Ser, Nada, Devir. Hegel e nós – Uma formalização

Despite its great speculative relevance and despite the fact that it is the very foundation of the Hegelian system, The Science of Logic by G. W. F. Hegel is practically an illegible book nowadays. Even for Germans it is a difficult reading. Other books by Hegel (except for the Encyclopedia) are reasonably readable. This is not the case of The Science of Logic. Almost all technical terms used by Hegel are defined by a conceptual network, in which the components are themselves related to one another. That is the reason for the difficulty of finding a reading guide to direct the reader from one chapter to the next. Initially, the authors of the present paper try to translate Hegel’s typical language into usual English, even if some of the richness of the original text is lost. In a second step, they attempt to formalize what has been translated. There is no intention of keeping fidelity to Hegelian orthodoxy; on the contrary, the authors attempt to correct everything they think is an error in the Hegelian system. Key words: dialectics, Hegel, formalization.A Ciência da Lógica de G. W. F. Hegel, embora de grande importância especulativa e embora seja o fundamento de todo o sistema hegeliano, tornou-se hoje um livro praticamente ilegível mesmo para pessoas de língua alemã. As outras obras (exceto a Enciclopédia) de Hegel são razoavelmente legíveis, A Ciência da Lógica, não. Isso porque quase todos os termos técnicos empregados por Hegel se definem por uma rede de remissões em que cada conceito adquire seu sentido pelo lugar que ocupa na rede de relações categoriais que, por sua vez, só são determinadas pelo mesmo método. Daí a dificuldade de encontrar um fio condutor que conduza o leitor de capítulo em capítulo. Os autores tentam, neste trabalho, num primeiro passo, traduzir o linguajar hegeliano – mesmo com a perda da riqueza que isso acarreta – para o inglês de hoje. Num segundo passo, é feita a tentativa de formalizar o que foi elaborado antes. – Não há a menor pretensão de fidelidade à ortodoxia hegeliana; muito pelo contrário, o que os autores consideraram erros do sistema foi objeto de tentativa de correção. Palavras-chave: dialética, Hegel, formalização

Epigenomics in Hurthle Cell Neoplasms: Filling in the Gaps Towards Clinical Application

It has been widely described that cancer genomes have frequent alterations to the epigenome, including epigenetic silencing of various tumor suppressor genes with functions in almost all cancer-relevant signalling pathways, such as apoptosis, cell proliferation, cell migration and DNA repair. Epigenetic alterations comprise DNA methylation, histone modification, and microRNAs dysregulated expression and they play a significant role in the differentiation and proliferation properties of TC. In this review, our group assessed the published evidence on the tumorigenic role of epigenomics in Hurthle cell neoplasms (HCN), highlighting the yet limited, heteregeneous and non-validated data preventing its current use in clinical practice, despite the well developed assessment techniques available. The identified evidence gaps call for a joint endeavour by the medical community towards a deeper and more systematic study of HCN, aiming at defining epigenetic markers in early diagnose, allowing for accurate stratification of maligancy and disease risk and for effective systemic treatment.This work was financed by FEDER—Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 —Operacional Programme for Competitiveness and Internationalization (POCI), Portugal 2020, and by Portuguese funds through FCT - Fundação para a Ciência e a Tecnologia/ Ministério da Ciência, Tecnologia e Inovação in the framework of the project “Institute for Research and Innovation in Health Sciences” (POCI-01-0145-FEDER-007274). Additional funding by the European Regional Development Fund (ERDF) through the Operational Programme for Competitiveness and Internationalization—COMPETE2020, and Portuguese national funds via FCT, under project POCI-01-0145-FEDER-016390: CANCEL STEM and from the FCT under the project POCI-01-0145-FEDER-031438: The other faces of telomerase: Looking beyond tumor immortalization (PDTC/MED_ONC/ 31438/2017). Additional funding through the Sociedade Portuguesa de Endocrinologia, Diabetes e Metabolismo – Bolsa Edward Limbert MERCK/SPEDM 2019. SC is supported by FCT in the framework of a PhD grant (SFRH/BD/ 147650/2019)

Development, Test and Validation of a Mechatronic Device for Spasticity Quantification

