JL
- Molin L
- Moriarty M
- Munoz N
- Neely SM
- Nemoto O
- Nilsson B
- Nishizuka Y
- Peck GL
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- Picozzi VJ
- Presant CA
- Raque CJ
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- Robert KH
- Romney SL
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- Saccomanno G
- Sahai A
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- Sankowski A
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- Schumacher A
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- Sporn MB
- Studer UE
- Surwit EA
- Thatcher N
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- Trinchieri G
- Verma AK
- Verret JL
- Wargon O
- Warrell RP
- Watson AB
- Weiner SA
- Windhorst DB
- Wolbach SB
- Yoshida O
- Zachariae H
- Ziegler JL
- Zile MH
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/08/1988
- Field of study
Vitamin A is essential for normal cellular growth and differentiation. A vast amount of laboratory data have clearly demonstrated the potent antiproliferative and differentiation-inducing effects of vitamin A and the synthetic analogues (retinoids). Recent in-vitro work has led to the exciting proposal that protein kinase-C may be centrally involved in many of retinoids' anticancer actions including the effects on ornithine decarboxylase induction, intracellular polyamine levels, and epidermal growth factor receptor number. Several intervention trials have clearly indicated that natural vitamin A at clinically tolerable doses has only limited activity against human neoplastic processes. Therefore, clinical work has focused on the synthetic derivatives with higher therapeutic indexes. In human cancer prevention, retinoids have been most effective for skin diseases, including actinic keratosis, keratoacanthoma, epidermodysplasia verruciformis, dysplastic nevus syndrome, and basal cell carcinoma. Several noncutaneous premaligancies, however, are currently receiving more attention in retinoid trials. Definite retinoid activity has been documented in oral leukoplakia, laryngeal papillomatosis, superficial bladder carcinoma, cervical dysplasia, bronchial metaplasia, and preleukemia. Significant therapeutic advances are also occurring with this class of drugs in some drug-resistant malignancies and several others that have become refractory, including advanced basal cell cancer, mycosis fungoides, melanoma, acute promyelocytic leukemia, and squamous cell carcinoma of the skin and of the head and neck. This report comprehensively presents the clinical data using retinoids as anticancer agents in human premalignant disorders and outlines the ongoing and planned studies with retinoids in combination and adjuvant therapy
Recommended from our members
Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
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- Aarestrup J
- Abarca-Gomez L
- Abbasi-Kangevari M
- Abdeen ZA
- Abdrakhmanova S
- Abdurrahmonova Z
- Abril GL
- Abu-Rmeileh NM
- Acosta-Cazares B
- Adam I
- Adamczyk M
- Adams RJ
- Adu-Afarwuah S
- Aekplakorn W
- Afsana K
- Afzal S
- Agbor VN
- Agdeppa IA
- Aghazadeh-Attari J
- Agren A
- Aguenaou H
- Aguilar-Salinas CA
- Aguilar-Salinas CA
- Agyemang C
- Ahmad MH
- Ahmad NA
- Ahmadi A
- Ahmadi N
- Ahmadi N
- Ahmed I
- Ahmed SH
- Ahrens W
- Aitmurzaeva G
- Ajlouni K
- Al Asfoor D
- Al Hourani HM
- Al Nsour M
- Al Qaoud NM
- Al-Hazzaa HM
- Al-Hinai H
- Al-Lahou B
- Al-Lawati JA
- Al-Raddadi R
- Alarouj M
- AlBuhairan F
- AlDhukair S
- Aldwairji MA
- Alexius S
- Ali MM
- Alieva AV
- Alkandari A
- Alkerwi A
- Alkhatib BM
- Allin K
- Alomary SA
- Alomirah HF
- Alshangiti AM
- Alvarez-Pedrerol M
- Aly E
- Amarapurkar DN
- Amoah J
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- Amouyel P
- Andersen LB
- Anderssen SA
