Depressive disorders in caregivers of dementia patients: a systematic review.

Although depressive symptomatology has been well studied in caregivers of patients with dementia, depressive disorders have been examined much less. We conducted a systematic literature search in major bibliographical databases (Medline, Psychinfo, Dissertation Abstracts), and included studies examining caregivers of dementia patients that reported the prevalence of major depressive disorder, according to diagnostic criteria as assessed with a standardized psychiatric diagnostic interview. Ten studies with a total of 790 caregivers were identified (sample sizes: 22–147). In only one of the studies, a representative community sample was used. A total of 176 subjects (22.3%) had a depressive disorder (prevalence range from 0.15–0.32). In the three studies reporting differential prevalence rates for men and women somewhat smaller prevalence rates were found for men than for women. In six studies caregivers were compared to a (mostly matched) control group. The relative risks of having a depressive disorder in caregivers ranged from 2.80–38.68 (all RR’s were significant). In the three prospective studies relatively high incidence rates were found (0.48). This study made it clear that prevalence and incidence of depressive disorders are increased in caregivers of dementia patients. More research is clearly needed in this population

Experimental investigation on camera calibration for 3D photogrammetric scanning of micro-features for micrometric resolution

[EN] Recently, it has been demonstrated that photogrammetry can be used for the measurement of small objects with micro-features, with good results and lower cost, compared to other established techniques such as interferometry, conoscopic holography, and 3D microscopy. Calibration is a critical step in photogrammetry and the classical pinhole camera model has been tested for magnifications lower than 2×. At higher magnification levels, because of the reduction of the depth of field (DOF), images can lead to calibration data with low reprojection errors. However, this could lead to bad results in the 3D reconstruction. With the aim of verifying the possibility of applying the camera model to magnifications higher than 2×, experiments have been conducted using reflex cameras with 60 mm macro lens, equipped with the combination of three extension tubes, corresponding to 2.06, 2.23, and 2.4 magnification levels, respectively. Experiments consisted of repeating calibration five times for each configuration and testing each calibration model, measuring two artifacts with different geometrical complexity. The calibration results have shown good repeatability of a subset of the internal calibration parameters. Despite the differences in the calibration reprojection error (RE), the quality of the photogrammetric 3D models retrieved was stable and satisfying. The experiment demonstrated the possibilities of the photogrammetric system presented, equipped to very high magnification levels, to retrieve accurate 3D reconstruction of micro-features with uncertainties of few micrometers, comparable with industry s expensive state-of-the-art technologies.Percoco, G.; Guerra, MG.; Sánchez Salmerón, AJ.; Galantucci, LM. (2017). Experimental investigation on camera calibration for 3D photogrammetric scanning of micro-features for micrometric resolution. The International Journal of Advanced Manufacturing Technology. 91(9-12):2935-2947. https://doi.org/10.1007/s00170-016-9949-6S29352947919-12Uhlmann E, Mullany B, Biermann D, Rajurkar KP, Hausotte T, Brinksmeier E (2016) Process chains for high-precision components with micro-scale features. CIRP Ann - Manuf Technol 65:549–572. doi: 10.1016/j.cirp.2016.05.001Savio E, De Chiffre L, Schmitt R (2007) Metrology of freeform shaped parts. CIRP Ann - Manuf Technol 56:810–835. doi: 10.1016/j.cirp.2007.10.008Rodríguez-martín M, Lagüela S, González-aguilera D, Rodríguez-gonzálvez P (2015) Optics & Laser Technology Procedure for quality inspection of welds based on macro-photogrammetric three-dimensional reconstruction;73:54–62Xu Z, Toncich D, Stefani S (1999) Vision-based measurement of three-dimensional geometric workpiece properties. Int J Adv