The ice-maiden ; and, The story of my life /

"Dalziel Brothers, Engravers & Printers"--T.p. verso.The ice-maiden -- The story of my life.Mode of access: Internet.From the Janice Dohm Collection

Temporary urbanism and urban sustainability after a natural disaster: transitional community-initiated open spaces in Christchurch, New Zealand

Temporary uses of vacant urban spaces are usually not foreseen in conventional urban planning and have often been linked to economic or political disturbances. In New Zealand, Christchurch’s vacant spaces came into existence after the city was hit by several devastating earthquakes in 2010 and 2011. Parallel to the ‘official’ rebuild discourse, temporary uses have emerged on vacant post-earthquake sites including community gardens, urban agriculture, art installations, event venues, eateries and cafés, and pocket parks. Based on the review and analysis of exemplary transitional community-initiated open spaces and correlated literature, the paper looks at how the post-disaster urban context in Christchurch has influenced particular aspects of temporary urbanism in comparison with case studies in non-disaster environments. By focusing on the anticipated benefits of community-initiated open spaces, the paper discusses the relevance of temporary uses of vacant urban spaces for urban sustainability in relationship to concepts of community resilience and raises questions about possible long-term values. © 2015 Taylor & Francis

D-livering the message:The importance of vitamin D status in chronic liver disease

SummaryVitamin D is synthesized predominantly in the liver and functions as an important secosteroid hormone with pleiotropic effects. While its key regulatory role in calcium and bone homeostasis is well established, recently there is increasing recognition that vitamin D also regulates cell proliferation and differentiation, and has immunomodulatory, anti-inflammatory and anti-fibrotic properties. These non-skeletal effects are relevant in the pathogenesis and treatment of many causes of chronic liver disease. Vitamin D deficiency is frequently present in chronic liver disease and may predict non-response to antiviral therapy in chronic hepatitis C. Small studies suggest that vitamin D supplementation improves sustained viral response rates, while 1α-hydroxylase polymorphisms and vitamin D-binding protein are also implicated in therapeutic outcomes. Vitamin D deficiency also closely relates to the severity of non-alcoholic fatty liver disease (NAFLD) and is implicated in the pathogenesis of insulin resistance, a key factor in the development of NAFLD. In preclinical studies, phototherapy and vitamin D supplementation ameliorate NAFLD histopathology, while vitamin D is a powerful anti-fibrotic against thioacetamide liver injury. In liver transplant recipients severe vitamin D deficiency predicts, and vitamin D supplementation prevents, acute cellular rejection. The role of vitamin D in the activation and regulation of both innate and adaptive immune systems may explain its importance in the above liver diseases. Further prospective studies are therefore warranted to investigate the therapeutic impact of vitamin D supplementation in chronic liver disease