Geothermal Energy Utilisation -Ireland Country Update

ABSTRACT Geothermal energy in Ireland is dominated by the exploitation of low temperature resources for space heating using heat pumps. Domestic ground source heat pumps installations for space heating and domestic hot water are the principal application despite a decline in the number of domestic installations between 2010 and 2014. The slower but steady increase in the number of heat pump units installed in Ireland between 2010 and 2014 accounts for a total of 177 MWt installed capacity (a 13 MWt increase from the WGC 2010 report). The recent difficult economic situation and the end of the dedicated financial support for domestic ground source heat pumps has resulted in fewer systems being installed during this period, with the main deployment attributed to large scale open and closed loop ground source systems with individual installed capacities of up to 2 MWt in size. Since the initial exploration drilling on the southern margin of the Dublin Basin, the deep geothermal energy sector has progressed very slowly. Despite encouraging results from 2D seismic reflection surveys at the Newcastle project and planning for the first deep geothermal electricity plant being granted in late 2010, the lack of subsidies for geothermal electricity generation and the holdup in the implementation of a legislative framework for licensing deep geothermal resource exploration and development have stalled the sector. Extensive research aimed at better understanding deep geothermal resources in different geological settings in Ireland is being undertaken. A number of initiatives to stimulate a sustainable future development of the shallow geothermal energy sector in Ireland are being implemented. These are aimed at tackling some of the barriers to the future development of the geothermal sector that have been identified. Technical guideline documentation and new interactive mapping of the shallow geothermal resources and their potential for deployment in Ireland are being developed with a view to providing standards for system installation and increasing public awareness amongst users and local authorities about shallow geothermal energy potential. The structure of a national database of ground source systems is being developed with a view to improving the reporting of shallow geothermal energy installations in Ireland. New comprehensive training initiatives and certification for industry stakeholders involved in design and installation of systems are currently being undertaken

Jizz and the joy of pattern recognition:virtuosity, discipline and the agency of insight in UK naturalists’ arts of seeing

Approaches to visual skilling from anthropology and STS have tended to highlight the forces of discipline and control in understanding how shared visual accounts of the world are created in the face of potential differences brought about by multi-sensorial perception. Drawing upon a range of observational and interview material from an immersion in naturalist training and biological recording activities between 2003 and 2009, I focus upon jizz, a distinct form of gestalt perception much coveted by naturalist communities in the UK. Jizz is described as a tacit and embodied way of seeing that instantaneously reveals the identity of a species, relying upon but simultaneously suspending the arduous and meticulous study of an organism’s diagnostic characteristics. I explore the potential and limitations of jizz to allow for both visual precision and an enchanted and varied form of encounter with nature. In so doing, I explore how the specific characteristics of wild, intangible and irreverent virtuoso performance work closely together with disciplining taxonomic standards. As such, discipline and irreverence work together, are mutually enabling, and allow for an accommodation rather than a segregation of potential difference brought about by perceptual variety

Contextuality and nonlocality in 'no signaling' theories

We define a family of 'no signaling' bipartite boxes with arbitrary inputs and binary outputs, and with a range of marginal probabilities. The defining correlations are motivated by the Klyachko version of the Kochen-Specker theorem, so we call these boxes Kochen-Specker-Klyachko boxes or, briefly, KS-boxes. The marginals cover a variety of cases, from those that can be simulated classically to the superquantum correlations that saturate the Clauser-Horne-Shimony-Holt inequality, when the KS-box is a generalized PR-box (hence a vertex of the `no signaling' polytope). We show that for certain marginal probabilities a KS-box is classical with respect to nonlocality as measured by the Clauser-Horne-Shimony-Holt correlation, i.e., no better than shared randomness as a resource in simulating a PR-box, even though such KS-boxes cannot be perfectly simulated by classical or quantum resources for all inputs. We comment on the significance of these results for contextuality and nonlocality in 'no signaling' theories.Comment: 22 pages. Changes to Introduction and final Commentary section. Added two tables, one to Section 5, and some new reference

Kaposiform hemangioendothelioma in tonsil of a child associated with cervical lymphangioma: a rare case report