Abstract Spasticity is a common pathological phenomenon in clinical practices, frequently expressed as a stroke, multiple sclerosis or cerebral palsy. The accurate quantification of spasticity allows early action to prevent the potentially irreversible consequences. The aim of this work is to develop and implement a mechatronic device for the accurate quantification of spasticity, which is able to differentiate spasticity from other motor disorders. The proposed method is based on the quantification of the tonic stretch reflex threshold (TSRT) for the assessment of the range of motion of the limb affected by spasticity. In order to validate the developed device, experimental trials have been conducted, considering the flexor muscle of the elbow joint. The developed device was tested, first in a laboratory environment with healthy subjects and secondly, in a clinical environment with the collaboration of patients with spasticity. The evaluations in th clinical environment were performed on three different days in order to evaluate the reproducibility of the obtained results. The experimental trials confirm the sensibility, reproducibility and reliability of spasticity quantification based on the TSRT method. This project has been developed in cooperation with the Hospital of Braga and Fisimaia rehabilitation clinic, both in Portugal

Ofertórios: um microcosmo estilístico de André da Silva Gomes (1752-1844)

Os ofertórios de André da Silva Gomes apresentam muitas características comuns concernentes aos parâmetros composicionais que comportam diferentes encaminhamentos no trato musical dos textos litúrgicos. Os elementos de sintaxe musical estão fundamentados nas soluções de expressividade associadas ao Barroco, incluindo o uso constante de figuras retórico-musicais, e são analisados à luz dos preceitos expostos no seu tratado musical A Arte Explicada do Contraponto. Essa série de obras pode ser considerada um microcosmo estilístico do compositor ao transitar com liberdade pelos diferentes estilos musicais vigentes em sua época, desde as rigorosas escolas de escrita contrapontística dos séculos XVI e XVIII, à importante música napolitana adaptada aos horizontes ibero-brasileiros

Dynamin-related protein 1 at the crossroads of cancer

Mitochondrial dynamics are known to have an important role in so-called age-related diseases, including cancer. Mitochondria is an organelle involved in many key cellular functions and responds to physiologic or stress stimuli by adapting its structure and function. Perhaps the most important structural changes involve mitochondrial dynamics (fission and fusion), which occur in normal cells as well as in cells under dysregulation, such as cancer cells. Dynamin-related protein 1 (DRP1), a member of the dynamin family of guanosine triphosphatases (GTPases), is the key component of mitochondrial fission machinery. Dynamin-related protein 1 is associated with different cell processes such as apoptosis, mitochondrial biogenesis, mitophagy, metabolism, and cell proliferation, differentiation, and transformation. The role of DRP1 in tumorigenesis may seem to be paradoxical, since mitochondrial fission is a key mediator of two very different processes, cellular apoptosis and cell mitosis. Dynamin-related protein 1 has been associated with the development of distinct human cancers, including changes in mitochondrial energetics and cellular metabolism, cell proliferation, and stem cell maintenance, invasion, and promotion of metastases. However, the underlying mechanism for this association is still being explored. Herein, we review the published knowledge on the role of DRP1 in cancer, exploring its interaction with different biological processes in the tumorigenesis context.Acknowledgments: The authors would like to acknowledge all the members of the Cancer Signalling and Metabolism research group at IPATIMUP/i3S for their input on different topics of the manuscript. This work was supported by Portuguese funds through FCT—Fundação para a Ciência e a Tecnologia—in the framework of project UID/BIM/04293/2013. It was also financed by FEDER—Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020—Operational Program for Competitiveness and Internationalization (POCI), Portugal 2020, and by Portuguese funds through FCT—Fundação para a Ciência e Tecnologia/Ministério da Ciência, Tecnologia e Inovação in the framework of the projects “Institute for Research and Innovation in Health Sciences” (POCI-01-0145-FEDER-007274). Further funding was obtained from the project “Advancing cancer research: from basic knowledgment to application” NORTE-01-0145-FEDER-000029: “Projetos Estruturados de I & D & I”, funded by Norte 2020—Programa Operacional Regional do Norte

Seasonality of net radiation in two sub-basins of Paractu by the use of modis sensor products.

