29 research outputs found
Does Childhood Executive Function Predict Adolescent Functional Outcomes in Girls with ADHD?
We prospectively followed an ethnically and socioeconomically diverse sample of preadolescent girls with ADHD (n = 140) and matched comparison girls (n = 88) over a period of 5 years, from middle childhood through early/mid-adolescence. Our aim was to examine the ability of measures of childhood executive function (EF) to predict functional outcomes in adolescence. Measures of neuropsychological functioning comprised the childhood predictors, with academic, social, and global functioning serving as adolescent criterion measures. Results indicated that childhood EF predicted (a) academic achievement and social functioning across our entire sample (independent of diagnostic group status) and (b) global functioning only in girls with ADHD (independent of IQ). These results highlight the non-specificity of EF deficits and suggest the importance of assessing and developing interventions that target EF impairments, particularly in those at high-risk for negative outcomes, in order to prevent long-term difficulties across a range of important functional domains
The reductive glycine pathway allows autotrophic growth of Desulfovibrio desulfuricans
Supplementary informationis available for this paper athttps://doi.org/10.1038/s41467-020-18906-7Six CO2 fixation pathways are known to operate in photoautotrophic and chemoautotrophic microorganisms. Here, we describe chemolithoautotrophic growth of the sulphate-reducing bacterium Desulfovibrio desulfuricans (strain G11) with hydrogen and sulphate as energy substrates. Genomic, transcriptomic, proteomic and metabolomic analyses reveal that D. desulfuricans assimilates CO2 via the reductive glycine pathway, a seventh CO2 fixation pathway. In this pathway, CO2 is first reduced to formate, which is reduced and condensed with a second CO2 to generate glycine. Glycine is further reduced in D. desulfuricans by glycine reductase to acetyl-P, and then to acetyl-CoA, which is condensed with another CO2 to form pyruvate. Ammonia is involved in the operation of the pathway, which is reflected in the dependence of the autotrophic growth rate on the ammonia concentration. Our study demonstrates microbial autotrophic growth fully supported by this highly ATP-efficient CO2 fixation pathway.We acknowledge Änne-Michaelis and William Newell for assistance with the LC-MS forthe metabolomics experiments and Daniel Amador-Noguez for access to the LC-MS usedfor13C intracellular metabolomic analysis. We thank Ines Cardoso Pereira and John vander Oost for critically reading the manuscript. This research was funded by the Neth-erlands Organisation for Scientific Research (NWO) through SIAM Gravitation Grant024.002.002 and the Innovation Program Microbiology (WUR), NJC acknowledgesfunding from NWO through a Rubicon Grant (019.163LW.035) and a Veni Grant(VI.Veni.192.156).info:eu-repo/semantics/publishedVersio
Gender difference in aerobic capacity in adolescents after cure from malignant disease in childhood.
Fluid flow through the sedimentary cover in northern Switzerland recorded by calcite-celestite veins (Oftringen borehole, Olten)
Abundant veins filled by calcite, celestite and pyrite were found in the
core of a 719 m deep borehole drilled in Oftringen near Olten, located
in the north-western Molasse basin, close to the thrust of the Folded
Jura. Host rocks are calcareous marl, argillaceous limestone and
limestone of the Dogger and Malm. The delta O-18 values of vein calcite
are lower than in host rock carbonate and, together with
microthermometric data from fluid inclusions in vein calcite, indicate
precipitation from a seawater-dominated fluid at average temperatures of
56-68A degrees C. Such temperatures were reached at the time of maximum
burial of the sedimentary pile in the late Miocene. The depth profile of
delta C-13 and Sr-87/Sr-86 values and Sr content of both whole-rock
carbonate and vein calcite show marked trends towards negative delta
C-13, high Sr-87/Sr-86, and low Sr content in the uppermost 50-150 m of
the Jurassic profile (upper Oxfordian). The Sr-87/Sr-86 of vein minerals
is generally higher than that of host rock carbonate, up to very high
values corresponding to Burdigalian seawater (Upper Marine Molasse,
Miocene), which represents the last marine incursion in the region. No
evidence for internally derived radiogenic Sr (clay minerals) has been
found and so an external source is required. S and O isotope composition
of vein celestite and pyrite can be explained by bacterial reduction of
Miocene seawater sulphate. The available data set suggests the vein
mineralization precipitated from descending Burdigalian seawater and not
from a fluid originating in the underlying Triassic evaporites
Clinical and empirical applications of the Rey-Osterrieth Complex Figure Test
The Rey-Osterrieth Complex Figure Test (ROCF), which was developed by Rey in 1941 and standardized by Osterrieth in 1944, is a widely used neuropsychological test for the evaluation of visuospatial constructional ability and visual memory. Recently, the ROCF has been a useful tool for measuring executive function that is mediated by the prefrontal lobe. The ROCF consists of three test conditions: Copy, Immediate Recall and Delayed Recall. At the first step, subjects are given the ROCF stimulus card, and then asked to draw the same figure. Subsequently, they are instructed to draw what they remembered. Then, after a delay of 30 min, they are required to draw the same figure once again. The anticipated results vary according to the scoring system used, but commonly include scores related to location, accuracy and organization. Each condition of the ROCF takes 10 min to complete and the overall time of completion is about 30 min