Manuf Technol 15:322–331. doi: 10.1007/s001700050074Galantucci LM, Lavecchia F, Percoco G (2013) Multistack close range photogrammetry for low cost submillimeter metrology. J Comput Inf Sci Eng 13:44501. doi: 10.1115/1.4024973Maté González, M.T., Yravedra, J., González-Aguilera, D., Palomeque-González, J.F., Domínguez-Rodrigo, M. Micro-photogrammetric characterization of cut marks on bones (2015) Journal of Archaeological Science, 62, pp. 128-142. doi: 10.1016/j.jas.2015.08.006Brown DC (1971) Close-range camera calibration. Photogramm Eng 37:855–866 doi:10.1.1.14.6358Tang R, Fritsch D (2013) Correlation analysis of camera self-calibration in close range photogrammetry. Photogramm Rec 28:86–95. doi: 10.1111/phor.12009Agisoft LLC (2011) Agisoft PhotoScan User Manual :37.Jcgm JCFGIM (2008) Evaluation of measurement data—guide to the expression of uncertainty in measurement- annex B "general metrological terms"- B.2.14. Int Organ Stand Geneva ISBN 50:134. doi: 10.1373/clinchem.2003.030528Yanagi, H., Chikatsu, H. Performance evaluation of macro lens in digital close range photogrammetry (2009) Proceedings of SPIE - The International Society for Optical Engineering, 7447, art. no. 74470J, doi: 10.1117/12.825817Galantucci LM, Pesce M, Lavecchia F (2015) A stereo photogrammetry scanning methodology, for precise and accurate 3D digitization of small parts with sub-millimeter sized features. CIRP Ann - Manuf Technol 64:507–510. doi: 10.1016/j.cirp.2015.04.016Galantucci LM, Pesce M, Lavecchia F (2015) A powerful scanning methodology for 3D measurements of small parts with complex surfaces and sub millimeter-sized features, based on close range photogrammetry. Precis Eng. doi: 10.1016/j.precisioneng.2015.07.010Percoco G, Sánchez Salmerón AJ (2015) Photogrammetric measurement of 3D freeform millimetre-sized objects with micro features: an experimental validation of the close-range camera calibration model for narrow angles of view. Meas Sci Technol 26:95203. doi: 10.1088/0957-0233/26/9/095203Gallo A, Muzzupappa M, Bruno F (2014) 3D reconstruction of small sized objects from a sequence of multi-focused images. J Cult Herit 15:173–182. doi: 10.1016/j.culher.2013.04.009Stamatopoulos C, Fraser CS, Cronk S (2010) On the self-calibration of long focal length lenses. Int Arch Photogramm Remote Sens Spat Inf Sci Newcastle upon Tyne, UK 2010 XXXVIII:560–564Atkinson KB (1996) Close range photogrammetry and machine vision. Whittles PublishingLuhmann T, Fraser C, Maas HG (2016) Sensor modelling and camera calibration for close-range photogrammetry. ISPRS J Photogramm Remote Sens 115:37–46. doi: 10.1016/j.isprsjprs.2015.10.006Tsai RY (1986) An efficient and accurate camera calibration technique for 3D machine vision. Proc IEEE Conf Comput Vis Pattern Recognition 1986Ricolfe-Viala C, Sanchez-Salmeron A-J (2011) Camera calibration under optimal conditions. Opt Express 19:10769–10775. doi: 10.1364/OE.19.010769Wang L, Wang W, Shen C, Duan F (2016) A convex relaxation optimization algorithm for multi-camera calibration with 1D objects. NeurocomputingRicolfe-Viala C, Sanchez-Salmeron A. Lens distortion models evaluation. Appl Opt 2010;49:5914–5928.Percoco G, Lavecchia F, Salmerón AJS (2015) Preliminary study on the 3D digitization of millimeter scale products by means of photogrammetry. Procedia CIRP 33:257–262. doi: 10.1016/j.procir.2015.06.046Bradski G (2000) The OpenCV Library. Dr Dobb’s J Softw ToolsRicolfe-Viala C, Sanchez-Salmeron A-J (2011) Optimal conditions for camera calibration using a planar template. 2011 18th IEEE. Int Conf Image Process, IEEE 2011:853–856. doi: 10.1109/ICIP.2011.6116691Lowe DG (1999) Object recognition from local scale-invariant features. Proc Seventh IEEE Int Conf Comput Vis 2:1150–1157. doi: 10.1109/ICCV.1999.790410Triggs B, Mclauchlan P, Hartley R, Fitzgibbon A, Triggs B, Mclauchlan P, et al. (2010) Bundle adjustment—a modern synthesis to cite this version: bundle adjustment—a modern synthesisCignoni P, Callieri M, Corsini M, Dellepiane M, Ganovelli F, Ranzuglia G (2008) Meshlab: an open-source mesh processing tool. Eurographics Ital Chapter Conf 2008:129–136Besl P, McKay N (1992) A method for registration of 3-D shapes. IEEE Trans Pattern Anal Mach Intell 14:239–256. doi: 10.1109/34.12179