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- Assuncao MCF
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- Bajramovic I
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- Bartosiewicz A
- Basit A
- Bastos JL
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- Batieha AM
- Batista AP
- Batista RL
- Battakova Z
- Baur LA
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- Villalpando S
- Vioque J
- Viriyautsahakul N
- Virtanen JK
- Visser M
- Visvikis-Siest S
- Viswanathan B
- Vladulescu M
- Vlasoff T
- Vocanec D
- Vollenweider P
- Volzke H
- Vourli G
- Voutilainen A
- Vrijheid M
- Vrijkotte TGM
- Vrkic TZ
- Vuletic S
- Wade AN
- Waldhor T
- Walton J
- Wambiya EOA
- Wanderley Junior RDS
- Wang C
- Wang H
- Wang L
- Wang L
- Wang M-D
- Wang N
- Wang Q
- Wang X
- Wang Y-W
- Wang YX
- Wannamethee SG
- Wareham N
- Wartha O
- Weber A
- Webster-Kerr K
- Webster-Kerr K
- Wedderkopp N
- Weghuber D
- Wei W
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- Westbury LD
- Whincup PH
- Wichstrom L
- Wickramasinghe K
- Widhalm K
- Widyahening IS
- Wiecek A
- Wild PS
- Wilks RJ
- Willeit J
- Willeit P
- Williams J
- Wilsgaard T
- Wirth JP
- Wojtyniak B
- Woldeyohannes M
- Wolf K
- Wong A
- Wong EB
- Wong JE
- Wong NI
- Wong TY
- Wong-McClure RA
- Woo J
- Woodward M
- Wu FC
- Wu H-Y
- Wu J
- Wu LJ
- Wu S
- Wyszynska J
- Xu H
- Xu L
- Yaacob NA
- Yamborisut U
- Yan L
- Yan W
- Yang L
- Yang X
- Yang Y
- Yardim N
- Yasuharu T
- Yiallouros PK
- Yngve A
- Yoosefi M
- Yoshihara A
- Yotov Y
- You QS
- You S-L
- Younger-Coleman NO
- Yu Y
- Yu Y-L
- Yusof SM
- Yusoff AF
- Yusoff MFM
- Zaccagni L
- Zafiropulos V
- Zainuddin AA
- Zakavi SR
- Zamani F
- Zambon S
- Zampelas A
- Zamrazilova H
- Zapata ME
- Zargar AH
- Zaw KK
- Zayed AA
- Zdrojewski T
- Zeglen M
- Zejglicova K
- Zeng Y
- Zentai A
- Zhang B
- Zhang L
- Zhang Z-Y
- Zhao D
- Zhao M-H
- Zhao W
- Zhecheva YV
- Zhen S
- Zheng W
- Zheng Y
- Zholdin B
- Zhou B
- Zhou M
- Zhu D
- Zimmet P
- Zins M
- Zitt E
- Zocalo Y
- Zoghlami N
- Zuziak M
- Publication venue
- Elsevier
- Publication date
- 14/03/2024
- Field of study
Background
Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories.
Methods
We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI 2 SD above the median).
Findings
From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining underweight or thinness.
Interpretation
The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesity.
Funding
UK Medical Research Council, UK Research and Innovation (Research England), UK Research and Innovation (Innovate UK), and European Union
Combined measurement of the Higgs boson mass from the H → γγ and H → ZZ∗ → 4ℓ decay channels with the ATLAS detector using √s = 7, 8, and 13 TeV pp collision data
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- Abbott B
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- Abicht NJ
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- Addepalli SV
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- Zhemchugov A
- Zheng J
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- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- American Physical Society
- Publication date
- 01/01/2023
- Field of study
A measurement of the mass of the Higgs boson combining the
H
→
Z
Z
∗
→
4
ℓ
and
H
→
γ
γ
decay channels is presented. The result is based on
140
fb
−
1
of proton-proton collision data collected by the ATLAS detector during LHC run 2 at a center-of-mass energy of 13 TeV combined with the run 1 ATLAS mass measurement, performed at center-of-mass energies of 7 and 8 TeV, yielding a Higgs boson mass of
125.11
±
0.09
(
stat
)
±
0.06
(
syst
)
=
125.11
±
0.11
GeV
. This corresponds to a 0.09% precision achieved on this fundamental parameter of the Standard Model of particle physics
- …