3,4-Vinylenedioxythiophene (VDOT): a new building block for thiophene-based π-conjugated systems

The synthesis of the title compound and its use as a building block in π-conjugated systems are presented

New Use for a Compound as a Matrix in the Specific Detection, Identification and/or Quantification of Alkaloids by MALDI-TOF Mass Spectrometry

The present invention relates to (i) a method of analysing small molecules that may have a mass of < 800 Da, in particular alkaloids, said method being generally referred to as MALDI-TOF-MS (or MALDI Time-of-Flight MAss Spectrometry) which is an acronym for a method of analysis by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry, to (ii) a molecule according to formula (I) and to the use thereof as a matrix in such an analysis method

Effects of structural factors on the pi-dimerization and/or disproportionation of the cation radical of extended TTF containing thiophene-based pi-conjugated spacers.

The electrochemical and chemical oxidation of extended TTF 4 and 5 are analysed by cyclic voltammetry, Visible/NIR and ESR spectroscopies, and the X-ray structures of the new salts 5·BF4(CH2Cl2) and 4·ClO4(THF)1/2 are presented. The effects of structural factors on the π-dimerization or the disproportionation reaction of the cation radical are shown. The oxidation of compound 4 presents the successive formation of stable cation radical and dication species both in dichloromethane (DCM) and in a CH3CN/THF mixture. In contrast, for compound 5, the stability of the oxidation states strongly depends on the nature of the solvent. In DCM, the oxidation of 5 proceeds by two close one-electron transfers while in CH3CN/THF the dication is directly formed via a two-electron process. The X-ray structures of the two salts reveal the formation of pi-dimers of cation radical. While the dimer (5(2))2+ is due mainly to π–π interactions between the conjugating spacer, the multiplication of the sulfur atoms in compound 4 contributes to stabilize the dimer by the combined effects of S–S and π–π interactions. Visible/NIR and ESR experiments confirm the higher tendency of 4+· to dimerize with the occurrence of dimer and monomer in solution, while for 5+· only the monomer is detected in DCM. On the other hand, by dissolution of 5·BF4(CH2Cl2) in CH3CN, only the neutral and the dicationic states of compounds 5 are observed owing to the disproportionation reaction

Synthesis and evaluation of naphthoic acid derivatives as fluorescent probes to screen advanced glycation end-products breakers

Advanced glycation end-products, namely AGEs, are involved in the pathogenesis of numerous diseases. If AGEs inhibitors are well-known, only few products are described as compounds able to destroy those deleterious products. In this work, we describe naphthoic acid derivatives, particularly 1-(naphthalen-1-yl)propane-1,2-dione 9, allowing the simple and rapid detection of AGEs breakers using a 96-well microplate fluorescence assay. Since the inaugurate publication about AGEs breakers whose activity was demonstrated using HPLC analysis, this work proposes the first assay suitable for automated and high throughput screening of AGEs breakers

Diagnosis and Management of Field Pollution in the Case of an Organochlorine Pesticide, the Chlordecone

International audienc

Matrix for specific detection of alkaloids by MALDI-​TOF mass spectrometry

The présent invention relates to a novel bithiophenic matrix for spécifie détection of alkaloids by MALDI-TOF mass spectrometr

On making nD images well-composed by a self-dual local interpolation

International audienceNatural and synthetic discrete images are generally not well-composed, leading to many topological issues: connectivities in binary images are not equivalent, the Jordan Separation theorem is not true anymore, and so on. Conversely, making images well-composed solves those problems and then gives access to many powerful tools already known in mathematical morphology as the Tree of Shapes which is of our principal interest. In this paper, we present two main results: a characterization of 3D well-composed gray-valued images; and a counter-example showing that no local self-dual interpolation satisfying a classical set of properties makes well-composed images with one subdivision in 3D, as soon as we choose the mean operator to interpolate in 1D. Then, we briefly discuss various constraints that could be interesting to change to make the problem solvable in nD