Kaposiform hemangioendothelioma (KHE) is an uncommon vascular tumor of intermediate malignant potential, usually occurs in the extremities and retroperitoneum of infants and is characterized by its association with lymphangiomatosis and Kasabach-Merritt phenomenenon (KMP) in certain cases. It has rarely been observed in the head and neck region and at times, can present without KMP. Herein, we present an extremely uncommon case of KHE occurring in tonsil of a child, associated with a neck swelling, but unassociated with KMP. A 2-year-old male child referred to us with history of sore throat, dyspnoea and right-sided neck swelling off and on, since birth, was clinicoradiologically diagnosed with recurrent tonsillitis, including right sided peritonsillar abscess, for which he underwent right-sided tonsillectomy, elsewhere. Histopathological sections from the excised tonsillar mass were reviewed and showed a tumor composed of irregular, infiltrating lobules of spindle cells arranged in kaposiform architecture with slit-like, crescentic vessels. The cells displayed focal lumen formation containing red blood cells (RBCs), along with platelet thrombi and eosinophilic hyaline bodies. In addition, there were discrete foci of several dilated lymphatic vessels containing lymph and lymphocytes. On immunohistochemistry (IHC), spindle cells were diffusely positive for CD34, focally for CD31 and smooth muscle actin (SMA), the latter marker was mostly expressed around the blood vessels. Immunostaining for HHV8 was negative and Ki-67 (proliferation marker) displayed focal positivity. Diagnosis of KHE was made. Platelet count was towards lower side of range. Postoperative imaging showed discrete, multiple fluid containing lesions in the right neck that were high on T2-weighed sequences, on magnetic resonance imaging (MRI) and ipsilateral intraoral mucosal growth. Fine needle aspiration cytology (FNAC) smears from neck swelling showed blood, fluid and lymphocytes. Possibility of a coexisting lymphangioma was considered. The patient was offered sclerotherapy and is on follow-up. This case forms the second documented case of KHE at this site, along with its unique association with neck lymphangioma. KHE has distinct histopathological features and can be sorted out from its other differentials like juvenile hemangioma and Kaposi's sarcoma. IHC stains are useful in substantiating a definite diagnosis

Inhibiting ERK Activation with CI-1040 Leads to Compensatory Upregulation of Alternate MAPKs and Plasminogen Activator Inhibitor-1 following Subtotal Nephrectomy with No Impact on Kidney Fibrosis

Extracellular-signal regulated kinase (ERK) activation by MEK plays a key role in many of the cellular processes that underlie progressive kidney fibrosis including cell proliferation, apoptosis and transforming growth factor β1-mediated epithelial to mesenchymal transition. We therefore assessed the therapeutic impact of ERK1/2 inhibition using a MEK inhibitor in the rat 5/6 subtotal nephrectomy (SNx) model of kidney fibrosis. There was a twentyfold upregulation in phospho-ERK1/2 expression in the kidney after SNx in Male Wistar rats. Rats undergoing SNx became hypertensive, proteinuric and developed progressive kidney failure with reduced creatinine clearance. Treatment with the MEK inhibitor, CI-1040 abolished phospho- ERK1/2 expression in kidney tissue and prevented phospho-ERK1/2 expression in peripheral lymphocytes during the entire course of therapy. CI-1040 had no impact on creatinine clearance, proteinuria, glomerular and tubular fibrosis, and α-smooth muscle actin expression. However, inhibition of ERK1/2 activation led to significant compensatory upregulation of the MAP kinases, p38 and JNK in kidney tissue. CI-1040 also increased the expression of plasminogen activator inhibitor-1 (PAI-1), a key inhibitor of plasmin-dependent matrix metalloproteinases. Thus inhibition of ERK1/2 activation has no therapeutic effect on kidney fibrosis in SNx possibly due to increased compensatory activation of the p38 and JNK signalling pathways with subsequent upregulation of PAI-1

Routes for breaching and protecting genetic privacy

We are entering the era of ubiquitous genetic information for research, clinical care, and personal curiosity. Sharing these datasets is vital for rapid progress in understanding the genetic basis of human diseases. However, one growing concern is the ability to protect the genetic privacy of the data originators. Here, we technically map threats to genetic privacy and discuss potential mitigation strategies for privacy-preserving dissemination of genetic data.Comment: Draft for comment

A cross-national study on the antecedents of work–life balance from the fit and balance perspective

Drawing on the perceived work–family fit and balance perspective, this study investigates demands and resources as antecedents of work–life balance (WLB) across four countries (New Zealand, France, Italy and Spain), so as to provide empirical cross-national evidence. Using structural equation modelling analysis on a sample of 870 full time employees, we found that work demands, hours worked and family demands were negatively related to WLB, while job autonomy and supervisor support were positively related to WLB. We also found evidence that resources (job autonomy and supervisor support) moderated the relationships between demands and work–life balance, with high resources consistently buffering any detrimental influence of demands on WLB. Furthermore, our study identified additional predictors of WLB that were unique to some national contexts. For example, in France and Italy, overtime hours worked were negatively associated with WLB, while parental status was positively associated with WLB. Overall, the implications for theory and practice are discussed.Peer ReviewedPostprint (author's final draft