Terrestrial exposure of a fresh Martian meteorite causes rapid changes in hydrogen isotopes and water concentrations

Determining the hydrogen isotopic compositions and H2O contents of meteorites and their components is important for addressing key cosmochemical questions about the abundance and source(s) of water in planetary bodies. However, deconvolving the effects of terrestrial contamination from the indigenous hydrogen isotopic compositions of these extraterrestrial materials is not trivial, because chondrites and some achondrites show only small deviations from terrestrial values such that even minor contamination can mask the indigenous values. Here we assess the effects of terrestrial weathering and contamination on the hydrogen isotope ratios and H2O contents of meteoritic minerals through monitored terrestrial weathering of Tissint, a recent Martian fall. Our findings reveal the rapidity with which this weathering affects nominally anhydrous phases in extraterrestrial materials, which illustrates the necessity of sampling the interiors of even relatively fresh meteorite falls and underlines the importance of sample return missions

Best in Class International Franchising: Report for the UK Retail Sector

Retailing is such a fast-moving industry it is difficult to keep on top of changes in domestic markets, let alone those in geographically and culturally distant foreign markets. Although it is tempting for a UK-based retailer to remain domestic and focus on strengthening their competitive position in the UK before going overseas, the most successful retailers continuously explore what it takes to operate effectively across national borders. UK retailers need to “think bigger” if they are to escape the economic slowdown of Western Europe. There is now a renewed push for internationalisation by UK firms and they are setting adventurous growth targets. Retailing is fast becoming a global industry and it is vital for “UK plc” that our leading retailers are successful in emerging markets. Against this backdrop, we conducted a study of one type of foreign market entry mode, namely franchising. We propose that franchising is to retailing what exporting is to manufacturing. It is a low-risk, low-involvement way for retailers to enter risky foreign markets, but which nevertheless must be professionally executed. In order to shed light on how UK retailers can make franchising work in emerging markets, we focus on the advanced franchising model used by one particular retailer. This model has been developed over decades of steady expansion of its franchising operations overseas. As well as examining their franchising operations, the study gathered a range of other information on international franchising in order to develop a complete picture of good practices. It is unlikely that a firm with a fast-moving, complex product assortment (e.g., general merchandise) will be able to follow the franchising model of dealing with many small franchisees across many foreign markets (i.e., the McDonald’s model). Indeed, the focal retailer uses an area development franchising approach, targeting franchisees that have capabilities sufficient to develop and manage a franchisor-branded store network in their country or region. While not equals, given the franchisor’s ownership of the brand, such relationships operate as partnerships. Franchisees are empowered to exert influence and use their local know-how to help meet the precise needs of foreign customers. Unlike in traditional franchising partnerships, where the franchisor is in control and intensively monitors across its network of franchisees, we observe that cross-border franchising may be optimally developed through openly communicating with and trusting a capable partner. The differences between emerging markets and the UK can be so extreme that it is difficult for the franchisor to control operations there, irrespective of their resource base and experience. In effect, the franchisor is reliant on the franchisee to make and implement decisions in the local marketplace and absorb risks. The overseas franchisees can effectively play a role in building the brand with the franchisor through a form of alliance. Knowledge exchange is crucial not only in the running of the franchise partnership but also for the franchisor’s learning about local market conditions and growth opportunities. When operating in emerging markets the franchisor needs to “learn from their experiences all the time”. UK retail brands resonate strongly amongst aspirational, emerging market customers. Yet, retailers can be slow to go overseas if they perceive differences in, and lack familiarity with, foreign markets. This is where franchising comes in. Far from being a basic business model, best-in-class franchising can be made to play a central role in overseas retailing due to its ability to mitigate threats and seek out growth opportunities. Furthermore, UK retailers can derive flexibility advantages from using franchising in emerging markets as the basis upon which to expand into other, higher-profit equity-based modes (e.g., joint ventures) if and when local circumstances dictate this

Time-to-birth prediction models and the influence of expert opinions

Preterm birth is the leading cause of death among children under five years old. The pathophysiology and etiology of preterm labor are not yet fully understood. This causes a large number of unnecessary hospitalizations due to high--sensitivity clinical policies, which has a significant psychological and economic impact. In this study, we present a predictive model, based on a new dataset containing information of 1,243 admissions, that predicts whether a patient will give birth within a given time after admission. Such a model could provide support in the clinical decision-making process. Predictions for birth within 48 h or 7 days after admission yield an Area Under the Curve of the Receiver Operating Characteristic (AUC) of 0.72 for both tasks. Furthermore, we show that by incorporating predictions made by experts at admission, which introduces a potential bias, the prediction effectiveness increases to an AUC score of 0.83 and 0.81 for these respective tasks

A 4% Geometric Distance to the Galaxy NGC4258 from Orbital Motions in a Nuclear Gas Disk

The water maser in the mildly active nucleus in the nearby galaxy NGC4258 traces a thin, nearly edge-on, subparsec-scale Keplerian disk. Using the technique of very long baseline interferometry, we have detected the proper motions of these masers as they sweep in front of the central black hole at an orbital velocity of about 1100 km/s. The average maser proper motion of 31.5 microarcseconds per year is used in conjunction with the observed acceleration of the masers to derive a purely geometric distance to the galaxy of 7.2 +- 0.3 Mpc. This is the most precise extragalactic distance measured to date, and, being independent of all other distance indicators, is likely to play an important role in calibrating the extragalactic distance scale.Comment: 11 pages, 3 figures. Accepted for publication in Natur

