Improving wellbeing for victims of crime

Being the victim of a crime constitutes a profound and lasting trauma for individuals and their communities. Depending on the circumstances of their victimisation, crime victims have little choice but to live with painful feelings, memories and ongoing physical and emotional experiences that can make wellbeing difficult to achieve. Additionally, victims of crime continue to report that their experiences of, and interactions with criminal justice systems in the pursuit of justice and recovery has not restored agency or dignity, and instead add to their feelings of powerlessness, anonymity and trauma. For governments, the policy challenge is how the criminal justice system can play an active role in helping victims regain wellbeing, and particularly of agency and control in their lives. This paper offers a case study of a project undertaken by the criminal justice system in (anonymised), using a human centred design approach to create design directions that will better meet victims' needs. The paper will present the workshop methodology and outline the policy directions that resulted

The effect of post-exercise drink macronutrient content on appetite and energy intake

Carbohydrate and protein ingestion post-exercise are known to facilitate muscle glycogen resynthesis and protein synthesis, respectively, but the effects of post-exercise nutrient intake on subsequent appetite are unknown. This study aimed to investigate whether protein induced satiety that has been reported at rest was still evident when pre-loads were consumed in a post-exercise context. Using a randomized, double blind, crossover design, 12 unrestrained healthy males completed 30 min of continuous cycling exercise at ~60% VO2peak, followed by five, 3 min intervals at ~85% VO2peak. Ten min post-exercise, subjects consumed 500 ml of either a low energy placebo (15 kJ) (PLA); a 6% whey protein isolate drink (528 kJ) (PRO); or a 6% sucrose drink (528 kJ) (CHO). Sixty min after drink ingestion, a homogenous ad-libitum pasta lunch was provided and energy intake at this lunch was quantified. Subjective appetite ratings were measured at various stages of the protocol. Energy consumed at the ad-libitum lunch was lower after PRO (5831 ± 960 kJ) than PLA (6406 ± 492 kJ) (P0.315). Considering the post-exercise drink, total energy intake was not different between trials (P=0.383). There were no differences between trials for any of the subjective appetite ratings. The results demonstrate that where post-exercise liquid protein ingestion may enhance the adaptive response of skeletal muscle, and this may be possible without affecting gross energy intake relative to consuming a low energy drink

Best in Class International Franchising: Report for the UK Retail Sector

Retailing is such a fast-moving industry it is difficult to keep on top of changes in domestic markets, let alone those in geographically and culturally distant foreign markets. Although it is tempting for a UK-based retailer to remain domestic and focus on strengthening their competitive position in the UK before going overseas, the most successful retailers continuously explore what it takes to operate effectively across national borders. UK retailers need to “think bigger” if they are to escape the economic slowdown of Western Europe. There is now a renewed push for internationalisation by UK firms and they are setting adventurous growth targets. Retailing is fast becoming a global industry and it is vital for “UK plc” that our leading retailers are successful in emerging markets. Against this backdrop, we conducted a study of one type of foreign market entry mode, namely franchising. We propose that franchising is to retailing what exporting is to manufacturing. It is a low-risk, low-involvement way for retailers to enter risky foreign markets, but which nevertheless must be professionally executed. In order to shed light on how UK retailers can make franchising work in emerging markets, we focus on the advanced franchising model used by one particular retailer. This model has been developed over decades of steady expansion of its franchising operations overseas. As well as examining their franchising operations, the study gathered a range of other information on international franchising in order to develop a complete picture of good practices. It is unlikely that a firm with a fast-moving, complex product assortment (e.g., general merchandise) will be able to follow the franchising model of dealing with many small franchisees across many foreign markets (i.e., the McDonald’s model). Indeed, the focal retailer uses an area development franchising approach, targeting franchisees that have capabilities sufficient to develop and manage a franchisor-branded store network in their country or region. While not equals, given the franchisor’s ownership of the brand, such relationships operate as partnerships. Franchisees are empowered to exert influence and use their local know-how to help meet the precise needs of foreign customers. Unlike in traditional franchising partnerships, where the franchisor is in control and intensively monitors across its network of franchisees, we observe that cross-border franchising may be optimally developed through openly communicating with and trusting a capable partner. The differences between emerging markets and the UK can be so extreme that it is difficult for the franchisor to control operations there, irrespective of their resource base and experience. In effect, the franchisor is reliant on the franchisee to make and implement decisions in the local marketplace and absorb risks. The overseas franchisees can effectively play a role in building the brand with the franchisor through a form of alliance. Knowledge exchange is crucial not only in the running of the franchise partnership but also for the franchisor’s learning about local market conditions and growth opportunities. When operating in emerging markets the franchisor needs to “learn from their experiences all the time”. UK retail brands resonate strongly amongst aspirational, emerging market customers. Yet, retailers can be slow to go overseas if they perceive differences in, and lack familiarity with, foreign markets. This is where franchising comes in. Far from being a basic business model, best-in-class franchising can be made to play a central role in overseas retailing due to its ability to mitigate threats and seek out growth opportunities. Furthermore, UK retailers can derive flexibility advantages from using franchising in emerging markets as the basis upon which to expand into other, higher-profit equity-based modes (e.g., joint ventures) if and when local circumstances dictate this