The net radiation (Rn) represents the main source of energy for physical and chemical processes that occur in the surface-atmosphere interface, and it is used for air and soil heating, water transfer, in the form of vapor from the surface to the atmosphere, and for the metabolism of plants, especially photosynthesis. If there is no record of net radiation in certain areas, the use of information is important to help determine it. Among them we can highlight those provided by remote sensing. In this context, this work aims to estimate the net radiation, with the use of products of MODIS sensor, in the sub-basins of Entre Ribeiros creek and Preto River, located between the Brazilian states of Goiás and Minas Gerais. The SEBAL (Surface Energy Balance Algorithm for Land) was used to obtain the Rn in four different days in the period of July to October, 2007. The Rn results obtained were consistent with others cited in the literature and are important because the orbital information can help determine the Rn in areas where there are not automatic weather stations to record the net radiation

Ser, Nada, Devir. Hegel e nós – Uma formalização

Despite its great speculative relevance and despite the fact that it is the very foundation of the Hegelian system, The Science of Logic by G. W. F. Hegel is practically an illegible book nowadays. Even for Germans it is a difficult reading. Other books by Hegel (except for the Encyclopedia) are reasonably readable. This is not the case of The Science of Logic. Almost all technical terms used by Hegel are defined by a conceptual network, in which the components are themselves related to one another. That is the reason for the difficulty of finding a reading guide to direct the reader from one chapter to the next. Initially, the authors of the present paper try to translate Hegel’s typical language into usual English, even if some of the richness of the original text is lost. In a second step, they attempt to formalize what has been translated. There is no intention of keeping fidelity to Hegelian orthodoxy; on the contrary, the authors attempt to correct everything they think is an error in the Hegelian system. Key words: dialectics, Hegel, formalization.A Ciência da Lógica de G. W. F. Hegel, embora de grande importância especulativa e embora seja o fundamento de todo o sistema hegeliano, tornou-se hoje um livro praticamente ilegível mesmo para pessoas de língua alemã. As outras obras (exceto a Enciclopédia) de Hegel são razoavelmente legíveis, A Ciência da Lógica, não. Isso porque quase todos os termos técnicos empregados por Hegel se definem por uma rede de remissões em que cada conceito adquire seu sentido pelo lugar que ocupa na rede de relações categoriais que, por sua vez, só são determinadas pelo mesmo método. Daí a dificuldade de encontrar um fio condutor que conduza o leitor de capítulo em capítulo. Os autores tentam, neste trabalho, num primeiro passo, traduzir o linguajar hegeliano – mesmo com a perda da riqueza que isso acarreta – para o inglês de hoje. Num segundo passo, é feita a tentativa de formalizar o que foi elaborado antes. – Não há a menor pretensão de fidelidade à ortodoxia hegeliana; muito pelo contrário, o que os autores consideraram erros do sistema foi objeto de tentativa de correção. Palavras-chave: dialética, Hegel, formalização

Water productivity in function of the regulated deficit of irrigation in the phase of maturation of grape Apirênica in the Valley of the San Francisco.

The aim of this work was to evaluate the effects o f irrigation water depths and cut-off timing in the maturation stage of Superior Seedles s grape grown in the of the San Francisco River region , to obtain simultaneously maximum yields and water use efficiency

The present and future offshore wind resource in the Southwestern African region

In the last decades, offshore wind harvesting has increased enormously, and is seen as a renewable energy resource with great potential in many regions of the world. Therefore, it is crucial to understand how this resource will evolve in a warming climate. In the present study, offshore wind resource in the Southwestern African region is analysed for the present and future climates. A ROM (REMO-OASIS-MPIOM) climate simulation in uncoupled and coupled atmosphere–ocean mode, at 25 km horizontal resolution, and a multi-model ensemble built with a set of regional climate models from the CORDEX-Africa experiment at 0.44° resolution were used. The projected changes of the offshore wind energy density throughout the twenty-first century are examined following the RCP4.5 and RCP8.5 greenhouse gas emissions scenarios. Characterised by strong coastal-parallel winds, the Southwestern African offshore region shows high values of wind energy density at 100 m, up to 1500 Wm⁻² near the coast, particularly offshore Namibia and west South Africa. Conversely, along Angola’s coast the available offshore wind energy density is lower. Throughout the twenty-first century, for the weaker climate mitigation scenario (RCP8.5), an increase of the offshore wind resource is projected to occur along Namibia and South African western coasts, more pronounced at the end of the century (+ 24%), while a decrease is projected along Angola’s coasts, reaching a negative anomaly of about − 32%. Smaller changes but with the same pattern are projected for the stronger climate mitigation scenario (RCP4.5). The future deployment of offshore floating hub turbines placed at higher heights may allow higher production of energy in this region. Along offshore Namibia and west South Africa, the wind energy density at 250 m showed differences that range between 30 and 50% relative to wind energy density at 100 m