\u201cGive, but Give until It Hurts\u201d: The Modulatory Role of Trait Emotional Intelligence on the Motivation to Help

Two studies investigated the effect of trait Emotional Intelligence (trait EI) on people\u2019s moti- vation to help. In Study 1, we developed a new computer-based paradigm that tested partic- ipants\u2019 motivation to help by measuring their performance on a task in which they could gain a hypothetical amount of money to help children in need. Crucially, we manipulated partici- pants\u2019 perceived efficacy by informing them that they had been either able to save the chil- dren (positive feedback) or unable to save the children (negative feedback). We measured trait EI using the Trait Emotional Intelligence Questionnaire\u2013Short Form (TEIQue-SF) and assessed participants\u2019 affective reactions during the experiment using the PANAS-X. Results showed that high and low trait EI participants performed differently after the presen- tation of feedback on their ineffectiveness in helping others in need. Both groups showed increasing negative affective states during the experiment when the feedback was negative; however, high trait EI participants better managed their affective reactions, modulating the impact of their emotions on performance and maintaining a high level of motivation to help. In Study 2, we used a similar computerized task and tested a control situation to explore the effect of trait EI on participants\u2019 behavior when facing failure or success in a scenario unre- lated to helping others in need. No effect of feedback emerged on participants\u2019 emotional states in the second study. Taken together our results show that trait EI influences the impact of success and failure on behavior only in affect-rich situation like those in which people are asked to help others in need

Patient-centric trials for therapeutic development in precision oncology

An enhanced understanding of the molecular pathology of disease gained from genomic studies is facilitating the development of treatments that target discrete molecular subclasses of tumours. Considerable associated challenges include how to advance and implement targeted drug-development strategies. Precision medicine centres on delivering the most appropriate therapy to a patient on the basis of clinical and molecular features of their disease. The development of therapeutic agents that target molecular mechanisms is driving innovation in clinical-trial strategies. Although progress has been made, modifications to existing core paradigms in oncology drug development will be required to realize fully the promise of precision medicine

Checkpoints are blind to replication restart and recombination intermediates that result in gross chromosomal rearrangements

Replication fork inactivation can be overcome by homologous recombination, but this can cause gross chromosomal rearrangements that subsequently missegregate at mitosis, driving further chromosome instability. It is unclear when the chromosome rearrangements are generated and whether individual replication problems or the resulting recombination intermediates delay the cell cycle. Here we have investigated checkpoint activation during HR-dependent replication restart using a site-specific replication fork-arrest system. Analysis during a single cell cycle shows that HR-dependent replication intermediates arise in S phase, shortly after replication arrest, and are resolved into acentric and dicentric chromosomes in G2. Despite this, cells progress into mitosis without delay. Neither the DNA damage nor the intra-S phase checkpoints are activated in the first cell cycle, demonstrating that these checkpoints are blind to replication and recombination intermediates as well as to rearranged chromosomes. The dicentrics form anaphase bridges that subsequently break, inducing checkpoint activation in the second cell cycle

A critical look at studies applying over-sampling on the TPEHGDB dataset

Preterm birth is the leading cause of death among young children and has a large prevalence globally. Machine learning models, based on features extracted from clinical sources such as electronic patient files, yield promising results. In this study, we review similar studies that constructed predictive models based on a publicly available dataset, called the Term-Preterm EHG Database (TPEHGDB), which contains electrohysterogram signals on top of clinical data. These studies often report near-perfect prediction results, by applying over-sampling as a means of data augmentation. We reconstruct these results to show that they can only be achieved when data augmentation is applied on the entire dataset prior to partitioning into training and testing set. This results in (i) samples that are highly correlated to data points from the test set are introduced and added to the training set, and (ii) artificial samples that are highly correlated to points from the training set being added to the test set. Many previously reported results therefore carry little meaning in terms of the actual effectiveness of the model in making predictions on unseen data in a real-world setting. After focusing on the danger of applying over-sampling strategies before data partitioning, we present a realistic baseline for the TPEHGDB dataset and show how the predictive performance and clinical use can be improved by incorporating features from electrohysterogram sensors and by applying over-sampling on the training set

Improving wellbeing for victims of crime

Being the victim of a crime constitutes a profound and lasting trauma for individuals and their communities. Depending on the circumstances of their victimisation, crime victims have little choice but to live with painful feelings, memories and ongoing physical and emotional experiences that can make wellbeing difficult to achieve. Additionally, victims of crime continue to report that their experiences of, and interactions with criminal justice systems in the pursuit of justice and recovery has not restored agency or dignity, and instead add to their feelings of powerlessness, anonymity and trauma. For governments, the policy challenge is how the criminal justice system can play an active role in helping victims regain wellbeing, and particularly of agency and control in their lives. This paper offers a case study of a project undertaken by the criminal justice system in (anonymised), using a human centred design approach to create design directions that will better meet victims' needs. The paper will present the workshop methodology and outline the policy directions that resulted

Does physical activity counselling enhance the effects of a pedometer-based intervention over the long-term : 12-month findings from the Walking for Wellbeing in the West study

Peer reviewedPublisher PD