Inherited polyglutamine spinocerebellar ataxias in South Africa

Objective. To determine the frequency and distribution ofpolyglutamine spinocerebellar ataxias (SCAs) from referrals over a24-year period to the National Health Laboratory Service (NHLS)in South Africa (SA).Methods. Paper-based clinical reports in the University ofCape Town laboratory and the NHLS electronic patient recorddatabase spanning a 24-year period were mined for informationregarding the molecular diagnosis, ethnicity and CAG repeatlength for individuals referred for molecular genetic testing for thepolyglutamine SCAs.Results. SCA1 and 7 are the most frequent types of polyglutamineSCA in the SA patient population, followed by SCA2, 3 and 6.SCA1 is the most common type in the coloured, white and Indianpopulations, whereas the majority of indigenous black Africanpatients are affected with SCA7 and 2. Of individuals tested, 22%were found to be positive for one of the polyglutamine SCAs.Conclusion. Although trends in the frequency and distributionof the polyglutamine SCAs in SA have not changed significantlysince our previous study in 2003, they differ remarkably from thosereported elsewhere, and reflect the unique genetic and demographicbackground of SA. The provision of accurate and complete patientinformation and family history is crucial to the diagnostic process,to enable comprehensive epidemiological studies and assist indeveloping therapeutic and patient management strategies

Terrestrial exposure of a fresh Martian meteorite causes rapid changes in hydrogen isotopes and water concentrations

Determining the hydrogen isotopic compositions and H2O contents of meteorites and their components is important for addressing key cosmochemical questions about the abundance and source(s) of water in planetary bodies. However, deconvolving the effects of terrestrial contamination from the indigenous hydrogen isotopic compositions of these extraterrestrial materials is not trivial, because chondrites and some achondrites show only small deviations from terrestrial values such that even minor contamination can mask the indigenous values. Here we assess the effects of terrestrial weathering and contamination on the hydrogen isotope ratios and H2O contents of meteoritic minerals through monitored terrestrial weathering of Tissint, a recent Martian fall. Our findings reveal the rapidity with which this weathering affects nominally anhydrous phases in extraterrestrial materials, which illustrates the necessity of sampling the interiors of even relatively fresh meteorite falls and underlines the importance of sample return missions

Conservation implications and opportunities of mining activities for terrestrial mammal habitat

Mining companies increasingly commit to a net positive impact on biodiversity. However, assessing the industry's progress toward achieving this goal is limited by knowledge of current mining threats to biodiversity and the relevant opportunities available for them to improve conservation outcomes. Here, we investigate the global exposure of terrestrial mammal habitat to mining activities, revealing the 136 species with > 30% of their habitat within 10 km of a mining property or exploration site. One third (n = 42) of these species are already threatened with extinction according to the International Union for Conservation of Nature (IUCN), suggesting projected increased demand for minerals may push some species beyond critical thresholds. Moreover, 28% (n = 33) of species are Data Deficient, illustrating tangible ways for industry to fill current knowledge gaps. However, large discrepancies between our results and the species currently listed as threatened by mining in the IUCN Red List, suggest other species may be at risk and that conservation tools and analyses based on these data may underestimate the benefits of averting such threats. We recommend ways to better capture mining threats to species within IUCN Red List assessments and discuss how these changes could improve conservation outcomes in mineral-rich areas

4D BIM integrated construction supply chain logistics to optimise on-site production

Loss of productivity through on-site delays and disruptions is a significant problem in the construction industry. This can be caused by workforce, materials, and equipment clashes. A major need for the industry is to improve construction logistic efficiencies for materials and equipment from manufacture to the point of use by the workforce. The authors investigate the effectiveness and efficiency of integrated construction supply chain logistics (ICSCL) using 4D Building Information Models (BIM), via three information streams: literature, a case study of the Elephant and Castle project (E&C), and a survey from UK construction professionals. The results illustrate, although BIM of various levels is currently in use throughout the UK, 4D BIM for ICSCL is not extensively utilised due to an absence of strategy, perceived costs of IT, and training requirements. That use could potentially add value with a trusted supply chain and disciplined planning using a multiple stream logistic model

18F-FDG PET/MRI for staging and interim response assessment in pediatric and adolescent Hodgkin lymphoma: a prospective study with 18F-FDG PET/CT as reference standard

Rationale: Treatment regimens for pediatric Hodgkin's lymphoma (HL) depend on accurate staging and treatment response assessment, based on accurate disease distribution and metabolic activity depiction. With the aim of radiation dose reduction, we compared the diagnostic performance of 18F-FDG PET/MR to a 18F-FDG PET/CT reference standard for staging and response assessment. Methods: Twenty-four patients (mean age 15.4 years, range 8-19.5 years) with histologically proven HL were prospectively and consecutively recruited in 2015 and 2016, undergoing both 18F-FDG PET/CT and 18F-FDG PET/MRI at initial staging (N n = 24) and at response assessment (N n = 21). Diagnostic accuracy of 18F-FDG PET/MRI for both nodal and extra-nodal disease was compared to 18F-FDG PET/CT, which was considered as the reference standard. Discrepancies were retrospectively classified as perceptual or technical errors and 18F-FDG PET/MRI and 18F-FDG PET/CT were corrected by removing perceptual error. Agreement with Ann-Arbor staging and Deauville grading was also assessed. Results: For nodal and extranodal sites combined, corrected staging 18F-FDG PET/MRI sensitivity was 100% (95% confidence interval (CI) 96.7%-100%), specificity 99.5% (95%CI 98.3%-99.9%). Corrected response assessment 18F-FDG PET/MRI sensitivity was 83.3% (95%CI 36.5%-99.1%), specificity 100% (95%CI 99.2%-100%). Modified Ann-Arbor staging agreement between F18-FDG PET/CT and 18F-FDG PET/MRI was perfect (k = 1.0, P = 0.000). Deauville grading agreement between 18F-FDG PET/MRI and 18F-FDG PET/CT was excellent (k = 0.835, P = 0.000). Conclusion:18F-FDG PET/MRI is a promising alternative to 18F-FDG PET/CT for staging and response assessment in children with Hodgkin lymphoma