A new technique for mandibular osteotomy

Sagittal split osteotomy (SSO) is a surgical technique largely employed for mandibular mobilizations in orthognatic procedures. However, the traditional design of buccal osteotomy, located at the junction of mandibular ramus and body, may prevent more extensive sliding between the bone segments, particularly on the advance, laterality and verticality of the mandibular body. The author proposes a new technical and conceptual solution, in which osteotomy is performed in a more distal region, next to the mental formamen. Technically, the area of contact between medullary-cancellous bone surfaces is increased, resulting in larger sliding rates among bone segments; it also facilitates the use of rigid fixation systems, with miniplates and monocortical screws. Conceptually, it interferes with the resistance arm of the mandible, seen as an interpotent lever of the third gender

Satisfação no trabalho da equipe de enfermagem: revisão integrativa

Job satisfaction consists of a feeling of wellbeing, resulting from the interaction of several occupational aspects, and may influence the worker's relationship with the organization, clients and family. Hence, it becomes important for the quality of nursing care to reflect on this topic in depth. Therefore, this study aimed to examine the scientific evidence related to job satisfaction in Brazilian nursing. An integrative literature review was carried out in the databases LILACS, MEDLINE, BDENF and Cochrane Library, totaling 17 publications, categorized in: Job Satisfaction, Job Dissatisfaction and Associated Factors. It was concluded that job satisfaction is determined by a complex network of factors and may vary depending on the group studied. Additional research, particularly of evidence level III in different nursing fields, covering all of Brazil, is necessary to support the implementation of occupational improvements.La satisfacción en el trabajo consiste en un sentimiento de bienestar resultante de la interacción de varios aspectos ocupacionales, pudiendo influenciar la relación del trabajador con la organización, clientes y familia. Es importante para la calidad de la asistencia de enfermería realizar una reflexión profunda sobre este tema, por eso se objetivó en este estudio analizar las evidencias científicas referentes a la satisfacción en el trabajo del equipo de enfermería brasileño. Se trató de una revisión integradora de la literatura en las bases de datos LILACS, MEDLINE, BDENF y Biblioteca Cochrane, totalizando 17 publicaciones categorizadas en: Satisfacción en el Trabajo, Insatisfacción en el Trabajo y Factores Asociados. Se concluyó que la satisfacción en el trabajo es determinada por una red compleja de factores, pudiendo variar conforme el grupo estudiado. Investigaciones adicionales, especialmente con niveles de evidencias III, en diferentes campos de actuación de la enfermería, abarcando todo el Brasil, son necesarias para subsidiar la implantación de mejorías ocupacionales.A satisfação no trabalho consiste em sentimento de bem-estar. resultante da interação de vários aspectos ocupacionais, podendo influenciar a relação do trabalhador com a organização, clientes e família. Torna-se importante, para a qualidade da assistência de enfermagem, reflexão aprofundada sobre esse tema, e, por isso, objetivou-se neste estudo analisar as evidências científicas referentes à satisfação no trabalho da equipe de enfermagem brasileira. Trata-se de revisão integrativa da literatura nas bases de dados LILACS, MEDLINE, BDENF e Biblioteca Cochrane, totalizando 17 publicações categorizadas em: satisfação no trabalho, insatisfação no trabalho e fatores associados. Conclui-se que a satisfação no trabalho é determinada por rede complexa de fatores, podendo variar conforme o grupo estudado. Pesquisas adicionais, especialmente com níveis de evidências III, em diferentes campos de atuação da enfermagem, abrangendo todo Brasil, são necessárias para subsidiar a implantação de melhorias ocupacionais

Temperature Modulation of Electric Fields in Biological Matter

Pulsed electric fields (PEF) have become an important minimally invasive surgical technology for various applications including genetic engineering, electrochemotherapy and tissue ablation. This study explores the hypothesis that temperature dependent electrical parameters of tissue can be used to modulate the outcome of PEF protocols, providing a new means for controlling and optimizing this minimally invasive surgical procedure. This study investigates two different applications of cooling temperatures applied during PEF. The first case utilizes an electrode which simultaneously delivers pulsed electric fields and cooling temperatures. The subsequent results demonstrate that changes in electrical properties due to temperature produced by this configuration can substantially magnify and confine the electric fields in the cooled regions while almost eliminating electric fields in surrounding regions. This method can be used to increase precision in the PEF procedure, and eliminate muscle contractions and damage to adjacent tissues. The second configuration considered introduces a third probe that is not electrically active and only applies cooling boundary conditions. This second study demonstrates that in this probe configuration the temperature induced changes in electrical properties of tissue substantially reduce the electric fields in the cooled regions. This novel treatment can potentially be used to protect sensitive tissues from the effect of the PEF. Perhaps the most important conclusion of this investigation is that temperature is a powerful and accessible mechanism to modulate and control electric fields in biological tissues and can therefore be used to optimize and control PEF treatments

Formyl Peptide Receptor as a Novel Therapeutic Target for Anxiety-Related Disorders

Formyl peptide receptors (FPR) belong to a family of sensors of the immune system that detect microbe-associated molecules and inform various cellular and sensorial mechanisms to the presence of pathogens in the host. Here we demonstrate that Fpr2/3-deficient mice show a distinct profile of behaviour characterised by reduced anxiety in the marble burying and light-dark box paradigms, increased exploratory behaviour in an open-field, together with superior performance on a novel object recognition test. Pharmacological blockade with a formyl peptide receptor antagonist, Boc2, in wild type mice reproduced most of the behavioural changes observed in the Fpr2/3(-/-) mice, including a significant improvement in novel object discrimination and reduced anxiety in a light/dark shuttle test. These effects were associated with reduced FPR signalling in the gut as shown by the significant reduction in the levels of p-p38. Collectively, these findings suggest that homeostatic FPR signalling exerts a modulatory effect on anxiety-like behaviours. These findings thus suggest that therapies targeting FPRs may be a novel approach to ameliorate behavioural abnormalities present in neuropsychiatric disorders at the cognitive-emotional interface

Prevention of Vitamin D deficiency in infancy: daily 400 IU vitamin D is sufficient

<p>Summary</p> <p>Aim-objective</p> <p>Vitamin D deficiency and rickets in developing countries continues to be a major health problem. Additionally, the increase of cases of rickets in children of some ethnic groups in the United States and European countries has provided this issue to be updated. Obviously, powerful strategies are necessary to prevent vitamin D deficiency nation-wide. In 2005, a nationwide prevention program for vitamin D deficiency was initiated, recommending 400 IU vitamin D per a day.</p> <p>This study was designed to evaluate the efficacy of the prevention program.</p> <p>Methods</p> <p>Eighty-five infants who were recalled as part of the national screening program for congenital hypothyroidism between February 2010 and August 2010 at Kocaeli University Children's Hospital were evaluated in terms of their vitamin D status as well. All babies had been provided with free vitamin D (Cholecalciferol) solution and recommended to receive 400 IU (3 drops) daily. Information regarding the age at start of supplementation, the dosage and compliance were obtained from the mothers with face-to-face interview. Serum 25-hydroxy vitamin D (25-OH-D), alkaline phosphatase (AP), parathormone (PTH) levels were measured.</p> <p>Results</p> <p>The mean age at which Vitamin D3 supplementation began was 16.5 ± 20.7 (3-120) days. Ninety percent of cases (n:76) were receiving 3 drops (400 IU) vitamin D3 per day as recommended; 70% of cases (n:59) were given vitamin D3 regularly, the remainder had imperfect compliance. Among those children who are older than 12 months, only 20% continued vitamin D supplementation. No subject had clinical signs of rickets. The mean 25-OH-D level was 42,5 ± 25,8 (median: 38.3) ng/ml. Ten subjects (12%) had their serum 25-OH-D levels lower than 20 ng/ml (6 between 15-20 ng/ml, 3 between 5-15 ng/ml and only one < 5 ng/ml).</p> <p>Conclusions</p> <p>400 U/day vitamin D seems adequate to prevent vitamin D deficiency. However, we believe that the program for preventing vitamin D deficiency in Turkey, needs to be reinforced to start immediately after birth, and to continue beyond 1 year of age at 400U regular daily dosage.</p